Published in Curr Opin Hematol on May 01, 2016
Narrowing Resection of Parametrial Tissues Is Feasible in Low-Risk Cases of Stage IA2-IB1 Cervical Cancer. J Cancer (2016) 0.77
The Role of Sialylated Glycans in Human Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)-mediated Trans Homophilic Interactions and Endothelial Cell Barrier Function. J Biol Chem (2016) 0.75
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature (2005) 6.86
Endothelial cell-cell junctions: happy together. Nat Rev Mol Cell Biol (2004) 5.37
PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science (1990) 5.28
PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med (1993) 4.81
A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions. J Exp Med (1989) 3.58
Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc Natl Acad Sci U S A (1999) 3.49
The endothelial glycocalyx: composition, functions, and visualization. Pflugers Arch (2007) 3.31
Siglecs--the major subfamily of I-type lectins. Glycobiology (2005) 3.25
Tight junctions of the blood-brain barrier: development, composition and regulation. Vascul Pharmacol (2002) 2.94
Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development. Development (1994) 2.71
EndoCAM: a novel endothelial cell-cell adhesion molecule. J Cell Biol (1990) 2.71
Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice. J Clin Invest (2002) 2.50
PECAM-1: a multi-functional molecule in inflammation and vascular biology. Arterioscler Thromb Vasc Biol (2007) 2.46
Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology. Arterioscler Thromb Vasc Biol (2003) 2.30
Involvement of endothelial PECAM-1/CD31 in angiogenesis. Am J Pathol (1997) 2.17
Molecular characterization and functional analysis of the leukocyte surface protein CD31. J Immunol (1990) 2.07
Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1. Curr Biol (2013) 2.02
PECAM-1: old friend, new partners. Curr Opin Cell Biol (2003) 1.96
Role of GTP hydrolysis in fission of caveolae directly from plasma membranes. Science (1996) 1.95
Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen. J Exp Med (1990) 1.77
Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells. J Cell Biol (1994) 1.70
The cell-adhesion and signaling molecule PECAM-1 is a molecular mediator of resistance to genotoxic chemotherapy. Cancer Biol Ther (2006) 1.65
Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice. Am J Pathol (2005) 1.65
Biochemistry and expression of myelomonocytic antigens. J Immunol (1986) 1.56
Signaling through CD31 protects endothelial cells from apoptosis. Transplantation (2001) 1.50
Individually distinct Ig homology domains in PECAM-1 regulate homophilic binding and modulate receptor affinity. J Biol Chem (1996) 1.50
Switched at birth: a new family for PECAM-1. J Clin Invest (1999) 1.47
Vascular endothelial cells synthesize a plasma membrane protein indistinguishable from the platelet membrane glycoprotein IIa. J Biol Chem (1985) 1.46
Endothelial cell PECAM-1 confers protection against endotoxic shock. Am J Physiol Heart Circ Physiol (2004) 1.44
Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration. Am J Physiol Cell Physiol (2002) 1.43
Residues on both faces of the first immunoglobulin fold contribute to homophilic binding sites of PECAM-1/CD31. J Biol Chem (1997) 1.41
Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expression. J Biol Chem (1996) 1.37
PECAM-1 (CD31) expression modulates bleeding time in vivo. Am J Pathol (2000) 1.36
The protein tyrosine phosphatase Shp-2 regulates RhoA activity. Curr Biol (2000) 1.35
PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis. Blood (2003) 1.33
PECAM-1: conflicts of interest in inflammation. Life Sci (2010) 1.30
Functional roles for PECAM-1 (CD31) and VE-cadherin (CD144) in tube assembly and lumen formation in three-dimensional collagen gels. Am J Pathol (1999) 1.29
Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin. J Immunol (1997) 1.25
Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway. Curr Biol (2012) 1.20
Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. FASEB J (2003) 1.20
Angiogenesis in platelet endothelial cell adhesion molecule-1-null mice. Am J Pathol (2009) 1.18
Platelet endothelial cell adhesion molecule-1 is a major SH-PTP2 binding protein in vascular endothelial cells. FEBS Lett (1997) 1.18
Human vascular endothelial cells express a membrane protein complex immunochemically indistinguishable from the platelet VLA-2 (glycoprotein Ia-IIa) complex. Blood (1989) 1.16
Alpha2,6-sialic acid on platelet endothelial cell adhesion molecule (PECAM) regulates its homophilic interactions and downstream antiapoptotic signaling. J Biol Chem (2010) 1.16
Homophilic PECAM-1(CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration. J Cell Sci (1999) 1.14
PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis. Am J Physiol Cell Physiol (2007) 1.14
Antibody against murine PECAM-1 inhibits tumor angiogenesis in mice. Angiogenesis (1999) 1.10
Contributions of the extracellular and cytoplasmic domains of platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) in regulating cell-cell localization. J Cell Sci (2000) 1.09
Thrombospondin-1, a natural inhibitor of angiogenesis, regulates platelet-endothelial cell adhesion molecule-1 expression and endothelial cell morphogenesis. Mol Biol Cell (1997) 1.06
The role of endothelial cell apoptosis in inflammatory and immune diseases. J Thromb Haemost (2005) 1.06
PECAM-1: regulator of endothelial junctional integrity. Cell Tissue Res (2014) 1.05
Role of immunoreceptor tyrosine-based inhibitory motifs of PECAM-1 in PECAM-1-dependent cell migration. Am J Physiol Cell Physiol (2004) 1.04
CD31 (PECAM-1) exists as a dimer and is heavily N-glycosylated. Biochem Biophys Res Commun (1999) 1.00
Monocytes stimulate expression of the Bcl-2 family member, A1, in endothelial cells and confer protection against apoptosis. J Immunol (1999) 0.99
The platelet endothelial cell adhesion molecule-1 (PECAM1) contributes to endothelial barrier function. FEBS Lett (1995) 0.96
Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity. J Cell Sci (2011) 0.96
Residues within a lipid-associated segment of the PECAM-1 cytoplasmic domain are susceptible to inducible, sequential phosphorylation. Blood (2011) 0.95
Endothelial adherens junctions: implications in the control of vascular permeability and angiogenesis. J Clin Invest (1997) 0.94
Characterization of a novel myeloid antigen regulated during differentiation of monocytic cells. Eur J Immunol (1989) 0.93
Local VE-cadherin mechanotransduction triggers long-ranged remodeling of endothelial monolayers. J Cell Sci (2015) 0.92
Tissue specific expression of alternatively spliced murine PECAM-1 isoforms. Dev Dyn (1999) 0.91
Immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated inhibitory signaling is regulated by sequential phosphorylation mediated by distinct nonreceptor tyrosine kinases: a case study involving PECAM-1. Biochemistry (2013) 0.91
Regulation of endothelial cell barrier function by antibody-driven affinity modulation of platelet endothelial cell adhesion molecule-1 (PECAM-1). J Biol Chem (2014) 0.90
Reactive oxygen species induce reversible PECAM-1 tyrosine phosphorylation and SHP-2 binding. Am J Physiol Heart Circ Physiol (2003) 0.88
NEU1 sialidase regulates the sialylation state of CD31 and disrupts CD31-driven capillary-like tube formation in human lung microvascular endothelia. J Biol Chem (2014) 0.86
PECAM-1 isoforms, eNOS and endoglin axis in regulation of angiogenesis. Clin Sci (Lond) (2015) 0.85
Modulation of PECAM-1 expression and alternative splicing during differentiation and activation of hematopoietic cells. J Cell Biochem (2003) 0.85
CD31 signals confer immune privilege to the vascular endothelium. Proc Natl Acad Sci U S A (2015) 0.84
An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling. J Cell Sci (2008) 0.83
Interaction of platelet endothelial cell adhesion molecule (PECAM) with α2,6-sialylated glycan regulates its cell surface residency and anti-apoptotic role. J Biol Chem (2014) 0.81
SHP-2 phosphatase activity is required for PECAM-1-dependent cell motility. Am J Physiol Cell Physiol (2010) 0.81
Structural basis for PECAM-1 homophilic binding. Blood (2015) 0.80
Identification and characterization of functional cation coordination sites in platelet endothelial cell adhesion molecule-1. Biochemistry (1997) 0.80
Human myeloid differentiation antigens identified by monoclonal antibodies to the myelomonocytic leukemia cell line RC-2A. Pathology (1988) 0.77
Integrins: dynamic scaffolds for adhesion and signaling in platelets. Blood (2004) 3.05
Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair. Proc Natl Acad Sci U S A (2006) 2.74
Site-specific effects of PECAM-1 on atherosclerosis in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol (2008) 1.78
Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood (2012) 1.72
Mutagenicity and sequence specificity of acrolein-DNA adducts. Chem Res Toxicol (2009) 1.65
The cell-adhesion and signaling molecule PECAM-1 is a molecular mediator of resistance to genotoxic chemotherapy. Cancer Biol Ther (2006) 1.65
Liver fat content is associated with increased carotid atherosclerosis in a Chinese middle-aged and elderly population: the Shanghai Changfeng study. Atherosclerosis (2012) 1.60
Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling. Blood (2011) 1.59
Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets. Blood (2008) 1.54
Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res (2013) 1.54
Platelet PECAM-1 inhibits thrombus formation in vivo. Blood (2005) 1.53
The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31). J Biol Chem (2007) 1.53
GPIbα regulates platelet size by controlling the subcellular localization of filamin. Blood (2011) 1.45
Endothelial cell PECAM-1 confers protection against endotoxic shock. Am J Physiol Heart Circ Physiol (2004) 1.44
Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis. J Clin Immunol (2011) 1.38
Association between MTR A2756G polymorphism and childhood acute lymphoblastic leukemia: a meta-analysis. Leuk Lymphoma (2013) 1.37
PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis. Blood (2003) 1.33
PECAM-1: conflicts of interest in inflammation. Life Sci (2010) 1.30
Tests of the extension and deadbolt models of integrin activation. J Biol Chem (2007) 1.28
Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain. J Clin Invest (2009) 1.24
miR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF. Carcinogenesis (2012) 1.24
Negative regulation of Toll-like receptor signaling pathway. Microbes Infect (2009) 1.22
miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect. Oncol Rep (2012) 1.16
Bone marrow and the control of immunity. Cell Mol Immunol (2011) 1.15
miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma. Oncol Rep (2012) 1.12
Impact of network structure and cellular response on spike time correlations. PLoS Comput Biol (2012) 1.12
Drug-dependent clearance of human platelets in the NOD/scid mouse by antibodies from patients with drug-induced immune thrombocytopenia. Blood (2010) 1.11
Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility. J Biol Chem (2012) 1.07
Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice. Am J Physiol Regul Integr Comp Physiol (2005) 1.05
PECAM-1: regulator of endothelial junctional integrity. Cell Tissue Res (2014) 1.05
Overexpression of EphA2, MMP-9, and MVD-CD34 in hepatocellular carcinoma: Implications for tumor progression and prognosis. Hepatol Res (2009) 1.05
Common genetic risk factors for venous thrombosis in the Chinese population. Am J Hum Genet (2013) 1.01
PECAM-1 negatively regulates GPIb/V/IX signaling in murine platelets. Blood (2003) 1.01
The alleles of PECAM-1. Gene (2006) 1.00
A novel NF-kappaB binding site controls human granzyme B gene transcription. J Immunol (2006) 0.99
Resveratrol downregulates the constitutional activation of nuclear factor-kappaB in multiple myeloma cells, leading to suppression of proliferation and invasion, arrest of cell cycle, and induction of apoptosis. Cancer Genet Cytogenet (2006) 0.99
Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets. Biochem J (2007) 0.98
Neutrophil transmigration mediated by the neutrophil-specific antigen CD177 is influenced by the endothelial S536N dimorphism of platelet endothelial cell adhesion molecule-1. J Immunol (2010) 0.98
Quantitative analysis of multiple methylated genes in plasma for the diagnosis and prognosis of hepatocellular carcinoma. Exp Mol Pathol (2011) 0.97
Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection. Thromb Haemost (2006) 0.97
NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells. J Cell Sci (2006) 0.97
Acrolein induced DNA damage, mutagenicity and effect on DNA repair. Mol Nutr Food Res (2011) 0.97
The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis. Am J Physiol Gastrointest Liver Physiol (2007) 0.97
Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity. J Cell Sci (2011) 0.96
The Shanghai Changfeng Study: a community-based prospective cohort study of chronic diseases among middle-aged and elderly: objectives and design. Eur J Epidemiol (2010) 0.96
Residues within a lipid-associated segment of the PECAM-1 cytoplasmic domain are susceptible to inducible, sequential phosphorylation. Blood (2011) 0.95
Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation. Blood (2011) 0.95
Phosphorylation of tau by death-associated protein kinase 1 antagonizes the kinase-induced cell apoptosis. J Alzheimers Dis (2013) 0.93
Phospholipase Cgamma2 contributes to stable thrombus formation on VWF. FEBS Lett (2004) 0.93
Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils. J Immunol (2012) 0.93
Blockade of maternal anti-HPA-1a-mediated platelet clearance by an HPA-1a epitope-specific F(ab') in an in vivo mouse model of alloimmune thrombocytopenia. Transfusion (2008) 0.92
Genetic background analysis of protein C deficiency demonstrates a recurrent mutation associated with venous thrombosis in Chinese population. PLoS One (2012) 0.92
Mapping early conformational changes in alphaIIb and beta3 during biogenesis reveals a potential mechanism for alphaIIbbeta3 adopting its bent conformation. Blood (2007) 0.92
Quantitative methylation analysis of multiple genes using methylation-sensitive restriction enzyme-based quantitative PCR for the detection of hepatocellular carcinoma. Exp Mol Pathol (2011) 0.91
Immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated inhibitory signaling is regulated by sequential phosphorylation mediated by distinct nonreceptor tyrosine kinases: a case study involving PECAM-1. Biochemistry (2013) 0.91
Regulation of endothelial cell barrier function by antibody-driven affinity modulation of platelet endothelial cell adhesion molecule-1 (PECAM-1). J Biol Chem (2014) 0.90
Rosuvastatin enhances angiogenesis via eNOS-dependent mobilization of endothelial progenitor cells. PLoS One (2013) 0.90
Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain. Biomaterials (2004) 0.90
Isolation and partial characterization of cyclic lipopeptide antibiotics produced by Paenibacillus ehimensis B7. BMC Microbiol (2013) 0.90
Negative regulation of Nmi on virus-triggered type I IFN production by targeting IRF7. J Immunol (2013) 0.89
Glycated haemoglobin in diagnosis of diabetes mellitus and pre-diabetes among middle-aged and elderly population: Shanghai Changfeng study. Biomed Environ Sci (2013) 0.89
Direct evidence for the critical role of NFAT3 in benzo[a]pyrene diol-epoxide-induced cell transformation through mediation of inflammatory cytokine TNF induction in mouse epidermal Cl41 cells. Carcinogenesis (2007) 0.89
Mechanisms of PECAM-1-mediated cytoprotection and implications for cancer cell survival. Leuk Lymphoma (2005) 0.89
Genotypes and toxin gene profiles of Staphylococcus aureus clinical isolates from China. PLoS One (2011) 0.89
Novel association of a PROC variant with ischemic stroke in a Chinese Han population. Hum Genet (2012) 0.88
Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding. Biochem Biophys Res Commun (2002) 0.88
Reactive oxygen species induce reversible PECAM-1 tyrosine phosphorylation and SHP-2 binding. Am J Physiol Heart Circ Physiol (2003) 0.88
Molecular basis of protein S deficiency in China. Am J Hematol (2013) 0.87
Efficient augmentation of a long-lasting immune responses in HIV-1 gag DNA vaccination by IL-15 plasmid boosting. Vaccine (2008) 0.87
The dynamics of hypertension prevalence, awareness, treatment, control and associated factors in Chinese adults: results from CHNS 1991-2011. J Hypertens (2015) 0.87
Connexin 43 interacts with Bax to regulate apoptosis of pancreatic cancer through a gap junction-independent pathway. Int J Oncol (2012) 0.87
Brain-derived neurotrophic factor induces proliferation, migration, and VEGF secretion in human multiple myeloma cells via activation of MEK-ERK and PI3K/AKT signaling. Tumour Biol (2010) 0.86
Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia. Blood (2013) 0.86
Resveratrol as a novel agent for treatment of multiple myeloma with matrix metalloproteinase inhibitory activity. Acta Pharmacol Sin (2006) 0.86
LDLR-mediated peptide-22-conjugated nanoparticles for dual-targeting therapy of brain glioma. Biomaterials (2013) 0.85
Mechanism of outside-in {alpha}IIb{beta}3-mediated activation of human platelets by the colonizing Bacterium, Streptococcus gordonii. Arterioscler Thromb Vasc Biol (2010) 0.85
Brain-derived neurotrophic factor inducing angiogenesis through modulation of matrix-degrading proteases. Chin Med J (Engl) (2006) 0.85
Diagnostic value of osteoporosis self-assessment tool for Asians (OSTA) and quantitative bone ultrasound (QUS) in detecting high-risk populations for osteoporosis among elderly Chinese men. J Bone Miner Metab (2014) 0.84
Low-grade albuminuria is associated with carotid atherosclerosis in normotensive and euglycemic Chinese middle-aged and elderly adults: the Shanghai Changfeng Study. Atherosclerosis (2013) 0.84
Acrolein- and 4-Aminobiphenyl-DNA adducts in human bladder mucosa and tumor tissue and their mutagenicity in human urothelial cells. Oncotarget (2014) 0.84
Prophylactic effects of interleukin-2 receptor antagonists against graft-versus-host disease following unrelated donor peripheral blood stem cell transplantation. Biol Blood Marrow Transplant (2011) 0.84
Measles incidence rate and a phylogenetic study of contemporary genotype H1 measles strains in China: is an improved measles vaccine needed? Virus Genes (2011) 0.84
Immune thrombocytopenia as a paraneoplastic syndrome in patients with nasopharyngeal cancer. Head Neck (2010) 0.84
Vav1-phospholipase C-γ1 (Vav1-PLC-γ1) pathway initiated by T cell antigen receptor (TCRγδ) activation is required to overcome inhibition by ubiquitin ligase Cbl-b during γδT cell cytotoxicity. J Biol Chem (2013) 0.83
An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling. J Cell Sci (2008) 0.83
A tissue factor targeted nanomedical system for thrombi-specific drug delivery. Biomaterials (2012) 0.83
TGF-betal transgenic mouse model of thoracic irradiation: modulation of MMP-2 and MMP-9 in the lung tissue. J Huazhong Univ Sci Technolog Med Sci (2006) 0.83
Plasma thrombomodulin, fibrinogen, and activity of tissue factor as risk factors for acute cerebral infarction. Am J Clin Pathol (2007) 0.83