Published in Nat Rev Genet on June 01, 2005
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Germline competent embryonic stem cells derived from rat blastocysts. Cell (2008) 5.52
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The porcine lung as a potential model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 2.53
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Pluripotency in the embryo and in culture. Cold Spring Harb Perspect Biol (2012) 1.93
Non-transgenic genome modifications in a hemimetabolous insect using zinc-finger and TAL effector nucleases. Nat Commun (2012) 1.90
An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells. Cell Stem Cell (2014) 1.83
Efficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease. Nucleic Acids Res (2013) 1.83
Generating genetically modified mice using CRISPR/Cas-mediated genome engineering. Nat Protoc (2014) 1.76
Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases. PLoS One (2011) 1.69
Safe harbours for the integration of new DNA in the human genome. Nat Rev Cancer (2011) 1.67
Triplex technology in studies of DNA damage, DNA repair, and mutagenesis. Biochimie (2011) 1.67
Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice. Genome Biol (2015) 1.64
Accelerated homologous recombination and subsequent genome modification in Drosophila. Development (2013) 1.55
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Generating knockout rats by transposon mutagenesis in spermatogonial stem cells. Nat Methods (2010) 1.46
A CRISPR view of development. Genes Dev (2014) 1.41
Generating gene knockout rats by homologous recombination in embryonic stem cells. Nat Protoc (2011) 1.32
A device for the simple and rapid transcervical transfer of mouse embryos eliminates the need for surgery and potential post-operative complications. Biotechniques (2009) 1.30
Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases. Nucleic Acids Res (2011) 1.25
Modeling disease mutations by gene targeting in one-cell mouse embryos. Proc Natl Acad Sci U S A (2012) 1.25
Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle. Cell Res (2011) 1.23
Human pluripotent stem cells: an emerging model in developmental biology. Development (2013) 1.22
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Genetically engineered mouse models in cancer research. Adv Cancer Res (2010) 1.18
Efficient homologous recombination-mediated genome engineering in zebrafish using TALE nucleases. Development (2014) 1.16
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Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals. BMC Genomics (2008) 1.14
Highly efficient targeted mutagenesis in mice using TALENs. Genetics (2013) 1.12
Advances in genome editing technology and its promising application in evolutionary and ecological studies. Gigascience (2014) 1.11
Targeted gene knockout in chickens mediated by TALENs. Proc Natl Acad Sci U S A (2014) 1.11
White matter inhibitors in CNS axon regeneration failure. Exp Neurol (2007) 1.10
Evaluation of OPEN zinc finger nucleases for direct gene targeting of the ROSA26 locus in mouse embryos. PLoS One (2012) 1.10
Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9. J Mol Cell Biol (2015) 1.07
Mouse genome engineering via CRISPR-Cas9 for study of immune function. Immunity (2015) 1.02
Nanoparticles and their applications in cell and molecular biology. Integr Biol (Camb) (2014) 1.02
Cell-type-specific labeling of synapses in vivo through synaptic tagging with recombination. Neuron (2014) 1.02
Development of a porcine model of cystic fibrosis. Trans Am Clin Climatol Assoc (2009) 1.02
Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease. Genetics (2015) 1.02
CRISPR/Cas9-mediated gene knock-down in post-mitotic neurons. PLoS One (2014) 1.00
Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA. Nat Protoc (2013) 0.99
Derivation of a germline competent transgenic Fischer 344 embryonic stem cell line. PLoS One (2013) 0.99
Engineering Human Stem Cell Lines with Inducible Gene Knockout using CRISPR/Cas9. Cell Stem Cell (2015) 0.98
Seamless genome editing in human pluripotent stem cells using custom endonuclease-based gene targeting and the piggyBac transposon. Nat Protoc (2013) 0.97
Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system. Mamm Genome (2014) 0.97
Reverse genetics in eukaryotes. Biol Cell (2010) 0.97
Efficient gene targeting in golden Syrian hamsters by the CRISPR/Cas9 system. PLoS One (2014) 0.96
Intron targeting-mediated and endogenous gene integrity-maintaining knockin in zebrafish using the CRISPR/Cas9 system. Cell Res (2015) 0.96
Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice. PLoS One (2013) 0.96
An enhanced gene targeting toolkit for Drosophila: Golic+. Genetics (2015) 0.95
Synergies between assisted reproduction technologies and functional genomics. Genet Sel Evol (2016) 0.95
Heritable targeted inactivation of myostatin gene in yellow catfish (Pelteobagrus fulvidraco) using engineered zinc finger nucleases. PLoS One (2011) 0.94
Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators. Front Mol Neurosci (2009) 0.94
Efficient detection, quantification and enrichment of subtle allelic alterations. DNA Res (2012) 0.93
Germline transmission of a novel rat embryonic stem cell line derived from transgenic rats. Stem Cells Dev (2012) 0.93
Predictably irrational: assaying cognitive inflexibility in mouse models of schizophrenia. Front Neurosci (2010) 0.93
Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes. BMC Biotechnol (2016) 0.93
Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos. Sci Rep (2015) 0.93
Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics. Neuropharmacology (2013) 0.92
Interpreting human genetic variation with in vivo zebrafish assays. Biochim Biophys Acta (2014) 0.92
Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair. Nucleic Acids Res (2016) 0.89
Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases. Genome Res (2014) 0.89
Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates. Proc Natl Acad Sci U S A (2012) 0.89
TALEN and CRISPR/Cas Genome Editing Systems: Tools of Discovery. Acta Naturae (2014) 0.89
A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9. Proc Natl Acad Sci U S A (2015) 0.89
Development of a mono-promoter-driven CRISPR/Cas9 system in mammalian cells. Sci Rep (2015) 0.88
A single blastocyst assay optimized for detecting CRISPR/Cas9 system-induced indel mutations in mice. BMC Biotechnol (2014) 0.88
Biallelic targeting of expressed genes in mouse embryonic stem cells using the Cas9 system. Methods (2014) 0.88
Efficient derivation and genetic modifications of human pluripotent stem cells on engineered human feeder cell lines. Stem Cells Dev (2012) 0.88
An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions. PLoS One (2011) 0.88
Analysis of the phytochrome gene family in Ceratodon purpureus by gene targeting reveals the primary phytochrome responsible for photo- and polarotropism. Planta (2009) 0.88
Culture parameters for stable expansion, genetic modification and germline transmission of rat pluripotent stem cells. Biol Open (2011) 0.87
Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos. FEBS Open Bio (2014) 0.87
Genetically engineered mouse models of Parkinson's disease. Brain Res Bull (2011) 0.86
Functional genetics for all: engineered nucleases, CRISPR and the gene editing revolution. Evodevo (2014) 0.86
Screening methods to identify TALEN-mediated knockout mice. Exp Anim (2014) 0.86
Rat traps: filling the toolbox for manipulating the rat genome. Genome Biol (2010) 0.86
Overview: generation of gene knockout mice. Curr Protoc Cell Biol (2009) 0.86
Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases. PLoS One (2011) 0.85
Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells. Proc Natl Acad Sci U S A (2014) 0.85
p53 gene targeting by homologous recombination in fish ES cells. PLoS One (2013) 0.83
TAL effectors: tools for DNA targeting. Brief Funct Genomics (2014) 0.83
Single-step generation of rabbits carrying a targeted allele of the tyrosinase gene using CRISPR/Cas9. Exp Anim (2014) 0.83
Cellular and Molecular Mechanisms of Palatogenesis. Curr Top Dev Biol (2015) 0.83
Gene correction in patient-specific iPSCs for therapy development and disease modeling. Hum Genet (2016) 0.83
Highly Efficient Mouse Genome Editing by CRISPR Ribonucleoprotein Electroporation of Zygotes. J Biol Chem (2016) 0.82