Published in Nat Protoc on May 26, 2011
An alternative pluripotent state confers interspecies chimaeric competency. Nature (2015) 1.90
Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nat Commun (2013) 1.23
Rapid and cost-effective gene targeting in rat embryonic stem cells by TALENs. J Genet Genomics (2012) 1.21
Rat placentation: an experimental model for investigating the hemochorial maternal-fetal interface. Placenta (2012) 1.15
CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos. Nat Protoc (2014) 1.08
Comparison of TALEN scaffolds in Xenopus tropicalis. Biol Open (2013) 1.04
A comparative study of protocols for mouse embryonic stem cell culturing. PLoS One (2013) 1.01
Targeted Germline Modifications in Rats Using CRISPR/Cas9 and Spermatogonial Stem Cells. Cell Rep (2015) 1.00
Derivation of a germline competent transgenic Fischer 344 embryonic stem cell line. PLoS One (2013) 0.99
2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research. J Cardiovasc Transl Res (2015) 0.94
STAT3 phosphorylation at tyrosine 705 and serine 727 differentially regulates mouse ESC fates. Stem Cells (2014) 0.94
Germline transmission of a novel rat embryonic stem cell line derived from transgenic rats. Stem Cells Dev (2012) 0.93
The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment. Nat Commun (2014) 0.90
Culture parameters for stable expansion, genetic modification and germline transmission of rat pluripotent stem cells. Biol Open (2011) 0.87
Rodent models in neuroscience research: is it a rat race? Dis Model Mech (2016) 0.82
Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector. PLoS One (2013) 0.81
The roles of ERAS during cell lineage specification of mouse early embryonic development. Open Biol (2015) 0.79
Efficient division and sampling of cell colonies using microcup arrays. Analyst (2012) 0.78
Induced neural stem cells generated from rat fibroblasts. Genomics Proteomics Bioinformatics (2013) 0.78
Rat embryonic stem cells create new era in development of genetically manipulated rat models. World J Stem Cells (2015) 0.78
Effect of leukemia inhibitory factor and forskolin on establishment of rat embryonic stem cell lines. J Reprod Dev (2013) 0.77
An Efficient Method for Generation of Transgenic Rats Avoiding Embryo Manipulation. Mol Ther Nucleic Acids (2016) 0.77
Enhancing stem cell survival in an ischemic heart by CRISPR-dCas9-based gene regulation. Med Hypotheses (2014) 0.76
Immortalized tumor derived rat fibroblasts as feeder cells facilitate the cultivation of male embryonic stem cells from the rat strain WKY/Ztm. Springerplus (2014) 0.75
Developing genetically engineered mouse models to study tumor suppression. Curr Protoc Mouse Biol (2012) 0.75
Tissue Specific Expression of Cre in Rat Tyrosine Hydroxylase and Dopamine Active Transporter-Positive Neurons. PLoS One (2016) 0.75
Identification and Characterization of the V(D)J Recombination Activating Gene 1 in Long-Term Memory of Context Fear Conditioning. Neural Plast (2015) 0.75
Efficient generation of selection-gene-free rat knockout models by homologous recombination in ES cells. FEBS Lett (2016) 0.75
May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells. Cells (2017) 0.75
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44
A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res (2003) 12.94
Knockout rats via embryo microinjection of zinc-finger nucleases. Science (2009) 12.33
Capture of authentic embryonic stem cells from rat blastocysts. Cell (2008) 6.60
Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century. Nat Rev Genet (2005) 6.05
Targeted integration in rat and mouse embryos with zinc-finger nucleases. Nat Biotechnol (2010) 5.60
Germline competent embryonic stem cells derived from rat blastocysts. Cell (2008) 5.52
Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol (2005) 4.79
Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells. Cell (2010) 4.24
Recombineering: a homologous recombination-based method of genetic engineering. Nat Protoc (2009) 4.15
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc Natl Acad Sci U S A (2010) 3.90
Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases. PLoS One (2010) 3.09
Production of p53 gene knockout rats by homologous recombination in embryonic stem cells. Nature (2010) 2.92
Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells. Science (1989) 2.90
Production of knockout rats using ENU mutagenesis and a yeast-based screening assay. Nat Biotechnol (2003) 2.69
Transposon-tagged mutagenesis in the rat. Nat Methods (2007) 2.06
Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn (1997) 2.05
Establishment and chimera analysis of 129/SvEv- and C57BL/6-derived mouse embryonic stem cell lines. Biotechniques (2000) 1.99
A new method for rapidly generating gene-targeting vectors by engineering BACs through homologous recombination in bacteria. Genome Res (2003) 1.77
Derivation of mouse embryonic stem cells. Nat Protoc (2006) 1.76
To knockout in 129 or in C57BL/6: that is the question. Trends Genet (2004) 1.76
Establishment of a germ-line competent C57BL/6 embryonic stem cell line. Exp Cell Res (1991) 1.70
A protocol for constructing gene targeting vectors: generating knockout mice for the cadherin family and beyond. Nat Protoc (2008) 1.69
Characterization of immunoglobulin heavy chain knockout rats. Eur J Immunol (2010) 1.63
Generation of genetically modified rats from embryonic stem cells. Proc Natl Acad Sci U S A (2010) 1.59
Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis. Immunol Rev (2001) 1.50
Generating knockout rats by transposon mutagenesis in spermatogonial stem cells. Nat Methods (2010) 1.46
Heritable and stable gene knockdown in rats. Proc Natl Acad Sci U S A (2006) 1.26
Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease. Hum Mol Genet (2006) 1.25
Use of coisogenic host blastocysts for efficient establishment of germline chimeras with C57BL/6J ES cell lines. Biotechniques (2001) 1.21
Gene targeting in C57BL/6 ES cells. Successful germ line transmission using recipient BALB/c blastocysts developmentally matured in vitro. Nucleic Acids Res (1997) 1.17
Establishment of rat embryonic stem cell lines that can participate in germline chimerae at high efficiency. Mol Reprod Dev (2010) 1.07
Efficient gene targeting by homologous recombination in rat embryonic stem cells. PLoS One (2010) 1.01
ENU mutagenesis to generate genetically modified rat models. Methods Mol Biol (2010) 1.00
Derivation of embryonic stem cells from Brown Norway rats blastocysts. J Genet Genomics (2010) 0.99
Rat transgenesis via embryonic stem cells electroporated with the Kusabira-orange gene. Mol Reprod Dev (2010) 0.96
Pronuclear DNA injection for the production of transgenic rats. Methods Mol Biol (2009) 0.95
Generating mutant rats using the Sleeping Beauty transposon system. Methods (2009) 0.87
Genetically engineered rat models for breast cancer. Breast Dis (2007) 0.83
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell (2004) 10.89
Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. PLoS Biol (2005) 9.12
Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol (2003) 8.61
Capture of authentic embryonic stem cells from rat blastocysts. Cell (2008) 6.60
Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nat Med (2011) 6.21
Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. JAMA (2009) 6.06
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab (2010) 5.82
Germline competent embryonic stem cells derived from rat blastocysts. Cell (2008) 5.52
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature (2011) 4.78
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem (2007) 4.58
Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysis. Lancet (2006) 4.42
Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem (2005) 4.30
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell (2010) 4.01
Reader's guide to critical appraisal of cohort studies: 2. Assessing potential for confounding. BMJ (2005) 3.94
When laboratories report estimated glomerular filtration rates in addition to serum creatinines, nephrology consults increase. Kidney Int (2009) 3.70
Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension (2003) 3.39
Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J Clin Invest (2003) 3.14
Mirid bug outbreaks in multiple crops correlated with wide-scale adoption of Bt cotton in China. Science (2010) 3.09
An integrated physical and genetic map of the rice genome. Plant Cell (2002) 3.07
Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. J Biol Chem (2005) 3.06
Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study. Arch Intern Med (2009) 2.96
Production of p53 gene knockout rats by homologous recombination in embryonic stem cells. Nature (2010) 2.92
Prevalence, predictors, and outcomes of primary nonadherence after acute myocardial infarction. Circulation (2008) 2.76
Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. Mol Cell (2010) 2.64
STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells. Blood (2010) 2.48
Nephrologist follow-up improves all-cause mortality of severe acute kidney injury survivors. Kidney Int (2013) 2.42
Antiretroviral therapy to prevent HIV transmission in serodiscordant couples in China (2003-11): a national observational cohort study. Lancet (2012) 2.41
Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens. Immunity (2005) 2.40
A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. J Neurosci (2005) 2.28
Extensive turnover of dendritic spines and vascular remodeling in cortical tissues recovering from stroke. J Neurosci (2007) 2.19
CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions. Nat Immunol (2003) 2.13
14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell (2009) 2.09
Promising clinical outcome of stereotactic body radiation therapy for patients with inoperable Stage I/II non-small-cell lung cancer. Int J Radiat Oncol Biol Phys (2006) 2.04
Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo. J Biol Chem (2005) 2.04
Knockdown of NOB1 expression by RNAi inhibits cellular proliferation and migration in human gliomas. Gene (2013) 2.03
Cholinesterase inhibitors and hospitalization for bradycardia: a population-based study. PLoS Med (2009) 1.94
A genome-wide association study identifies two new risk loci for Graves' disease. Nat Genet (2011) 1.92
Sex-and age-based differences in the delivery and outcomes of critical care. CMAJ (2007) 1.91
Diagnosis of severe acute respiratory syndrome (SARS) by detection of SARS coronavirus nucleocapsid antibodies in an antigen-capturing enzyme-linked immunosorbent assay. J Clin Microbiol (2003) 1.85
Two-photon imaging of stroke onset in vivo reveals that NMDA-receptor independent ischemic depolarization is the major cause of rapid reversible damage to dendrites and spines. J Neurosci (2008) 1.79
Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity. Mol Microbiol (2006) 1.79
Infection-associated clinical outcomes in hospitalized medical evacuees after traumatic injury: trauma infectious disease outcome study. J Trauma (2011) 1.77
Readers guide to critical appraisal of cohort studies: 3. Analytical strategies to reduce confounding. BMJ (2005) 1.76
Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression. J Biol Chem (2006) 1.73
Double knockout pigs deficient in N-glycolylneuraminic acid and galactose α-1,3-galactose reduce the humoral barrier to xenotransplantation. Xenotransplantation (2013) 1.72
PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle. Am J Physiol Cell Physiol (2009) 1.72
Contemporary clinical research of traditional Chinese medicines for chronic hepatitis B in China: an analytical review. Hepatology (2010) 1.71
Voluntary running induces fiber type-specific angiogenesis in mouse skeletal muscle. Am J Physiol Cell Physiol (2004) 1.71
Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis. Mol Cell (2002) 1.67
Atypical antipsychotics and parkinsonism. Arch Intern Med (2005) 1.66
Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. Science (2007) 1.64
Statins and intracerebral hemorrhage: a retrospective cohort study. Arch Neurol (2011) 1.63
Detection of survivin-expressing circulating cancer cells (CCCs) in peripheral blood of patients with gastric and colorectal cancer reveals high risks of relapse. Ann Surg Oncol (2008) 1.62
Safety and cross-reactive immunogenicity of candidate AS03-adjuvanted prepandemic H5N1 influenza vaccines: a randomized controlled phase 1/2 trial in adults. J Infect Dis (2010) 1.60
γδT Cell-derived interleukin-17A via an interleukin-1β-dependent mechanism mediates cardiac injury and fibrosis in hypertension. Hypertension (2014) 1.59
Risk of mycobacterial infections associated with rheumatoid arthritis in Ontario, Canada. Chest (2014) 1.57
Invasive mold infections following combat-related injuries. Clin Infect Dis (2012) 1.55
Construction of genetic linkage maps and comparative genome analysis of catfish using gene-associated markers. Genetics (2009) 1.55
Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1. EMBO J (2013) 1.50
Safety and long-term humoral immune response in adults after vaccination with an H1N1 2009 pandemic influenza vaccine with or without AS03 adjuvant. J Infect Dis (2012) 1.50
Patients With Ankylosing Spondylitis Have Increased Cardiovascular and Cerebrovascular Mortality: A Population-Based Study. Ann Intern Med (2015) 1.49
Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Mol Pharmacol (2008) 1.46
Results of a randomized controlled trial on statin use in dialysis patients had no influence on statin prescription. Kidney Int (2009) 1.45
An AFLP-based genetic linkage map of channel catfish (Ictalurus punctatus) constructed by using an interspecific hybrid resource family. Genetics (2003) 1.44
Relationship of erythrocyte transfusion with short- and long-term mortality in a population-based surgical cohort. Anesthesiology (2012) 1.42
p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice. PLoS One (2009) 1.41
Dose-sparing H5N1 A/Indonesia/05/2005 pre-pandemic influenza vaccine in adults and elderly adults: a phase III, placebo-controlled, randomized study. J Infect Dis (2011) 1.40
Potentially unintended discontinuation of long-term medication use after elective surgical procedures. Arch Intern Med (2006) 1.38
Immunogenicity of Renal Microvascular Endothelial Cells From Genetically Modified Pigs. Transplantation (2016) 1.38
Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes. J Exp Med (2002) 1.38
Establishment of a reverse genetics system for Schmallenberg virus, a newly emerged orthobunyavirus in Europe. J Gen Virol (2012) 1.38
Effects of missing marker and segregation distortion on QTL mapping in F2 populations. Theor Appl Genet (2010) 1.35
ErbB2 promotes Src synthesis and stability: novel mechanisms of Src activation that confer breast cancer metastasis. Cancer Res (2005) 1.35
Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter. Am J Nephrol (2005) 1.33
Role of the cytoplasmic tail domains of Bunyamwera orthobunyavirus glycoproteins Gn and Gc in virus assembly and morphogenesis. J Virol (2007) 1.33
Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies. Clin Cancer Res (2011) 1.32
Quality evaluation of Radix Astragali through a simultaneous determination of six major active isoflavonoids and four main saponins by high-performance liquid chromatography coupled with diode array and evaporative light scattering detectors. J Chromatogr A (2006) 1.31
TNF-alpha and pathologic bone resorption. Keio J Med (2005) 1.31
Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Am J Pathol (2007) 1.30
Assembly of 500,000 inter-specific catfish expressed sequence tags and large scale gene-associated marker development for whole genome association studies. Genome Biol (2010) 1.29
Development of traditional Chinese medicine clinical data warehouse for medical knowledge discovery and decision support. Artif Intell Med (2010) 1.28
Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure. Am J Physiol Renal Physiol (2003) 1.28
Detection of medically important Ehrlichia by quantitative multicolor TaqMan real-time polymerase chain reaction of the dsb gene. J Mol Diagn (2005) 1.26
Requirement of the N-terminal region of orthobunyavirus nonstructural protein NSm for virus assembly and morphogenesis. J Virol (2006) 1.26
The leader proteinase of foot-and-mouth disease virus negatively regulates the type I interferon pathway by acting as a viral deubiquitinase. J Virol (2011) 1.25
Inhibition of glycolipid shedding rescues recognition of a CD1+ T cell lymphoma by natural killer T (NKT) cells. Proc Natl Acad Sci U S A (2002) 1.25
The emergence of competing modules in bilingualism. Trends Cogn Sci (2005) 1.24
Phenazinium methyl sulfate. Acta Crystallogr Sect E Struct Rep Online (2012) 1.24
Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell Biol (2003) 1.23
Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nat Commun (2013) 1.23
Rapid and cost-effective gene targeting in rat embryonic stem cells by TALENs. J Genet Genomics (2012) 1.21
Molecular epidemiology of measles viruses in China, 1995-2003. Virol J (2007) 1.20
Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis. Mol Ther (2002) 1.19