Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetes.

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Published in Exp Diabetes Res on October 01, 2011

Authors

Udayakumar Karunakaran1, Han-Jong Kim, Joon-Young Kim, In-Kyu Lee

Author Affiliations

1: Departments of Internal Medicine, Biochemistry and Cell Biology, Research Institute of Aging and Metabolism and World Class University Program, Kyungpook National University School of Medicine, Daegu 700-721, Republic of Korea.

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Unbound free fatty acid levels in human serum. J Lipid Res (1995) 1.88

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