Published in Chem Commun (Camb) on August 29, 2012
Discovery of a capuramycin analog that kills nonreplicating Mycobacterium tuberculosis and its synergistic effects with translocase I inhibitors. J Antibiot (Tokyo) (2014) 0.83
Transcription yield of fully 2'-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants. Nucleic Acids Res (2015) 0.82
In vitro selection using modified or unnatural nucleotides. Curr Protoc Nucleic Acid Chem (2002) 0.81
In vitro evolution of chemically-modified nucleic acid aptamers: Pros and cons, and comprehensive selection strategies. RNA Biol (2016) 0.81
In vitro selection using modified or unnatural nucleotides. Curr Protoc Nucleic Acid Chem (2014) 0.76
In vitro RNA SELEX for the generation of chemically-optimized therapeutic RNA drugs. Methods (2016) 0.75
Exploring the Chemistry of Genetic Information Storage and Propagation through Polymerase Engineering. Acc Chem Res (2017) 0.75
Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chem Biol (2004) 5.44
En bloc vascular resection for locally advanced pancreatic malignancies infiltrating major blood vessels: perioperative outcome and long-term survival in 136 patients. Ann Surg (2008) 2.64
Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat Struct Mol Biol (2005) 2.50
Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I. Nat Struct Mol Biol (2010) 2.13
Ligand-induced folding of the adenosine deaminase A-riboswitch and implications on riboswitch translational control. Chembiochem (2007) 2.12
Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center. Mol Cell (2011) 1.96
Conformational capture of the SAM-II riboswitch. Nat Chem Biol (2011) 1.84
The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis. Chem Biol (2008) 1.79
Ligand-induced folding of the thiM TPP riboswitch investigated by a structure-based fluorescence spectroscopic approach. Nucleic Acids Res (2007) 1.79
Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length. Nucleic Acids Res (2007) 1.73
Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagus. Mod Pathol (2006) 1.56
Efficacy and safety of imatinib in adult patients with c-kit-positive acute myeloid leukemia. Blood (2004) 1.55
The dynamic nature of RNA as key to understanding riboswitch mechanisms. Acc Chem Res (2011) 1.39
Folding of a transcriptionally acting preQ1 riboswitch. Proc Natl Acad Sci U S A (2010) 1.34
Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451. Nucleic Acids Res (2005) 1.29
KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry. Nat Chem Biol (2012) 1.24
Improved LNA probe-based assay for the detection of African and South American yellow fever virus strains. J Clin Virol (2010) 1.22
Pseudoknot preorganization of the preQ1 class I riboswitch. J Am Chem Soc (2012) 1.20
Efficient ribosomal peptidyl transfer critically relies on the presence of the ribose 2'-OH at A2451 of 23S rRNA. J Am Chem Soc (2006) 1.20
Novel strategies for the site-specific covalent labelling of nucleic acids. Chem Commun (Camb) (2008) 1.18
Syntheses of RNAs with up to 100 nucleotides containing site-specific 2'-methylseleno labels for use in X-ray crystallography. J Am Chem Soc (2005) 1.18
Replication through an abasic DNA lesion: structural basis for adenine selectivity. EMBO J (2010) 1.16
An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination. Nucleic Acids Res (2007) 1.15
Structural insights into DNA replication without hydrogen bonds. J Am Chem Soc (2013) 1.15
Chemical synthesis of selenium-modified oligoribonucleotides and their enzymatic ligation leading to an U6 SnRNA stem-loop segment. J Am Chem Soc (2004) 1.15
The preparation of site-specifically modified riboswitch domains as an example for enzymatic ligation of chemically synthesized RNA fragments. Nat Protoc (2008) 1.15
Stem cells are differentially regulated during development, regeneration and homeostasis in flatworms. Dev Biol (2009) 1.11
Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme. Nucleic Acids Res (2007) 1.11
Bistable secondary structures of small RNAs and their structural probing by comparative imino proton NMR spectroscopy. J Mol Biol (2003) 1.11
RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma. Int J Cancer (2012) 1.10
Tuning a riboswitch response through structural extension of a pseudoknot. Proc Natl Acad Sci U S A (2013) 1.09
Folding and ligand recognition of the TPP riboswitch aptamer at single-molecule resolution. Proc Natl Acad Sci U S A (2013) 1.08
Ribose 2'-F labeling: a simple tool for the characterization of RNA secondary structure equilibria by 19F NMR spectroscopy. J Am Chem Soc (2005) 1.06
Evidence for pseudoknot formation of class I preQ1 riboswitch aptamers. Chembiochem (2009) 1.05
Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activation. Nat Chem Biol (2010) 1.01
Synthesis of defined ubiquitin dimers. J Am Chem Soc (2010) 1.01
Long non-coding RNAs as targets for cytosine methylation. RNA Biol (2013) 1.00
Synthesis of (6-(13)C)pyrimidine nucleotides as spin-labels for RNA dynamics. J Am Chem Soc (2012) 0.99
5-Fluoro pyrimidines: labels to probe DNA and RNA secondary structures by 1D 19F NMR spectroscopy. Nucleic Acids Res (2009) 0.99
Activated leukocyte cell adhesion molecule (CD166)--its prognostic power for colorectal cancer patients. J Surg Res (2012) 0.97
A general approach for the identification of site-specific RNA binders by 19F NMR spectroscopy: proof of concept. Angew Chem Int Ed Engl (2006) 0.96
Non-hydrolyzable RNA-peptide conjugates: a powerful advance in the synthesis of mimics for 3'-peptidyl tRNA termini. Angew Chem Int Ed Engl (2009) 0.96
A powerful approach for the selection of 2-aminopurine substitution sites to investigate RNA folding. J Am Chem Soc (2011) 0.96
Expression and prognostic relevance of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of patients with multiple myeloma. Exp Mol Pathol (2010) 0.96
Synthesis, oxidation behavior, crystallization and structure of 2'-methylseleno guanosine containing RNAs. J Am Chem Soc (2006) 0.95
19F NMR spectroscopy for the analysis of RNA secondary structure populations. J Am Chem Soc (2008) 0.94
Chemical synthesis of site-specifically 2'-azido-modified RNA and potential applications for bioconjugation and RNA interference. Chembiochem (2011) 0.94
2'-Azido RNA, a versatile tool for chemical biology: synthesis, X-ray structure, siRNA applications, click labeling. ACS Chem Biol (2012) 0.93
Prolonged intrathecal release of soluble Fas following severe traumatic brain injury in humans. J Neuroimmunol (2002) 0.92
Evolving a thermostable DNA polymerase that amplifies from highly damaged templates. Angew Chem Int Ed Engl (2007) 0.92
Implications of active site constraints on varied DNA polymerase selectivity. J Am Chem Soc (2002) 0.92
A molecular beacon for quantitative monitoring of the DNA polymerase reaction in real-time. Angew Chem Int Ed Engl (2002) 0.92
Enhanced fidelity in mismatch extension by DNA polymerase through directed combinatorial enzyme design. Angew Chem Int Ed Engl (2005) 0.91
Escherichia coli ribosomal protein S1 unfolds structured mRNAs onto the ribosome for active translation initiation. PLoS Biol (2013) 0.91
A fast selenium derivatization strategy for crystallization and phasing of RNA structures. RNA (2009) 0.91
Triggering of RNA secondary structures by a functionalized nucleobase. Angew Chem Int Ed Engl (2004) 0.91
DNA-templated synthesis: more versatile than expected. Angew Chem Int Ed Engl (2002) 0.90
New light-sensitive nucleosides for caged DNA strand breaks. Chembiochem (2002) 0.90
Opposed steric constraints in human DNA polymerase beta and E. coli DNA polymerase I. J Am Chem Soc (2008) 0.89
A nucleoside triphosphate for site-specific labelling of DNA by the Staudinger ligation. Chem Commun (Camb) (2007) 0.89
Evaluation of the stereotactic 8G vacuum-assisted breast biopsy in the histologic evaluation of suspicious mammography findings (BI-RADS IV). Invest Radiol (2005) 0.89
Efficient access to 3'-terminal azide-modified RNA for inverse click-labeling patterns. Bioconjug Chem (2013) 0.89
Efficient access to nonhydrolyzable initiator tRNA based on the synthesis of 3'-azido-3'-deoxyadenosine RNA. Angew Chem Int Ed Engl (2010) 0.89
Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site. Angew Chem Int Ed Engl (2008) 0.88
Generation of a mono-ubiquitinated PCNA mimic by click chemistry. Chembiochem (2011) 0.88
A DNA polymerase with increased reactivity for ribonucleotides and C5-modified deoxyribonucleotides. Chembiochem (2010) 0.87
Crossing the Rubicon: when pancreatic resection with curative intent ends in an R2 status. Impact of "desmoplastic pseudo-pancreatitis" and anatomical site of irresectability. Ann Surg Oncol (2009) 0.87
Structures of KOD and 9°N DNA polymerases complexed with primer template duplex. Chembiochem (2013) 0.87
Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase. Proc Natl Acad Sci U S A (2010) 0.86
An efficient method for the construction of functionalized DNA bearing amino acid groups through cross-coupling reactions of nucleoside triphosphates followed by primer extension or PCR. Chemistry (2007) 0.86
Evolving thermostable reverse transcriptase activity in a DNA polymerase scaffold. Angew Chem Int Ed Engl (2006) 0.86
Direct sensing of 5-methylcytosine by polymerase chain reaction. Angew Chem Int Ed Engl (2014) 0.86
Thermodynamics of HIV-1 reverse transcriptase in action elucidates the mechanism of action of non-nucleoside inhibitors. J Am Chem Soc (2013) 0.86
Rapid labeling of metabolically engineered cell-surface glycoconjugates with a carbamate-linked cyclopropene reporter. Bioconjug Chem (2013) 0.86
GFAP-independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells. Glia (2011) 0.86
2'-Methylseleno-modified oligoribonucleotides for X-ray crystallography synthesized by the ACE RNA solid-phase approach. Nucleic Acids Res (2007) 0.85
Cytogenetics of extramedullary manifestations in multiple myeloma. Br J Haematol (2013) 0.84
Reliable semi-synthesis of hydrolysis-resistant 3'-peptidyl-tRNA conjugates containing genuine tRNA modifications. Nucleic Acids Res (2010) 0.84
BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl (2009) 0.84
2'-SCF3 uridine-a powerful label for probing structure and function of RNA by 19F NMR spectroscopy. Angew Chem Int Ed Engl (2012) 0.84
Native chemical ligation of hydrolysis-resistant 3'-peptidyl-tRNA mimics. J Am Chem Soc (2011) 0.84
Engineered DNA polymerases in biotechnology. Chembiochem (2010) 0.84
Specific incorporation of an artificial nucleotide opposite a mutagenic DNA adduct by a DNA polymerase. J Am Chem Soc (2014) 0.83
Enzymatic synthesis of multiple spin-labeled DNA. Angew Chem Int Ed Engl (2008) 0.83
Lesion bypass activity of DNA polymerase A from the extremely radioresistant organism Deinococcus radiodurans. J Biol Chem (2007) 0.83
Structures of KlenTaq DNA polymerase caught while incorporating C5-modified pyrimidine and C7-modified 7-deazapurine nucleoside triphosphates. J Am Chem Soc (2012) 0.83
Ligand-detected relaxation dispersion NMR spectroscopy: dynamics of preQ1-RNA binding. Angew Chem Int Ed Engl (2014) 0.83
Dissecting ubiquitin signaling with linkage-defined and protease resistant ubiquitin chains. Angew Chem Int Ed Engl (2014) 0.83
Anterior, thoracoscopic-assisted reduction and stabilization of a thoracic burst fracture (T8) in a pregnant woman. Eur Spine J (2011) 0.83
Taking fingerprints of DNA polymerases: multiplex enzyme profiling on DNA arrays. Angew Chem Int Ed Engl (2009) 0.83
Selective desulfurization significantly expands sequence variety of 3'-peptidyl-tRNA mimics obtained by native chemical ligation. Chembiochem (2012) 0.83
Enzymatic ligation strategies for the preparation of purine riboswitches with site-specific chemical modifications. Methods Mol Biol (2009) 0.82
Similar incidences of TP53 deletions in extramedullary organ infiltrations, soft tissue and osteolyses of patients with multiple myeloma. Anticancer Res (2012) 0.82
Learning from directed evolution: Thermus aquaticus DNA polymerase mutants with translesion synthesis activity. Chembiochem (2011) 0.82
A class of mild surfactants that keep integral membrane proteins water-soluble for functional studies and crystallization. Mol Membr Biol (2011) 0.82
Synthesis and stability of phosphate modified ATP analogues. J Org Chem (2012) 0.82
Functionalized polystyrene supports for solid-phase synthesis of glycyl-, alanyl-, and isoleucyl-RNA conjugates as hydrolysis-resistant mimics of peptidyl-tRNAs. Bioorg Med Chem (2011) 0.82
Novel DNA catalysts based on G-quadruplex recognition. Chembiochem (2008) 0.82
Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m2 2G:A pairs. RNA (2008) 0.82