Published in Int J Exp Pathol on August 01, 2005
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13
Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol (1999) 16.81
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol (2000) 13.46
Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol (2003) 6.49
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res (2004) 6.38
A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev (1999) 6.34
Histone H2A variants H2AX and H2AZ. Curr Opin Genet Dev (2002) 5.11
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell (1995) 4.64
Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science (1995) 4.19
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev (2002) 3.83
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene (1999) 3.23
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res (2000) 3.06
Characterization of 21 newly established esophageal cancer cell lines. Cancer (1992) 2.87
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J Biol Chem (2003) 2.54
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Biochem J (2002) 2.18
High-LET radiations induce a large proportion of non-rejoining DNA breaks. Nature (1977) 1.64
Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs. Radiat Res (1993) 1.64
Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature (1997) 1.54
A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse. Cancer Res (2000) 1.44
DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage. Nature (1999) 1.25
The initial physical damage produced by ionizing radiations. Int J Radiat Biol (1989) 1.13
Results of radical radiotherapy of squamous cell carcinoma of the oesophagus. Clin Radiol (1982) 1.07
Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. J Immunol (1995) 1.02
Regulation of DNA-dependent protein kinase activity by ionizing radiation-activated abl kinase is an ATM-dependent process. J Biol Chem (2000) 0.94
Visualization of focal nuclear sites of DNA repair synthesis induced by bleomycin in human cells. Radiat Res (2001) 0.90
Comparison of DNA repair protein expression and activities between human fibroblast cell lines with different radiosensitivities. Int J Cancer (2000) 0.88
Lethality of heavy ion-induced DNA double-strand breaks in mammalian cells. Int J Radiat Biol (1993) 0.82
Cell culture in esophageal squamous cell carcinoma and the association with molecular markers. Clin Cancer Res (2003) 0.80
Radiation therapy for squamous cell carcinoma of the esophagus. J Surg Oncol (1988) 0.80
ATM mutations in patients with ataxia telangiectasia screened by a hierarchical strategy. Hum Mutat (1998) 0.80
Rejoining of DNA double-strand breaks induced by accelerated nitrogen ions. Int J Radiat Biol (1996) 0.78
Clinical results of radiation therapy for stage I esophageal cancer: a single institutional experience. Am J Clin Oncol (2005) 0.78
Radiosensitivity of skin fibroblasts from atomic bomb survivors with and without breast cancer. Cancer Res (1990) 0.77
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet (2003) 7.98
Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell (2002) 5.69
Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res (2008) 4.19
Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells (2009) 4.08
miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis (2009) 3.45
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Nat Genet (2010) 2.92
Surgery plus chemotherapy compared with surgery alone for localized squamous cell carcinoma of the thoracic esophagus: a Japan Clinical Oncology Group Study--JCOG9204. J Clin Oncol (2003) 2.86
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines. J Natl Cancer Inst (2010) 2.79
High incidence of renal stones among HIV-infected patients on ritonavir-boosted atazanavir than in those receiving other protease inhibitor-containing antiretroviral therapy. Clin Infect Dis (2012) 2.44
Long-term exposure to tenofovir continuously decrease renal function in HIV-1-infected patients with low body weight: results from 10 years of follow-up. AIDS (2014) 2.26
Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract. Nat Med (2002) 2.18
TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas. Hepatology (2002) 2.05
Mutations in EFHC1 cause juvenile myoclonic epilepsy. Nat Genet (2004) 1.98
The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer. Cancer Res (2011) 1.98
Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma. Cancer Res (2004) 1.98
Genetic variants in C5 and poor response to eculizumab. N Engl J Med (2014) 1.91
The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53. Cancer Cell (2005) 1.90
Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Nat Genet (2010) 1.90
The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD). Am J Hum Genet (2004) 1.86
A Proteomic Approach for the Diagnosis of 'Oketsu' (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine. Evid Based Complement Alternat Med (2007) 1.77
MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1). J Biol Chem (2010) 1.76
PPM1D is a potential target for 17q gain in neuroblastoma. Cancer Res (2003) 1.75
YAP is a candidate oncogene for esophageal squamous cell carcinoma. Carcinogenesis (2010) 1.75
MicroRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma. J Hum Genet (2011) 1.71
The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma. PLoS One (2013) 1.69
Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease. Ann Neurol (2006) 1.66
PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. Cell (2009) 1.65
Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese. Nat Genet (2012) 1.59
Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Cancer Res (2004) 1.58
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. Proc Natl Acad Sci U S A (2003) 1.56
The prognostic relevance of fascin expression in human gastric carcinoma. Oncology (2004) 1.56
Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. Cancer Res (2002) 1.56
miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer. Cancer Res (2011) 1.55
Gene amplification of ESR1 in breast cancers--fact or fiction? A fluorescence in situ hybridization and multiplex ligation-dependent probe amplification study. J Pathol (2012) 1.55
Four cases of panic disorder successfully treated with Kampo (Japanese herbal) medicines: Kami-shoyo-san and Hange-koboku-to. Psychiatry Clin Neurosci (2002) 1.55
Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets. Clin Cancer Res (2003) 1.53
Clinical application of array-based comparative genomic hybridization by two-stage screening for 536 patients with mental retardation and multiple congenital anomalies. J Hum Genet (2010) 1.49
Cyclooxygenase-2 impairs treatment effects of radiotherapy for cervical cancer by inhibition of radiation-induced apoptosis. Int J Radiat Oncol Biol Phys (2006) 1.49
Prognostic significance of fascin overexpression in human esophageal squamous cell carcinoma. Clin Cancer Res (2005) 1.48
Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines. Oncogene (2004) 1.48
CSF-1 receptor-mediated differentiation of a new type of monocytic cell with B cell-stimulating activity: its selective dependence on IL-34. J Leukoc Biol (2013) 1.47
Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma. Carcinogenesis (2009) 1.46
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. EMBO J (2009) 1.46
Concomitant microduplications of MECP2 and ATRX in male patients with severe mental retardation. J Hum Genet (2011) 1.45
A dietary restriction influences the progression but not the initiation of MSG-Induced nonalcoholic steatohepatitis. J Med Food (2014) 1.41
Villin1, a novel diagnostic marker for cervical adenocarcinoma. Cancer Biol Ther (2009) 1.40
Human RAD18 is involved in S phase-specific single-strand break repair without PCNA monoubiquitination. Nucleic Acids Res (2006) 1.40
The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase. J Cell Biol (2006) 1.39
The effect of a herbal medicine (Mao-to) for the prevention of interferon-induced psychiatric complications in chronic hepatitis C: a pilot study. Hum Psychopharmacol (2004) 1.38
Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers. Cancer Res (2006) 1.37
PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma. Cancer Sci (2006) 1.36
Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. Clin Cancer Res (2003) 1.35
Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosis. Cancer (2003) 1.35
Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells. Blood (2008) 1.30
Neurotrophin receptor p75(NTR) characterizes human esophageal keratinocyte stem cells in vitro. Oncogene (2003) 1.30
Impact of small body weight on tenofovir-associated renal dysfunction in HIV-infected patients: a retrospective cohort study of Japanese patients. PLoS One (2011) 1.29
Usefulness of blood supply visualization by indocyanine green fluorescence for reconstruction during esophagectomy. Esophagus (2011) 1.29
Gli-1 expression is associated with lymph node metastasis and tumor progression in esophageal squamous cell carcinoma. Oncology (2006) 1.28
The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma. Clin Cancer Res (2005) 1.28
Involvement of TSLC1 in progression of esophageal squamous cell carcinoma. Cancer Res (2003) 1.27
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. Hum Mol Genet (2005) 1.26
Identification of ZASC1 encoding a Krüppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas. Cancer Res (2003) 1.25
PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas. Hepatology (2003) 1.23
Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells. J Immunol (2008) 1.23
Establishment of a Radiogenomics Consortium. Int J Radiat Oncol Biol Phys (2010) 1.23
Reduced levels of ATF-2 predispose mice to mammary tumors. Mol Cell Biol (2006) 1.22
PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer. Clin Cancer Res (2007) 1.21
Krüppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression. Int J Cancer (2009) 1.18
Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas. Clin Cancer Res (2008) 1.18
Association of over-expressed TFDP1 with progression of hepatocellular carcinomas. J Hum Genet (2003) 1.17
Renal function declines more in tenofovir- than abacavir-based antiretroviral therapy in low-body weight treatment-naïve patients with HIV infection. PLoS One (2012) 1.16
Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features. Clin Cancer Res (2005) 1.15
Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance. Mod Pathol (2009) 1.15
Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer. Cancer Sci (2007) 1.14
TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers. Clin Cancer Res (2003) 1.14
Prognostic significance of NANOG and KLF4 for breast cancer. Breast Cancer (2012) 1.13
Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer. Cancer Res (2007) 1.13
Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis (2002) 1.12
ABCG2 expression is an independent unfavorable prognostic factor in esophageal squamous cell carcinoma. Oncology (2007) 1.12
NPAT expression is regulated by E2F and is essential for cell cycle progression. Mol Cell Biol (2003) 1.12
Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma. Carcinogenesis (2010) 1.11
Correlation of KIT and EGFR overexpression with invasive ductal breast carcinoma of the solid-tubular subtype, nuclear grade 3, and mesenchymal or myoepithelial differentiation. Cancer Sci (2005) 1.11
Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma. Int J Cancer (2009) 1.10
SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells. J Biol Chem (2008) 1.10
Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma. Int J Oncol (2008) 1.09
miR-655 Is an EMT-suppressive microRNA targeting ZEB1 and TGFBR2. PLoS One (2013) 1.09
Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t(1;19)(q23;p13). Cancer Sci (2004) 1.08
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization. Cancer Sci (2005) 1.08
The suppression of aurora-A/STK15/BTAK expression enhances chemosensitivity to docetaxel in human esophageal squamous cell carcinoma. Clin Cancer Res (2007) 1.08