Published in J Leukoc Biol on July 20, 2005
Flagellin as an adjuvant: cellular mechanisms and potential. J Immunol (2010) 2.68
Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis. Infect Immun (2006) 1.92
Incorporation of membrane-anchored flagellin into influenza virus-like particles enhances the breadth of immune responses. J Virol (2008) 1.34
Natural killer (NK) cells in antibacterial innate immunity: angels or devils? Mol Med (2012) 1.25
Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin. J Immunol (2009) 1.20
Induction of adaptive immunity by flagellin does not require robust activation of innate immunity. Eur J Immunol (2009) 1.19
CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes. J Immunol (2008) 1.18
Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure. J Pharmacol Exp Ther (2012) 1.09
Toll-like receptor ligand activation of murine bone marrow-derived dendritic cells. Immunology (2008) 1.08
Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2). PLoS One (2012) 1.07
A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity. PLoS One (2014) 1.00
Toll-like receptors expression and interferon-γ production by NK cells in human sepsis. Crit Care (2012) 0.98
FimH can directly activate human and murine natural killer cells via TLR4. Mol Ther (2010) 0.97
Recombinant rabies viruses expressing GM-CSF or flagellin are effective vaccines for both intramuscular and oral immunizations. PLoS One (2013) 0.93
Rickettsiae stimulate dendritic cells through toll-like receptor 4, leading to enhanced NK cell activation in vivo. J Infect Dis (2009) 0.93
Nonproteolytic properties of murine alternatively spliced tissue factor: implications for integrin-mediated signaling in murine models. Mol Med (2012) 0.85
The MSHA strain of Pseudomonas aeruginosa activated TLR pathway and enhanced HIV-1 DNA vaccine immunoreactivity. PLoS One (2012) 0.83
Accessory-cell-mediated activation of porcine NK cells by toll-like receptor 7 (TLR7) and TLR8 agonists. Clin Vaccine Immunol (2009) 0.80
Recombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice. PLoS One (2014) 0.80
Mucosal vaccine delivery: Current state and a pediatric perspective. J Control Release (2016) 0.80
Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation. Proc Natl Acad Sci U S A (2013) 0.78
Vaccine technologies: From whole organisms to rationally designed protein assemblies. Biochem Pharmacol (2016) 0.78
mTORC1 Regulates Flagellin-Induced Inflammatory Response in Macrophages. PLoS One (2015) 0.75
Rational considerations about development of live attenuated Yersinia pestis vaccines. Curr Pharm Biotechnol (2013) 0.75
Natural Killer Cell Functions during the Innate Immune Response to Pathogenic Streptococci. Front Microbiol (2017) 0.75
Bacterial flagellin-a potent immunomodulatory agent. Exp Mol Med (2017) 0.75
Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A (2013) 16.74
A network-based analysis of systemic inflammation in humans. Nature (2005) 12.60
A genomic storm in critically injured humans. J Exp Med (2011) 6.67
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med (2007) 5.48
Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation. Eur J Immunol (2007) 4.19
Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155. J Virol (2007) 4.19
Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A (2005) 3.49
Whole blood and leukocyte RNA isolation for gene expression analyses. Physiol Genomics (2004) 3.22
Identification of cellular genes targeted by KSHV-encoded microRNAs. PLoS Pathog (2007) 3.16
Outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms in 200 consecutive cases. Clin Gastroenterol Hepatol (2007) 3.13
A four-tiered transcriptional regulatory circuit controls flagellar biogenesis in Pseudomonas aeruginosa. Mol Microbiol (2003) 3.05
Endoscopic submucosal dissection of esophageal squamous cell neoplasms. Clin Gastroenterol Hepatol (2006) 2.75
Risk factors for an adverse outcome in early invasive colorectal carcinoma. Gastroenterology (2004) 2.66
Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes. Diabetes (2005) 2.63
Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach. Mol Cell Proteomics (2005) 2.50
Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med (2003) 2.30
Tissue damage of different submucosal injection solutions for EMR. Gastrointest Endosc (2005) 2.27
High dynamic range characterization of the trauma patient plasma proteome. Mol Cell Proteomics (2006) 2.25
A second-look endoscopy after endoscopic submucosal dissection for gastric epithelial neoplasm may be unnecessary: a retrospective analysis of postendoscopic submucosal dissection bleeding. Gastrointest Endosc (2009) 2.24
Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. J Trauma Acute Care Surg (2012) 2.24
New criteria for histologic grading of colorectal cancer. Am J Surg Pathol (2012) 2.20
Anti-TNF-alpha therapies: the next generation. Nat Rev Drug Discov (2003) 2.18
The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock. Crit Care Med (2012) 2.17
Successful outcomes of a novel endoscopic treatment for GI tumors: endoscopic submucosal dissection with a mixture of high-molecular-weight hyaluronic acid, glycerin, and sugar. Gastrointest Endosc (2006) 2.13
Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg (2012) 2.07
A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Mol Med (2010) 2.06
The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas (2004) 2.05
Clinical microfluidics for neutrophil genomics and proteomics. Nat Med (2010) 2.02
Different roles of EIIABMan and EIIGlc in regulation of energy metabolism, biofilm development, and competence in Streptococcus mutans. J Bacteriol (2006) 2.00
B cells enhance early innate immune responses during bacterial sepsis. J Exp Med (2011) 1.99
Characteristics of recurrence and surveillance tools after curative resection for colorectal cancer: a multicenter study. Surgery (2006) 1.96
Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry. Proteomics (2005) 1.94
Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Crit Care Med (2013) 1.94
Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. Blood (2008) 1.94
Limited gastrectomy with dissection of sentinel node stations for early gastric cancer with negative sentinel node biopsy. Ann Surg (2009) 1.93
Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol (2006) 1.86
Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc Natl Acad Sci U S A (2006) 1.82
Interleukin-10: a complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug. Crit Care Med (2002) 1.78
Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria. Infect Immun (2003) 1.75
Indication and benefit of pelvic sidewall dissection for rectal cancer. Dis Colon Rectum (2006) 1.74
Multicenter study of the long-term outcomes of endoscopic submucosal dissection for early gastric cancer in patients 80 years of age or older. Gastric Cancer (2011) 1.74
Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes. Hepatology (2008) 1.73
CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis. J Immunol (2005) 1.71
Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis. Shock (2005) 1.71
Clinicopathological and prognostic relevance of uptake level using 18F-fluorodeoxyglucose positron emission tomography/computed tomography fusion imaging (18F-FDG PET/CT) in primary breast cancer. Jpn J Clin Oncol (2008) 1.68
Gut ischemia-reperfusion affects gut mucosal immunity: a possible mechanism for infectious complications after severe surgical insults. Crit Care Med (2006) 1.63
Longitudinal studies of inter-alpha inhibitor proteins in severely septic patients: a potential clinical marker and mediator of severe sepsis. Crit Care Med (2007) 1.63
A better understanding of why murine models of trauma do not recapitulate the human syndrome. Crit Care Med (2014) 1.62
Human transcriptome array for high-throughput clinical studies. Proc Natl Acad Sci U S A (2011) 1.62
Continuous flow microfluidic device for rapid erythrocyte lysis. Anal Chem (2004) 1.61
Therapeutic results for hepatic metastasis of colorectal cancer with special reference to effectiveness of hepatectomy: analysis of prognostic factors for 763 cases recorded at 18 institutions. Dis Colon Rectum (2003) 1.60
Impact of postoperative infection on long-term survival after potentially curative resection for gastric cancer. Ann Surg Oncol (2008) 1.59
CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14). Crit Care Med (2004) 1.58
Pseudomonas aeruginosa regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients. Proc Natl Acad Sci U S A (2004) 1.58
Role of Toll-like receptors in the development of sepsis. Shock (2008) 1.57
Clinical pharmacogenetics implementation: approaches, successes, and challenges. Am J Med Genet C Semin Med Genet (2014) 1.57
ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells. Mol Cancer (2008) 1.56
Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice. J Hepatol (2010) 1.54
Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol (2010) 1.54
Distinct transcriptional profiles characterize oral epithelium-microbiota interactions. Cell Microbiol (2005) 1.51
Pretreatment CD133 and cyclooxygenase-2 expression as the predictive markers of the pathological effect of chemoradiotherapy in rectal cancer patients. Dis Colon Rectum (2011) 1.51
A novel type I IFN-producing cell subset in murine lupus. J Immunol (2008) 1.50
Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis. Shock (2007) 1.50