Published in Drugs Aging on January 01, 2005
Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol (2008) 2.23
Immunosenescence and Challenges of Vaccination against Influenza in the Aging Population. Aging Dis (2011) 1.23
Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. J Immunol (2014) 1.18
Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways. Curr Opin Pharmacol (2010) 1.14
Immunity from smallpox vaccine persists for decades: a longitudinal study. Am J Med (2008) 1.11
Serum levels of the immune activation marker neopterin change with age and gender and are modified by race, BMI, and percentage of body fat. J Gerontol A Biol Sci Med Sci (2010) 1.03
New respiratory viruses and the elderly. Open Respir Med J (2011) 1.02
Activation of B cells by antigens on follicular dendritic cells. Trends Immunol (2010) 0.99
Immunosupportive therapies in aging. Clin Interv Aging (2007) 0.97
Mechanisms of murine dendritic cell antitumor dysfunction in aging. Cancer Immunol Immunother (2008) 0.96
The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging. Immun Ageing (2005) 0.94
Acute disseminated encephalomyelitis: a follow-up study in Taiwan. J Neurol Neurosurg Psychiatry (2006) 0.91
Flow-cytometric assessment of cellular poly(ADP-ribosyl)ation capacity in peripheral blood lymphocytes. Immun Ageing (2006) 0.87
Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response. PLoS One (2012) 0.87
Comparative kinetic analyses of gene profiles of naïve CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterations. Aging Cell (2011) 0.87
Preexisting Immunity, More Than Aging, Influences Influenza Vaccine Responses. Open Forum Infect Dis (2015) 0.85
Immune biomarkers predictive of respiratory viral infection in elderly nursing home residents. PLoS One (2014) 0.83
Parity-dependent association between TNF-α and LTF gene polymorphisms and clinical mastitis in dairy cattle. BMC Vet Res (2013) 0.82
Mitochondrial Dysfunction in Alzheimer's Disease and the Rationale for Bioenergetics Based Therapies. Aging Dis (2016) 0.81
Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly. Cell Commun Signal (2014) 0.81
Aging, immunosenescence and membrane rafts: the lipid connection. Longev Healthspan (2012) 0.79
Immunomodulatory role of high-density lipoproteins: impact on immunosenescence. Age (Dordr) (2014) 0.78
Immunosenescence in the nursing home elderly. BMC Geriatr (2014) 0.78
Nanonized black soybean enhances immune response in senescence-accelerated mice. Int J Nanomedicine (2009) 0.78
Immunosenescence and organ transplantation. Transplant Rev (Orlando) (2013) 0.78
A dual character of flavonoids in influenza A virus replication and spread through modulating cell-autonomous immunity by MAPK signaling pathways. Sci Rep (2014) 0.78
Aging adults and seasonal influenza: does the vitamin d status (h)arm the body? J Aging Res (2011) 0.78
Premature T Cell Senescence in Pediatric CKD. J Am Soc Nephrol (2016) 0.76
Cardio-metabolic and immunological impacts of extra virgin olive oil consumption in overweight and obese older adults: a randomized controlled trial. Nutr Metab (Lond) (2015) 0.75
A need to study the immune status of frail older adults. Immun Ageing (2006) 0.75
IFN production ability and healthy ageing: mixed model analysis of a 24 year longitudinal study in Japan. BMJ Open (2013) 0.75
Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival. Nat Med (2012) 5.44
Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells. Immunity (2012) 3.58
Cancer classification using the Immunoscore: a worldwide task force. J Transl Med (2012) 2.88
Epigenetic and immune function profiles associated with posttraumatic stress disorder. Proc Natl Acad Sci U S A (2010) 2.85
Human immunosenescence: is it infectious? Immunol Rev (2005) 2.83
Is immunosenescence infectious? Trends Immunol (2004) 2.47
Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers. Clin Cancer Res (2011) 2.44
Defining the critical hurdles in cancer immunotherapy. J Transl Med (2011) 2.32
Cytomegalovirus and human immunosenescence. Rev Med Virol (2009) 2.31
Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity (2005) 2.19
An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. J Gerontol A Biol Sci Med Sci (2005) 2.15
B-cell diversity decreases in old age and is correlated with poor health status. Aging Cell (2008) 2.15
T cells and aging, January 2002 update. Front Biosci (2002) 2.14
Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1). Exp Gerontol (2003) 2.11
Aging of the immune system as a prognostic factor for human longevity. Physiology (Bethesda) (2008) 2.09
Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States. PLoS One (2011) 2.08
Functional T cells targeting NY-ESO-1 or Melan-A are predictive for survival of patients with distant melanoma metastasis. J Clin Oncol (2012) 1.97
Aging and innate immunity. Immunity (2006) 1.95
Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old. J Clin Immunol (2003) 1.94
Cytomegalovirus infection: a driving force in human T cell immunosenescence. Ann N Y Acad Sci (2007) 1.87
The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning. Mech Ageing Dev (2006) 1.85
Immunosenescence and vaccine failure in the elderly. Aging Clin Exp Res (2009) 1.75
Recreational music-making modulates natural killer cell activity, cytokines, and mood states in corporate employees. Med Sci Monit (2007) 1.67
Is human aging still mysterious enough to be left only to scientists? Bioessays (2002) 1.59
Immunosenescence and vaccination in nursing home residents. Clin Infect Dis (2009) 1.57
Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people. Immun Ageing (2008) 1.57
Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly. Exp Gerontol (2004) 1.55
Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. J Immunol (2006) 1.54
The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines. Vaccine (2012) 1.54
Human cytomegalovirus infection and T cell immunosenescence: a mini review. Mech Ageing Dev (2006) 1.53
No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study. Exp Gerontol (2007) 1.51
Biomarkers of human immunosenescence: impact of Cytomegalovirus infection. Curr Opin Immunol (2009) 1.51
Expression of Foxp2, a gene involved in speech and language, in the developing and adult striatum. J Neurosci Res (2003) 1.47
Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients. J Immunother (2009) 1.44
Hallmark features of immunosenescence are absent in familial longevity. J Immunol (2010) 1.43
Myeloid-derived suppressor cells predict survival of patients with advanced melanoma: comparison with regulatory T cells and NY-ESO-1- or melan-A-specific T cells. Clin Cancer Res (2013) 1.43
Multi-parametric phospho-flow cytometry: a crucial tool for T lymphocyte signaling studies. Cytometry A (2013) 1.41
Signal transduction and functional changes in neutrophils with aging. Aging Cell (2004) 1.41
The genetics of human longevity. Ann N Y Acad Sci (2006) 1.30
Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans. J Gen Virol (2011) 1.29
Pretreatment frequency of circulating IL-17+ CD4+ T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients. Int J Cancer (2009) 1.24
The immune system in the aging human. Immunol Res (2012) 1.24
Immunosenescence and Cytomegalovirus: where do we stand after a decade? Immun Ageing (2010) 1.22
Role of persistent CMV infection in configuring T cell immunity in the elderly. Immun Ageing (2007) 1.21
Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow. J Exp Med (2013) 1.21
Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity. Biogerontology (2006) 1.20
Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease. J Alzheimers Dis (2009) 1.20
Report from the second cytomegalovirus and immunosenescence workshop. Immun Ageing (2011) 1.19
Mechanisms of immunosenescence. Immun Ageing (2009) 1.19
Simultaneous infiltration of polyfunctional effector and suppressor T cells into renal cell carcinomas. Cancer Res (2009) 1.19
CMV and Immunosenescence: from basics to clinics. Immun Ageing (2012) 1.17
Gene expression analysis of mTOR pathway: association with human longevity. Aging Cell (2012) 1.17
An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness. Mech Ageing Dev (2003) 1.17
Circulating levels of proinflammatory cytokines and neutrophil-platelet aggregates in patients with coronary artery disease. Am J Cardiol (2005) 1.14
Immunity, ageing and cancer. Immun Ageing (2008) 1.13
Aging, immunity, and cancer. Discov Med (2011) 1.11
Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination. Vaccine (2012) 1.10
Oxidative stress modulation and T cell activation. Exp Gerontol (2007) 1.10
Potential role of immunosenescence in cancer development. Ann N Y Acad Sci (2010) 1.10
Morbidity does not influence the T-cell immune risk phenotype in the elderly: findings in the Swedish NONA Immune Study using sample selection protocols. Mech Ageing Dev (2003) 1.08
Expression of TNF receptors and related signaling molecules in the bone marrow from patients with myelodysplastic syndromes. Leuk Res (2003) 1.08
Simultaneous evaluation of circulating chemokine and cytokine profiles in elderly subjects by multiplex technology: relationship with zinc status. Biogerontology (2006) 1.07
Hepatocellular carcinoma with osteoclast-like giant cells: possibility of osteoclastogenesis by hepatocyte-derived cells. Pathol Int (2003) 1.07
High response rate after intratumoral treatment with interleukin-2: results from a phase 2 study in 51 patients with metastasized melanoma. Cancer (2010) 1.07
Impact of age on T cell signaling: a general defect or specific alterations? Ageing Res Rev (2010) 1.07
Immunity and ageing in man: Annual Review 2006/2007. Exp Gerontol (2007) 1.07
Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people. Age (Dordr) (2012) 1.06
Human mesenchymal stromal cells express CD14 cross-reactive epitopes. Cytometry A (2011) 1.06
Ageing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing - a biochemical paradigm for the ageing immune system. Arthritis Res Ther (2003) 1.05
Association of IFN-gamma signal transduction defects with impaired HLA class I antigen processing in melanoma cell lines. Clin Cancer Res (2011) 1.04
Relationship of job satisfaction, psychological distress and stress-related biological parameters among healthy nurses: a longitudinal study. J Occup Health (2009) 1.02
Effect of zinc supplementation on plasma IL-6 and MCP-1 production and NK cell function in healthy elderly: interactive influence of +647 MT1a and -174 IL-6 polymorphic alleles. Exp Gerontol (2007) 1.02
Modulation of human lymphocyte proliferative response with aging. Exp Gerontol (2002) 1.02
OMIP-020: phenotypic characterization of human γδ T-cells by multicolor flow cytometry. Cytometry A (2014) 1.01
Zinc dyshomeostasis: a key modulator of neuronal injury. J Alzheimers Dis (2005) 1.00
Expression of FOXP2 in the developing monkey forebrain: comparison with the expression of the genes FOXP1, PBX3, and MEIS2. J Comp Neurol (2008) 1.00
Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis. Ageing Res Rev (2008) 1.00