Published in Proc Natl Acad Sci U S A on May 26, 2005
30 nm chromatin fibre decompaction requires both H4-K16 acetylation and linker histone eviction. J Mol Biol (2008) 2.62
Single-molecule force spectroscopy reveals a highly compliant helical folding for the 30-nm chromatin fiber. Nat Struct Mol Biol (2009) 2.02
Multiscale modeling of nucleosome dynamics. Biophys J (2006) 1.63
Role of histone tails in chromatin folding revealed by a mesoscopic oligonucleosome model. Proc Natl Acad Sci U S A (2006) 1.59
Evidence for heteromorphic chromatin fibers from analysis of nucleosome interactions. Proc Natl Acad Sci U S A (2009) 1.53
A computational study of nucleosomal DNA flexibility. Biophys J (2006) 1.42
A tale of tails: how histone tails mediate chromatin compaction in different salt and linker histone environments. J Phys Chem A (2009) 1.39
Topoisomerase II, not topoisomerase I, is the proficient relaxase of nucleosomal DNA. EMBO J (2006) 1.38
Flexible histone tails in a new mesoscopic oligonucleosome model. Biophys J (2006) 1.35
Nucleosome geometry and internucleosomal interactions control the chromatin fiber conformation. Biophys J (2008) 1.28
The nucleosome: a transparent, slippery, sticky and yet stable DNA-protein complex. Eur Phys J E Soft Matter (2006) 1.13
Modeling studies of chromatin fiber structure as a function of DNA linker length. J Mol Biol (2010) 1.09
Biomolecularmodeling and simulation: a field coming of age. Q Rev Biophys (2011) 1.06
The effect of internucleosomal interaction on folding of the chromatin fiber. Biophys J (2008) 1.06
Computer modeling demonstrates that electrostatic attraction of nucleosomal DNA is mediated by histone tails. Biophys J (2006) 0.98
H3 and H4 histone tails play a central role in the interactions of recombinant NCPs. Biophys J (2007) 0.97
Molecular dynamics-based approaches for enhanced sampling of long-time, large-scale conformational changes in biomolecules. F1000 Biol Rep (2009) 0.96
A computational framework for mechanical response of macromolecules: application to the salt concentration dependence of DNA bendability. Biophys J (2009) 0.96
Selective association between nucleosomes with identical DNA sequences. Nucleic Acids Res (2012) 0.94
Electrostatic origin of salt-induced nucleosome array compaction. Biophys J (2010) 0.94
Mesoscale simulations of two nucleosome-repeat length oligonucleosomes. Phys Chem Chem Phys (2009) 0.93
Local geometry and elasticity in compact chromatin structure. Biophys J (2010) 0.92
Electric fields generated by synchronized oscillations of microtubules, centrosomes and chromosomes regulate the dynamics of mitosis and meiosis. Theor Biol Med Model (2012) 0.90
Computer modeling reveals that modifications of the histone tail charges define salt-dependent interaction of the nucleosome core particles. Biophys J (2009) 0.88
Exploring the conformational space of chromatin fibers and their stability by numerical dynamic phase diagrams. Biophys J (2010) 0.88
Structure and phase diagram of nucleosome core particles aggregated by multivalent cations. Biophys J (2007) 0.86
Partial Unwrapping and Histone Tail Dynamics in Nucleosome Revealed by Coarse-Grained Molecular Simulations. PLoS Comput Biol (2015) 0.85
The role of histone tails in the nucleosome: a computational study. Biophys J (2014) 0.85
Microseconds dynamics simulations of the outer-membrane protease T. Biophys J (2007) 0.83
Effect of capsid confinement on the chromatin organization of the SV40 minichromosome. Nucleic Acids Res (2012) 0.83
Chromatin ionic atmosphere analyzed by a mesoscale electrostatic approach. Biophys J (2010) 0.83
Chromatin compaction in terminally differentiated avian blood cells: the role of linker histone H5 and non-histone protein MENT. Chromosome Res (2011) 0.83
Elucidating internucleosome interactions and the roles of histone tails. Biophys J (2013) 0.82
Choreography for nucleosomes: the conformational freedom of the nucleosomal filament and its limitations. Nucleic Acids Res (2007) 0.81
Monte Carlo, harmonic approximation, and coarse-graining approaches for enhanced sampling of biomolecular structure. F1000 Biol Rep (2009) 0.81
Insights into chromatin fibre structure by in vitro and in silico single-molecule stretching experiments. Biochem Soc Trans (2013) 0.81
Salt-modulated structure of polyelectrolyte-macroion complex fibers. Eur Phys J E Soft Matter (2011) 0.80
Hierarchies in eukaryotic genome organization: Insights from polymer theory and simulations. BMC Biophys (2011) 0.80
Electric oscillation and coupling of chromatin regulate chromosome packaging and transcription in eukaryotic cells. Theor Biol Med Model (2012) 0.79
Forced unraveling of chromatin fibers with nonuniform linker DNA lengths. J Phys Condens Matter (2015) 0.76
Histone acetylation dependent energy landscapes in tri-nucleosome revealed by residue-resolved molecular simulations. Sci Rep (2016) 0.75
Effects of charge-modifying mutations in histone H2A α3-domain on nucleosome stability assessed by single-pair FRET and MD simulations. Sci Rep (2017) 0.75
Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature (1997) 44.55
Controlling the double helix. Nature (2003) 8.61
Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution. J Mol Biol (2002) 8.42
Electrostatic interactions in macromolecules: theory and applications. Annu Rev Biophys Biophys Chem (1990) 7.40
Cellular memory and the histone code. Cell (2002) 7.30
Solenoidal model for superstructure in chromatin. Proc Natl Acad Sci U S A (1976) 6.65
Frictional coefficients of multisubunit structures. I. Theory. Biopolymers (1967) 4.70
Pulling a single chromatin fiber reveals the forces that maintain its higher-order structure. Proc Natl Acad Sci U S A (2000) 3.86
Nucleosome arrays reveal the two-start organization of the chromatin fiber. Science (2004) 3.83
The nucleosome: from genomic organization to genomic regulation. Cell (2004) 3.83
Conformational dynamics of the chromatin fiber in solution: determinants, mechanisms, and functions. Annu Rev Biophys Biomol Struct (2001) 3.51
Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin. Proc Natl Acad Sci U S A (1998) 3.16
Participation of core histone "tails" in the stabilization of the chromatin solenoid. J Cell Biol (1982) 2.68
A chromatin folding model that incorporates linker variability generates fibers resembling the native structures. Proc Natl Acad Sci U S A (1993) 2.67
Structure of the 300A chromatin filament: X-ray diffraction from oriented samples. Cell (1985) 2.54
HYDRO: a computer program for the prediction of hydrodynamic properties of macromolecules. Biophys J (1994) 2.42
Structure, dynamics, and function of chromatin in vitro. Annu Rev Biophys Biomol Struct (1998) 2.41
Review: chromatin structural features and targets that regulate transcription. J Struct Biol (2000) 2.36
Structure and function of the core histone N-termini: more than meets the eye. Biochemistry (1998) 2.23
Homogeneous reconstituted oligonucleosomes, evidence for salt-dependent folding in the absence of histone H1. Biochemistry (1989) 2.20
Electrostatic mechanism of chromatin folding. J Mol Biol (1990) 2.18
Role of the histone "tails" in the folding of oligonucleosomes depleted of histone H1. J Biol Chem (1992) 2.17
Structure and dynamic behavior of nucleosomes. Curr Opin Genet Dev (2003) 2.15
Structure of chromatin and the linking number of DNA. Proc Natl Acad Sci U S A (1981) 2.04
Higher order structure of chromatin: orientation of nucleosomes within the 30 nm chromatin solenoid is independent of species and spacer length. Cell (1983) 1.99
What determines the folding of the chromatin fiber? Proc Natl Acad Sci U S A (1996) 1.91
Computer simulation of the 30-nanometer chromatin fiber. Biophys J (2002) 1.80
Preferential interaction of the core histone tail domains with linker DNA. Proc Natl Acad Sci U S A (2001) 1.58
Dynamics of site juxtaposition in supercoiled DNA. Proc Natl Acad Sci U S A (2001) 1.50
Computational modeling predicts the structure and dynamics of chromatin fiber. Structure (2001) 1.48
Internal motion of supercoiled DNA: brownian dynamics simulations of site juxtaposition. J Mol Biol (1998) 1.36
The mechanism of nucleosome assembly onto oligomers of the sea urchin 5 S DNA positioning sequence. J Biol Chem (1991) 1.35
DNA folding: structural and mechanical properties of the two-angle model for chromatin. Biophys J (2001) 1.34
Salt-induced conformation and interaction changes of nucleosome core particles. Biophys J (2002) 1.33
The superstructure of chromatin and its condensation mechanism. II. Theoretical analysis of the X-ray scattering patterns and model calculations. Eur Biophys J (1986) 1.32
A defined structure of the 30 nm chromatin fibre which accommodates different nucleosomal repeat lengths. EMBO J (1984) 1.32
Nucleosome core particle stability and conformational change. Effect of temperature, particle and NaCl concentrations, and crosslinking of histone H3 sulfhydryl groups. J Mol Biol (1984) 1.30
Structures and interactions of the core histone tail domains. Biopolymers (2003) 1.28
Role of histone tails in the conformation and interactions of nucleosome core particles. Biochemistry (2004) 1.25
Pulling chromatin fibers: computer simulations of direct physical micromanipulations. J Mol Biol (2000) 1.24
Modeling salt-mediated electrostatics of macromolecules: the discrete surface charge optimization algorithm and its application to the nucleosome. Biopolymers (2001) 1.24
Rearrangement of the histone H2A C-terminal domain in the nucleosome. Proc Natl Acad Sci U S A (1994) 1.20
Constructing irregular surfaces to enclose macromolecular complexes for mesoscale modeling using the discrete surface charge optimization (DISCO) algorithm. J Comput Chem (2003) 1.20
Chromatin fiber structure: morphology, molecular determinants, structural transitions. Biophys J (1998) 1.19
Major role of the histones H3-H4 in the folding of the chromatin fiber. Biochem Biophys Res Commun (1997) 1.15
Dynamics and equilibria of nucleosomes at elevated ionic strength. J Biol Chem (1984) 1.14
Chromatin fibers, one-at-a-time. J Mol Biol (2003) 1.07
Global statistics of protein sequences: implications for the origin, evolution, and prediction of structure. Annu Rev Biophys Biomol Struct (1994) 0.93
Internal structure of the 30 nm chromatin fiber. J Cell Sci (1994) 0.86
Automated electron microscope tomography of frozen-hydrated chromatin: the irregular three-dimensional zigzag architecture persists in compact, isolated fibers. J Struct Biol (1997) 0.83
Modeling chain folding in protein-constrained circular DNA. Biophys J (1998) 0.81
Influence of nucleosome structure on the three-dimensional folding of idealized minichromosomes. Structure (1999) 0.79
Effect of DNA superhelicity and bound proteins on mechanistic aspects of the Hin-mediated and Fis-enhanced inversion. Biophys J (2003) 0.78
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet (2008) 16.17
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science (2002) 9.59
The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schema. Nucleic Acids Res (2005) 7.81
The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell (2008) 4.90
Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks. Proc Natl Acad Sci U S A (2002) 4.85
Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem (2004) 4.40
Biventricular pacing in patients with bradycardia and normal ejection fraction. N Engl J Med (2009) 4.17
The complete genome sequence of Mycobacterium avium subspecies paratuberculosis. Proc Natl Acad Sci U S A (2005) 4.16
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90
Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell (2011) 3.88
Obesity: a challenge to esophagogastric junction integrity. Gastroenterology (2006) 3.72
Single-layer MoS2 phototransistors. ACS Nano (2011) 3.43
Quantifying esophageal peristalsis with high-resolution manometry: a study of 75 asymptomatic volunteers. Am J Physiol Gastrointest Liver Physiol (2006) 3.41
Benign prostatic hyperplasia: prostatic arterial embolization versus transurethral resection of the prostate--a prospective, randomized, and controlled clinical trial. Radiology (2013) 3.32
ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death. N Engl J Med (2013) 3.27
Quantifying EGJ morphology and relaxation with high-resolution manometry: a study of 75 asymptomatic volunteers. Am J Physiol Gastrointest Liver Physiol (2006) 3.12
Tissue Doppler imaging is superior to strain rate imaging and postsystolic shortening on the prediction of reverse remodeling in both ischemic and nonischemic heart failure after cardiac resynchronization therapy. Circulation (2004) 3.12
The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Res (2008) 3.04
Human chromosome 7: DNA sequence and biology. Science (2003) 3.02
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. Nat Cell Biol (2008) 2.93
Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis. Gastrointest Endosc (2006) 2.89
Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nat Genet (2003) 2.78
A randomized controlled trial of Licartin for preventing hepatoma recurrence after liver transplantation. Hepatology (2007) 2.66
The Molecular Biology Toolkit (MBT): a modular platform for developing molecular visualization applications. BMC Bioinformatics (2005) 2.60
Deglutitive upper esophageal sphincter relaxation: a study of 75 volunteer subjects using solid-state high-resolution manometry. Am J Physiol Gastrointest Liver Physiol (2006) 2.57
High-resolution manometry of the EGJ: an analysis of crural diaphragm function in GERD. Am J Gastroenterol (2007) 2.56
Predictors of left ventricular reverse remodeling after cardiac resynchronization therapy for heart failure secondary to idiopathic dilated or ischemic cardiomyopathy. Am J Cardiol (2003) 2.53
A mouse to human search for plasma proteome changes associated with pancreatic tumor development. PLoS Med (2008) 2.31
Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease. Blood (2011) 2.24
Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes. Am J Hum Genet (2006) 2.22
Left ventricular reverse remodeling but not clinical improvement predicts long-term survival after cardiac resynchronization therapy. Circulation (2005) 2.22
Decreased STAT1 expression by promoter methylation in squamous cell carcinogenesis. J Natl Cancer Inst (2006) 2.21
Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol Biol Evol (2005) 2.18
Quantitative analysis of acrylamide labeled serum proteins by LC-MS/MS. J Proteome Res (2006) 2.10
Progression of systolic abnormalities in patients with "isolated" diastolic heart failure and diastolic dysfunction. Circulation (2002) 2.09
Elafin is a biomarker of graft-versus-host disease of the skin. Sci Transl Med (2010) 2.08
Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia. Crit Care Med (2004) 2.07
Immunomic analysis of the repertoire of T-cell specificities for influenza A virus in humans. J Virol (2008) 2.07
Molecular and clinical genetics of mitochondrial diseases due to POLG mutations. Hum Mutat (2008) 2.04
Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing. BMC Genomics (2009) 2.04
Contribution of protein fractionation to depth of analysis of the serum and plasma proteomes. J Proteome Res (2007) 2.04
A novel tool to assess systolic asynchrony and identify responders of cardiac resynchronization therapy by tissue synchronization imaging. J Am Coll Cardiol (2005) 2.03
Direct laser writing of micro-supercapacitors on hydrated graphite oxide films. Nat Nanotechnol (2011) 2.02
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell (2010) 1.95
Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol Endocrinol (2003) 1.93
Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. J Biol Chem (2003) 1.88
Independent and incremental prognostic value of early mitral annulus velocity in patients with impaired left ventricular systolic function. J Am Coll Cardiol (2005) 1.85
Comparison of the Bravo wireless and Digitrapper catheter-based pH monitoring systems for measuring esophageal acid exposure. Am J Gastroenterol (2005) 1.78
Multilocus short sequence repeat sequencing approach for differentiating among Mycobacterium avium subsp. paratuberculosis strains. J Clin Microbiol (2004) 1.78
Automating document classification for the Immune Epitope Database. BMC Bioinformatics (2007) 1.76
Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path sampling of DNA polymerase beta's closing. Proc Natl Acad Sci U S A (2004) 1.76
Genome scale comparison of Mycobacterium avium subsp. paratuberculosis with Mycobacterium avium subsp. avium reveals potential diagnostic sequences. J Clin Microbiol (2002) 1.73
Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells. Cancer Res (2011) 1.73
Proteomic analysis of ovarian cancer cells reveals dynamic processes of protein secretion and shedding of extra-cellular domains. PLoS One (2008) 1.72
Benefits of cardiac resynchronization therapy for heart failure patients with narrow QRS complexes and coexisting systolic asynchrony by echocardiography. J Am Coll Cardiol (2006) 1.70
Fabrication of single- and multilayer MoS2 film-based field-effect transistors for sensing NO at room temperature. Small (2011) 1.69
Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light-ear gene. Nat Genet (2002) 1.67
Congenital fibrovascular pupillary membranes: clinical and histopathologic findings. Ophthalmology (2011) 1.67
Exploring the repertoire of RNA secondary motifs using graph theory; implications for RNA design. Nucleic Acids Res (2003) 1.63
Surprising complexity of the ancestral apoptosis network. Genome Biol (2007) 1.63
RAG: RNA-As-Graphs database--concepts, analysis, and features. Bioinformatics (2004) 1.63
Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell (2005) 1.62
Diastolic and systolic asynchrony in patients with diastolic heart failure: a common but ignored condition. J Am Coll Cardiol (2006) 1.62
Human bocavirus in children hospitalized for acute gastroenteritis: a case-control study. Clin Infect Dis (2008) 1.61
Biventricular pacing is superior to right ventricular pacing in bradycardia patients with preserved systolic function: 2-year results of the PACE trial. Eur Heart J (2011) 1.61
Role of histone tails in chromatin folding revealed by a mesoscopic oligonucleosome model. Proc Natl Acad Sci U S A (2006) 1.59
Giant cell tumor of the extremity: retrospective analysis of 621 Chinese patients from one institution. J Bone Joint Surg Am (2012) 1.58
CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease. Am J Gastroenterol (2004) 1.57
Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly. J Am Chem Soc (2004) 1.55
Effect of left ventricular lead concordance to the delayed contraction segment on echocardiographic and clinical outcomes after cardiac resynchronization therapy. J Cardiovasc Electrophysiol (2008) 1.54
Evidence for heteromorphic chromatin fibers from analysis of nucleosome interactions. Proc Natl Acad Sci U S A (2009) 1.53
An analysis of the epitope knowledge related to Mycobacteria. Immunome Res (2007) 1.53
Impact of reduction in early- and late-systolic functional mitral regurgitation on reverse remodelling after cardiac resynchronization therapy. Eur Heart J (2010) 1.50
Complete genomic sequence of bacteriophage felix o1. Viruses (2010) 1.50
The BBSome controls IFT assembly and turnaround in cilia. Nat Cell Biol (2012) 1.50
Clinical versus echocardiographic parameters to assess response to cardiac resynchronization therapy. Am J Cardiol (2005) 1.50
HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma. Mol Cancer Res (2007) 1.48
Association between the A/A genotype at the lymphotoxin-alpha+250 site and increased mortality in children with positive blood cultures. Pediatr Crit Care Med (2002) 1.46
The intracellular domain of CD44 promotes the fusion of macrophages. Blood (2005) 1.45
Few-layer MoS2: a promising layered semiconductor. ACS Nano (2014) 1.44
Genomic homogeneity between Mycobacterium avium subsp. avium and Mycobacterium avium subsp. paratuberculosis belies their divergent growth rates. BMC Microbiol (2003) 1.44
Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology (2002) 1.44
Polymerase beta simulations suggest that Arg258 rotation is a slow step rather than large subdomain motions per se. J Mol Biol (2002) 1.43
Computational approaches to 3D modeling of RNA. J Phys Condens Matter (2010) 1.42
Adaptive optics scanning laser ophthalmoscopy images in a family with the mitochondrial DNA T8993C mutation. Invest Ophthalmol Vis Sci (2008) 1.42
Beta2-adrenergic receptor polymorphisms in African American children with status asthmaticus. Pediatr Crit Care Med (2006) 1.42
The effect of continuous nursing intervention guided by chronotherapeutics on ambulatory blood pressure of older hypertensive patients in the community. J Clin Nurs (2014) 1.40
Candidate porcine Kobuvirus, China. Emerg Infect Dis (2009) 1.40
Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection. Biochemistry (2006) 1.40
Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer. Cancer Res (2009) 1.40
VEGF-mediated inflammation precedes angiogenesis in adult brain. Exp Neurol (2004) 1.39
A tale of tails: how histone tails mediate chromatin compaction in different salt and linker histone environments. J Phys Chem A (2009) 1.39
Effect of a Health Belief Model-based nursing intervention on Chinese patients with moderate to severe chronic obstructive pulmonary disease: a randomised controlled trial. J Clin Nurs (2013) 1.39
Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines. Blood (2004) 1.38
Usefulness of tissue Doppler velocity and strain dyssynchrony for predicting left ventricular reverse remodeling response after cardiac resynchronization therapy. Am J Cardiol (2007) 1.37
Analysis of four-way junctions in RNA structures. J Mol Biol (2009) 1.37
Targets of the tumor suppressor miR-200 in regulation of the epithelial-mesenchymal transition in cancer. Cancer Res (2011) 1.37
Mutations in the MPV17 gene are responsible for rapidly progressive liver failure in infancy. Hepatology (2007) 1.37
Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma. Cancer Res (2006) 1.35