Published in J Neurochem on September 16, 2008
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat Rev Neurosci (2010) 5.27
The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults. Neuron (2012) 1.97
Coupling of the NMDA receptor to neuroprotective and neurodestructive events. Biochem Soc Trans (2009) 1.50
Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection. Prog Neurobiol (2012) 1.41
Suppression of the intrinsic apoptosis pathway by synaptic activity. J Neurosci (2010) 1.40
Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin. Mol Cells (2009) 1.26
Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning. Proc Natl Acad Sci U S A (2010) 1.22
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. Free Radic Biol Med (2015) 1.17
Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis. Genes Dev (2010) 1.17
Reduction of cysteine sulfinic acid in eukaryotic, typical 2-Cys peroxiredoxins by sulfiredoxin. Antioxid Redox Signal (2010) 1.17
Neuronal activity regulates astrocytic Nrf2 signaling. Proc Natl Acad Sci U S A (2013) 1.13
Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III. J Biol Chem (2009) 1.11
Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms. Cell Death Differ (2011) 1.06
Sulforaphane as a potential protective phytochemical against neurodegenerative diseases. Oxid Med Cell Longev (2013) 1.03
Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning. Oxid Med Cell Longev (2011) 0.99
Oxidative stress response and Nrf2 signaling in aging. Free Radic Biol Med (2015) 0.99
Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration. Invest Ophthalmol Vis Sci (2012) 0.97
Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system. Nat Commun (2015) 0.96
Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2. Epigenetics (2009) 0.95
Neuronal activity controls the antagonistic balance between peroxisome proliferator-activated receptor-γ coactivator-1α and silencing mediator of retinoic acid and thyroid hormone receptors in regulating antioxidant defenses. Antioxid Redox Signal (2011) 0.92
Redox regulation of lipopolysaccharide-mediated sulfiredoxin induction, which depends on both AP-1 and Nrf2. J Biol Chem (2010) 0.91
Involvement of redox state in the aging of Drosophila melanogaster. Antioxid Redox Signal (2013) 0.91
Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes. J Neurochem (2011) 0.91
Hydrogen peroxide - production, fate and role in redox signaling of tumor cells. Cell Commun Signal (2015) 0.91
3H-1,2-dithiole-3-thione protects retinal pigment epithelium cells against Ultra-violet radiation via activation of Akt-mTORC1-dependent Nrf2-HO-1 signaling. Sci Rep (2016) 0.87
Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Nat Commun (2015) 0.86
fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior. Neuropsychopharmacology (2012) 0.84
Curcumin pretreatment and post-treatment both improve the antioxidative ability of neurons with oxygen-glucose deprivation. Neural Regen Res (2015) 0.83
Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration. Br J Clin Pharmacol (2013) 0.82
SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites. J Neurochem (2012) 0.82
Dithiol-based compounds maintain expression of antioxidant protein peroxiredoxin 1 that counteracts toxicity of mutant huntingtin. J Biol Chem (2012) 0.80
Glycogen Synthase Kinase 3β Influences Injury Following Cerebral Ischemia/Reperfusion in Rats. Int J Biol Sci (2016) 0.79
Adaptive regulation of the brain's antioxidant defences by neurons and astrocytes. Free Radic Biol Med (2016) 0.77
Sulforaphane enhances the ability of human retinal pigment epithelial cell against oxidative stress, and its effect on gene expression profile evaluated by microarray analysis. Oxid Med Cell Longev (2013) 0.77
Sulforaphane decreases endothelial cell apoptosis in fuchs endothelial corneal dystrophy: a novel treatment. Invest Ophthalmol Vis Sci (2013) 0.77
Sulfiredoxin-1 exerts anti-apoptotic and neuroprotective effects against oxidative stress-induced injury in rat cortical astrocytes following exposure to oxygen-glucose deprivation and hydrogen peroxide. Int J Mol Med (2015) 0.77
The sulfiredoxin-peroxiredoxin (Srx-Prx) axis in cell signal transduction and cancer development. Cancer Lett (2015) 0.77
Excitotoxic insults lead to peroxiredoxin hyperoxidation. Oxid Med Cell Longev (2010) 0.77
Comparative analysis of NRF2-responsive gene expression in AcPC-1 pancreatic cancer cell line. Genes Genomics (2014) 0.76
Role of sulfiredoxin in systemic diseases influenced by oxidative stress. Redox Biol (2014) 0.75
The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding. Toxicol Sci (2015) 0.75
Thioredoxin 1 protects astrocytes from oxidative stress by maintaining peroxiredoxin activity. Mol Med Rep (2016) 0.75
Structure, mechanism and regulation of peroxiredoxins. Trends Biochem Sci (2003) 8.84
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci (2002) 7.57
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science (2004) 5.88
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem (2003) 5.67
Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol (2002) 5.57
Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev (2006) 4.71
ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin. Nature (2003) 4.45
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci (2008) 4.04
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci (2001) 4.02
Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress. J Neurosci (2003) 3.54
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence. Biochem J (2003) 3.13
Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity. Nat Neurosci (2001) 2.79
Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Dev Cell (2008) 2.66
Nrf2, a multi-organ protector? FASEB J (2005) 2.61
Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine. J Biol Chem (2004) 2.32
A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. J Neurosci (2005) 2.28
The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress. Free Radic Biol Med (2004) 2.22
Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection. J Neurosci (2005) 2.16
Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers. Proc Natl Acad Sci U S A (2006) 2.15
Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer. Mol Cell Biol (1995) 1.86
Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins. J Biol Chem (2004) 1.86
Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress. Am J Physiol Cell Physiol (2003) 1.77
S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease. Proc Natl Acad Sci U S A (2007) 1.73
Peroxiredoxins, oxidative stress, and cell proliferation. Antioxid Redox Signal (2005) 1.71
Antioxidant activities of bile pigments. Antioxid Redox Signal (2004) 1.65
Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease. Neuron (2007) 1.65
Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents. Neurosci Lett (2005) 1.57
Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention. Bioessays (2006) 1.55
Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace. Nature (2008) 1.52
Oxidative activation of antioxidant defence. Trends Biochem Sci (2005) 1.47
Nrf2-mediated protection against 6-hydroxydopamine. Brain Res (2007) 1.42
Sulfiredoxin, the cysteine sulfinic acid reductase specific to 2-Cys peroxiredoxin: its discovery, mechanism of action, and biological significance. Kidney Int Suppl (2007) 1.37
The involvement of thioredoxin and thioredoxin binding protein-2 on cellular proliferation and aging process. Ann N Y Acad Sci (2005) 1.28
Mitochondrial peroxiredoxin-3 protects hippocampal neurons from excitotoxic injury in vivo. J Neurochem (2003) 1.27
Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness. J Neurochem (2005) 1.22
Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model. Mol Cell Neurosci (2007) 1.19
Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals. BMC Cell Biol (2006) 1.11
Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury. J Neurosci Res (2007) 1.00
Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains. Cell Mol Life Sci (2003) 0.97
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem (2003) 5.67
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci (2008) 4.04
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem (2010) 3.84
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence. Biochem J (2003) 3.13
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex. J Biol Chem (2006) 2.66
Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection. J Neurosci (2005) 2.16
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc Natl Acad Sci U S A (2012) 2.14
SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol Cell Biol (2011) 2.08
The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults. Neuron (2012) 1.97
Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability. J Neurosci (2006) 1.94
Administering a glyceryl trinitrate infusion: faster is better than slower. Emerg Med J (2008) 1.91
Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron. J Biol Chem (2004) 1.81
Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. J Biol Chem (2008) 1.73
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals. Proc Natl Acad Sci U S A (2010) 1.72
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome. Arch Biochem Biophys (2005) 1.71
The dichotomy of NMDA receptor signaling. Neuroscientist (2007) 1.61
Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand. J Neurosci (2008) 1.58
Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents. Cancer Res (2006) 1.51
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. Free Radic Biol Med (2009) 1.41
Suppression of the intrinsic apoptosis pathway by synaptic activity. J Neurosci (2010) 1.40
Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha. Proc Natl Acad Sci U S A (2007) 1.40
Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice. Hepatology (2004) 1.39
Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. Biochem J (2006) 1.37
Nomenclature for mammalian soluble glutathione transferases. Methods Enzymol (2005) 1.36
Nrf2, a guardian of healthspan and gatekeeper of species longevity. Integr Comp Biol (2010) 1.34
Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype. Proc Natl Acad Sci U S A (2005) 1.32
Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents. Toxicol Appl Pharmacol (2009) 1.30
Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals. Nat Commun (2013) 1.30
Antioxidant and cytoprotective responses to redox stress. Biochem Soc Symp (2004) 1.29
Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis. Mol Cell Biol (2012) 1.28
Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin. Mol Cells (2009) 1.26
Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity. PLoS One (2009) 1.24
Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning. Proc Natl Acad Sci U S A (2010) 1.22
Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness. J Neurochem (2005) 1.22
Compartmentalized NMDA receptor signalling to survival and death. J Physiol (2007) 1.21
Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene. Channels (Austin) (2009) 1.21
Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents. Drug Metab Rev (2011) 1.16
The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation. Biochem J (2007) 1.14
The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. Hepatology (2008) 1.13
Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals. BMC Cell Biol (2006) 1.11
Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Sci Transl Med (2013) 1.11
RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2. Cancer Res (2013) 1.07
The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors. Biochem J (2009) 1.07
Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy. Antioxid Redox Signal (2014) 1.05
The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613. Antioxid Redox Signal (2013) 1.04
Presynaptic efficacy directs normalization of synaptic strength in layer 2/3 rat neocortex after paired activity. J Neurophysiol (2007) 1.02
Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning. Oxid Med Cell Longev (2011) 0.99
CNS peroxiredoxins and their regulation in health and disease. Antioxid Redox Signal (2011) 0.99
Incidence and predictors of acute mountain sickness among trekkers on Mount Kilimanjaro. High Alt Med Biol (2010) 0.99
Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes. Proc Natl Acad Sci U S A (2014) 0.97
Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones. Chem Biol (2010) 0.97
Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity. Toxicol Sci (2006) 0.97
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance. Nat Neurosci (2012) 0.96
Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein. Toxicol Appl Pharmacol (2007) 0.95
The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence. J Biol Chem (2008) 0.95
Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2. Epigenetics (2009) 0.95
Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction. Free Radic Biol Med (2011) 0.94
Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways. Mol Pharmacol (2005) 0.94
Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons. J Neurosci (2014) 0.94
Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins. Biochem J (2002) 0.92
Neuronal activity controls the antagonistic balance between peroxisome proliferator-activated receptor-γ coactivator-1α and silencing mediator of retinoic acid and thyroid hormone receptors in regulating antioxidant defenses. Antioxid Redox Signal (2011) 0.92
The influence of synaptic activity on neuronal health. Curr Opin Neurobiol (2011) 0.92
The use of automated quantitative analysis to evaluate epithelial-to-mesenchymal transition associated proteins in clear cell renal cell carcinoma. PLoS One (2012) 0.92
2,7-Bis-(4-amidinobenzylidene)-cycloheptan-1-one dihydrochloride, tPA stop, prevents tPA-enhanced excitotoxicity both in vitro and in vivo. J Cereb Blood Flow Metab (2004) 0.91
Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element. Mol Pharmacol (2003) 0.90
Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase. Biochem J (2003) 0.89
Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane. Biochem J (2010) 0.89
Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents. Biochem Pharmacol (2003) 0.88
Direct comparison of the nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity. Toxicol Appl Pharmacol (2002) 0.88
The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity. Sci Rep (2013) 0.88
Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2. Biochem Biophys Res Commun (2003) 0.87
PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity. J Neurosci (2012) 0.87
The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics. Chem Biol Interact (2010) 0.87
P3 peptide, a truncated form of A beta devoid of synaptotoxic effect, does not assemble into soluble oligomers. FEBS Lett (2008) 0.87
Toward self-assembled ferroelectric random access memories: hard-wired switching capacitor arrays with almost Tb/in.(2) densities. Nano Lett (2007) 0.86
Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression. Channels (Austin) (2009) 0.86