Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity.

PubWeight™: 1.16‹?› | Rank: Top 10%

🔗 View Article (PMID 19704116)

Published in Blood on August 24, 2009

Authors

Stephanie M Wood1, Marie Meeths, Samuel C C Chiang, Anne Grete Bechensteen, Jaap J Boelens, Carsten Heilmann, Hisanori Horiuchi, Steen Rosthøj, Olga Rutynowska, Jacek Winiarski, Jennifer L Stow, Magnus Nordenskjöld, Jan-Inge Henter, Hans-Gustaf Ljunggren, Yenan T Bryceson

Author Affiliations

1: Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden. Stephanie.Wood@ki.se

Articles citing this

Controlling natural killer cell responses: integration of signals for activation and inhibition. Annu Rev Immunol (2013) 3.38

Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis. Blood (2010) 2.00

Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules. Nat Rev Immunol (2010) 1.93

Natural killer cell deficiency. J Allergy Clin Immunol (2013) 1.74

Human NK cell lytic granules and regulation of their exocytosis. Front Immunol (2012) 1.10

Cell biological steps and checkpoints in accessing NK cell cytotoxicity. Immunol Cell Biol (2014) 1.07

LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity. Blood (2013) 1.00

Distinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cells. PLoS One (2010) 0.99

Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein. Mol Biol Cell (2012) 0.98

MUNC13-4 protein regulates the oxidative response and is essential for phagosomal maturation and bacterial killing in neutrophils. J Biol Chem (2012) 0.96

Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils. J Biol Chem (2010) 0.93

Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors. J Leukoc Biol (2013) 0.91

Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity. Front Immunol (2014) 0.88

A signaling network stimulated by β2 integrin promotes the polarization of lytic granules in cytotoxic cells. Sci Signal (2014) 0.87

Late steps in secretory lysosome exocytosis in cytotoxic lymphocytes. Front Immunol (2013) 0.87

Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency. J Exp Med (2014) 0.85

Stepwise maturation of lytic granules during differentiation and activation of human CD8+ T lymphocytes. PLoS One (2011) 0.83

An essential role for Rab27a GTPase in eosinophil exocytosis. J Leukoc Biol (2013) 0.82

The natural killer cell cytotoxic function is modulated by HIV-1 accessory proteins. Viruses (2011) 0.81

Chediak-Higashi syndrome: Lysosomal trafficking regulator domains regulate exocytosis of lytic granules but not cytokine secretion by natural killer cells. J Allergy Clin Immunol (2015) 0.81

Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane. J Biol Chem (2015) 0.81

Evidence for defective Rab GTPase-dependent cargo traffic in immune disorders. Exp Cell Res (2013) 0.80

Activation of Lymphocyte Cytolytic Machinery: Where are We? Front Immunol (2013) 0.79

A role for Rab27 in neutrophil chemotaxis and lung recruitment. BMC Cell Biol (2014) 0.79

Munc13-4*rab27 complex tethers secretory lysosomes at the plasma membrane. Commun Integr Biol (2012) 0.78

Novel 47.5-kb deletion in RAB27A results in severe Griscelli Syndrome Type 2. Mol Genet Metab (2010) 0.78

Genetic dissection of NK cell responses. Front Immunol (2013) 0.77

Orchestrating Lymphocyte Polarity in Cognate Immune Cell-Cell Interactions. Int Rev Cell Mol Biol (2016) 0.76

Insights into primary immune deficiency from quantitative microscopy. J Allergy Clin Immunol (2015) 0.75

Munc13-4 functions as a Ca2+ sensor for homotypic secretory granule fusion to generate endosomal exocytic vacuoles. Mol Biol Cell (2017) 0.75

Differences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak-Higashi Syndrome Patients. Front Immunol (2017) 0.75

UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion. J Immunol (2015) 0.75

Articles by these authors

HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer (2007) 16.96

Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy. Science (2013) 5.34

Why rare diseases are an important medical and social issue. Lancet (2008) 4.20

Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion. Blood (2005) 3.99

Talking about death with children who have severe malignant disease. N Engl J Med (2004) 3.92

Birt-Hogg-Dubé syndrome: diagnosis and management. Lancet Oncol (2009) 3.60

Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education. Blood (2010) 3.58

Regulation of human NK-cell cytokine and chemokine production by target cell recognition. Blood (2009) 3.46

Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968-99. Lancet (2003) 3.44

Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells. J Exp Med (2005) 3.41

Activation, coactivation, and costimulation of resting human natural killer cells. Immunol Rev (2006) 3.30

Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling. Science (2004) 3.08

HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). Nat Genet (2006) 3.03

Heat-shock proteins as activators of the innate immune system. Trends Immunol (2002) 2.96

Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus. J Exp Med (2010) 2.89

Education of human natural killer cells by activating killer cell immunoglobulin-like receptors. Blood (2009) 2.88

Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin. Mol Biol Cell (2005) 2.74

Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11. Hum Mol Genet (2005) 2.70

The ins and outs of E-cadherin trafficking. Trends Cell Biol (2004) 2.70

Improved outcome in multisystem Langerhans cell histiocytosis is associated with therapy intensification. Blood (2007) 2.61

Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis. Blood (2013) 2.46

A role for the phagosome in cytokine secretion. Science (2005) 2.45

Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice. Cardiovasc Res (2003) 2.44

Serum vaccine antibody concentrations in children exposed to perfluorinated compounds. JAMA (2012) 2.41

Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol. Blood (2011) 2.35

Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients. Blood (2007) 2.32

Oxidative stress markers and antioxidant status after oral iron supplementation to very low birth weight infants. J Pediatr (2007) 2.25

Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion. Nat Med (2007) 2.21

Activation of NK cells by an endocytosed receptor for soluble HLA-G. PLoS Biol (2006) 2.08

Characterization of E-cadherin endocytosis in isolated MCF-7 and chinese hamster ovary cells: the initial fate of unbound E-cadherin. J Biol Chem (2003) 2.05

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs. Blood (2013) 2.04

The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB J (2006) 2.04

Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haemopoietic stem-cell transplantation: an open-label, phase 3, randomised controlled trial. Lancet (2012) 2.02

Neonatal screening for severe primary immunodeficiency diseases using high-throughput triplex real-time PCR. Blood (2011) 1.96

Memory CD8+ T cells provide an early source of IFN-gamma. J Immunol (2003) 1.93

A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes. Blood (2012) 1.92

KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression. Blood (2009) 1.92

Nationwide survey of hemophagocytic lymphohistiocytosis in Japan. Int J Hematol (2007) 1.90

Impact of thymoglobulin prior to pediatric unrelated umbilical cord blood transplantation on immune reconstitution and clinical outcome. Blood (2013) 1.90

Improved survival after allogeneic hematopoietic stem cell transplantation in recent years. A single-center study. Biol Blood Marrow Transplant (2011) 1.90

Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target. J Clin Invest (2011) 1.87

Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection. Gastroenterology (2010) 1.85

CD1d-dependent activation of NKT cells aggravates atherosclerosis. J Exp Med (2004) 1.80

Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis. Am J Physiol Cell Physiol (2008) 1.76

Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses. Immunity (2009) 1.74

Long-term follow-up of Langerhans cell histiocytosis: 39 years' experience at a single centre. Acta Paediatr (2005) 1.72

Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation. Blood (2007) 1.71

Parents' intellectual and emotional awareness of their child's impending death to cancer: a population-based long-term follow-up study. Lancet Oncol (2007) 1.67

Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines. Int Immunol (2002) 1.66

EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. J Cell Sci (2007) 1.64

Haematopoietic stem cell transplantation in haemophagocytic lymphohistiocytosis. Br J Haematol (2005) 1.64

A population-based nationwide study of parents' perceptions of a questionnaire on their child's death due to cancer. Lancet (2004) 1.64

Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors. Blood (2009) 1.62

Unexpectedly High Prevalence of Acquired von Willebrand Syndrome in Patients with Severe Aortic Stenosis as Evaluated with a Novel Large Multimer Index. J Atheroscler Thromb (2015) 1.60

Cryptic subtelomeric 6p deletion in a girl with congenital malformations and severe language impairment. Eur J Hum Genet (2003) 1.56

Parvovirus B19 infection in children with acute lymphoblastic leukemia is associated with cytopenia resulting in prolonged interruptions of chemotherapy. Clin Infect Dis (2008) 1.55

The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure. Traffic (2007) 1.54

Insulin-like growth factor axis (insulin-like growth factor-I/insulin-like growth factor-binding protein-3) as a prognostic predictor of heart failure: association with adiponectin. Eur J Heart Fail (2010) 1.54

Duration and morbidity of newly diagnosed idiopathic thrombocytopenic purpura in children: A prospective Nordic study of an unselected cohort. J Pediatr (2003) 1.54

Incidence and pattern of radiological central nervous system Langerhans cell histiocytosis in children: a population based study. Pediatr Blood Cancer (2011) 1.54

Enzyme replacement therapy and/or hematopoietic stem cell transplantation at diagnosis in patients with mucopolysaccharidosis type I: results of a European consensus procedure. Orphanet J Rare Dis (2011) 1.54

Anxiety and depression in parents 4-9 years after the loss of a child owing to a malignancy: a population-based follow-up. Psychol Med (2004) 1.53

Risk factors for the development of cytomegalovirus disease after allogeneic stem cell transplantation. Haematologica (2006) 1.52

Receptor function, dominant negative activity and phenotype correlations for MC1R variant alleles. Hum Mol Genet (2007) 1.52

Anxiety is contagious-symptoms of anxiety in the terminally ill child affect long-term psychological well-being in bereaved parents. Pediatr Blood Cancer (2010) 1.48

GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network. J Biol Chem (2002) 1.48

Organ-specific features of natural killer cells. Nat Rev Immunol (2011) 1.48

Autoimmune hepatitis in children in Eastern Denmark. J Pediatr Gastroenterol Nutr (2012) 1.47

Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice. Nat Genet (2007) 1.47

Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition. J Immunol (2004) 1.46

Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets. J Biol Chem (2003) 1.45

Profiling of copy number variations (CNVs) in healthy individuals from three ethnic groups using a human genome 32 K BAC-clone-based array. Hum Mutat (2008) 1.45

DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Cancer Res (2007) 1.45

Protein kinase C regulates endocytosis and recycling of E-cadherin. Am J Physiol Cell Physiol (2002) 1.44

Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin. Mol Biol Cell (2004) 1.43

Predicting the risk of multiple endocrine neoplasia type 1 for patients with commonly occurring endocrine tumors. Eur J Endocrinol (2012) 1.43

The socioeconomic and psychosocial circumstances of adult long-term survivors of hematopoietic stem cell transplantation in childhood. Pediatr Transplant (2011) 1.42

Characterization of the antiplatelet effect of aspirin at enrollment and after 2-year follow-up in a real clinical setting in Japan. Circ J (2010) 1.41

Pillars article: Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 1989. 340: 443-448. J Immunol (2007) 1.40

Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha. J Biol Chem (2005) 1.39

Experiences with fetomaternal alloimmune thrombocytopenia at a Swedish hospital over a 10-year period. Acta Obstet Gynecol Scand (2003) 1.39

Nuclear translocation of cell-surface receptors: lessons from fibroblast growth factor. Traffic (2005) 1.39

Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells. J Immunol (2009) 1.38

[QF-PCR or karyotyping in amniocentesis most often not the woman's decision. Difficult to give basis for an informed choice]. Lakartidningen (2007) 1.38

Care-related distress: a nationwide study of parents who lost their child to cancer. J Clin Oncol (2005) 1.38

Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions. Blood (2005) 1.37

Inactivation of BHD in sporadic renal tumors. Cancer Res (2003) 1.36

ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis. Proc Natl Acad Sci U S A (2011) 1.35

Cytokine release from innate immune cells: association with diverse membrane trafficking pathways. Blood (2011) 1.34

Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5, and OCA2/P loci. J Invest Dermatol (2008) 1.33