Published in Hum Mol Genet on June 22, 2005
A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the cavefish Astyanax mexicanus. PLoS Genet (2009) 1.98
Molecular and functional basis of phenotypic convergence in white lizards at White Sands. Proc Natl Acad Sci U S A (2009) 1.82
Functional melanocortin 1 receptor Mc1r is not necessary for an inflammatory response to UV radiation in adult mouse skin. Exp Dermatol (2013) 1.49
Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs. Trends Endocrinol Metab (2009) 1.12
Aberrant trafficking of human melanocortin 1 receptor variants associated with red hair and skin cancer: Steady-state retention of mutant forms in the proximal golgi. J Cell Physiol (2009) 1.03
Defining MC1R regulation in human melanocytes by its agonist α-melanocortin and antagonists agouti signaling protein and β-defensin 3. J Invest Dermatol (2012) 1.01
MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation. Pigment Cell Melanoma Res (2014) 0.97
Obesity-linked variants of melanocortin-4 receptor are misfolded in the endoplasmic reticulum and can be rescued to the cell surface by a chemical chaperone. Mol Endocrinol (2010) 0.97
Melanocortin MC₁ receptor in human genetics and model systems. Eur J Pharmacol (2011) 0.92
Spatial and temporal localization of the melanocortin 1 receptor and its ligand α-melanocyte-stimulating hormone during cutaneous wound repair. J Histochem Cytochem (2011) 0.91
Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptors. Adv Pharmacol (2011) 0.91
Selected melanocortin 1 receptor single-nucleotide polymorphisms differentially alter multiple signaling pathways. J Pharmacol Exp Ther (2012) 0.91
Chaperoning G protein-coupled receptors: from cell biology to therapeutics. Endocr Rev (2014) 0.91
MC1R genotype may modify the effect of sun exposure on melanoma risk in the GEM study. Cancer Causes Control (2010) 0.90
Melanocortin-1 receptor-mediated signalling pathways activated by NDP-MSH and HBD3 ligands. Pigment Cell Melanoma Res (2012) 0.88
Identification of novel functional variants of the melanocortin 1 receptor gene originated from Asians. Hum Genet (2006) 0.84
Race and Melanocortin 1 Receptor Polymorphism R163Q Are Associated with Post-Burn Hypertrophic Scarring: A Prospective Cohort Study. J Invest Dermatol (2015) 0.83
A brief history of melanoma: from mummies to mutations. Melanoma Res (2012) 0.83
Reciprocal responses of fibroblasts and melanocytes to α-MSH depending on MC1R polymorphisms. Dermatoendocrinol (2011) 0.81
Pharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptors. Recent Pat Endocr Metab Immune Drug Discov (2011) 0.81
Interaction between p53 codon 72 polymorphism and melanocortin 1 receptor variants on suntan response and cutaneous melanoma risk. Br J Dermatol (2008) 0.81
Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens. Pharmacol Res (2013) 0.81
Significance of the Melanocortin 1 and Endothelin B Receptors in Melanocyte Homeostasis and Prevention of Sun-Induced Genotoxicity. Front Genet (2016) 0.79
Distribution of MC1R variants among melanoma subtypes: p.R163Q is associated with lentigo maligna melanoma in a Mediterranean population. Br J Dermatol (2013) 0.77
Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis. Photochem Photobiol (2016) 0.76
Prediction of the damage-associated non-synonymous single nucleotide polymorphisms in the human MC1R gene. PLoS One (2015) 0.76
The Relationship between MC1R Mutation and Plumage Color Variation in Pigeons. Biomed Res Int (2016) 0.75
Red hair, MC1R variants, and risk for Parkinson's disease - a meta-analysis. Ann Clin Transl Neurol (2017) 0.75
Cell signalling: Red alert about lipid's role in skin cancer. Nature (2017) 0.75
Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors. J Invest Dermatol (2008) 2.80
Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin. Mol Biol Cell (2005) 2.74
The ins and outs of E-cadherin trafficking. Trends Cell Biol (2004) 2.70
Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival. J Clin Oncol (2011) 2.52
A role for the phagosome in cytokine secretion. Science (2005) 2.45
A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation. Am J Hum Genet (2006) 2.14
Characterization of the Melanoma miRNAome by Deep Sequencing. PLoS One (2010) 2.08
Characterization of E-cadherin endocytosis in isolated MCF-7 and chinese hamster ovary cells: the initial fate of unbound E-cadherin. J Biol Chem (2003) 2.05
Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma. J Invest Dermatol (2009) 1.81
Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis. Am J Physiol Cell Physiol (2008) 1.76
Interactive effects of MC1R and OCA2 on melanoma risk phenotypes. Hum Mol Genet (2004) 1.75
A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway. Cell (2013) 1.75
EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. J Cell Sci (2007) 1.64
IRF4 variants have age-specific effects on nevus count and predispose to melanoma. Am J Hum Genet (2010) 1.55
The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure. Traffic (2007) 1.54
Receptor function, dominant negative activity and phenotype correlations for MC1R variant alleles. Hum Mol Genet (2007) 1.52
GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network. J Biol Chem (2002) 1.48
A genome scan for eye color in 502 twin families: most variation is due to a QTL on chromosome 15q. Twin Res (2004) 1.47
Protein kinase C regulates endocytosis and recycling of E-cadherin. Am J Physiol Cell Physiol (2002) 1.44
Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin. Mol Biol Cell (2004) 1.43
Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc. J Invest Dermatol (2008) 1.42
Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha. J Biol Chem (2005) 1.39
Nuclear translocation of cell-surface receptors: lessons from fibroblast growth factor. Traffic (2005) 1.39
Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. Cancer Res (2008) 1.37
Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor. Pigment Cell Melanoma Res (2011) 1.35
Cytokine release from innate immune cells: association with diverse membrane trafficking pathways. Blood (2011) 1.34
Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5, and OCA2/P loci. J Invest Dermatol (2008) 1.33
Domains of the TGN: coats, tethers and G proteins. Traffic (2004) 1.32
Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFalpha. J Cell Biol (2007) 1.32
Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup. J Biol Chem (2006) 1.27
Red hair is the null phenotype of MC1R. Hum Mutat (2008) 1.26
A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo. Proc Natl Acad Sci U S A (2008) 1.24
Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation. FASEB J (2010) 1.23
The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion. Curr Biol (2003) 1.22
N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. J Cell Sci (2004) 1.20
Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma. Int J Cancer (2002) 1.20
Human melanoblasts in culture: expression of BRN2 and synergistic regulation by fibroblast growth factor-2, stem cell factor, and endothelin-3. J Invest Dermatol (2003) 1.19
Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella. EMBO J (2010) 1.19
E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by golgin-97. Traffic (2005) 1.19
Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity. Blood (2009) 1.16
Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells. J Biol Chem (2008) 1.16
Nestin and SOX9 and SOX10 transcription factors are coexpressed in melanoma. Exp Dermatol (2010) 1.14
The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis. Int J Biochem Cell Biol (2007) 1.13
The role of melanocortin-1 receptor polymorphism in skin cancer risk phenotypes. Pigment Cell Res (2003) 1.12
Fusion, fission, and secretion during phagocytosis. Physiology (Bethesda) (2007) 1.11
Targeting of a tropomyosin isoform to short microfilaments associated with the Golgi complex. Mol Biol Cell (2003) 1.08
Cytokine secretion is distinct from secretion of cytotoxic granules in NK cells. J Immunol (2010) 1.07
Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN. J Cell Sci (2004) 1.07
Post-transcriptional regulation of melanin biosynthetic enzymes by cAMP and resveratrol in human melanocytes. J Invest Dermatol (2007) 1.04
Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion. J Cell Biol (2010) 1.03
Co-expression of SOX9 and SOX10 during melanocytic differentiation in vitro. Exp Cell Res (2005) 1.02
Dynamin-dependent endocytosis is necessary for convergent-extension movements in Xenopus animal cap explants. Int J Dev Biol (2002) 1.02
GWAS findings for human iris patterns: associations with variants in genes that influence normal neuronal pattern development. Am J Hum Genet (2011) 1.01
The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking. Traffic (2011) 1.01
Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages. Traffic (2011) 1.00
Absence of classical MAP kinase pathway signalling in Merkel cell carcinoma. J Invest Dermatol (2006) 1.00
Quantitative analysis of MC1R gene expression in human skin cell cultures. Pigment Cell Res (2006) 0.98
Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas. J Clin Virol (2011) 0.98
Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice. Proc Natl Acad Sci U S A (2011) 0.98
Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma. Int J Cancer (2002) 0.97
SOX9 and SOX10 but not BRN2 are required for nestin expression in human melanoma cells. J Invest Dermatol (2008) 0.97
Human melanocytes expressing MC1R variant alleles show impaired activation of multiple signaling pathways. Peptides (2007) 0.96
Contextual binding of p120ctn to E-cadherin at the basolateral plasma membrane in polarized epithelia. J Biol Chem (2003) 0.95
The myotubularin phosphatase MTMR4 regulates sorting from early endosomes. J Cell Sci (2010) 0.95
Automated organelle-based colocalization in whole-cell imaging. Cytometry A (2009) 0.94
POU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis. Pigment Cell Melanoma Res (2008) 0.94
Activation of the cAMP pathway by variant human MC1R alleles expressed in HEK and in melanoma cells. Peptides (2005) 0.94
Screening of human primary melanocytes of defined melanocortin-1 receptor genotype: pigmentation marker, ultrastructural and UV-survival studies. Pigment Cell Res (2003) 0.94
VAMP3 regulates podosome organisation in macrophages and together with Stx4/SNAP23 mediates adhesion, cell spreading and persistent migration. Exp Cell Res (2011) 0.94
Osteonectin downregulates E-cadherin, induces osteopontin and focal adhesion kinase activity stimulating an invasive melanoma phenotype. Int J Cancer (2007) 0.93
Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as quantity of melanin. Pigment Cell Res (2006) 0.93
Melanocortin MC₁ receptor in human genetics and model systems. Eur J Pharmacol (2011) 0.92
Secretion of apolipoprotein E from macrophages occurs via a protein kinase A and calcium-dependent pathway along the microtubule network. Circ Res (2007) 0.92
The melanocortin-1 receptor gene polymorphism and association with human skin cancer. Prog Mol Biol Transl Sci (2009) 0.91
MC1R variant allele effects on UVR-induced phosphorylation of p38, p53, and DDB2 repair protein responses in melanocytic cells in culture. J Invest Dermatol (2012) 0.89
Osteonectin/SPARC induction by ectopic beta(3) integrin in human radial growth phase primary melanoma cells. Cancer Res (2002) 0.89
Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells. Pigment Cell Melanoma Res (2011) 0.88
Novel MC1R variants in Ligurian melanoma patients and controls. Hum Mutat (2004) 0.88
PPARgamma agonists attenuate proliferation and modulate Wnt/beta-catenin signalling in melanoma cells. Int J Biochem Cell Biol (2008) 0.88