Published in Nat Med on August 31, 2003
Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior. Proc Natl Acad Sci U S A (2004) 2.11
MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells. Immunity (2014) 1.95
The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol (2010) 1.95
Glucocorticoids suppress bone formation via the osteoclast. J Clin Invest (2006) 1.92
Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection. PLoS Pathog (2010) 1.88
Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase. Blood (2007) 1.48
Glucocorticoids in T cell apoptosis and function. Cell Mol Life Sci (2006) 1.48
The role of the forebrain glucocorticoid receptor in acute and chronic stress. Endocrinology (2008) 1.45
Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning. Proc Natl Acad Sci U S A (2008) 1.41
The five Rs of glucocorticoid action during inflammation: ready, reinforce, repress, resolve, and restore. Trends Endocrinol Metab (2013) 1.21
Transcriptome analysis of age-, gender- and diet-associated changes in murine thymus. Cell Immunol (2007) 1.14
Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. Proc Natl Acad Sci U S A (2011) 1.12
Deletion of forebrain glucocorticoid receptors impairs neuroendocrine stress responses and induces depression-like behavior in males but not females. Neuroscience (2011) 1.07
Hypothalamic-pituitary-adrenal axis dysregulation and behavioral analysis of mouse mutants with altered glucocorticoid or mineralocorticoid receptor function. Stress (2008) 1.06
One hormone, two actions: anti- and pro-inflammatory effects of glucocorticoids. Neuroimmunomodulation (2014) 1.02
Changing glucocorticoid action: 11β-hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation. J Steroid Biochem Mol Biol (2013) 0.97
Two nested developmental waves demarcate a compartment boundary in the mouse lung. Nat Commun (2014) 0.96
Glucocorticoid-induced apoptosis of healthy and malignant lymphocytes. Prog Brain Res (2010) 0.96
Stress-induced glucocorticoids at the earliest stages of herpes simplex virus-1 infection suppress subsequent antiviral immunity, implicating impaired dendritic cell function. J Immunol (2010) 0.94
A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure. Am J Physiol Endocrinol Metab (2012) 0.94
Dynamic modulation of thymic microRNAs in response to stress. PLoS One (2011) 0.92
Disrupting hypothalamic glucocorticoid receptors causes HPA axis hyperactivity and excess adiposity. Mol Endocrinol (2013) 0.91
TAK1 targeting by glucocorticoids determines JNK and IkappaB regulation in Toll-like receptor-stimulated macrophages. Blood (2010) 0.90
Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation. J Neurosci (2013) 0.89
Behavioral insights from mouse models of forebrain--and amygdala-specific glucocorticoid receptor genetic disruption. Mol Cell Endocrinol (2010) 0.88
Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. Br J Cancer (2009) 0.86
The intracellular progesterone receptor regulates CD4+ T cells and T cell-dependent antibody responses. J Leukoc Biol (2013) 0.86
Defining brain region-specific glucocorticoid action during stress by conditional gene disruption in mice. Brain Res (2009) 0.85
Glucocorticoid receptors in the retina, Müller glia and the formation of Müller glia-derived progenitors. Development (2014) 0.85
Genetic Approaches to Hypothalamic-Pituitary-Adrenal Axis Regulation. Neuropsychopharmacology (2015) 0.83
Brain-specific homeobox factor as a target selector for glucocorticoid receptor in energy balance. Mol Cell Biol (2013) 0.82
Adipocyte glucocorticoid receptors mediate fat-to-brain signaling. Psychoneuroendocrinology (2015) 0.80
Site-specific modulation of brain glucocorticoid receptor and corticotropin-releasing hormone expression using lentiviral vectors. Mol Cell Endocrinol (2012) 0.79
Thymus-derived glucocorticoids are insufficient for normal thymus homeostasis in the adult mouse. BMC Immunol (2004) 0.78
Knockdown of BNST GluN2B-containing NMDA receptors mimics the actions of ketamine on novelty-induced hypophagia. Transl Psychiatry (2013) 0.77
Forebrain glucocorticoid receptor gene deletion attenuates behavioral changes and antidepressant responsiveness during chronic stress. Brain Res (2014) 0.76
Transforming growth factor-β-activated kinase 1 resistance limits glucocorticoid responsiveness to Toll-like receptor 4-mediated inflammation. Immunology (2015) 0.76
Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation. Endocrinology (2016) 0.75
Glucocorticoids and Reproduction: Traffic Control on the Road to Reproduction. Trends Endocrinol Metab (2017) 0.75
Increased antidepressant sensitivity after prefrontal cortex glucocorticoid receptor gene deletion in mice. Physiol Behav (2014) 0.75
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34
Racial disparity in the frequency of recurrence of preterm birth. Am J Obstet Gynecol (2007) 4.30
53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature (2008) 3.47
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature (2006) 3.35
Paternal race is a risk factor for preterm birth. Am J Obstet Gynecol (2007) 3.24
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell (2007) 2.78
Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice. Hepatology (2004) 2.62
Genetic epidemiologic studies of preterm birth: guidelines for research. Am J Obstet Gynecol (2007) 2.56
An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development (2002) 2.31
Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults. Neurobiol Dis (2004) 2.24
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J (2012) 2.21
The imprinted gene Magel2 regulates normal circadian output. Nat Genet (2007) 2.18
Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior. Proc Natl Acad Sci U S A (2004) 2.11
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol Cell (2009) 2.08
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell (2013) 2.05
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol (2009) 1.98
An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-alpha and -beta knockout mice. Proc Natl Acad Sci U S A (2003) 1.93
Glucocorticoids suppress bone formation via the osteoclast. J Clin Invest (2006) 1.92
Ethanol-induced caspase-3 activation in the in vivo developing mouse brain. Neurobiol Dis (2002) 1.92
DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature (2008) 1.88
Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. J Neurosci (2005) 1.87
Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J (2009) 1.83
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers. Nat Immunol (2012) 1.82
Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases. Neuron (2002) 1.79
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature (2010) 1.78
A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma. J Lipid Res (2011) 1.76
Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG. Cell Cycle (2009) 1.75
Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host Microbe (2007) 1.71
Vascular respiratory uncoupling increases blood pressure and atherosclerosis. Nature (2005) 1.68
Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family. J Cell Biol (2005) 1.68
The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol (2012) 1.64
The growth factor midkine is modulated by both glucocorticoid and retinoid in fetal lung development. Am J Respir Cell Mol Biol (2003) 1.62
Forebrain glucocorticoid receptors modulate anxiety-associated locomotor activation and adrenal responsiveness. J Neurosci (2006) 1.56
Genetic contributions to preterm birth: implications from epidemiological and genetic association studies. Ann Med (2008) 1.51
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med (2009) 1.50
Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc. Proc Natl Acad Sci U S A (2009) 1.50
Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase. Blood (2007) 1.48
Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse. Eur J Immunol (2008) 1.48
Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning. Proc Natl Acad Sci U S A (2008) 1.41
Microarray analysis of uterine gene expression in mouse and human pregnancy. Mol Endocrinol (2003) 1.41
Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J Immunol (2002) 1.39
Proteasome activator PA200 is required for normal spermatogenesis. Mol Cell Biol (2006) 1.38
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol (2011) 1.36
Allelic exclusion at the TCRbeta locus. Curr Opin Immunol (2002) 1.30
Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes. J Exp Med (2007) 1.29
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Nat Immunol (2010) 1.28
Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity. J Neurosci (2005) 1.28
A short interpregnancy interval is a risk factor for preterm birth and its recurrence. Am J Obstet Gynecol (2007) 1.27
Heritability of parturition timing: an extended twin design analysis. Am J Obstet Gynecol (2008) 1.26
Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis. Proc Natl Acad Sci U S A (2009) 1.25
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
Loss of ATM kinase activity leads to embryonic lethality in mice. J Cell Biol (2012) 1.23
Type 8 adenylyl cyclase is targeted to excitatory synapses and required for mossy fiber long-term potentiation. J Neurosci (2003) 1.22
Analyses of hepatocellular proliferation in a mouse model of alpha-1-antitrypsin deficiency. Hepatology (2004) 1.18
Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help. J Exp Med (2006) 1.17
Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses. J Immunol (2006) 1.16
A specific role for Ca2+-dependent adenylyl cyclases in recovery from adaptive presynaptic silencing. J Neurosci (2008) 1.15
Insights into parturition biology from genetically altered mice. Pediatr Res (2008) 1.14
Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice. J Biol Chem (2001) 1.13
Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. Proc Natl Acad Sci U S A (2011) 1.12
Mother's genome or maternally-inherited genes acting in the fetus influence gestational age in familial preterm birth. Hum Hered (2009) 1.11
Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior. J Neurosci (2010) 1.11
Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biol (2011) 1.11
Intra- and inter-allelic ordering of T cell receptor beta chain gene assembly. Eur J Immunol (2005) 1.11
Inadvertent social information and the avoidance of parasitized male mice: a role for oxytocin. Proc Natl Acad Sci U S A (2006) 1.10
Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory. J Neurosci (2008) 1.09
Mapping a new spontaneous preterm birth susceptibility gene, IGF1R, using linkage, haplotype sharing, and association analysis. PLoS Genet (2011) 1.09
Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages. J Biol Chem (2012) 1.08
Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling. J Lipid Res (2013) 1.07
Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice. J Neurosci (2010) 1.07
Mouse strain susceptibility to gonadectomy-induced adrenocortical tumor formation correlates with the expression of GATA-4 and luteinizing hormone receptor. Endocrinology (2003) 1.06
Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain. J Neurosci (2012) 1.06
ATG5 regulates plasma cell differentiation. Autophagy (2013) 1.06
Hypothalamic-pituitary-adrenal axis dysregulation and behavioral analysis of mouse mutants with altered glucocorticoid or mineralocorticoid receptor function. Stress (2008) 1.06
Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility. Nat Immunol (2005) 1.06
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A (2011) 1.05
Impaired steroidogenesis and implantation failure in Bmal1-/- mice. Endocrinology (2008) 1.05
Revision of T cell receptor {alpha} chain genes is required for normal T lymphocyte development. Proc Natl Acad Sci U S A (2005) 1.04
Glucocorticoids differentially regulate degradation of MyoD and Id1 by N-terminal ubiquitination to promote muscle protein catabolism. Proc Natl Acad Sci U S A (2008) 1.04
Collateral damage from antigen receptor gene diversification. Cell (2008) 1.03
MAPK p38 alpha is dispensable for lymphocyte development and proliferation. J Immunol (2005) 1.03
β-Catenin induces T-cell transformation by promoting genomic instability. Proc Natl Acad Sci U S A (2013) 1.03
Preterm birth in pregnancies complicated by major congenital malformations: a population-based study. Am J Obstet Gynecol (2008) 1.02
Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice. Mol Endocrinol (2007) 1.02
Analysis of cyclooxygenase 2 (COX-2) expression during malignant melanoma progression. Cancer Biol Ther (2003) 1.00
T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes. Proc Natl Acad Sci U S A (2003) 0.99
COX-2 inhibition attenuates anorexia during systemic inflammation without impairing cytokine production. Am J Physiol Endocrinol Metab (2002) 0.97
Maternal coding variants in complement receptor 1 and spontaneous idiopathic preterm birth. Hum Genet (2013) 0.95
Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination. Cell Cycle (2011) 0.95
Coordinate regulation of prostaglandin metabolism for induction of parturition in mice. Endocrinology (2002) 0.94