Published in Cancer Biol Ther on July 04, 2005
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci U S A (2007) 3.23
An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. Mol Cancer Ther (2008) 2.21
Differences in gastric carcinoma microenvironment stratify according to EBV infection intensity: implications for possible immune adjuvant therapy. PLoS Pathog (2013) 1.43
Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet (2011) 1.42
Epigenetics and epigenetic alterations in pancreatic cancer. Int J Clin Exp Pathol (2008) 1.05
Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts. J Mol Diagn (2008) 1.04
Hedgehog signaling in cancer stem cells: a focus on hematological cancers. Stem Cells Cloning (2015) 0.93
Implications of hedgehog signaling antagonists for cancer therapy. Acta Biochim Biophys Sin (Shanghai) (2008) 0.92
Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms. Blood Cancer J (2012) 0.90
SERPINB5 and AKAP12 - expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma. BMC Cancer (2010) 0.90
Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer. Cancer Biol Ther (2011) 0.86
Hedgehog pathway maintains cell survival under stress conditions, and drives drug resistance in lung adenocarcinoma. Oncotarget (2016) 0.84
A potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues. BMC Mol Biol (2006) 0.81
Identification of signature genes for detecting hedgehog pathway activation in esophageal cancer. Pathol Oncol Res (2011) 0.81
Human hedgehog interacting protein expression and promoter methylation in medulloblastoma cell lines and primary tumor samples. J Neurooncol (2010) 0.80
Regulation of gene expression in HBV- and HCV-related hepatocellular carcinoma: integrated GWRS and GWGS analyses. Int J Clin Exp Med (2014) 0.78
Identification of interconnected markers for T-cell acute lymphoblastic leukemia. Biomed Res Int (2013) 0.77
Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumor samples. Tumour Biol (2014) 0.76
Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells. Cancer Biol Ther (2014) 0.75
Hhip regulates tumor-stroma-mediated upregulation of tumor angiogenesis. Exp Mol Med (2017) 0.75
Long-term consequences of Kawasaki disease. A 10- to 21-year follow-up study of 594 patients. Circulation (1996) 7.29
The relation between health insurance coverage and clinical outcomes among women with breast cancer. N Engl J Med (1993) 6.37
Progression model for pancreatic cancer. Clin Cancer Res (2000) 4.60
Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res (1997) 4.54
Biological and chemical detection of trichothecene mycotoxins of Fusarium species. Appl Microbiol (1973) 4.37
Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE). Clin Cancer Res (2001) 4.19
ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J Cell Biol (1994) 4.09
Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J Cell Biol (1996) 4.06
Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. Am J Clin Nutr (1997) 3.75
Application of typing by pulsed-field gel electrophoresis to the study of Clostridium difficile in a neonatal intensive care unit. J Clin Microbiol (1994) 3.51
Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J Neurosci (1997) 3.49
Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10. Eur J Immunol (1992) 3.39
Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes. Proc Natl Acad Sci U S A (1999) 3.21
Artificial surfactant therapy in hyaline-membrane disease. Lancet (1980) 3.21
The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma. Clin Cancer Res (2001) 3.02
Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J Cell Biol (1994) 2.93
Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. Cell (1991) 2.84
Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood (1977) 2.76
Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol (1994) 2.74
Small peptides as potent mimetics of the protein hormone erythropoietin. Science (1996) 2.70
Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am J Pathol (1999) 2.59
JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol Cell Biol (1994) 2.55
Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma. Cancer Res (2001) 2.50
FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions. Radiology (2001) 2.46
Comparative toxicology of trichothec mycotoxins: inhibition of protein synthesis in animal cells. J Biochem (1973) 2.45
Hypermethylation of multiple genes in pancreatic adenocarcinoma. Cancer Res (2000) 2.40
Radixin is a novel member of the band 4.1 family. J Cell Biol (1991) 2.40
Toxicological approaches to the metabolites of Fusaria. V. Neosolaniol, T-2 toxin and butenolide, toxic metabolites of Fusarium sporotrichioides NRRL 3510 and Fusarium poae 3287. Jpn J Exp Med (1972) 2.37
Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. Cancer Res (1998) 2.23
Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures. J Cell Sci (1996) 2.20
Long-term therapy of chronic delta hepatitis with peginterferon alfa. Aliment Pharmacol Ther (2014) 2.19
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nat Cell Biol (1999) 2.14
Localization of insulinomas to regions of the pancreas by intra-arterial stimulation with calcium. Ann Intern Med (1995) 2.05
Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer. J Natl Cancer Inst (1999) 2.03
Muscle-fiber pennation angles are greater in hypertrophied than in normal muscles. J Appl Physiol (1985) (1993) 2.01
Acute infectious mononucleosis. CD30 (Ki-1) antigen expression and histologic correlations. Am J Clin Pathol (1990) 1.99
Increased risk of incident pancreatic cancer among first-degree relatives of patients with familial pancreatic cancer. Clin Cancer Res (2001) 1.98
Toxicological approaches to the metabolites of Fusaria. VI. Vomiting factor from moldy corn infected with Fusarium spp. Jpn J Exp Med (1974) 1.95
Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J Neurosci (1995) 1.95
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas. J Natl Cancer Inst (2000) 1.94
STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathol (2001) 1.89
Concentration of an integral membrane protein, CD43 (leukosialin, sialophorin), in the cleavage furrow through the interaction of its cytoplasmic domain with actin-based cytoskeletons. J Cell Biol (1993) 1.88
Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis. Cell Death Differ (2001) 1.87
Endoscopic ultrasound examination for mediastinal lymph node metastases of lung cancer. Chest (1990) 1.85
Bisulfite sequencing and dinucleotide content analysis of 15 imprinted mouse differentially methylated regions (DMRs): paternally methylated DMRs contain less CpGs than maternally methylated DMRs. Cytogenet Genome Res (2006) 1.84
Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. Gut (2008) 1.82
A mutant of Escherichia coli that requires high concentrations of biotin. Proc Natl Acad Sci U S A (1972) 1.78
Diffuse pachymeningeal hyperintensity and subdural effusion/hematoma detected by fluid-attenuated inversion recovery MR imaging in patients with spontaneous intracranial hypotension. AJNR Am J Neuroradiol (2008) 1.77
Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. Br J Cancer (2001) 1.77
Troglitazone reduces plasma leptin concentration but increases hunger in NIDDM patients. Diabetes Care (1998) 1.76
Improved intratumoral penetration of radiolabeled streptavidin in intraperitoneal tumors pretargeted with biotinylated antibody. J Nucl Med (1998) 1.76
Effect of growth temperature on lipid and fatty acid compositions in the blue-green algae, Anabaena variabilis and Anacystis nidulans. Biochim Biophys Acta (1979) 1.71
Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. Cancer Res (1998) 1.71
Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma. Cancer Res (1991) 1.71
Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: A newly described and characterized entity. Am J Pathol (2000) 1.69
Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET. Eur J Biochem (2001) 1.68
Structure and regulation of rat long-chain acyl-CoA synthetase. J Biol Chem (1990) 1.68
Actions of tumor necrosis factor on cultured vascular endothelial cells: morphologic modulation, growth inhibition, and cytotoxicity. J Natl Cancer Inst (1986) 1.68
Effect of albendazole on recurrent and residual alveolar echinococcosis of the liver after surgery. Hepatology (1997) 1.68
Gains, losses, and amplifications of genomic materials in primary gastric cancers analyzed by comparative genomic hybridization. Genes Chromosomes Cancer (1999) 1.68
Vascular endothelial growth factor-C (VEGF-C) expression in human colorectal cancer tissues. Br J Cancer (2000) 1.67
Pharmacological evidence for the persistent activation of ATP-sensitive K+ channels in early phase of reperfusion and its protective role against myocardial stunning. Circulation (1995) 1.67
Distinction between hyperaldosteronism due to bilateral hyperplasia and unilateral aldosteronoma: reliability of CT. Radiology (1992) 1.66
Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft. Diabetologia (2009) 1.65
Vaccination of recurrent glioma patients with tumour lysate-pulsed dendritic cells elicits immune responses: results of a clinical phase I/II trial. Br J Cancer (2003) 1.63
Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis. Gut (2003) 1.63
Coating of CaTiO3 on titanium substrates by hydrothermal reactions using calcium-ethylene diamine tetra acetic acid chelate. J Mater Sci Mater Med (1998) 1.61
Cholesterol granuloma in the petrous apex: case report and review. Acta Neurochir (Wien) (2001) 1.61
Real-time sound spectroanalysis for diagnosis of malfunctioning prosthetic valves. J Thorac Cardiovasc Surg (1980) 1.60
Association of duration of television viewing in early childhood with the subsequent development of asthma. Thorax (2009) 1.59
Establishment and characterization of a breast cancer cell line expressing Na+/I- symporters for radioiodide concentrator gene therapy. J Nucl Med (2000) 1.59
Insulinomas: localization with selective intraarterial injection of calcium. Radiology (1991) 1.58
Continuous release of endostatin from microencapsulated engineered cells for tumor therapy. Nat Biotechnol (2001) 1.57
Dynamic reorientation of cultured cells and stress fibers under mechanical stress from periodic stretching. Exp Cell Res (2001) 1.56
Molecular pathology of pancreatic cancer. Cancer J (2001) 1.56
Gastrinomas: localization by means of selective intraarterial injection of secretin. Radiology (1990) 1.56
CHD7 mutations in patients initially diagnosed with Kallmann syndrome--the clinical overlap with CHARGE syndrome. Clin Genet (2008) 1.56
Extensive lymphopenia due to apoptosis of uninfected lymphocytes in acute measles patients. Arch Virol (2000) 1.55
Location of promoter and operator sites in the biotin gene cluster of Escherichia coli. Proc Natl Acad Sci U S A (1972) 1.55
NOS and COX isoforms and abnormal microvessel responses to CO2 and H+ in hyperoxia-injured lungs. Eur Respir J (2002) 1.54
SNARE complex oligomerization by synaphin/complexin is essential for synaptic vesicle exocytosis. Cell (2001) 1.53
Functional delineation of the human occipito-temporal areas related to face and scene processing. A PET study. Brain (2000) 1.52
Interleukin-6 prevents dexamethasone-induced myeloma cell death. Blood (1994) 1.52
Structure and organization of the mitochondrial genome of the unicellular red alga Cyanidioschyzon merolae deduced from the complete nucleotide sequence. Nucleic Acids Res (1998) 1.52
A severe outbreak of haemorrhagic colitis and haemolytic uraemic syndrome associated with Escherichia coli O157:H7 in Japan. Eur J Pediatr (1994) 1.52
Familial pancreatic cancer. Cancer J (2001) 1.51
Determination of optimum retrograde cerebral perfusion conditions. J Thorac Cardiovasc Surg (1994) 1.51
Effective control of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis with immunochemotherapy. Histiocyte Society. Blood (1999) 1.51
Ethanol-induced vasoconstriction causes focal hepatocellular injury in the isolated perfused rat liver. Hepatology (1992) 1.50
Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2. Biochem Biophys Res Commun (1999) 1.50
3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmacokinetic properties. Magn Reson Med (2001) 1.49
Deficiency of glycosyl-phosphatidylinositol anchored proteins on paroxysmal nocturnal haemoglobinuria (PNH) neutrophils and monocytes: heterogeneous deficiency of decay-accelerating factor (DAF) and CD16 on PNH neutrophils. Br J Haematol (1990) 1.49
Polymerization and depolymerization of microtubules in vitro as studied by flow birefringence. FEBS Lett (1974) 1.48
Temperature shift-induced responses in lipids in the blue-green alga, Anabaena variabilis: the central role of diacylmonogalactosylglycerol in thermo-adaptation. Biochim Biophys Acta (1980) 1.48
Autofluorescence endoscopy: feasibility of detection of GI neoplasms unapparent to white light endoscopy with an evolving technology. Gastrointest Endosc (2001) 1.48
Fat-free mass is related to one-mile race performance in elite standardbred horses. Vet J (2002) 1.48
Cardiopulmonary bypass and cellular immunity: changes in lymphocyte subsets and natural killer cell activity. Ann Thorac Surg (1993) 1.47