Pathogenesis of type 2 diabetes mellitus.

PubWeight™: 2.18‹?› | Rank: Top 2%

🔗 View Article (PMID 15925010)

Published in Arch Med Res on May 31, 2005

Authors

Jack L Leahy1

Author Affiliations

1: University of Vermont College of Medicine, Burlington, VT 05405, USA. jleahy@uvm.edu

Articles citing this

Islet beta cell failure in type 2 diabetes. J Clin Invest (2006) 7.67

Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nat Rev Drug Discov (2009) 3.26

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab (2008) 2.86

Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS One (2010) 2.84

Network-based analysis of affected biological processes in type 2 diabetes models. PLoS Genet (2007) 2.54

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J (2012) 2.21

Exposure to recurrent sleep restriction in the setting of high caloric intake and physical inactivity results in increased insulin resistance and reduced glucose tolerance. J Clin Endocrinol Metab (2009) 2.16

Formation of a human β-cell population within pancreatic islets is set early in life. J Clin Endocrinol Metab (2012) 2.01

Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. Diabetes (2008) 1.72

Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels. Eur J Nutr (2009) 1.66

Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins. Proc Natl Acad Sci U S A (2007) 1.62

Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2. Proc Natl Acad Sci U S A (2008) 1.56

In vitro metabolic stability of exendin-4: pharmacokinetics and identification of cleavage products. PLoS One (2015) 1.40

Individualizing therapies in type 2 diabetes mellitus based on patient characteristics: what we know and what we need to know. J Clin Endocrinol Metab (2010) 1.34

Proteome, phosphoproteome, and hydroxyproteome of liver mitochondria in diabetic rats at early pathogenic stages. Mol Cell Proteomics (2009) 1.27

The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach. Mol Cell Proteomics (2008) 1.27

Mitochondrial dysfunction and β-cell failure in type 2 diabetes mellitus. Exp Diabetes Res (2011) 1.25

Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules (2015) 1.23

Comparison of dietary conjugated linoleic acid with safflower oil on body composition in obese postmenopausal women with type 2 diabetes mellitus. Am J Clin Nutr (2009) 1.19

Misfolded proinsulin affects bystander proinsulin in neonatal diabetes. J Biol Chem (2009) 1.15

Direct autocrine action of insulin on β-cells: does it make physiological sense? Diabetes (2013) 1.12

Combined influence of insulin resistance, overweight/obesity, and fatty liver as risk factors for type 2 diabetes. Diabetes Care (2012) 1.09

Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes (2015) 1.06

Sleep Apnea and Metabolic Dysfunction: Cause or Co-Relation? Sleep Med Clin (2007) 1.04

Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide. J Biol Chem (2009) 1.03

Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity. Diabetologia (2012) 0.99

The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Mol Endocrinol (2010) 0.99

Use of DPP-4 inhibitors in type 2 diabetes: focus on sitagliptin. Diabetes Metab Syndr Obes (2010) 0.98

Perinatal bisphenol A exposure and adult glucose homeostasis: identifying critical windows of exposure. PLoS One (2013) 0.97

Degradation of IRS1 leads to impaired glucose uptake in adipose tissue of the type 2 diabetes mouse model TALLYHO/Jng. J Endocrinol (2009) 0.96

GLP1-derived nonapeptide GLP1(28-36)amide protects pancreatic β-cells from glucolipotoxicity. J Endocrinol (2012) 0.95

Duration of abdominal obesity beginning in young adulthood and incident diabetes through middle age: the CARDIA study. Diabetes Care (2012) 0.94

Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations. Endocrinology (2009) 0.94

Dopamine synthesis and D3 receptor activation in pancreatic β-cells regulates insulin secretion and intracellular [Ca(2+)] oscillations. Mol Endocrinol (2012) 0.93

In vivo pancreatic β-cell-specific expression of antiaging gene Klotho: a novel approach for preserving β-cells in type 2 diabetes. Diabetes (2014) 0.92

Natural history of β-cell adaptation and failure in type 2 diabetes. Mol Aspects Med (2014) 0.91

GPR43 Potentiates β-Cell Function in Obesity. Diabetes (2015) 0.89

Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes. Mol Aspects Med (2015) 0.88

Oxidative stress and protein carbonylation in adipose tissue - implications for insulin resistance and diabetes mellitus. J Proteomics (2013) 0.88

Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetes. Exp Diabetes Res (2011) 0.87

Liver-specific overexpression of pancreatic-derived factor (PANDER) induces fasting hyperglycemia in mice. Endocrinology (2010) 0.86

Functional deficiencies of subsarcolemmal mitochondria in the type 2 diabetic human heart. Am J Physiol Heart Circ Physiol (2014) 0.84

Hepatitis C virus induced a novel apoptosis-like death of pancreatic beta cells through a caspase 3-dependent pathway. PLoS One (2012) 0.84

Effects of increasing doses of glucagon-like peptide-1 on insulin-releasing phases during intravenous glucose administration in mice. Am J Physiol Regul Integr Comp Physiol (2011) 0.83

Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance. Nutrients (2013) 0.83

Weight changes following the diagnosis of type 2 diabetes: the impact of recent and past weight history before diagnosis. results from the Danish Diabetes Care in General Practice (DCGP) study. PLoS One (2015) 0.82

Reduced cytochrome C is an essential regulator of sustained insulin secretion by pancreatic islets. J Biol Chem (2011) 0.82

Effect of the urotensin-II receptor antagonist palosuran on secretion of and sensitivity to insulin in patients with Type 2 diabetes mellitus. Br J Clin Pharmacol (2009) 0.82

Pancreatic β-Cell Membrane Fluidity and Toxicity Induced by Human Islet Amyloid Polypeptide Species. Sci Rep (2016) 0.82

The role of peroxidation of mitochondrial membrane phospholipids in pancreatic β -cell failure. Curr Diabetes Rev (2012) 0.80

Maternal antioxidants prevent β-cell apoptosis and promote formation of dual hormone-expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure. J Diabetes (2012) 0.79

Cardiovascular Risk in Children and Adolescents with Type 1 and Type 2 Diabetes Mellitus. Curr Cardiovasc Risk Rep (2012) 0.78

A tripeptide Diapin effectively lowers blood glucose levels in male type 2 diabetes mice by increasing blood levels of insulin and GLP-1. PLoS One (2013) 0.78

Diabetes Alters the Expression and Translocation of the Insulin-Sensitive Glucose Transporters 4 and 8 in the Atria. PLoS One (2015) 0.77

Clinical and laboratory data of a large series of patients with congenital generalized lipodystrophy. Diabetol Metab Syndr (2016) 0.77

The Role of Immunogenicity in Cardiovascular Disease. World Heart J (2011) 0.77

Effect of probiotic fermented milk (kefir) on glycemic control and lipid profile in type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Iran J Public Health (2015) 0.77

Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival. Sci Rep (2016) 0.77

Resveratrol supplementation restores high-fat diet-induced insulin secretion dysfunction by increasing mitochondrial function in islet. Exp Biol Med (Maywood) (2014) 0.76

Mechanisms of β-cell functional adaptation to changes in workload. Diabetes Obes Metab (2016) 0.76

Nr2e1 Deficiency Augments Palmitate-Induced Oxidative Stress in Beta Cells. Oxid Med Cell Longev (2015) 0.75

APPL1 acts as a protective factor against podocytes injury in high glucose environment. Int J Clin Exp Pathol (2015) 0.75

Modeling fructose-load-induced hepatic de-novo lipogenesis by model simplification. Gene Regul Syst Bio (2017) 0.75

Increased prevalence of abnormal glucose tolerance among obese siblings of children with type 2 diabetes. J Pediatr (2008) 0.75

Fat feeding potentiates the diabetogenic effect of dexamethasone in Wistar rats. Int Arch Med (2008) 0.75

Adipocyte dysfunction in rats with streptozotocin-nicotinamide-induced diabetes. Int J Exp Pathol (2014) 0.75

Maternal nicotine exposure and fetal programming of vascular oxidative stress in adult offspring. Br J Pharmacol (2011) 0.75

Group VIB Phospholipase A(2) promotes proliferation of INS-1 insulinoma cells and attenuates lipid peroxidation and apoptosis induced by inflammatory cytokines and oxidant agents. Oxid Med Cell Longev (2012) 0.75

Increased density of inhibitory noradrenergic parenchymal nerve fibers in hypertrophic islets of Langerhans of obese mice. Nutr Metab Cardiovasc Dis (2013) 0.75

Rac1-NADPH oxidase signaling promotes CD36 activation under glucotoxic conditions in pancreatic beta cells. Redox Biol (2016) 0.75

Insulin resistance in Alzheimer's disease. Transl Res (2016) 0.75

Effects of the Combined Extracts of Grape Pomace and Omija Fruit on Hyperglycemia and Adiposity in Type 2 Diabetic Mice. Prev Nutr Food Sci (2015) 0.75

Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty. Physiology (Bethesda) (2017) 0.75

Attitudes Regarding Participation in a Diabetes Screening Test among an Assyrian Immigrant Population in Sweden. Nurs Res Pract (2016) 0.75

Cardiac Mitochondrial Respiratory Dysfunction and Tissue Damage in Chronic Hyperglycemia Correlate with Reduced Aldehyde Dehydrogenase-2 Activity. PLoS One (2016) 0.75

Neurogenic hyperadrenergic orthostatic hypotension: a newly recognized variant of orthostatic hypotension in older adults with elevated norepinephrine (noradrenaline). Clin Sci (Lond) (2015) 0.75

Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure. BMJ Open Diabetes Res Care (2016) 0.75

Nanoformulation of Leonotis leonurus to improve its bioavailability as a potential antidiabetic drug. 3 Biotech (2017) 0.75

Temporal characterization of β cell-adaptive and -maladaptive mechanisms during chronic high-fat feeding in C57BL/6NTac mice. J Biol Chem (2017) 0.75