Formation of a human β-cell population within pancreatic islets is set early in life.

PubWeight™: 2.01‹?› | Rank: Top 2%

🔗 View Article (PMC 3431572)

Published in J Clin Endocrinol Metab on June 28, 2012

Authors

Brigid E Gregg1, Patrick C Moore, Damien Demozay, Ben A Hall, Mei Li, Aliya Husain, Amy J Wright, Mark A Atkinson, Christopher J Rhodes

Author Affiliations

1: The Kovler Diabetes Center, University of Chicago, 900 East 57th Street, Chicago, Illinois 60637, USA.

Articles citing this

Type 1 diabetes. Lancet (2013) 3.45

Insulin resistance alters islet morphology in nondiabetic humans. Diabetes (2013) 2.01

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes. Diabetes (2015) 1.88

Islet β cell mass in diabetes and how it relates to function, birth, and death. Ann N Y Acad Sci (2013) 1.84

SerpinB1 Promotes Pancreatic β Cell Proliferation. Cell Metab (2015) 1.72

The streetlight effect in type 1 diabetes. Diabetes (2015) 1.66

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function. Diabetes (2015) 1.50

The role of aging upon β cell turnover. J Clin Invest (2013) 1.50

The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings. Pediatr Diabetes (2013) 1.46

A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development. Elife (2016) 1.46

β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. Diabetes Care (2014) 1.42

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication. Nat Med (2015) 1.25

Current concepts on the pathogenesis of type 1 diabetes--considerations for attempts to prevent and reverse the disease. Diabetes Care (2015) 1.25

Direct autocrine action of insulin on β-cells: does it make physiological sense? Diabetes (2013) 1.12

Beta cell dysfunction and insulin resistance. Front Endocrinol (Lausanne) (2013) 1.07

Pancreatic β-cell proliferation in obesity. Adv Nutr (2014) 1.02

Age-related impairment of pancreatic Beta-cell function: pathophysiological and cellular mechanisms. Front Endocrinol (Lausanne) (2014) 0.99

Age at the time of sulfonylurea initiation influences treatment outcomes in KCNJ11-related neonatal diabetes. Diabetologia (2015) 0.99

Betatrophin versus bitter-trophin and the elephant in the room: time for a new normal in β-cell regeneration research. Diabetes (2014) 0.95

New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation. Curr Diab Rep (2014) 0.93

Nervous glucose sensing regulates postnatal β cell proliferation and glucose homeostasis. J Clin Invest (2013) 0.93

β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes. World J Diabetes (2015) 0.92

Birth and death of human β-cells in pancreases from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice. Cell Transplant (2013) 0.92

Natural history of β-cell adaptation and failure in type 2 diabetes. Mol Aspects Med (2014) 0.91

Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese. J Diabetes Investig (2013) 0.90

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function. Cell Metab (2016) 0.90

β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. J Clin Endocrinol Metab (2014) 0.90

Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells. Diabetes (2014) 0.89

From immunobiology to β-cell biology: the changing perspective on type 1 diabetes. Islets (2014) 0.88

Structural similarities and differences between the human and the mouse pancreas. Islets (2015) 0.88

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells. Diabetes (2015) 0.87

Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells. Curr Opin Genet Dev (2015) 0.86

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation. Diabetes (2016) 0.86

Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning. Nat Commun (2015) 0.85

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas. Cell Metab (2016) 0.85

Islet neogenesis: a possible pathway for beta-cell replenishment. Rev Diabet Stud (2012) 0.83

Advances in β cell replacement and regeneration strategies for treating diabetes. J Clin Invest (2016) 0.82

A 3D map of the islet routes throughout the healthy human pancreas. Sci Rep (2015) 0.82

Making β cells from adult cells within the pancreas. Curr Diab Rep (2013) 0.81

Organ donor specimens: What can they tell us about type 1 diabetes? Pediatr Diabetes (2015) 0.80

Effects of Obesity and Diabetes on α- and β-Cell Mass in Surgically Resected Human Pancreas. J Clin Endocrinol Metab (2016) 0.79

Life course health care and preemptive approach to non-communicable diseases. Proc Jpn Acad Ser B Phys Biol Sci (2013) 0.79

Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement. Transplantation (2016) 0.79

Pancreatic islet cell development and regeneration. Curr Opin Endocrinol Diabetes Obes (2015) 0.79

Early and Late G1/S Cyclins and Cdks Act Complementarily to Enhance Authentic Human β-Cell Proliferation and Expansion. Diabetes (2015) 0.79

The negative cell cycle regulators, p27(Kip1), p18(Ink4c), and GSK-3, play critical role in maintaining quiescence of adult human pancreatic β-cells and restrict their ability to proliferate. Islets (2013) 0.79

Pancreas development in humans. Curr Opin Endocrinol Diabetes Obes (2014) 0.79

The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions. Diabetes (2016) 0.79

Replicative capacity of β-cells and type 1 diabetes. J Autoimmun (2016) 0.78

Biomarkers of β-Cell Stress and Death in Type 1 Diabetes. Curr Diab Rep (2016) 0.77

Human β-cell regeneration: progress, hurdles, and controversy. Curr Opin Endocrinol Diabetes Obes (2014) 0.77

Lymphangiogenesis and angiogenesis during human fetal pancreas development. Vasc Cell (2014) 0.77

Increasing β-cell mass requires additional stimulation for adaptation to secretory demand. Mol Endocrinol (2015) 0.76

Islet biology, the CDKN2A/B locus and type 2 diabetes risk. Diabetologia (2016) 0.76

Adult tissue sources for new β cells. Transl Res (2013) 0.76

Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion. Diabetes (2015) 0.76

Good news for the ageing beta cell. Diabetologia (2013) 0.76

Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regeneration. Am J Physiol Endocrinol Metab (2016) 0.75

Proproliferative and antiapoptotic action of exogenously introduced YAP in pancreatic β cells. JCI Insight (2016) 0.75

From bugs to beta cells. Elife (2016) 0.75

Definition of a Skp2-c-Myc Pathway to Expand Human Beta-cells. Sci Rep (2016) 0.75

Sex differences in adult rat insulin and glucose responses to arginine: programming effects of neonatal separation, hypoxia, and hypothermia. Physiol Rep (2016) 0.75

Dynamics and Regulation of Insulin Secretion in Pancreatic Islets from Normal Young Children. PLoS One (2016) 0.75

"RAS"ling β cells to proliferate for diabetes: why do we need MEN? J Clin Invest (2014) 0.75

Evaluation of immunohistochemical staining for glucagon in human pancreatic tissue. J Histotechnol (2016) 0.75

Case Report: Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11-related Diabetes. J Clin Endocrinol Metab (2016) 0.75

Dynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implications. J Diabetes Investig (2015) 0.75

β-cells persist in T1D pancreata without evidence for ongoing β-cell turnover or neogenesis. J Clin Endocrinol Metab (2017) 0.75

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. J Clin Invest (2017) 0.75

Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication. J Diabetes Res (2017) 0.75

Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease. Sci Rep (2017) 0.75

Articles cited by this

Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes (2008) 5.23

Type 2 diabetes-a matter of beta-cell life and death? Science (2005) 4.46

Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy. J Histochem Cytochem (2005) 4.40

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy. Diabetologia (2010) 2.91

Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating. J Clin Endocrinol Metab (2010) 2.85

Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy. Diabetes (2000) 2.75

Regulation of pancreatic beta cell mass by neuronal signals from the liver. Science (2008) 2.74

The replication of beta cells in normal physiology, in disease and for therapy. Nat Clin Pract Endocrinol Metab (2007) 2.72

Intrauterine growth retardation leads to the development of type 2 diabetes in the rat. Diabetes (2001) 2.66

Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes (2006) 2.53

Innervation patterns of autonomic axons in the human endocrine pancreas. Cell Metab (2011) 2.48

Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res (1997) 2.46

Pathogenesis of type 2 diabetes mellitus. Arch Med Res (2005) 2.18

Islet architecture: A comparative study. Islets (2010) 2.09

Beta-cell growth and regeneration: replication is only part of the story. Diabetes (2010) 1.92

The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality. Diabetologia (2009) 1.83

Paracrinology of islets and the paracrinopathy of diabetes. Proc Natl Acad Sci U S A (2010) 1.79

Epithelial dynamics of pancreatic branching morphogenesis. Development (2010) 1.65

Genetic and environmental interactions in obesity and type 2 diabetes. J Am Diet Assoc (2008) 1.43

Interplay of nutrients and hormones in the regulation of insulin release. Endocrinology (1985) 1.41

Proliferation and differentiation in the human fetal endocrine pancreas. Diabetologia (1997) 1.39

The emerging genetics of type 2 diabetes. Trends Mol Med (2010) 1.38

The dangerous road of catch-up growth. J Physiol (2002) 1.35

Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells. J Biol Chem (2006) 1.31

Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development. Diabetes (2011) 1.30

Brain glucose sensing and neural regulation of insulin and glucagon secretion. Diabetes Obes Metab (2011) 1.26

Convergence of the insulin and serotonin programs in the pancreatic β-cell. Diabetes (2011) 1.18

Formation and regeneration of the endocrine pancreas. Curr Opin Cell Biol (2007) 1.08

Beta-cell development and turnover during prenatal life in humans. Eur J Endocrinol (2009) 1.07

Identification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturity. J Histochem Cytochem (2010) 0.99

Defective glucagon secretion during sustained hypoglycemia following successful islet allo- and autotransplantation in humans. Diabetes (1997) 0.99

A quantitative immunofluorescent study of the endocrine cell populations in the developing human pancreas. Diabetes (1983) 0.96

Immunohistochemical study of caspase-3-expressing cells within the pancreas of non-obese diabetic mice during cyclophosphamide-accelerated diabetes. Histochem Cell Biol (2003) 0.95

Evidence that suppression of insulin secretion by insulin itself is neurally mediated. Metabolism (1993) 0.89

Proinsulin processing in the diabetic Goto-Kakizaki rat. J Endocrinol (2002) 0.85

Abundance of somatostatin cells in the human neonatal pancreas. Diabetologia (1980) 0.85

The development and cytodifferentiation of the islets of Langerhans in human embryos and foetuses. Acta Anat (Basel) (1967) 0.84

Somatostatin localization in tissues. Scand J Gastroenterol Suppl (1986) 0.81

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis (2004) 6.83

MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med (2007) 5.48

Multilocus sequence typing scheme for Enterococcus faecium. J Clin Microbiol (2002) 5.09

MultiPipMaker and supporting tools: Alignments and analysis of multiple genomic DNA sequences. Nucleic Acids Res (2003) 4.97

Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem (2004) 3.54

The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem (2004) 3.31

Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy. J Am Soc Nephrol (2007) 3.08

A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity (2005) 3.07

Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab (2009) 3.07

Toward defining the autoimmune microbiome for type 1 diabetes. ISME J (2010) 3.03

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Neuron (2002) 2.98

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med (2012) 2.86

The "perfect storm" for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity. Diabetes (2008) 2.77

Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J Exp Med (2009) 2.77

Notch3 gene amplification in ovarian cancer. Cancer Res (2006) 2.66

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes. Diabetes (2005) 2.63

Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes (2008) 2.52

Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab (2005) 2.52

Fen1 mutations result in autoimmunity, chronic inflammation and cancers. Nat Med (2007) 2.48

Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth. Infect Immun (2004) 2.47

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol (2007) 2.23

Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell (2011) 2.22

Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS One (2011) 2.18

Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest (2005) 2.14

Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse. Am J Pathol (2004) 2.09

In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes (2004) 2.01

B cells enhance early innate immune responses during bacterial sepsis. J Exp Med (2011) 1.99

Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology (2003) 1.99

Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol Endocrinol (2003) 1.93

Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology (2009) 1.92

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A (2013) 1.88

Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol (2006) 1.86

Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci (2009) 1.85

Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab (2011) 1.85

Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice. J Clin Invest (2012) 1.84

Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metab (2006) 1.83

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem (2003) 1.76

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem (2002) 1.76

How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited. Diabetes (2011) 1.74

Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model. ISME J (2009) 1.74

Why can't we prevent type 1 diabetes?: maybe it's time to try a different combination. Diabetes Care (2003) 1.71

Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats. PLoS One (2010) 1.70

Proinsulin maturation, misfolding, and proteotoxicity. Proc Natl Acad Sci U S A (2007) 1.69

Influence of fecal sample storage on bacterial community diversity. Open Microbiol J (2009) 1.68

Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1. J Biol Chem (2006) 1.64

Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proc Natl Acad Sci U S A (2009) 1.63

Tumor-induced osteomalacia: an important cause of adult-onset hypophosphatemic osteomalacia in China: Report of 39 cases and review of the literature. J Bone Miner Res (2012) 1.63

Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11. Immunology (2007) 1.63

Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. J Biol Chem (2007) 1.61

High expression of p300 has an unfavorable impact on survival in resectable esophageal squamous cell carcinoma. Ann Thorac Surg (2011) 1.60

The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion. J Biol Chem (2006) 1.59

Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes. JAMA (2012) 1.57

Histological characteristics of singleton placentas delivered before the 28th week of gestation. Pathology (2008) 1.56

Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells. J Biol Chem (2004) 1.54

Urinary trypsin inhibitors afford cardioprotective effects through activation of PI3K-Akt and ERK signal transduction and inhibition of p38 MAPK and JNK. Cardiology (2009) 1.53

Recovery of continence function following simulated birth trauma involves repair of muscle and nerves in the urethra in the female mouse. Eur Urol (2009) 1.52

Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells. Mol Endocrinol (2007) 1.49

Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes? Trends Mol Med (2002) 1.49

Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? Am J Physiol Endocrinol Metab (2004) 1.49

Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin. J Invest Dermatol (2008) 1.48

Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice. Diabetes (2009) 1.48

The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings. Pediatr Diabetes (2013) 1.46

Insulin secretory deficiency and glucose intolerance in Rab3A null mice. J Biol Chem (2003) 1.46

Identification and characterization of a novel adhesin unique to oral fusobacteria. J Bacteriol (2005) 1.45

Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation. J Invest Dermatol (2004) 1.45

Temporal morphological and functional impact of complete urinary diversion on the bladder: a model of bladder disuse in rats. J Urol (2010) 1.44

Comparison of sirolimus with azathioprine in a tacrolimus-based immunosuppressive regimen in lung transplantation. Am J Respir Crit Care Med (2010) 1.43

Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala. J Neurosci (2010) 1.43

Visual event-related potential changes in two subtypes of multiple system atrophy, MSA-C and MSA-P. J Neurol (2002) 1.42

It's time to consider changing the rules: the rationale for rethinking control groups in clinical trials aimed at reversing type 1 diabetes. Diabetes (2011) 1.42

Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury. Neurol Sci (2012) 1.42

IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease. J Am Soc Nephrol (2005) 1.41

Detection of hepatitis B virus PreS1 antigen using a time-resolved fluoroimmunoassay. J Immunoassay Immunochem (2012) 1.41

In vitro bacterial polysaccharide biosynthesis: defining the functions of Wzy and Wzz. Nat Chem Biol (2010) 1.41

Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J Med Chem (2008) 1.41

Intraoperative frozen section assessment of pelvic lymph nodes during radical prostatectomy is of limited value. BJU Int (2010) 1.39

Xingshentongqiao decoction mediates proliferation, apoptosis, orexin-A receptor and orexin-B receptor messenger ribonucleic acid expression and represses mitogen-activated protein kinase signaling. Chin Med J (Engl) (2015) 1.38

Escherichia coli O86 O-antigen biosynthetic gene cluster and stepwise enzymatic synthesis of human blood group B antigen tetrasaccharide. J Am Chem Soc (2005) 1.38

Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc Natl Acad Sci U S A (2007) 1.38

Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung. Am J Respir Cell Mol Biol (2009) 1.36

Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin. J Biol Chem (2003) 1.36

Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled. EMBO J (2002) 1.36

Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells. J Cell Sci (2005) 1.35

Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-mediated Th17 bias. J Immunol (2011) 1.34

Autologous umbilical cord blood infusion for type 1 diabetes. Exp Hematol (2008) 1.34

Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion. J Immunol (2003) 1.32

Glucocorticoid receptor antagonism as a novel therapy for triple-negative breast cancer. Clin Cancer Res (2013) 1.31

Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells. J Biol Chem (2006) 1.31

Rapidly increasing rates of hip fracture in Beijing, China. J Bone Miner Res (2012) 1.30

S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-x(S). Hepatology (2004) 1.30

Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials. Diabetes (2013) 1.30

TSLP produced by keratinocytes promotes allergen sensitization through skin and thereby triggers atopic march in mice. J Invest Dermatol (2012) 1.29

Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis. Blood (2007) 1.29

Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells. Infect Immun (2003) 1.28

Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation. Mol Cell Biol (2006) 1.26

High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients. Mol Med (2010) 1.26

Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells. Am J Pathol (2008) 1.25

Autologous umbilical cord blood transfusion in very young children with type 1 diabetes. Diabetes Care (2009) 1.24