PubRank

Mitchell A Lazar

Author PubWeight™ 221.09‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The many faces of PPARgamma. Cell 2005 6.24
2 A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science 2011 5.91
3 Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell 2002 5.19
4 PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev 2008 4.83
5 Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol 2011 4.72
6 Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science 2007 4.68
7 DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol 2008 4.56
8 Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Dev 2007 4.23
9 Physiology. The health risk of obesity--better metrics imperative. Science 2013 4.19
10 Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest 2004 4.16
11 Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev 2008 3.90
12 Regulation of fasted blood glucose by resistin. Science 2004 3.54
13 Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 2005 3.52
14 International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev 2006 3.48
15 New developments in adipogenesis. Trends Endocrinol Metab 2009 3.44
16 Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev 2005 3.30
17 Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature 2008 3.23
18 A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat Med 2002 3.22
19 HDAC3 is a critical negative regulator of long-term memory formation. J Neurosci 2011 3.06
20 RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. Proc Natl Acad Sci U S A 2004 3.05
21 Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function. Genes Dev 2012 2.83
22 Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock. Science 2006 2.62
23 Resistin and obesity-associated insulin resistance. Trends Endocrinol Metab 2001 2.54
24 An inflammatory cascade leading to hyperresistinemia in humans. PLoS Med 2004 2.51
25 Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages. Mol Cell Biol 2010 2.47
26 The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene. Mol Endocrinol 2005 2.36
27 Propagation of adipogenic signals through an epigenomic transition state. Genes Dev 2010 2.23
28 International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev 2006 2.22
29 The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor. Mol Cell Biol 2003 2.15
30 Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation. Eur J Immunol 2007 2.10
31 The current biology of resistin. J Intern Med 2004 2.06
32 International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacol Rev 2006 2.04
33 Peroxisome proliferator-activated receptor gamma in diabetes and metabolism. Trends Pharmacol Sci 2004 1.97
34 Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. J Cell Biol 2003 1.92
35 Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat Med 2012 1.87
36 CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans. J Am Coll Cardiol 2007 1.87
37 Clocks, metabolism, and the epigenome. Mol Cell 2012 1.84
38 The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1. J Biol Chem 2006 1.73
39 A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev 2006 1.70
40 Adipokines and the peripheral and neural control of energy balance. Mol Endocrinol 2008 1.66
41 Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis. J Clin Invest 2006 1.66
42 Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. J Clin Invest 2009 1.63
43 A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation. EMBO J 2003 1.62
44 PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. Am J Physiol Endocrinol Metab 2007 1.61
45 Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity. Dev Cell 2003 1.60
46 Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Nature 2013 1.59
47 Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter. J Biol Chem 2005 1.57
48 Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation. Genes Dev 2011 1.54
49 Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes Dev 2002 1.53
50 Bacterial colonization leads to the colonic secretion of RELMbeta/FIZZ2, a novel goblet cell-specific protein. Gastroenterology 2003 1.53
51 Human resistin: found in translation from mouse to man. Trends Endocrinol Metab 2011 1.51
52 Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol 2009 1.49
53 PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1. J Clin Invest 2005 1.49
54 Bifunctional role of Rev-erbalpha in adipocyte differentiation. Mol Cell Biol 2008 1.45
55 Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo. Nat Struct Mol Biol 2013 1.43
56 GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. ACS Chem Biol 2010 1.41
57 Loss of resistin improves glucose homeostasis in leptin deficiency. Diabetes 2006 1.40
58 Abnormal glucose homeostasis due to chronic hyperresistinemia. Diabetes 2004 1.39
59 Differential gene regulation by PPARgamma agonist and constitutively active PPARgamma2. Mol Endocrinol 2002 1.37
60 Inflamed about obesity. Nat Med 2004 1.37
61 Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors. Proc Natl Acad Sci U S A 2005 1.35
62 ETO interacting proteins. Oncogene 2004 1.35
63 Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency. J Immunol 2010 1.31
64 Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha. Genes Dev 2009 1.30
65 Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. J Clin Invest 2012 1.29
66 Dissociating fatty liver and diabetes. Trends Endocrinol Metab 2012 1.29
67 Brown fat in humans: turning up the heat on obesity. Diabetes 2009 1.28
68 Central resistin induces hepatic insulin resistance via neuropeptide Y. J Neurosci 2007 1.28
69 The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3. EMBO Rep 2005 1.28
70 Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation. Nat Med 2008 1.27
71 Activation of SOCS-3 by resistin. Mol Cell Biol 2005 1.27
72 Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism. Nucl Recept Signal 2010 1.27
73 Species-specific strategies underlying conserved functions of metabolic transcription factors. Mol Endocrinol 2011 1.25
74 Re-expression of GATA2 cooperates with peroxisome proliferator-activated receptor-gamma depletion to revert the adipocyte phenotype. J Biol Chem 2009 1.24
75 Mechanisms regulating adipocyte expression of resistin. J Biol Chem 2002 1.24
76 Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ. Proc Natl Acad Sci U S A 2013 1.24
77 Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue. Diabetes 2006 1.23
78 E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha. Proc Natl Acad Sci U S A 2010 1.23
79 Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist. Mol Endocrinol 2007 1.22
80 Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists. Chem Biol 2009 1.14
81 Endogenous ligands for nuclear receptors: digging deeper. J Biol Chem 2010 1.14
82 A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods. Mol Endocrinol 2012 1.13
83 The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor. Mol Endocrinol 2005 1.13
84 Retinol saturase promotes adipogenesis and is downregulated in obesity. Proc Natl Acad Sci U S A 2009 1.11
85 Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. J Biol Chem 2011 1.10
86 Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action. J Biol Chem 2005 1.09
87 A chromatin immunoprecipitation screen reveals protein kinase Cbeta as a direct RUNX1 target gene. J Biol Chem 2003 1.09
88 Transcriptional repressor E4-binding protein 4 (E4BP4) regulates metabolic hormone fibroblast growth factor 21 (FGF21) during circadian cycles and feeding. J Biol Chem 2010 1.08
89 The humoral side of insulin resistance. Nat Med 2006 1.07
90 Cooperative function of Aml1-ETO corepressor recruitment domains in the expansion of primary bone marrow cells. Cancer Res 2002 1.06
91 HIV protease inhibitor-specific alterations in human adipocyte differentiation and metabolism. Obesity (Silver Spring) 2006 1.05
92 The interaction between nuclear receptor corepressor and histone deacetylase 3 regulates both positive and negative thyroid hormone action in vivo. Mol Endocrinol 2010 1.05
93 Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding proteins. J Biol Chem 2009 1.04
94 Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha. Cell Metab 2005 1.03
95 Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers. Genes Dev 2014 1.03
96 Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival. J Biol Chem 2002 1.02
97 Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells. Proc Natl Acad Sci U S A 2011 1.02
98 The corepressor silencing mediator for retinoid and thyroid hormone receptor facilitates cellular recovery from DNA double-strand breaks. Cancer Res 2006 0.98
99 The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome. J Biol Chem 2003 0.97
100 Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver. BMC Genomics 2013 0.97
101 Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction. Nat Struct Mol Biol 2010 0.97
102 Endoplasmic reticulum stress regulates adipocyte resistin expression. Diabetes 2009 0.97
103 Nuclear factor-κB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome. Proc Natl Acad Sci U S A 2012 0.95
104 A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity. Mol Pharmacol 2007 0.95
105 Resistin levels in human immunodeficiency virus-infected patients with lipoatrophy decrease in response to rosiglitazone. J Clin Endocrinol Metab 2005 0.93
106 Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract. Circ Res 2011 0.93
107 Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbα. Mol Endocrinol 2014 0.92
108 The dawn of the SPPARMs? Sci STKE 2002 0.92
109 Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. J Am Chem Soc 2008 0.91
110 The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor. EMBO J 2006 0.91
111 Gaining weight: the Keystone Symposium on PPAR and LXR. Genes Dev 2005 0.91
112 Inflammatory induction of human resistin causes insulin resistance in endotoxemic mice. Diabetes 2011 0.90
113 Resistin: molecular history and prognosis. J Mol Med (Berl) 2003 0.89
114 Selective partial agonism of liver X receptor alpha is related to differential corepressor recruitment. Mol Endocrinol 2008 0.87
115 Biochemical isolation and analysis of a nuclear receptor corepressor complex. Methods Enzymol 2003 0.85
116 Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues. BMC Genomics 2013 0.85
117 Resistin levels in lupus and associations with disease-specific measures, insulin resistance, and coronary calcification. J Rheumatol 2011 0.82
118 The orphan nuclear receptors at their 25-year reunion. J Mol Endocrinol 2013 0.80
119 Human resistin in chemotherapy-induced heart failure in humanized male mice and in women treated for breast cancer. Endocrinology 2013 0.78
120 A hormone sends instant messages to the genome. Cell 2011 0.78
121 Adipogenic hotspots: where the action is. EMBO J 2011 0.78
122 Pruning of the adipocyte peroxisome proliferator-activated receptor γ cistrome by hematopoietic master regulator PU.1. Mol Cell Biol 2013 0.77
123 Cell-specific integration of nuclear receptor function at the genome. Wiley Interdiscip Rev Syst Biol Med 2013 0.76
124 Fingered for a fat fate. Cell Metab 2010 0.75
125 Maturing of the nuclear receptor family. J Clin Invest 2017 0.75
126 Double SET point: G9a makes its mark in adipogenesis. EMBO J 2012 0.75
127 Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice. J Clin Invest 2017 0.75