Published in Angew Chem Int Ed Engl on July 25, 2005
Minor groove hydrogen bonds and the replication of unnatural base pairs. J Am Chem Soc (2007) 1.23
A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic Acids Res (2009) 1.00
Evolving a polymerase for hydrophobic base analogues. J Am Chem Soc (2009) 0.95
CyDNA: synthesis and replication of highly Cy-dye substituted DNA by an evolved polymerase. J Am Chem Soc (2010) 0.95
Directed polymerase evolution. FEBS Lett (2013) 0.86
Human DNA polymerase beta mutations allowing efficient abasic site bypass. J Biol Chem (2010) 0.78
Reprogramming cells with synthetic proteins. Asian J Androl (2015) 0.76
Exploring the Chemistry of Genetic Information Storage and Propagation through Polymerase Engineering. Acc Chem Res (2017) 0.75
Variants of a Thermus aquaticus DNA polymerase with increased selectivity for applications in allele- and methylation-specific amplification. PLoS One (2014) 0.75
Selectivity of Enzymatic Conversion of Oligonucleotide Probes during Nucleotide Polymorphism Analysis of DNA. Acta Naturae (2010) 0.75
Variants of sequence family B Thermococcus kodakaraensis DNA polymerase with increased mismatch extension selectivity. PLoS One (2017) 0.75
Insights into the high fidelity of a DNA polymerase I mutant. J Mol Model (2009) 0.75
C(α) torsion angles as a flexible criterion to extract secrets from a molecular dynamics simulation. J Mol Model (2014) 0.75
Engineering human PrimPol into an efficient RNA-dependent-DNA primase/polymerase. Nucleic Acids Res (2017) 0.75
En bloc vascular resection for locally advanced pancreatic malignancies infiltrating major blood vessels: perioperative outcome and long-term survival in 136 patients. Ann Surg (2008) 2.64
Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length. Nucleic Acids Res (2007) 1.73
Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagus. Mod Pathol (2006) 1.56
Efficacy and safety of imatinib in adult patients with c-kit-positive acute myeloid leukemia. Blood (2004) 1.55
KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry. Nat Chem Biol (2012) 1.24
Improved LNA probe-based assay for the detection of African and South American yellow fever virus strains. J Clin Virol (2010) 1.22
Novel strategies for the site-specific covalent labelling of nucleic acids. Chem Commun (Camb) (2008) 1.18
Replication through an abasic DNA lesion: structural basis for adenine selectivity. EMBO J (2010) 1.16
Structural insights into DNA replication without hydrogen bonds. J Am Chem Soc (2013) 1.15
RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma. Int J Cancer (2012) 1.10
Synthesis of defined ubiquitin dimers. J Am Chem Soc (2010) 1.01
Activated leukocyte cell adhesion molecule (CD166)--its prognostic power for colorectal cancer patients. J Surg Res (2012) 0.97
Expression and prognostic relevance of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of patients with multiple myeloma. Exp Mol Pathol (2010) 0.96
Prolonged intrathecal release of soluble Fas following severe traumatic brain injury in humans. J Neuroimmunol (2002) 0.92
A molecular beacon for quantitative monitoring of the DNA polymerase reaction in real-time. Angew Chem Int Ed Engl (2002) 0.92
Evolving a thermostable DNA polymerase that amplifies from highly damaged templates. Angew Chem Int Ed Engl (2007) 0.92
Implications of active site constraints on varied DNA polymerase selectivity. J Am Chem Soc (2002) 0.92
New light-sensitive nucleosides for caged DNA strand breaks. Chembiochem (2002) 0.90
DNA-templated synthesis: more versatile than expected. Angew Chem Int Ed Engl (2002) 0.90
Opposed steric constraints in human DNA polymerase beta and E. coli DNA polymerase I. J Am Chem Soc (2008) 0.89
A nucleoside triphosphate for site-specific labelling of DNA by the Staudinger ligation. Chem Commun (Camb) (2007) 0.89
Evaluation of the stereotactic 8G vacuum-assisted breast biopsy in the histologic evaluation of suspicious mammography findings (BI-RADS IV). Invest Radiol (2005) 0.89
Generation of a mono-ubiquitinated PCNA mimic by click chemistry. Chembiochem (2011) 0.88
Structures of KOD and 9°N DNA polymerases complexed with primer template duplex. Chembiochem (2013) 0.87
Crossing the Rubicon: when pancreatic resection with curative intent ends in an R2 status. Impact of "desmoplastic pseudo-pancreatitis" and anatomical site of irresectability. Ann Surg Oncol (2009) 0.87
A DNA polymerase with increased reactivity for ribonucleotides and C5-modified deoxyribonucleotides. Chembiochem (2010) 0.87
Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase. Proc Natl Acad Sci U S A (2010) 0.86
Rapid labeling of metabolically engineered cell-surface glycoconjugates with a carbamate-linked cyclopropene reporter. Bioconjug Chem (2013) 0.86
GFAP-independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells. Glia (2011) 0.86
Evolving thermostable reverse transcriptase activity in a DNA polymerase scaffold. Angew Chem Int Ed Engl (2006) 0.86
An efficient method for the construction of functionalized DNA bearing amino acid groups through cross-coupling reactions of nucleoside triphosphates followed by primer extension or PCR. Chemistry (2007) 0.86
Direct sensing of 5-methylcytosine by polymerase chain reaction. Angew Chem Int Ed Engl (2014) 0.86
Cytogenetics of extramedullary manifestations in multiple myeloma. Br J Haematol (2013) 0.84
BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl (2009) 0.84
Engineered DNA polymerases in biotechnology. Chembiochem (2010) 0.84
Specific incorporation of an artificial nucleotide opposite a mutagenic DNA adduct by a DNA polymerase. J Am Chem Soc (2014) 0.83
Enzymatic synthesis of multiple spin-labeled DNA. Angew Chem Int Ed Engl (2008) 0.83
Anterior, thoracoscopic-assisted reduction and stabilization of a thoracic burst fracture (T8) in a pregnant woman. Eur Spine J (2011) 0.83
Dissecting ubiquitin signaling with linkage-defined and protease resistant ubiquitin chains. Angew Chem Int Ed Engl (2014) 0.83
Structures of KlenTaq DNA polymerase caught while incorporating C5-modified pyrimidine and C7-modified 7-deazapurine nucleoside triphosphates. J Am Chem Soc (2012) 0.83
Lesion bypass activity of DNA polymerase A from the extremely radioresistant organism Deinococcus radiodurans. J Biol Chem (2007) 0.83
Taking fingerprints of DNA polymerases: multiplex enzyme profiling on DNA arrays. Angew Chem Int Ed Engl (2009) 0.83
Screening mutant libraries of T7 RNA polymerase for candidates with increased acceptance of 2'-modified nucleotides. Chem Commun (Camb) (2012) 0.82
Novel DNA catalysts based on G-quadruplex recognition. Chembiochem (2008) 0.82
Similar incidences of TP53 deletions in extramedullary organ infiltrations, soft tissue and osteolyses of patients with multiple myeloma. Anticancer Res (2012) 0.82
A class of mild surfactants that keep integral membrane proteins water-soluble for functional studies and crystallization. Mol Membr Biol (2011) 0.82
Synthesis and stability of phosphate modified ATP analogues. J Org Chem (2012) 0.82
Learning from directed evolution: Thermus aquaticus DNA polymerase mutants with translesion synthesis activity. Chembiochem (2011) 0.82
PTEN deletion is rare but often homogeneous in gastric cancer. J Clin Pathol (2012) 0.81
A new photoactive building block for investigation of DNA backbone interactions: photoaffinity labeling of human DNA polymerase beta. Chembiochem (2006) 0.81
Replacing 32 proline residues by a noncanonical amino acid results in a highly active DNA polymerase. J Am Chem Soc (2010) 0.81
Structures of DNA polymerases caught processing size-augmented nucleotide probes. Angew Chem Int Ed Engl (2010) 0.81
Sustained complete hematologic remission after administration of the tyrosine kinase inhibitor imatinib mesylate in a patient with refractory, secondary AML. Blood (2002) 0.80
Directed evolution of DNA polymerases: construction and screening of DNA polymerase mutant libraries. Curr Protoc Chem Biol (2010) 0.80
Small Molecule Inhibitors of Human DNA Polymerase λ. ACS Chem Biol (2011) 0.80
Amino acid templating mechanisms in selection of nucleotides opposite abasic sites by a family a DNA polymerase. J Biol Chem (2012) 0.80
Enzymatic synthesis of perfluoroalkylated DNA. Bioorg Med Chem (2009) 0.80
Diamondoid-modified DNA. Org Biomol Chem (2011) 0.79
4'C-ethynyl-thymidine acts as a chain terminator during DNA-synthesis catalyzed by HIV-1 reverse transcriptase. Bioorg Med Chem Lett (2005) 0.79
Depth of submucosal tumor infiltration and its relevance in lymphatic metastasis formation for T1b squamous cell and adenocarcinomas of the esophagus. J Gastrointest Surg (2013) 0.79
Tuning PCR specificity by chemically modified primer probes. Angew Chem Int Ed Engl (2002) 0.79
Low N-acetyltransferase 2 activity in isoniazid-associated acute hepatitis requiring liver transplantation. Transpl Int (2009) 0.79
Thiamine pyrophosphate stimulates acetone activation by Desulfococcus biacutus as monitored by a fluorogenic ATP analogue. ACS Chem Biol (2014) 0.79
Efficient labelling of enzymatically synthesized vinyl-modified DNA by an inverse-electron-demand Diels-Alder reaction. Chem Commun (Camb) (2014) 0.79
Directed DNA polymerase evolution: effects of mutations in motif C on the mismatch-extension selectivity of thermus aquaticus DNA polymerase. Chembiochem (2007) 0.79
Solution structure and conformational dynamics of deoxyxylonucleic acids (dXNA): an orthogonal nucleic acid candidate. Chemistry (2011) 0.79
The use of enzymes for construction of DNA-based objects and assemblies. Chem Soc Rev (2011) 0.79
New branched DNA constructs. Chemistry (2007) 0.79
Direct measurement of electrical transport through G-quadruplex DNA with mechanically controllable break junction electrodes. Angew Chem Int Ed Engl (2010) 0.78
MALDI imaging on large-scale tissue microarrays identifies molecular features associated with tumour phenotype in oesophageal cancer. Histopathology (2013) 0.78
Hydrophobic amino acid and single-atom substitutions increase DNA polymerase selectivity. Chem Biol (2007) 0.78
Human DNA polymerase beta mutations allowing efficient abasic site bypass. J Biol Chem (2010) 0.78
Formation of ubiquitin dimers via azide-alkyne click reaction. Methods Mol Biol (2012) 0.78
Determination of the relative configuration of a five-membered lactone from residual dipolar couplings. Angew Chem Int Ed Engl (2006) 0.78
Exploring the effects of active site constraints on HIV-1 reverse transcriptase DNA polymerase fidelity. J Biol Chem (2002) 0.78
Patients with multiple myeloma develop SOX2-specific autoantibodies after allogeneic stem cell transplantation. Clin Dev Immunol (2011) 0.78
Increased single-nucleotide discrimination in allele-specific polymerase chain reactions through primer probes bearing nucleobase and 2'-deoxyribose modifications. Chemistry (2007) 0.78
Differential minor groove interactions between DNA polymerase and sugar backbone of primer and template strands. J Am Chem Soc (2002) 0.78
Structure and function of an RNA-reading thermostable DNA polymerase. Angew Chem Int Ed Engl (2013) 0.78
Proline-modified DNA as catalyst of the aldol reaction. Angew Chem Int Ed Engl (2007) 0.78
Concordance of HER2 status in primary tumour and lymph node metastases in patients with esophageal carcinoma. Anticancer Res (2013) 0.78
New strategies for DNA polymerase library screening. Nucleic Acids Symp Ser (Oxf) (2008) 0.78
Synthesis of DNA oligonucleotides containing 5-(mercaptomethyl)-2'-deoxyuridine moieties. Bioorg Med Chem (2006) 0.78
Mutant DNA polymerase for improved detection of single-nucleotide variations in microarrayed primer extension. Chembiochem (2008) 0.78
A highly active DNA polymerase with a fluorous core. Angew Chem Int Ed Engl (2010) 0.78
Expanding the scope of human DNA polymerase λ and β inhibitors. ACS Chem Biol (2013) 0.78
Synthesis and fluorescence characteristics of ATP-based FRET probes. Org Biomol Chem (2013) 0.78
Increased single-nucleotide discrimination of PCR by primer probes bearing hydrophobic 4'C modifications. Chembiochem (2004) 0.77
Barcoded nucleotides. Angew Chem Int Ed Engl (2011) 0.77
Synthesis of DNA strands site-specifically damaged by c8-arylamine purine adducts and effects on various DNA polymerases. Chemistry (2008) 0.77
Nucleotide insertion and bypass synthesis of pyrene- and BODIPY-modified oligonucleotides by DNA polymerases. Chem Commun (Camb) (2008) 0.77
Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site. Chem Commun (Camb) (2012) 0.77
DNA Polymerase Selectivity: Sugar Interactions Monitored with High-Fidelity Nucleotides This work was supported by a grant from the Deutsche Forschungsgemeinschaft. We thank Professor Dr. Michael Famulok for his continuing support. Angew Chem Int Ed Engl (2001) 0.77
Genotyping--from genomic DNA to genotype in a single tube. Angew Chem Int Ed Engl (2005) 0.77
Treatment with dasatinib for chronic myeloid leukemia following imatinib-induced hepatotoxicity. Int J Hematol (2013) 0.77
DNA minor groove hydration probed with 4'-alkylated thymidines. Chem Commun (Camb) (2002) 0.77
Structure-function relationship of thiazolide-induced apoptosis in colorectal tumor cells. ACS Chem Biol (2014) 0.77
An adamantane-based building block for DNA networks. Chem Asian J (2011) 0.77
Chain-terminating and clickable NAD⁺ analogues for labeling the target proteins of ADP-ribosyltransferases. Angew Chem Int Ed Engl (2014) 0.77
Synthesis of C8-arylamine-modified 2'-deoxyadenosine phosphoramidites and their site-specific incorporation into oligonucleotides. Chembiochem (2012) 0.77