Published in Cell on September 08, 1995
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80
Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J (1996) 6.08
Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J (1998) 5.79
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol (1997) 4.70
Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J (1996) 4.58
The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J (1996) 4.45
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J (1996) 3.99
Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol Cell Biol (1996) 3.57
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc Natl Acad Sci U S A (1996) 3.31
Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death. J Exp Med (1996) 3.16
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO J (1999) 3.13
DNA end-joining catalyzed by human cell-free extracts. Proc Natl Acad Sci U S A (1998) 3.11
Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids. Nucleic Acids Res (1998) 3.11
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol Cell Biol (1996) 3.08
Characterization of Schizosaccharomyces pombe Hus1: a PCNA-related protein that associates with Rad1 and Rad9. Mol Cell Biol (2000) 2.91
The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. Nucleic Acids Res (1996) 2.90
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining. Mol Cell Biol (1999) 2.86
Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc Natl Acad Sci U S A (1996) 2.77
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol Cell Biol (2003) 2.74
Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J (2002) 2.62
The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast. Proc Natl Acad Sci U S A (1996) 2.53
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.51
DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J (2006) 2.48
DNA looping by Ku and the DNA-dependent protein kinase. Proc Natl Acad Sci U S A (1997) 2.39
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways. J Cell Sci (2000) 2.37
DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. Proc Natl Acad Sci U S A (1998) 2.30
Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0. J Virol (1996) 2.25
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Biochem J (2002) 2.18
Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding. Structure (2008) 2.17
PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells. EMBO J (2001) 2.14
Mitotic DNA damage and replication checkpoints in yeast. Curr Opin Cell Biol (1998) 2.11
Biochemical evidence for Ku-independent backup pathways of NHEJ. Nucleic Acids Res (2003) 2.05
Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol Cell Biol (1996) 2.02
Fragments of ATM which have dominant-negative or complementing activity. Mol Cell Biol (1997) 1.99
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J (1996) 1.97
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats. Nature (2009) 1.97
The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol Cell Biol (2001) 1.94
Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell (1996) 1.93
Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle. Mol Cell Biol (1997) 1.79
Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage. EMBO J (1998) 1.74
Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination. Nucleic Acids Res (2000) 1.65
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Mol Cell Biol (2004) 1.63
DNA double strand break repair via non-homologous end-joining. Transl Cancer Res (2013) 1.61
Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. Proc Natl Acad Sci U S A (1997) 1.61
Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity. Mol Biol Cell (1998) 1.61
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem J (1997) 1.60
Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence. Nucleic Acids Res (2007) 1.56
Structure of DNA-dependent protein kinase: implications for its regulation by DNA. EMBO J (1999) 1.54
Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses. Mol Cell Biol (2001) 1.53
Modulation of Sp1 phosphorylation by human immunodeficiency virus type 1 Tat. J Virol (1998) 1.53
Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex. Mol Cell Biol (1998) 1.50
Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM. Proc Natl Acad Sci U S A (1999) 1.50
Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice. Mol Cell Biol (1998) 1.49
FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse. Proc Natl Acad Sci U S A (2001) 1.48
Structure of nonhairpin coding-end DNA breaks in cells undergoing V(D)J recombination. Mol Cell Biol (1998) 1.45
The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction. Proc Natl Acad Sci U S A (1996) 1.44
The Schizosaccharomyces pombe S-phase checkpoint differentiates between different types of DNA damage. Genetics (1998) 1.43
Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis. Mol Cell Biol (1998) 1.40
The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage. Proc Natl Acad Sci U S A (1997) 1.39
Processing of DNA for nonhomologous end-joining by cell-free extract. EMBO J (2005) 1.38
Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells. Nucleic Acids Res (2001) 1.36
The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications. Curr Genomics (2007) 1.33
Developmental modulation of nonhomologous end joining in Caenorhabditis elegans. Genetics (2006) 1.33
Ku-dependent nonhomologous DNA end joining in Xenopus egg extracts. Mol Cell Biol (1999) 1.31
DNA-PK: a dynamic enzyme in a versatile DSB repair pathway. DNA Repair (Amst) (2014) 1.31
Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. Genes Dev (1998) 1.31
Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20. Nucleic Acids Res (1998) 1.30
Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions. EMBO J (1997) 1.28
Human members of the eukaryotic protein kinase family. Genome Biol (2002) 1.25
Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response. Nucleic Acids Res (2000) 1.25
Role of PI 3-kinase and PIP3 in submandibular gland branching morphogenesis. Dev Biol (2003) 1.24
Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs). Proc Natl Acad Sci U S A (2005) 1.23
Cell-cycle regulation of mammalian DNA double-strand-break repair. Am J Hum Genet (1997) 1.22
Identification of a novel pathway essential for the immediate-early, interferon-independent antiviral response to enveloped virions. J Virol (2006) 1.21
Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action. Clin Microbiol Rev (1999) 1.21
c-kit receptor signaling through its phosphatidylinositide-3'-kinase-binding site and protein kinase C: role in mast cell enhancement of degranulation, adhesion, and membrane ruffling. Mol Biol Cell (1997) 1.21
Host proteins interacting with the Moloney murine leukemia virus integrase: multiple transcriptional regulators and chromatin binding factors. Retrovirology (2008) 1.20
The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity. Nucleic Acids Res (2000) 1.19
The membrane form of the DNA repair protein Ku interacts at the cell surface with metalloproteinase 9. EMBO J (2004) 1.18
Beyond DNA repair: DNA-PK function in cancer. Cancer Discov (2014) 1.16
Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1. Mol Cell Biol (2001) 1.16
DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D. Genes Dev (1998) 1.16
Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation. Mol Cell Biol (1997) 1.15
The RAD5 gene product is involved in the avoidance of non-homologous end-joining of DNA double strand breaks in the yeast Saccharomyces cerevisiae. Nucleic Acids Res (1997) 1.15
Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype. Proc Natl Acad Sci U S A (1997) 1.11
UV sensitivity and impaired nucleotide excision repair in DNA-dependent protein kinase mutant cells. Nucleic Acids Res (1998) 1.09
Visualization of a DNA-PK/PARP1 complex. Nucleic Acids Res (2012) 1.08
Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein. Nucleic Acids Res (2002) 1.08
RecQ helicases in DNA double strand break repair and telomere maintenance. Mutat Res (2011) 1.08
Enhancer activation requires trans-recruitment of a mega transcription factor complex. Cell (2014) 1.06
PRKDC mutations in a SCID patient with profound neurological abnormalities. J Clin Invest (2013) 1.06
XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation. Nucleic Acids Res (1998) 1.04
Receptor-mediated endocytosis of albumin by kidney proximal tubule cells is regulated by phosphatidylinositide 3-kinase. J Clin Invest (1998) 1.04
Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time. DNA Repair (Amst) (2014) 1.03
New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors. J Mol Histol (2006) 1.02
Recognition and repair of chemically heterogeneous structures at DNA ends. Environ Mol Mutagen (2014) 1.00
The leucine rich region of DNA-PKcs contributes to its innate DNA affinity. Nucleic Acids Res (2005) 1.00
Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase. Biochem J (1997) 1.00
A central region of Ku80 mediates interaction with Ku70 in vivo. Nucleic Acids Res (1998) 1.00
An ATM homologue from Arabidopsis thaliana: complete genomic organisation and expression analysis. Nucleic Acids Res (2000) 1.00
The sequence of the human genome. Science (2001) 101.55
Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care (1997) 23.95
Primary structure, gene organization and polypeptide expression of poliovirus RNA. Nature (1981) 16.61
p21 is a universal inhibitor of cyclin kinases. Nature (1993) 15.55
Processing of adenovirus 2-induced proteins. J Virol (1973) 12.52
Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89
DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet (2001) 10.77
Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science (1987) 10.25
A novel method for nucleic acid sequence determination. J Theor Biol (1988) 9.74
Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins. Nature (1990) 7.91
DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev (1998) 7.78
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell (1993) 7.17
Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science (1995) 7.00
SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell (1993) 6.95
Ecological degradation in protected areas: the case of Wolong Nature Reserve for giant pandas. Science (2001) 6.52
The cost effectiveness of combination antiretroviral therapy for HIV disease. N Engl J Med (2001) 5.89
The DNA-dependent protein kinase. Genes Dev (1999) 5.80
Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J (1998) 5.79
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell (1995) 5.58
A second virus-encoded proteinase involved in proteolytic processing of poliovirus polyprotein. Cell (1986) 5.53
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell (1992) 5.51
Proteolytic processing of poliovirus polypeptides: antibodies to polypeptide P3-7c inhibit cleavage at glutamine-glycine pairs. Proc Natl Acad Sci U S A (1982) 5.50
A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas. Cell (1988) 5.49
Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem (2001) 5.43
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr Biol (1999) 5.40
Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer (2001) 5.36
A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature (2001) 5.28
Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science (1994) 4.99
Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy. JAMA (1999) 4.98
DNA end-joining: from yeast to man. Trends Biochem Sci (1998) 4.94
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A (1999) 4.90
NF-AT components define a family of transcription factors targeted in T-cell activation. Nature (1994) 4.90
Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc Natl Acad Sci U S A (2001) 4.79
Structure of the gene V protein of bacteriophage f1 determined by multiwavelength x-ray diffraction on the selenomethionyl protein. Proc Natl Acad Sci U S A (1994) 4.67
Secondary structure of the 5' nontranslated regions of hepatitis C virus and pestivirus genomic RNAs. Nucleic Acids Res (1992) 4.58
Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J (1996) 4.58
Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB. Cell (1993) 4.57
Familial transmission of substance use disorders. Arch Gen Psychiatry (1998) 4.57
Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Cell (1989) 4.49
Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res (1996) 4.37
Mapping of late adenovirus genes by cell-free translation of RNA selected by hybridization to specific DNA fragments. Proc Natl Acad Sci U S A (1975) 4.35
Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci U S A (1996) 4.20
Aggregation-based crystal growth and microstructure development in natural iron oxyhydroxide biomineralization products. Science (2000) 4.03
Identification of the SV40 agnogene product: a DNA binding protein. Nature (1981) 3.80
Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes Dev (1988) 3.72
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev (1993) 3.70
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol (1992) 3.68
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr Biol (1997) 3.67
ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet (1998) 3.66
XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell (2001) 3.66
Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene (2009) 3.64
The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell (2000) 3.64
Identification of the initiation site of poliovirus polyprotein synthesis. J Virol (1982) 3.62
Membrane-dependent uridylylation of the genome-linked protein VPg of poliovirus. Proc Natl Acad Sci U S A (1983) 3.58
Location and identification of the genes for adenovirus type 2 early polypeptides. Cell (1976) 3.58
The DISC Predictive Scales (DPS): efficiently screening for diagnoses. J Am Acad Child Adolesc Psychiatry (2001) 3.52
Cell-free synthesis of adenovirus 2 proteins programmed by fractionated messenger RNA: a comparison of polypeptide products and messenger RNA lengths. Proc Natl Acad Sci U S A (1974) 3.52
A human RNA polymerase II complex associated with SRB and DNA-repair proteins. Nature (1996) 3.50
Clinical and biologic activity of an estrogenic herbal combination (PC-SPES) in prostate cancer. N Engl J Med (1998) 3.47
Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription. Cell (1991) 3.46
Identification of a yeast snRNP protein and detection of snRNP-snRNP interactions. Cell (1987) 3.46
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J (1999) 3.46
Sorting of beta-actin mRNA and protein to neurites and growth cones in culture. J Neurosci (1998) 3.45
Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc Natl Acad Sci U S A (2000) 3.44
Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. Genes Dev (1990) 3.44
Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform. Proc Natl Acad Sci U S A (1997) 3.42
PKS1, a substrate phosphorylated by phytochrome that modulates light signaling in Arabidopsis. Science (1999) 3.42
Adenovirus early region 1B 58,000-dalton tumor antigen is physically associated with an early region 4 25,000-dalton protein in productively infected cells. J Virol (1984) 3.38
Direct mapping of adeno-associated virus capsid proteins B and C: a possible ACG initiation codon. Proc Natl Acad Sci U S A (1985) 3.31
Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Mol Cell Biol (1990) 3.30
Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair. EMBO J (1997) 3.29
Microcolinearity in sh2-homologous regions of the maize, rice, and sorghum genomes. Proc Natl Acad Sci U S A (1997) 3.29
Membrane fractions active in poliovirus RNA replication contain VPg precursor polypeptides. Virology (1983) 3.28
Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proc Natl Acad Sci U S A (1998) 3.26
Regulation of p53 in response to DNA damage. Oncogene (1999) 3.23
Erythropoietin response is blunted in critically ill patients. Intensive Care Med (1997) 3.20
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc Natl Acad Sci U S A (1997) 3.19
The FHA domain is a modular phosphopeptide recognition motif. Mol Cell (1999) 3.16
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J (1991) 3.15
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO J (1999) 3.13
A membrane-associated precursor to poliovirus VPg identified by immunoprecipitation with antibodies directed against a synthetic heptapeptide. Cell (1982) 3.07
The TATA-binding protein: a general transcription factor in eukaryotes and archaebacteria. Science (1994) 3.06
Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature (1995) 3.06
Repression of RNA polymerase III transcription by the retinoblastoma protein. Nature (1996) 3.04
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci (2000) 3.00
Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Curr Biol (1999) 2.98
Socioeconomic status and type 2 diabetes in African American and non-Hispanic white women and men: evidence from the Third National Health and Nutrition Examination Survey. Am J Public Health (2001) 2.96
Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1. Nature (1997) 2.93
A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance. Circulation (2007) 2.93
Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase. J Virol (1999) 2.93
DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr Opin Cell Biol (2001) 2.93
The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit. J Biol Chem (1996) 2.92
Poliovirus replication proteins: RNA sequence encoding P3-1b and the sites of proteolytic processing. Proc Natl Acad Sci U S A (1981) 2.91
DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc Natl Acad Sci U S A (1995) 2.87
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med (2001) 2.87
Menage à trois: double strand break repair, V(D)J recombination and DNA-PK. Bioessays (1995) 2.86
West Nile virus infection in the golden hamster (Mesocricetus auratus): a model for West Nile encephalitis. Emerg Infect Dis (2001) 2.85
An information-based sequence distance and its application to whole mitochondrial genome phylogeny. Bioinformatics (2001) 2.80