PathwayExplorer: web service for visualizing high-throughput expression data on biological pathways.

PubWeight™: 2.12‹?› | Rank: Top 2%

🔗 View Article (PMC 1160152)

Published in Nucleic Acids Res on July 01, 2005

Authors

Bernhard Mlecnik1, Marcel Scheideler, Hubert Hackl, Jürgen Hartler, Fatima Sanchez-Cabo, Zlatko Trajanoski

Author Affiliations

1: Institute for Genomics and Bioinformatics and Christian-Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, Graz 8010, Austria.

Articles citing this

Visualization of omics data for systems biology. Nat Methods (2010) 4.59

VANTED: a system for advanced data analysis and visualization in the context of biological networks. BMC Bioinformatics (2006) 4.38

KOBAS server: a web-based platform for automated annotation and pathway identification. Nucleic Acids Res (2006) 2.59

VisANT 3.0: new modules for pathway visualization, editing, prediction and construction. Nucleic Acids Res (2007) 2.17

MARS: microarray analysis, retrieval, and storage system. BMC Bioinformatics (2005) 2.14

Gene expression profiling of human mesenchymal stem cells derived from bone marrow during expansion and osteoblast differentiation. BMC Genomics (2007) 1.90

Pathway projector: web-based zoomable pathway browser using KEGG atlas and Google Maps API. PLoS One (2009) 1.57

Babelomics: advanced functional profiling of transcriptomics, proteomics and genomics experiments. Nucleic Acids Res (2008) 1.53

SubpathwayMiner: a software package for flexible identification of pathways. Nucleic Acids Res (2009) 1.45

graphite - a Bioconductor package to convert pathway topology to gene network. BMC Bioinformatics (2012) 1.44

TiSGeD: a database for tissue-specific genes. Bioinformatics (2010) 1.41

BiologicalNetworks: visualization and analysis tool for systems biology. Nucleic Acids Res (2006) 1.40

PathExpress: a web-based tool to identify relevant pathways in gene expression data. Nucleic Acids Res (2007) 1.37

CoPub: a literature-based keyword enrichment tool for microarray data analysis. Nucleic Acids Res (2008) 1.31

Visualizing post genomics data-sets on customized pathway maps by ProMeTra-aeration-dependent gene expression and metabolism of Corynebacterium glutamicum as an example. BMC Syst Biol (2009) 1.18

Molecular processes during fat cell development revealed by gene expression profiling and functional annotation. Genome Biol (2005) 1.16

Bioinformatics and systems biology of the lipidome. Chem Rev (2011) 1.14

Identification of evolutionarily conserved genetic regulators of cellular aging. Aging Cell (2010) 1.09

enRoute: dynamic path extraction from biological pathway maps for exploring heterogeneous experimental datasets. BMC Bioinformatics (2013) 1.00

GEPS: the Gene Expression Pattern Scanner. Nucleic Acids Res (2006) 1.00

Genome Expression Pathway Analysis Tool--analysis and visualization of microarray gene expression data under genomic, proteomic and metabolic context. BMC Bioinformatics (2007) 1.00

Scientific frontiers: emerging technologies for salivary diagnostics. Adv Dent Res (2011) 0.99

NemaPath: online exploration of KEGG-based metabolic pathways for nematodes. BMC Genomics (2008) 0.96

CoryneCenter - an online resource for the integrated analysis of corynebacterial genome and transcriptome data. BMC Syst Biol (2007) 0.96

Novel insights into adipogenesis from omics data. Curr Med Chem (2009) 0.95

Inferring the functional effect of gene expression changes in signaling pathways. Nucleic Acids Res (2013) 0.92

PathExpress update: the enzyme neighbourhood method of associating gene-expression data with metabolic pathways. Nucleic Acids Res (2009) 0.92

Muscle wasting and the temporal gene expression pattern in a novel rat intensive care unit model. BMC Genomics (2011) 0.90

SEAS: a system for SEED-based pathway enrichment analysis. PLoS One (2011) 0.86

Mining metabolic pathways through gene expression. Bioinformatics (2010) 0.86

GeneBrowser 2: an application to explore and identify common biological traits in a set of genes. BMC Bioinformatics (2010) 0.86

Visualizing genome and systems biology: technologies, tools, implementation techniques and trends, past, present and future. Gigascience (2015) 0.85

Protein biomarkers distinguish between high- and low-risk pediatric acute lymphoblastic leukemia in a tissue specific manner. J Hematol Oncol (2013) 0.85

Cardiovascular genomics: a biomarker identification pipeline. IEEE Trans Inf Technol Biomed (2012) 0.81

The existence of multipotent stem cells with epithelial-mesenchymal transition features in the human liver bud. Int J Biochem Cell Biol (2010) 0.80

Sequencing and comparative genomic analysis of 1227 Felis catus cDNA sequences enriched for developmental, clinical and nutritional phenotypes. BMC Genomics (2012) 0.80

A novel regulatory event-based gene set analysis method for exploring global functional changes in heterogeneous genomic data sets. BMC Genomics (2009) 0.79

MaGnET: Malaria Genome Exploration Tool. Bioinformatics (2013) 0.79

Public databases and software for the pathway analysis of cancer genomes. Cancer Inform (2007) 0.77

Current trends and new challenges of databases and web applications for systems driven biological research. Front Physiol (2010) 0.77

LinkinPath: from sequence to interconnected pathway. Bioinformatics (2011) 0.76

Elucidating the identity of resistance mechanisms to prednisolone exposure in acute lymphoblastic leukemia cells through transcriptomic analysis: A computational approach. J Clin Bioinforma (2011) 0.76

An editor for pathway drawing and data visualization in the Biopathways Workbench. BMC Syst Biol (2009) 0.76

Prioritising risk pathways of complex human diseases based on functional profiling. Eur J Hum Genet (2012) 0.75

Data integration in biological research: an overview. J Biol Res (Thessalon) (2015) 0.75

Articles cited by this

Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A (1998) 192.97

Statistical significance for genomewide studies. Proc Natl Acad Sci U S A (2003) 88.64

Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol Biol Cell (1998) 62.20

The KEGG resource for deciphering the genome. Nucleic Acids Res (2004) 53.05

RefSeq and LocusLink: NCBI gene-centered resources. Nucleic Acids Res (2001) 45.29

Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci U S A (1999) 39.79

The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics (2003) 32.92

Knowledge-based analysis of microarray gene expression data by using support vector machines. Proc Natl Acad Sci U S A (2000) 19.39

GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat Genet (2002) 14.69

Computational assignment of the EC numbers for genomic-scale analysis of enzymatic reactions. J Am Chem Soc (2004) 11.50

Large-scale temporal gene expression mapping of central nervous system development. Proc Natl Acad Sci U S A (1998) 9.06

Correspondence analysis applied to microarray data. Proc Natl Acad Sci U S A (2001) 3.19

PathFinder: reconstruction and dynamic visualization of metabolic pathways. Bioinformatics (2002) 2.43

Pathway Miner: extracting gene association networks from molecular pathways for predicting the biological significance of gene expression microarray data. Bioinformatics (2004) 1.95

ArrayXPath: mapping and visualizing microarray gene-expression data with integrated biological pathway resources using Scalable Vector Graphics. Nucleic Acids Res (2004) 1.79

BioMiner--modeling, analyzing, and visualizing biochemical pathways and networks. Bioinformatics (2002) 1.55

PathMAPA: a tool for displaying gene expression and performing statistical tests on metabolic pathways at multiple levels for Arabidopsis. BMC Bioinformatics (2003) 1.52

Client-server environment for high-performance gene expression data analysis. Bioinformatics (2003) 0.99

Java editor for biological pathways. Bioinformatics (2003) 0.98

Articles by these authors

Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science (2006) 24.54

Effector memory T cells, early metastasis, and survival in colorectal cancer. N Engl J Med (2005) 12.64

Genesis: cluster analysis of microarray data. Bioinformatics (2002) 10.50

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics (2009) 8.60

Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J Clin Oncol (2011) 5.63

In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer. J Clin Oncol (2009) 3.97

A survey of tools for variant analysis of next-generation genome sequencing data. Brief Bioinform (2013) 3.60

Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity (2013) 3.50

CARMAweb: comprehensive R- and bioconductor-based web service for microarray data analysis. Nucleic Acids Res (2006) 2.93

Coordination of intratumoral immune reaction and human colorectal cancer recurrence. Cancer Res (2009) 2.37

miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging. Aging Cell (2010) 2.31

MARS: microarray analysis, retrieval, and storage system. BMC Bioinformatics (2005) 2.14

Global gene expression profiling reveals widespread yet distinctive translational responses to different eukaryotic translation initiation factor 2B-targeting stress pathways. Mol Cell Biol (2005) 2.13

Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer. Gastroenterology (2009) 2.01

microRNA miR-27b impairs human adipocyte differentiation and targets PPARgamma. Biochem Biophys Res Commun (2009) 1.98

Gene expression profiling of human mesenchymal stem cells derived from bone marrow during expansion and osteoblast differentiation. BMC Genomics (2007) 1.90

Evolution of genomic instability in diethylnitrosamine-induced hepatocarcinogenesis in mice. Hepatology (2011) 1.56

Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays. Nucleic Acids Res (2009) 1.37

Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy. Genome Biol (2015) 1.35

MASPECTRAS: a platform for management and analysis of proteomics LC-MS/MS data. BMC Bioinformatics (2007) 1.34

Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis. Stem Cells (2008) 1.32

Activin a plays a critical role in proliferation and differentiation of human adipose progenitors. Diabetes (2010) 1.31

YPL.db: the Yeast Protein Localization database. Nucleic Acids Res (2002) 1.26

SIMPLEX: cloud-enabled pipeline for the comprehensive analysis of exome sequencing data. PLoS One (2012) 1.22

A quantization method based on threshold optimization for microarray short time series. BMC Bioinformatics (2005) 1.21

Mutations in ROGDI Cause Kohlschütter-Tönz Syndrome. Am J Hum Genet (2012) 1.21

Generic features of tertiary chromatin structure as detected in natural chromosomes. Mol Cell Biol (2004) 1.19

A comprehensive method for lipid profiling by liquid chromatography-ion cyclotron resonance mass spectrometry. J Lipid Res (2011) 1.19

Proteomic analysis of human cataract aqueous humour: Comparison of one-dimensional gel LCMS with two-dimensional LCMS of unlabelled and iTRAQ®-labelled specimens. J Proteomics (2010) 1.18

MicroRNA-30c promotes human adipocyte differentiation and co-represses PAI-1 and ALK2. RNA Biol (2011) 1.16

Molecular processes during fat cell development revealed by gene expression profiling and functional annotation. Genome Biol (2005) 1.16

TAMEE: data management and analysis for tissue microarrays. BMC Bioinformatics (2007) 1.15

Identification of differential and functionally active miRNAs in both anaplastic lymphoma kinase (ALK)+ and ALK- anaplastic large-cell lymphoma. Proc Natl Acad Sci U S A (2010) 1.15

New trends in bioinformatics: from genome sequence to personalized medicine. Exp Gerontol (2003) 1.15

iLAP: a workflow-driven software for experimental protocol development, data acquisition and analysis. BMC Bioinformatics (2009) 1.14

Identification of evolutionarily conserved genetic regulators of cellular aging. Aging Cell (2010) 1.09

Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis. BMC Genomics (2008) 1.09

Differential transcriptional modulation of biological processes in adipocyte triglyceride lipase and hormone-sensitive lipase-deficient mice. Genomics (2008) 1.07

QPCR: Application for real-time PCR data management and analysis. BMC Bioinformatics (2009) 1.04

Differentiation of Human Adipose-Derived Stem Cells into "Brite" (Brown-in-White) Adipocytes. Front Endocrinol (Lausanne) (2011) 1.03

High levels of oncomiR-21 contribute to the senescence-induced growth arrest in normal human cells and its knock-down increases the replicative lifespan. Aging Cell (2013) 1.02

YPL.db2: the Yeast Protein Localization database, version 2.0. Yeast (2005) 1.01

The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p. FEBS J (2007) 1.00

Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes. J Leukoc Biol (2009) 0.99

Client-server environment for high-performance gene expression data analysis. Bioinformatics (2003) 0.99

Java editor for biological pathways. Bioinformatics (2003) 0.98

MicroRNA-26 family is required for human adipogenesis and drives characteristics of brown adipocytes. Stem Cells (2014) 0.97

Assessment of transcapillary glucose exchange in human skeletal muscle and adipose tissue. Am J Physiol Endocrinol Metab (2003) 0.96

Lipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress. J Lipid Res (2012) 0.95

Novel insights into adipogenesis from omics data. Curr Med Chem (2009) 0.95

Transcription factories. Front Genet (2012) 0.95

SPARQLGraph: a web-based platform for graphically querying biological Semantic Web databases. BMC Bioinformatics (2014) 0.95

A modified scoring of the NCCN-IPI is more accurate in the elderly and is improved by albumin and β2 -microglobulin. Br J Haematol (2014) 0.94

Stathmin-like 2, a developmentally-associated neuronal marker, is expressed and modulated during osteogenesis of human mesenchymal stem cells. Biochem Biophys Res Commun (2008) 0.94

Organization of chromatin and histone modifications at a transcription site. J Cell Biol (2007) 0.93

MEMOSys: Bioinformatics platform for genome-scale metabolic models. BMC Syst Biol (2011) 0.93

Assessment of a six gene panel for the molecular detection of circulating tumor cells in the blood of female cancer patients. BMC Cancer (2010) 0.93

MASPECTRAS 2: An integration and analysis platform for proteomic data. Proteomics (2010) 0.93

Overexpression of primary microRNA 221/222 in acute myeloid leukemia. BMC Cancer (2013) 0.92

In vitro brown and "brite"/"beige" adipogenesis: human cellular models and molecular aspects. Biochim Biophys Acta (2012) 0.91

GPViz: dynamic visualization of genomic regions and variants affecting protein domains. Bioinformatics (2013) 0.90

Bioinformatics for cancer immunology and immunotherapy. Cancer Immunol Immunother (2012) 0.90

A bioinformatics approach for integrated transcriptomic and proteomic comparative analyses of model and non-sequenced anopheline vectors of human malaria parasites. Mol Cell Proteomics (2012) 0.90

The role of intramyocellular lipids during hypoglycemia in patients with intensively treated type 1 diabetes. J Clin Endocrinol Metab (2005) 0.89

High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer. BMC Cancer (2014) 0.89

Comprehensive analysis of alterations in the miRNome in response to photodynamic treatment. J Photochem Photobiol B (2013) 0.88

Reconstruction of gene association network reveals a transmembrane protein required for adipogenesis and targeted by PPARγ. Cell Mol Life Sci (2010) 0.87

Arsenic trioxide induces apoptosis preferentially in B-CLL cells of patients with unfavourable prognostic factors including del17p13. J Mol Med (Berl) (2008) 0.87

Antimyeloma activity of the sesquiterpene lactone cnicin: impact on Pim-2 kinase as a novel therapeutic target. J Mol Med (Berl) (2011) 0.86

Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation. Cardiovasc Res (2013) 0.86

microRNAs in nociceptive circuits as predictors of future clinical applications. Front Mol Neurosci (2013) 0.85