Published in Curr Mol Med on March 01, 2005
Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber). Aging Cell (2010) 1.69
A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice. Proc Natl Acad Sci U S A (2008) 1.37
DNA damage responses in neural cells: Focus on the telomere. Neuroscience (2007) 1.23
The E6 oncoproteins from human betapapillomaviruses differentially activate telomerase through an E6AP-dependent mechanism and prolong the lifespan of primary keratinocytes. J Virol (2008) 1.08
Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae. DNA Repair (Amst) (2008) 1.01
Hypoxia induces telomerase reverse transcriptase (TERT) gene expression in non-tumor fish tissues in vivo: the marine medaka (Oryzias melastigma) model. BMC Mol Biol (2006) 0.97
Telomere dysfunction in human diseases: the long and short of it! Int J Clin Exp Pathol (2009) 0.89
Telomerase inhibition in cancer therapeutics: molecular-based approaches. Curr Med Chem (2006) 0.87
Microenvironmental regulation of telomerase isoforms in human embryonic stem cells. Stem Cells Dev (2014) 0.84
Gene therapy in pancreatic cancer. World J Gastroenterol (2014) 0.81
Telomerase and primary T cells: biology and immortalization for adoptive immunotherapy. Immunotherapy (2011) 0.80
Telomerase as a useful target in cancer fighting-the breast cancer case. Tumour Biol (2013) 0.79
Leishmania major telomerase TERT protein has a nuclear/mitochondrial eclipsed distribution that is affected by oxidative stress. Infect Immun (2014) 0.79
Saccharomyces cerevisiae as a model for the study of extranuclear functions of mammalian telomerase. Curr Genet (2015) 0.79
Immortalization of neural precursors when telomerase is overexpressed in embryonal carcinomas and stem cells. Mol Biol Cell (2008) 0.79
Insights into the evolution of mammalian telomerase: platypus TERT shares similarities with genes of birds and other reptiles and localizes on sex chromosomes. BMC Genomics (2012) 0.78
Differential antigen processing by dendritic cell subsets in vivo. Science (2007) 8.42
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet (2006) 4.43
Knockout mice created by TALEN-mediated gene targeting. Nat Biotechnol (2013) 4.31
Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J Exp Med (2012) 2.51
A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q. Cell (2006) 2.37
Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases. Genome Res (2013) 2.28
Flt3 signaling-dependent dendritic cells protect against atherosclerosis. Immunity (2011) 2.14
Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract. J Exp Med (2013) 1.99
Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves. J Exp Med (2009) 1.93
Cutting edge: langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo. J Immunol (2008) 1.68
Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. Nat Genet (2003) 1.57
Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production. Proc Natl Acad Sci U S A (2008) 1.46
Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. EMBO J (2009) 1.45
Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody. Blood (2010) 1.40
Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. Mol Biol Cell (2003) 1.32
Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade. EMBO Rep (2012) 1.25
Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice. J Biol Chem (2008) 1.24
Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice. Proc Natl Acad Sci U S A (2013) 1.24
Telomeres and telomerase in aging, regeneration and cancer. Mol Cells (2003) 1.22
West Nile virus capsid protein induces p53-mediated apoptosis via the sequestration of HDM2 to the nucleolus. Cell Microbiol (2007) 1.18
Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity. J Neurosci (2004) 1.17
Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2. J Biol Chem (2006) 1.14
A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T-cell immunity in vivo. Eur J Immunol (2011) 1.14
Aerosol delivery of urocanic acid-modified chitosan/programmed cell death 4 complex regulated apoptosis, cell cycle, and angiogenesis in lungs of K-ras null mice. Mol Cancer Ther (2006) 1.09
Acceleration of gastric tumorigenesis through MKRN1-mediated posttranslational regulation of p14ARF. J Natl Cancer Inst (2012) 1.07
Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol (2002) 1.07
Jab1 mediates cytoplasmic localization and degradation of West Nile virus capsid protein. J Biol Chem (2006) 1.06
Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis. Nat Commun (2012) 1.06
Generation and application of new rat monoclonal antibodies against synthetic FLAG and OLLAS tags for improved immunodetection. J Immunol Methods (2007) 1.05
Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague. Eur J Immunol (2010) 1.05
The roles of FADD in extrinsic apoptosis and necroptosis. BMB Rep (2012) 1.03
Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus. Cancer Res (2003) 1.00
Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression. Mol Cell Biol (2006) 0.98
Telomerase deficiency affects normal brain functions in mice. Neurochem Res (2009) 0.98
Mouse genetics: catalogue and scissors. BMB Rep (2012) 0.97
Dynamic rearrangement of telomeres during spermatogenesis in mice. Dev Biol (2005) 0.96
Short dysfunctional telomeres impair the repair of arsenite-induced oxidative damage in mouse cells. J Cell Physiol (2008) 0.96
MKRN1 induces degradation of West Nile virus capsid protein by functioning as an E3 ligase. J Virol (2010) 0.95
STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy. Clin Exp Metastasis (2012) 0.94
Loss of extracellular superoxide dismutase induces severe IL-23-mediated skin inflammation in mice. J Invest Dermatol (2012) 0.92
The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis. Cancer Res (2003) 0.91
The pleiotropy of telomerase against cell death. Mol Cells (2005) 0.91
Jab1 as a mediator of nuclear export and cytoplasmic degradation of p53. Mol Cells (2006) 0.91
Separation of function between isotype switching and affinity maturation in vivo during acute immune responses and circulating autoantibodies in UNG-deficient mice. J Immunol (2013) 0.90
Interferon regulatory factor-1 (IRF-1) is a mediator for interferon-gamma induced attenuation of telomerase activity and human telomerase reverse transcriptase (hTERT) expression. Oncogene (2003) 0.90
PML-IV functions as a negative regulator of telomerase by interacting with TERT. J Cell Sci (2009) 0.89
Functional genomics approach using mice. J Biochem Mol Biol (2004) 0.89
Galectin-3 activates PPARγ and supports white adipose tissue formation and high-fat diet-induced obesity. Endocrinology (2015) 0.89
TCR-independent and caspase-independent apoptosis of murine thymocytes by CD24 cross-linking. J Immunol (2004) 0.86
A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression. Oncogene (2002) 0.86
Essential role of p53 in TPEN-induced neuronal apoptosis. FEBS Lett (2009) 0.85
Targeting Notch signaling by γ-secretase inhibitor I enhances the cytotoxic effect of 5-FU in gastric cancer. Clin Exp Metastasis (2015) 0.85
Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation. Proc Natl Acad Sci U S A (2013) 0.85
Oncogenic potential of a dominant negative mutant of interferon regulatory factor 3. J Biol Chem (2003) 0.85
MafK positively regulates NF-κB activity by enhancing CBP-mediated p65 acetylation. Sci Rep (2013) 0.84
Hsp70 functions as a negative regulator of West Nile virus capsid protein through direct interaction. Biochem Biophys Res Commun (2006) 0.84
Control of dendritic cell migration, T cell-dependent immunity, and autoimmunity by protein tyrosine phosphatase PTPN12 expressed in dendritic cells. Mol Cell Biol (2013) 0.84
Early complement factors in the local tissue immunocomplex generated during intestinal ischemia/reperfusion injury. Mol Immunol (2009) 0.83
Robust T-cell stimulation by Epstein-Barr virus-transformed B cells after antigen targeting to DEC-205. Blood (2013) 0.83
Inactivation of Mxi1 induces Il-8 secretion activation in polycystic kidney. Biochem Biophys Res Commun (2007) 0.83
EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity. Oncotarget (2013) 0.82
The multifaceted factor peroxisome proliferator-activated receptor γ (PPARγ) in metabolism, immunity, and cancer. Arch Pharm Res (2015) 0.82
The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumoniae. Neurosci Lett (2008) 0.82
Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation. Mol Cells (2003) 0.81
Transgenic overexpression of p23 induces spontaneous hydronephrosis in mice. Int J Exp Pathol (2011) 0.81
An analysis of an interactome for apoptosis factor, Ei24/PIG8, using the inducible expression system and shotgun proteomics. J Proteome Res (2010) 0.81
Mouse models for telomere and telomerase biology. Exp Mol Med (2003) 0.81
Sensitizing effects of cadmium on TNF-alpha- and TRAIL-mediated apoptosis of NIH3T3 cells with distinct expression patterns of p53. Carcinogenesis (2002) 0.80
Anti-cancer effect of a quinoxaline derivative GK13 as a transglutaminase 2 inhibitor. J Cancer Res Clin Oncol (2013) 0.80
Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response. Cancer Res (2010) 0.80
Hes6 controls cell proliferation via interaction with cAMP-response element-binding protein-binding protein in the promyelocytic leukemia nuclear body. J Biol Chem (2007) 0.80
Role of INK4a locus in normal eye development and cataract genesis. Mech Ageing Dev (2006) 0.79
Air quality during demolition and recovery activities in post-Katrina New Orleans. Environ Toxicol Chem (2010) 0.79
Ei24-deficiency attenuates protein kinase Cα signaling and skin carcinogenesis in mice. Int J Biochem Cell Biol (2012) 0.79
VEGF and angiopoietins promote inflammatory cell recruitment and mature blood vessel formation in murine sponge/Matrigel model. J Cell Biochem (2015) 0.78
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene. Cell Cycle (2012) 0.78
Up-regulation of Idh3alpha causes reduction of neuronal differentiation in PC12 cells. BMB Rep (2010) 0.78
Identification of a novel Rb-regulated gene associated with the cell cycle. Mol Cells (2007) 0.78
Differentiation of West Nile virus-infected animals from vaccinated animals by competitive ELISA using monoclonal antibodies against non-structural protein 1. Vector Borne Zoonotic Dis (2012) 0.78
Mxi1 regulates cell proliferation through insulin-like growth factor binding protein-3. Biochem Biophys Res Commun (2011) 0.77
Clinical implications of antitelomeric drugs with respect to the nontelomeric functions of telomerase in cancer. Onco Targets Ther (2013) 0.77
Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation. J Biol Chem (2013) 0.77
CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis. J Immunol (2014) 0.76
Jab1 has negative effects on p53-mediated genotoxic stresses. BMB Rep (2009) 0.76
Extracting extra-telomeric phenotypes from telomerase mouse models. Yonsei Med J (2014) 0.76
Hematopoietic malignancies associated with increased Stat5 and Bcl-x(L) expressions in Ink4a/Arf-deficient mice. Mech Ageing Dev (2005) 0.76