Published in Biochem Biophys Res Commun on January 24, 2003
HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol (2010) 7.16
Heat shock proteins: essential proteins for apoptosis regulation. J Cell Mol Med (2008) 1.93
Regulators of endothelial and epithelial barrier integrity and function in acute lung injury. Biochem Pharmacol (2009) 1.85
Apoptosis and molecular targeting therapy in cancer. Biomed Res Int (2014) 1.47
Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis. Am J Respir Crit Care Med (2007) 1.24
Fever and the thermal regulation of immunity: the immune system feels the heat. Nat Rev Immunol (2015) 1.09
Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction. Br J Cancer (2010) 1.09
The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis. J Mol Biol (2015) 0.98
HILI inhibits TGF-β signaling by interacting with Hsp90 and promoting TβR degradation. PLoS One (2012) 0.95
Activation of peroxisome proliferator-activated receptor-β/-δ (PPAR-β/-δ) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes. Diabetes (2011) 0.92
Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma. Proc Natl Acad Sci U S A (2009) 0.92
Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway. Arch Biochem Biophys (2007) 0.89
Modulation of STAT3 folding and function by TRiC/CCT chaperonin. PLoS Biol (2014) 0.88
Hsp90, the concertmaster: tuning transcription. Front Oncol (2015) 0.87
Regulation of embryonic stem cell pluripotency by heat shock protein 90. Stem Cells (2012) 0.87
Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3. PLoS One (2012) 0.81
Key role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulation. Br J Pharmacol (2016) 0.77
CD24 promoted cancer cell angiogenesis via Hsp90-mediated STAT3/VEGF signaling pathway in colorectal cancer. Oncotarget (2016) 0.77
Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule. Oncotarget (2016) 0.77
Proteomic profiling of rabbit embryonic stem cells derived from parthenotes and fertilized embryos. PLoS One (2013) 0.77
Hsp90 blockade modulates bullous pemphigoid IgG-induced IL-8 production by keratinocytes. Cell Stress Chaperones (2014) 0.77
Contribution of chaperones to STAT pathway signaling. JAKSTAT (2014) 0.76
HSP110 promotes colorectal cancer growth through STAT3 activation. Oncogene (2016) 0.75
Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome. Blood (2016) 0.75
Myocyte derived Hsp90 modulates collagen upregulation via biphasic activation of STAT-3 in fibroblasts during cardiac hypertrophy. Mol Cell Biol (2016) 0.75
Stress-induced phosphoprotein-1 maintains the stability of JAK2 in cancer cells. Oncotarget (2016) 0.75
A small molecule screen reveals that HSP90β promotes the conversion of iPSC-derived endoderm to a hepatic fate and regulates HNF4A turnover. Development (2017) 0.75
The FOXP2-Driven Network in Developmental Disorders and Neurodegeneration. Front Cell Neurosci (2017) 0.75
The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study. Ophthalmology (2004) 4.95
The clinical research office of the endourological society ureteroscopy global study: indications, complications, and outcomes in 11,885 patients. J Endourol (2013) 2.82
Refractive errors in an elderly Japanese population: the Tajimi study. Ophthalmology (2008) 2.28
Risk factors for open-angle glaucoma in a Japanese population: the Tajimi Study. Ophthalmology (2006) 2.14
A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3. J Exp Med (2009) 2.11
Current use of the artificial urinary sphincter and its long-term durability: a nationwide survey in Japan. Int J Urol (2009) 1.96
Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy. Metabolism (2003) 1.90
Prevalence and causes of low vision and blindness in a Japanese adult population: the Tajimi Study. Ophthalmology (2006) 1.81
Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer. Cancer Sci (2008) 1.67
Outcome of different post-orchiectomy management for stage I seminoma: Japanese multi-institutional study including 425 patients. Int J Urol (2010) 1.65
Phase I/IIa trial of autologous formalin-fixed tumor vaccine concomitant with fractionated radiotherapy for newly diagnosed glioblastoma. Clinical article. J Neurosurg (2011) 1.63
The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. Biochem Biophys Res Commun (2002) 1.62
Perioperative management of transurethral surgery for benign prostatic hyperplasia: a nationwide survey in Japan. Int J Urol (2011) 1.55
Increased frequency of metabolic syndrome and its individual metabolic abnormalities in Japanese patients with primary gout. J Clin Rheumatol (2010) 1.51
Ultrasound mediated intravesical transfection enhanced by treatment with lidocaine or heat. J Urol (2004) 1.49
Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma. Am J Ophthalmol (2003) 1.43
Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma. Invest Ophthalmol Vis Sci (2008) 1.43
Retroperitoneal ancient schwannoma presenting as an adrenal incidentaloma: CT and MR findings. Magn Reson Imaging (2006) 1.42
Alternative nonsteroidal antiandrogen therapy for advanced prostate cancer that relapsed after initial maximum androgen blockade. J Urol (2008) 1.41
Serum pro-gastrin-releasing peptide (31-98) in benign prostatic hyperplasia and prostatic carcinoma. Urology (2002) 1.40
Surgical outcome of laparoscopic radical prostatectomy: summary of early multiinstitutional experience in Japan. Int J Clin Oncol (2003) 1.38
Clinical trial of autologous formalin-fixed tumor vaccine for glioblastoma multiforme patients. Cancer Sci (2007) 1.30
Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1. Nat Biotechnol (2008) 1.23
Neuroendocrine differentiation in the progression of prostate cancer. Int J Urol (2009) 1.21
Reactive oxygen species (ROS) control the expression of Bcl-2 family proteins by regulating their phosphorylation and ubiquitination. Cancer Sci (2004) 1.21
Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells. Cancer Sci (2005) 1.18
The involvement of hypoxia-inducible factor-1alpha in the susceptibility to gamma-rays and chemotherapeutic drugs of oral squamous cell carcinoma cells. Int J Cancer (2007) 1.18
In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma and quantitative analysis of in vivo induction pathway. Toxicol Appl Pharmacol (2006) 1.16
Laser scanning tomography of optic discs of the normal Japanese population in a population-based setting. Ophthalmology (2008) 1.15
Effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats. Acta Diabetol (2007) 1.13
Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice. Hum Mol Genet (2010) 1.13
Detection of IDH1 mutation in human gliomas: comparison of immunohistochemistry and sequencing. Brain Tumor Pathol (2011) 1.12
Nationwide survey for bisphosphonate-related osteonecrosis of the jaws in Japan. J Oral Maxillofac Surg (2011) 1.11
Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2. EMBO J (2006) 1.11
Mild encephalitis/encephalopathy with a reversible splenial lesion: evaluation by diffusion tensor imaging. Two case reports. Neurol Med Chir (Tokyo) (2010) 1.10
Novel pathway for LPS-induced afferent vagus nerve activation: possible role of nodose ganglion. Auton Neurosci (2005) 1.10
Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout. Clin Exp Nephrol (2014) 1.09
Transgenic mice overexpressing murine thrombopoietin develop myelofibrosis and osteosclerosis. Leuk Res (2005) 1.08
Green tea polyphenols induce differentiation and proliferation in epidermal keratinocytes. J Pharmacol Exp Ther (2003) 1.08
Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3. J Biol Chem (2003) 1.08
Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma. Hum Mol Genet (2013) 1.06
Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages. J Immunol (2006) 1.05
Cross-talk between bone morphogenic proteins and estrogen receptor signaling. Endocrinology (2002) 1.05
Roles of Stat3 and ERK in G-CSF signaling. Stem Cells (2005) 1.04
Phase I/II trial of hyperfractionated concomitant boost proton radiotherapy for supratentorial glioblastoma multiforme. Int J Radiat Oncol Biol Phys (2009) 1.04
Determination of the transphosphorylation sites of Jak2 kinase. Biochem Biophys Res Commun (2004) 1.03
Differential effects of phthalate esters on transcriptional activities via human estrogen receptors alpha and beta, and androgen receptor. Toxicology (2005) 1.03
Preoperative endovascular embolization for hemangioblastoma in the posterior fossa. Neurol Med Chir (Tokyo) (2012) 1.03
PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3. Sci Signal (2011) 1.02
Phase 2 randomized clinical study of a Rho kinase inhibitor, K-115, in primary open-angle glaucoma and ocular hypertension. Am J Ophthalmol (2013) 1.02
Immunohistochemical detection of IDH1 mutation, p53, and internexin as prognostic factors of glial tumors. J Neurooncol (2012) 1.01
Standardization of patient outcomes reporting in percutaneous nephrolithotomy. J Endourol (2014) 1.01
Roles of cell signaling pathways in cell-to-cell contact-mediated Epstein-Barr virus transmission. J Virol (2012) 1.00
A new model of retinal photoreceptor cell degeneration induced by a chemical hypoxia-mimicking agent, cobalt chloride. Brain Res (2006) 1.00
Laparoscopic resection of adrenal and extra-adrenal pheochromocytoma. J Endourol (2013) 0.99
LIF- and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation. Biol Pharm Bull (2007) 0.99
Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice. J Hepatol (2009) 0.99
A case surviving for over a year of renal tubular dysgenesis with compound heterozygous angiotensinogen gene mutations. Am J Med Genet A (2006) 0.99
Target intraocular pressure for stability of visual field loss progression in normal-tension glaucoma. Jpn J Ophthalmol (2010) 0.98
The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals. Int Immunol (2004) 0.98
Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA. FEBS Lett (2005) 0.98
Receptor for advanced glycation end products regulates adipocyte hypertrophy and insulin sensitivity in mice: involvement of Toll-like receptor 2. Diabetes (2012) 0.98
Characterization of chromatin structure and enhancer elements for murine recombination activating gene-2. J Immunol (2002) 0.98
Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1. J Immunol (2004) 0.98
STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation. Biochem Biophys Res Commun (2009) 0.97
Expression of cyclooxygenase 2 and cytosolic phospholipase A(2) in the liver tissue of patients with chronic hepatitis and liver cirrhosis. Hepatol Res (2002) 0.97
A novel approach to the prevention of postoperative delirium in the elderly after gastrointestinal surgery. Surg Today (2002) 0.97
Huge pelvic mass secondary to wear debris causing ureteral obstruction. J Arthroplasty (2005) 0.96
Acute subdural hematoma without subarachnoid hemorrhage caused by ruptured A1-A2 junction aneurysm. Case report. Neurol Med Chir (Tokyo) (2012) 0.96
Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells. Mol Cell Endocrinol (2013) 0.96
Maternal feeding controls fetal biological clock. PLoS One (2008) 0.96
HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A. Biochem Biophys Res Commun (2009) 0.96
Efficacy of keishibukuryogan, a traditional Japanese herbal medicine, in treating cold sensation and numbness after stroke: clinical improvement and skin temperature normalization in 22 stroke patients. Neurol Med Chir (Tokyo) (2010) 0.96
Results of long-term monitoring of normal-tension glaucoma patients receiving medical therapy: results of an 18-year follow-up. Graefes Arch Clin Exp Ophthalmol (2014) 0.96
Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells. J Immunol (2002) 0.95
A novel calpain inhibitor, ((1S)-1-((((1S)-1-Benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester (SNJ-1945), reduces murine retinal cell death in vitro and in vivo. J Pharmacol Exp Ther (2009) 0.95
Physical and functional interactions between STAT3 and ZIP kinase. Int Immunol (2005) 0.95
Allopurinol improves cardiac dysfunction after ischemia-reperfusion via reduction of oxidative stress in isolated perfused rat hearts. Circ J (2003) 0.95
Carcinosarcoma arising in mixed epithelial and stromal tumor of the kidney. APMIS (2008) 0.94
STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. J Biol Chem (2003) 0.94
Serum active hepatocyte growth factor (AHGF) in benign prostatic disease and prostate cancer. Prostate (2009) 0.94
Molecular dynamics of STAT3 on IL-6 signaling pathway in living cells. Biochem Biophys Res Commun (2004) 0.94
Green tea polyphenol-induced epidermal keratinocyte differentiation is associated with coordinated expression of p57/KIP2 and caspase 14. J Pharmacol Exp Ther (2004) 0.94
Thr-774 (transmembrane segment M5), Val-920 (M8), and Glu-954 (M9) are involved in Na+ transport, and Gln-923 (M8) is essential for Na,K-ATPase activity. J Biol Chem (2005) 0.93
Comparative study on the nuclear hormone receptor activity of various phytochemicals and their metabolites by reporter gene assays using Chinese hamster ovary cells. Biol Pharm Bull (2009) 0.93
Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-beta signaling. Biochem Biophys Res Commun (2008) 0.93