Published in Exp Mol Med on September 01, 2017
Pathogen recognition and innate immunity. Cell (2006) 44.14
Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol Mol Biol Rev (1998) 17.27
MAP kinase signalling cascade in Arabidopsis innate immunity. Nature (2002) 11.40
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity (2011) 11.15
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol (2006) 10.55
Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol (2005) 9.70
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol (2006) 9.64
A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J Clin Invest (1995) 7.68
Toll-like receptors control activation of adaptive immune responses. Nat Immunol (2001) 7.54
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol (2005) 6.81
Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol (2001) 6.62
Control of B-cell responses by Toll-like receptors. Nature (2005) 6.44
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature (2011) 6.38
Mucosal immunity and vaccines. Nat Med (2005) 5.44
Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest (2004) 5.39
Recognition of pathogen-associated molecular patterns by TLR family. Immunol Lett (2003) 5.27
Innate immune recognition: mechanisms and pathways. Immunol Rev (2000) 5.15
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol (2008) 5.10
Complete atomic model of the bacterial flagellar filament by electron cryomicroscopy. Nature (2003) 4.99
An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science (2008) 4.89
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med (2007) 4.39
Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med (2006) 4.30
Toll-like receptors stimulate human neutrophil function. Blood (2003) 4.29
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol (2006) 4.15
Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat Immunol (2008) 4.08
ANTIGENS IN IMMUNITY. IV. CELLULAR LOCALIZATION OF 125-I- AND 131-I-LABELLED FLAGELLA IN LYMPH NODES. Aust J Exp Biol Med Sci (1964) 4.00
Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J Exp Med (2003) 3.86
Evasion of Toll-like receptor 5 by flagellated bacteria. Proc Natl Acad Sci U S A (2005) 3.35
A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med (2003) 3.30
TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer. Cancer Res (2006) 3.21
TLR3 can directly trigger apoptosis in human cancer cells. J Immunol (2006) 2.79
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J Immunol (2003) 2.73
Flagellin as an adjuvant: cellular mechanisms and potential. J Immunol (2010) 2.68
Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa. Trends Microbiol (2004) 2.66
The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science (1994) 2.53
Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium. J Immunol (2000) 2.48
Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature (2007) 2.47
Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. J Immunol (2003) 2.43
Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells. J Immunol (2005) 2.27
Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo. J Immunol (2002) 2.22
Mechanisms of costimulation. Immunol Rev (2009) 2.13
Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response. J Immunol (2004) 2.13
Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells. Proc Natl Acad Sci U S A (2001) 2.12
Flagellin induces antibody responses through a TLR5- and inflammasome-independent pathway. J Immunol (2014) 2.11
Flagellin treatment protects against chemicals, bacteria, viruses, and radiation. J Immunol (2008) 2.07
A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol (2003) 2.04
Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells. J Clin Invest (2000) 1.96
Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction. Immunity (2011) 1.95
Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis. Infect Immun (2006) 1.92
Endotoxin-induced lung injury in mice: structural, functional, and biochemical responses. Am J Physiol Lung Cell Mol Physiol (2004) 1.91
Triggering of Toll-like receptor 4 expressed on human head and neck squamous cell carcinoma promotes tumor development and protects the tumor from immune attack. Cancer Res (2009) 1.85
Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity. Vaccine (2006) 1.74
Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes. J Immunol (2003) 1.73
Salmonella flagellin induces tumor necrosis factor alpha in a human promonocytic cell line. Infect Immun (1998) 1.72
Radioprotectors and mitigators of radiation-induced normal tissue injury. Oncologist (2010) 1.71
Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer. Gastroenterology (2008) 1.70
High-affinity interaction between gram-negative flagellin and a cell surface polypeptide results in human monocyte activation. Infect Immun (2000) 1.70
A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity. J Infect Dis (2007) 1.68
A bacterial flagellin, Vibrio vulnificus FlaB, has a strong mucosal adjuvant activity to induce protective immunity. Infect Immun (2006) 1.63
Effects of flagellin on innate and adaptive immunity. Immunol Res (2005) 1.58
Mucosal administration of flagellin induces innate immunity in the mouse lung. Infect Immun (2004) 1.56
Salmonella typhi flagella are potent inducers of proinflammatory cytokine secretion by human monocytes. Infect Immun (1999) 1.55
Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-kappaB and MAP kinase pathways and the upregulated expression of interleukin 8. Cell Microbiol (2002) 1.54
Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori. Int J Med Microbiol (2005) 1.49
Flagellin fusion proteins as adjuvants or vaccines induce specific immune responses. Infect Immun (2004) 1.49
Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin. Sci Transl Med (2017) 1.48
Divergence of quaternary structures among bacterial flagellar filaments. Science (2008) 1.46
Identification of conserved domains in Salmonella muenchen flagellin that are essential for its ability to activate TLR5 and to induce an inflammatory response in vitro. J Biol Chem (2003) 1.46
Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the protein. J Immunol (2001) 1.46
Humoral immune response to flagellin requires T cells and activation of innate immunity. J Immunol (2006) 1.45
Efficacious recombinant influenza vaccines produced by high yield bacterial expression: a solution to global pandemic and seasonal needs. PLoS One (2008) 1.44
TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin. Eur J Immunol (2010) 1.37
Incorporation of membrane-anchored flagellin into influenza virus-like particles enhances the breadth of immune responses. J Virol (2008) 1.34
Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates. Clin Vaccine Immunol (2008) 1.33
Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growth. Cancer Res (2011) 1.30
Both radioresistant and hemopoietic cells promote innate and adaptive immune responses to flagellin. J Immunol (2008) 1.30
Regulation of T lymphocyte trafficking into lymph nodes during an immune response by the chemokines macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta. J Immunol (1998) 1.30
Antitumor activity of the TLR-5 ligand flagellin in mouse models of cancer. J Immunol (2006) 1.26
Safety and immunogenicity of a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125) in healthy young adults. Vaccine (2010) 1.24
Segment IV of a Salmonella flagellin gene specifies flagellar antigen epitopes. Mol Microbiol (1991) 1.24
Toll-like receptor signaling in anti-cancer immunity. J Med Invest (2003) 1.22
Epitope-based vaccine against influenza. Expert Rev Vaccines (2007) 1.19
Evaluation of a truncated recombinant flagellin subunit vaccine against Campylobacter jejuni. Infect Immun (1999) 1.19
Salmonella flagellin induces bystander activation of splenic dendritic cells and hinders bacterial replication in vivo. J Immunol (2007) 1.18
Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist. Proc Natl Acad Sci U S A (2013) 1.16
Superior efficacy of a recombinant flagellin:H5N1 HA globular head vaccine is determined by the placement of the globular head within flagellin. Vaccine (2009) 1.16
Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125, STF2.HA1 SI). Vaccine (2011) 1.14
A universal epitope-based influenza vaccine and its efficacy against H5N1. Vaccine (2009) 1.14
Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine. Vaccine (2009) 1.14
Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions. J Leukoc Biol (2005) 1.12
Mucosal adjuvant activity of flagellin in aged mice. Mech Ageing Dev (2008) 1.12
A fusion protein vaccine containing OprF epitope 8, OprI, and type A and B flagellins promotes enhanced clearance of nonmucoid Pseudomonas aeruginosa. Infect Immun (2009) 1.12
Intestinal epithelial toll-like receptors: to protect. And serve? Curr Pharm Des (2003) 1.12
Effect of pre-existing carrier immunity on the efficacy of synthetic influenza vaccine. Immunol Lett (1998) 1.11
A recombinant flagellin-poxvirus fusion protein vaccine elicits complement-dependent protection against respiratory challenge with vaccinia virus in mice. Viral Immunol (2010) 1.11
New malaria vaccine candidates based on the Plasmodium vivax Merozoite Surface Protein-1 and the TLR-5 agonist Salmonella Typhimurium FliC flagellin. Vaccine (2008) 1.09
Synthetic recombinant influenza vaccine induces efficient long-term immunity and cross-strain protection. Vaccine (1996) 1.08
Toll-like receptor 5 (TLR5) expression is a novel predictive marker for recurrence and survival in squamous cell carcinoma of the tongue. Br J Cancer (2013) 1.06