Published in Cancer Sci on July 01, 2005
LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer. Mol Cancer Ther (2009) 2.43
Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration. PLoS One (2009) 1.65
Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced by in vitro ischemia through deteriorating cellular redox environment. J Neurochem (2009) 1.10
Hypoxia inducible factor 1 as a therapeutic target in ischemic stroke. Curr Med Chem (2009) 1.08
Hypoxia inducible factor-1: its potential role in cerebral ischemia. Cell Mol Neurobiol (2012) 1.05
Sub-sets of cancer stem cells differ intrinsically in their patterns of oxygen metabolism. PLoS One (2013) 0.94
Preconditioning of bone marrow mesenchymal stem cells by prolyl hydroxylase inhibition enhances cell survival and angiogenesis in vitro and after transplantation into the ischemic heart of rats. Stem Cell Res Ther (2014) 0.94
Dimethyloxaloylglycine increases the bone healing capacity of adipose-derived stem cells by promoting osteogenic differentiation and angiogenic potential. Stem Cells Dev (2014) 0.89
Nanoparticle delivery of HIF1α siRNA combined with photodynamic therapy as a potential treatment strategy for head-and-neck cancer. Cancer Lett (2015) 0.88
Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1α. PLoS One (2012) 0.88
Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types. PLoS One (2012) 0.86
Suppressing the malignant phenotypes of glioma cells by lentiviral delivery of small hairpin RNA targeting hypoxia-inducible factor-1α. Int J Clin Exp Pathol (2013) 0.86
Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response. J Natl Cancer Inst (2013) 0.84
Protection of cells in physiological oxygen tensions against DNA damage-induced apoptosis. J Biol Chem (2010) 0.83
High concentrations of L-ascorbic acid specifically inhibit the growth of human leukemic cells via downregulation of HIF-1α transcription. PLoS One (2013) 0.83
G-rich oligonucleotides inhibit HIF-1alpha and HIF-2alpha and block tumor growth. Mol Ther (2009) 0.83
Transcutaneous carbon dioxide induces mitochondrial apoptosis and suppresses metastasis of oral squamous cell carcinoma in vivo. PLoS One (2014) 0.80
Advantage of FMISO-PET over FDG-PET for predicting histological response to preoperative chemotherapy in patients with oral squamous cell carcinoma. Eur J Nucl Med Mol Imaging (2014) 0.79
Clinicopathological Significance of MicroRNA-20b Expression in Hepatocellular Carcinoma and Regulation of HIF-1α and VEGF Effect on Cell Biological Behaviour. Dis Markers (2015) 0.79
Radiation/paclitaxel treatment of p53-abnormal non-small cell lung cancer xenograft tumor and associated mechanism. Cancer Biother Radiopharm (2012) 0.77
A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis. Neural Regen Res (2014) 0.77
HIF-1α -1790G>A polymorphism significantly increases the risk of digestive tract cancer: a meta-analysis. World J Gastroenterol (2015) 0.76
MEG3, HCN3 and linc01105 influence the proliferation and apoptosis of neuroblastoma cells via the HIF-1α and p53 pathways. Sci Rep (2016) 0.76
RNA interference in head and neck oncology. Oncol Lett (2016) 0.75
Regulation of the hypoxic tumor environment in hepatocellular carcinoma using RNA interference. Cancer Cell Int (2017) 0.75
Suppression of HSP27 increases the anti‑tumor effects of quercetin in human leukemia U937 cells. Mol Med Rep (2015) 0.75
Endothelial progenitor cells transplantation attenuated blood-brain barrier damage after ischemia in diabetic mice via HIF-1α. Stem Cell Res Ther (2017) 0.75
The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study. Ophthalmology (2004) 4.95
Refractive errors in an elderly Japanese population: the Tajimi study. Ophthalmology (2008) 2.28
Risk factors for open-angle glaucoma in a Japanese population: the Tajimi Study. Ophthalmology (2006) 2.14
Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy. Metabolism (2003) 1.90
Prevalence and causes of low vision and blindness in a Japanese adult population: the Tajimi Study. Ophthalmology (2006) 1.81
Phase I/IIa trial of autologous formalin-fixed tumor vaccine concomitant with fractionated radiotherapy for newly diagnosed glioblastoma. Clinical article. J Neurosurg (2011) 1.63
Increased frequency of metabolic syndrome and its individual metabolic abnormalities in Japanese patients with primary gout. J Clin Rheumatol (2010) 1.51
Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma. Am J Ophthalmol (2003) 1.43
Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma. Invest Ophthalmol Vis Sci (2008) 1.43
Retroperitoneal ancient schwannoma presenting as an adrenal incidentaloma: CT and MR findings. Magn Reson Imaging (2006) 1.42
Clinical trial of autologous formalin-fixed tumor vaccine for glioblastoma multiforme patients. Cancer Sci (2007) 1.30
Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1. Nat Biotechnol (2008) 1.23
Reactive oxygen species (ROS) control the expression of Bcl-2 family proteins by regulating their phosphorylation and ubiquitination. Cancer Sci (2004) 1.21
The involvement of hypoxia-inducible factor-1alpha in the susceptibility to gamma-rays and chemotherapeutic drugs of oral squamous cell carcinoma cells. Int J Cancer (2007) 1.18
Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3. Biochem Biophys Res Commun (2003) 1.15
Laser scanning tomography of optic discs of the normal Japanese population in a population-based setting. Ophthalmology (2008) 1.15
Effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats. Acta Diabetol (2007) 1.13
Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice. Hum Mol Genet (2010) 1.13
Detection of IDH1 mutation in human gliomas: comparison of immunohistochemistry and sequencing. Brain Tumor Pathol (2011) 1.12
Nationwide survey for bisphosphonate-related osteonecrosis of the jaws in Japan. J Oral Maxillofac Surg (2011) 1.11
Mild encephalitis/encephalopathy with a reversible splenial lesion: evaluation by diffusion tensor imaging. Two case reports. Neurol Med Chir (Tokyo) (2010) 1.10
Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout. Clin Exp Nephrol (2014) 1.09
Green tea polyphenols induce differentiation and proliferation in epidermal keratinocytes. J Pharmacol Exp Ther (2003) 1.08
Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3. J Biol Chem (2003) 1.08
Decreased excretion of antimicrobial proteins and peptides in saliva of patients with oral candidiasis. J Oral Pathol Med (2003) 1.07
Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma. Hum Mol Genet (2013) 1.06
Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages. J Immunol (2006) 1.05
Phase I/II trial of hyperfractionated concomitant boost proton radiotherapy for supratentorial glioblastoma multiforme. Int J Radiat Oncol Biol Phys (2009) 1.04
Preoperative endovascular embolization for hemangioblastoma in the posterior fossa. Neurol Med Chir (Tokyo) (2012) 1.03
Phase 2 randomized clinical study of a Rho kinase inhibitor, K-115, in primary open-angle glaucoma and ocular hypertension. Am J Ophthalmol (2013) 1.02
Immunohistochemical detection of IDH1 mutation, p53, and internexin as prognostic factors of glial tumors. J Neurooncol (2012) 1.01
A new model of retinal photoreceptor cell degeneration induced by a chemical hypoxia-mimicking agent, cobalt chloride. Brain Res (2006) 1.00
Green tea polyphenol causes differential oxidative environments in tumor versus normal epithelial cells. J Pharmacol Exp Ther (2003) 0.99
Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice. J Hepatol (2009) 0.99
Target intraocular pressure for stability of visual field loss progression in normal-tension glaucoma. Jpn J Ophthalmol (2010) 0.98
Receptor for advanced glycation end products regulates adipocyte hypertrophy and insulin sensitivity in mice: involvement of Toll-like receptor 2. Diabetes (2012) 0.98
Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1. J Immunol (2004) 0.98
Expression of cyclooxygenase 2 and cytosolic phospholipase A(2) in the liver tissue of patients with chronic hepatitis and liver cirrhosis. Hepatol Res (2002) 0.97
A novel approach to the prevention of postoperative delirium in the elderly after gastrointestinal surgery. Surg Today (2002) 0.97
Huge pelvic mass secondary to wear debris causing ureteral obstruction. J Arthroplasty (2005) 0.96
Acute subdural hematoma without subarachnoid hemorrhage caused by ruptured A1-A2 junction aneurysm. Case report. Neurol Med Chir (Tokyo) (2012) 0.96
Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells. Mol Cell Endocrinol (2013) 0.96
Efficacy of keishibukuryogan, a traditional Japanese herbal medicine, in treating cold sensation and numbness after stroke: clinical improvement and skin temperature normalization in 22 stroke patients. Neurol Med Chir (Tokyo) (2010) 0.96
Results of long-term monitoring of normal-tension glaucoma patients receiving medical therapy: results of an 18-year follow-up. Graefes Arch Clin Exp Ophthalmol (2014) 0.96
A novel calpain inhibitor, ((1S)-1-((((1S)-1-Benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester (SNJ-1945), reduces murine retinal cell death in vitro and in vivo. J Pharmacol Exp Ther (2009) 0.95
Allopurinol improves cardiac dysfunction after ischemia-reperfusion via reduction of oxidative stress in isolated perfused rat hearts. Circ J (2003) 0.95
STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. J Biol Chem (2003) 0.94
Protective effects of EGCG on salivary gland cells treated with gamma-radiation or cis-platinum(II)diammine dichloride. Anticancer Res (2004) 0.94
Green tea polyphenol-induced epidermal keratinocyte differentiation is associated with coordinated expression of p57/KIP2 and caspase 14. J Pharmacol Exp Ther (2004) 0.94
Thr-774 (transmembrane segment M5), Val-920 (M8), and Glu-954 (M9) are involved in Na+ transport, and Gln-923 (M8) is essential for Na,K-ATPase activity. J Biol Chem (2005) 0.93
Detection of retinal nerve fiber layer defects on retinal fundus images for early diagnosis of glaucoma. J Biomed Opt (2010) 0.93
Allopurinol reduces neointimal hyperplasia in the carotid artery ligation model in spontaneously hypertensive rats. Hypertens Res (2006) 0.92
The clinical characteristics of sudden cardiac arrest in asymptomatic patients with congenital heart disease. Heart Vessels (2013) 0.92
Myopia and advanced-stage open-angle glaucoma. Ophthalmology (2002) 0.92
Navigation-guided endoscopic biopsy for intraparenchymal brain tumor. Neurol Med Chir (Tokyo) (2011) 0.92
Low peripheral lymphocyte count before focal radiotherapy plus concomitant temozolomide predicts severe lymphopenia during malignant glioma treatment. Neurol Med Chir (Tokyo) (2010) 0.92
A multicenter phase I/II study of the BCNU implant (Gliadel(®) Wafer) for Japanese patients with malignant gliomas. Neurol Med Chir (Tokyo) (2013) 0.92
Ionizing irradiation induces apoptotic damage of salivary gland acinar cells via NADPH oxidase 1-dependent superoxide generation. Biochem Biophys Res Commun (2007) 0.92
Coexistent B-cell lymphoma and cutaneous T-cell lymphoma. Intern Med (2006) 0.91
Thyroid carcinomas found incidentally in the cervical lymph nodes: do they arise from heterotopic thyroid tissues? J Oral Maxillofac Surg (2008) 0.91
Blue light differentially alters cellular redox properties. J Biomed Mater Res B Appl Biomater (2005) 0.90
Roles of catalase and hydrogen peroxide in green tea polyphenol-induced chemopreventive effects. J Pharmacol Exp Ther (2003) 0.89
Low-grade myofibroblastic sarcoma of the palate. Int J Oral Sci (2012) 0.89
Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas. Oral Surg Oral Med Oral Pathol Oral Radiol (2011) 0.89
Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice. Invest Ophthalmol Vis Sci (2006) 0.89
Decrease in the apparent diffusion coefficient in peritumoral edema for the assessment of recurrent glioblastoma treated by bevacizumab. Acta Neurochir Suppl (2013) 0.89
A mechanism-based in vitro anticancer drug screening approach for phenolic phytochemicals. Assay Drug Dev Technol (2003) 0.89
Antimicrobial peptides enhance the candidacidal activity of antifungal drugs by promoting the efflux of ATP from Candida cells. J Antimicrob Chemother (2005) 0.89
Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis. Anticancer Res (2003) 0.88
Phase 1 clinical trials of a selective Rho kinase inhibitor, K-115. JAMA Ophthalmol (2013) 0.87
Tissue type plasminogen activator facilitates NMDA-receptor-mediated retinal apoptosis through an independent fibrinolytic cascade. Invest Ophthalmol Vis Sci (2005) 0.87
Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice. Blood (2002) 0.87
Phase I/IIa trial of fractionated radiotherapy, temozolomide, and autologous formalin-fixed tumor vaccine for newly diagnosed glioblastoma. J Neurosurg (2014) 0.87
Multicenter, open-label study of long-term administration of febuxostat (TMX-67) in Japanese patients with hyperuricemia including gout. J Clin Rheumatol (2011) 0.87
Response of the donor and recipient cells in mesenchymal cell transplantation to cartilage defect. Microsc Res Tech (2002) 0.86
Acquired hemophilia first manifesting as life-threatening intracranial hemorrhage: case report. Neurol Med Chir (Tokyo) (2009) 0.86
The endogenous reactive oxygen species promote NF-kappaB activation by targeting on activation of NF-kappaB-inducing kinase in oral squamous carcinoma cells. Free Radic Res (2007) 0.86
Navigation-guided endoscopic biopsy for pathological diagnosis for intraparenchymal pure germinoma near the ventricular trigone. Surg Neurol Int (2012) 0.86
Enhancement of apoptotic damage of squamous cell carcinoma cells by inhibition of the mitochondrial DNA repairing system. Cancer Sci (2008) 0.86
Bone transport and bone graft using auto-tooth bone for alveolar cleft repair. J Craniofac Surg (2013) 0.86
Topographic characteristics of the optic nerve head measured with scanning laser tomography in normal Japanese subjects. Jpn J Ophthalmol (2005) 0.86
Effects of corneal thickness on intraocular pressure measured with three different tonometers. Jpn J Ophthalmol (2009) 0.86
Hypoxia-inducible factor 1α expression is a prognostic biomarker in patients with astrocytic tumors associated with necrosis on MR image. J Neurooncol (2010) 0.85
Randomized crossover study of latanoprost and travoprost in eyes with open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol (2011) 0.85
Endogenous tissue type plasminogen activator facilitates NMDA-induced retinal damage. Toxicol Appl Pharmacol (2004) 0.85
Autoimmune thyroid disease (Graves' disease and hashimoto's thyroiditis) in two patients with Crohn's disease: case reports and literature review. Intern Med (2005) 0.85