Published in Genes Dev on May 15, 2008
PRDM16 controls a brown fat/skeletal muscle switch. Nature (2008) 13.08
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest (2010) 6.96
Forcing cells to change lineages. Nature (2009) 5.99
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature (2009) 4.98
Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol (2011) 4.72
Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov (2010) 4.23
What we talk about when we talk about fat. Cell (2014) 4.12
Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev (2013) 3.74
Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS One (2012) 3.34
PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab (2012) 3.09
Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr (2011) 2.98
Transcriptional control of brown fat development. Cell Metab (2010) 2.97
White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis. Cell Metab (2011) 2.68
Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes Dev (2009) 2.66
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis. Cell Metab (2009) 2.52
EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature (2013) 2.40
Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proc Natl Acad Sci U S A (2012) 2.24
Mir193b-365 is essential for brown fat differentiation. Nat Cell Biol (2011) 2.20
Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. Cell Metab (2016) 2.15
C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists. Mol Cell Biol (2009) 1.98
Brown fat as a therapy for obesity and diabetes. Curr Opin Endocrinol Diabetes Obes (2010) 1.93
MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metab (2013) 1.87
A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annu Rev Physiol (2013) 1.86
EBF2 determines and maintains brown adipocyte identity. Cell Metab (2013) 1.85
Identification of Hipk2 as an essential regulator of white fat development. Proc Natl Acad Sci U S A (2014) 1.75
Thyroid hormone regulation of metabolism. Physiol Rev (2014) 1.70
Molecular determinants of brown adipocyte formation and function. Genes Dev (2008) 1.68
The role of sirtuins in the control of metabolic homeostasis. Ann N Y Acad Sci (2009) 1.62
Brown and Beige Fat: Physiological Roles beyond Heat Generation. Cell Metab (2015) 1.60
Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. J Clin Invest (2015) 1.56
Transcriptional and epigenetic control of brown and beige adipose cell fate and function. Nat Rev Mol Cell Biol (2016) 1.53
Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure. Cell Metab (2015) 1.49
A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis. Diabetes (2016) 1.43
Mitochondrial dysfunction in obesity. Curr Opin Endocrinol Diabetes Obes (2010) 1.42
IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell (2014) 1.34
Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. PLoS One (2008) 1.28
Adipogenesis. Cold Spring Harb Perspect Biol (2012) 1.23
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metab (2013) 1.22
Mitochondrial dysfunction in white adipose tissue. Trends Endocrinol Metab (2012) 1.22
Chromatin modification of Notch targets in olfactory receptor neuron diversification. Nat Neurosci (2011) 1.20
Brown adipose tissue--a new role in humans? Nat Rev Endocrinol (2010) 1.18
Emerging roles for XBP1, a sUPeR transcription factor. Gene Expr (2010) 1.17
Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes. Biosci Rep (2013) 1.14
The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span. Proc Natl Acad Sci U S A (2009) 1.14
Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat. Mol Cell (2015) 1.13
The sirtuin family's role in aging and age-associated pathologies. J Clin Invest (2013) 1.12
PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders. Diabetes (2013) 1.12
Dicer is required for the formation of white but not brown adipose tissue. J Cell Physiol (2011) 1.09
MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function. Mol Cell Biol (2014) 1.09
Recruitment of brown adipose tissue as a therapy for obesity-associated diseases. Front Endocrinol (Lausanne) (2012) 1.07
Brown and Beige Fat: Molecular Parts of a Thermogenic Machine. Diabetes (2015) 1.07
An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins. Nat Commun (2014) 1.06
The many facets of PPARgamma: novel insights for the skeleton. Am J Physiol Endocrinol Metab (2010) 1.04
Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding proteins. J Biol Chem (2009) 1.04
Regulation of gene expression by FSP27 in white and brown adipose tissue. BMC Genomics (2010) 1.04
PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program. Genes Dev (2015) 1.04
Dual functions of TAF7L in adipocyte differentiation. Elife (2013) 1.03
The origin, molecular regulation and therapeutic potential of myogenic stem cell populations. J Anat (2009) 1.03
The brain and brown fat. Ann Med (2014) 1.02
A High Fat Diet Increases Bone Marrow Adipose Tissue (MAT) But Does Not Alter Trabecular or Cortical Bone Mass in C57BL/6J Mice. J Cell Physiol (2015) 1.01
Role of histone methylation and demethylation in adipogenesis and obesity. Organogenesis (2010) 1.01
De Novo Reconstruction of Adipose Tissue Transcriptomes Reveals Long Non-coding RNA Regulators of Brown Adipocyte Development. Cell Metab (2015) 0.98
Emerging roles of zinc finger proteins in regulating adipogenesis. Cell Mol Life Sci (2013) 0.98
Brown adipose tissue: Recent insights into development, metabolic function and therapeutic potential. Adipocyte (2012) 0.96
Erythropoietin, a novel versatile player regulating energy metabolism beyond the erythroid system. Int J Biol Sci (2014) 0.96
Dynamic regulation of genes involved in mitochondrial DNA replication and transcription during mouse brown fat cell differentiation and recruitment. PLoS One (2009) 0.95
PPARalpha blocks glucocorticoid receptor alpha-mediated transactivation but cooperates with the activated glucocorticoid receptor alpha for transrepression on NF-kappaB. Proc Natl Acad Sci U S A (2009) 0.95
Longitudinal trends in the association of metabolic syndrome with 550 k single-nucleotide polymorphisms in the Framingham Heart Study. BMC Proc (2009) 0.94
The genetics of brown adipocyte induction in white fat depots. Front Endocrinol (Lausanne) (2011) 0.94
p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity. Cell Death Differ (2013) 0.93
Inhibitory effects of transcription factor Ikaros on the expression of liver cancer stem cell marker CD133 in hepatocellular carcinoma. Oncotarget (2014) 0.93
Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology. Semin Immunopathol (2013) 0.93
A chromatin perspective of adipogenesis. Organogenesis (2010) 0.92
Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation. Diabetes (2015) 0.91
Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation. Proc Natl Acad Sci U S A (2015) 0.91
Review: Epigenetic regulation of adipocyte differentiation and adipogenesis. J Zhejiang Univ Sci B (2010) 0.89
The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain. J Biol Chem (2011) 0.89
Mechanism of the anti-obesity effects induced by a novel melanin-concentrating hormone 1-receptor antagonist in mice. Br J Pharmacol (2009) 0.89
PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue. PLoS One (2013) 0.88
Recent advance in brown adipose physiology and its therapeutic potential. Exp Mol Med (2014) 0.88
Adipose tissue insulin receptor knockdown via a new primate-derived hybrid recombinant AAV serotype. Mol Ther Methods Clin Dev (2014) 0.87
Recent progress in the study of brown adipose tissue. Cell Biosci (2011) 0.87
PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1. Genes Dev (2015) 0.87
Shades of brown: a model for thermogenic fat. Front Endocrinol (Lausanne) (2015) 0.85
AMPK is involved in mediation of erythropoietin influence on metabolic activity and reactive oxygen species production in white adipocytes. Int J Biochem Cell Biol (2014) 0.85
Non-human lnc-DC orthologs encode Wdnm1-like protein. F1000Res (2014) 0.85
A role for phosphodiesterase 3B in acquisition of brown fat characteristics by white adipose tissue in male mice. Endocrinology (2013) 0.85
C-Terminal Binding Protein: A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer. Int J Cell Biol (2013) 0.84
PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation. Biology (Basel) (2013) 0.83
Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo. Blood (2014) 0.83
Inhibition of in vitro and in vivo brown fat differentiation program by myostatin. Obesity (Silver Spring) (2013) 0.83
GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis. J Biol Chem (2010) 0.83
Fluorescence Imaging of Interscapular Brown Adipose Tissue in Living Mice. J Mater Chem B Mater Biol Med (2015) 0.82
Functions of Prdm16 in thermogenic fat cells. Temperature (Austin) (2015) 0.82
Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning. Sci Rep (2015) 0.82
Regulatory networks of non-coding RNAs in brown/beige adipogenesis. Biosci Rep (2015) 0.82
Transcriptional targets in adipocyte biology. Expert Opin Ther Targets (2009) 0.82
Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev (2016) 0.82
Regulation of brown adipose tissue recruitment, metabolism and thermogenic function by peroxisome proliferator-activated receptor γ. Temperature (Austin) (2015) 0.82
Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol (1996) 72.84
Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis (1999) 45.01
Inflammation and metabolic disorders. Nature (2006) 33.33
Brown adipose tissue: function and physiological significance. Physiol Rev (2004) 23.00
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell (2004) 21.30
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell (1998) 18.32
Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature (2000) 18.26
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell (1994) 17.58
The hormone resistin links obesity to diabetes. Nature (2001) 15.49
Effects of the obese gene product on body weight regulation in ob/ob mice. Science (1995) 13.57
Weight-reducing effects of the plasma protein encoded by the obese gene. Science (1995) 13.05
A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res (2003) 12.94
PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell (1999) 10.08
PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell (1999) 9.74
Adipocytes as regulators of energy balance and glucose homeostasis. Nature (2006) 9.52
Transcriptional control of adipocyte formation. Cell Metab (2006) 9.50
Obesity and the regulation of energy balance. Cell (2001) 9.48
Developmental origin of fat: tracking obesity to its source. Cell (2007) 8.80
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev (2002) 8.78
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell (2004) 8.58
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature (1994) 7.86
Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum Gene Ther (1996) 7.12
Towards a molecular understanding of adaptive thermogenesis. Nature (2000) 7.04
Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A (2003) 6.82
Transcriptional control of brown fat determination by PRDM16. Cell Metab (2007) 6.79
Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature (2003) 6.48
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev (2002) 6.46
Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol (2000) 6.40
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev (2005) 5.50
FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell (2001) 5.22
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab (2006) 5.01
Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest (1998) 4.94
Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell (1999) 4.89
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell (2001) 4.58
betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science (2002) 4.47
SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell (2002) 4.31
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc Natl Acad Sci U S A (2003) 4.31
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med (2001) 4.19
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem (2003) 4.12
Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc Natl Acad Sci U S A (2004) 3.67
Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis. J Chromatogr A (1998) 3.64
Regulation of fasted blood glucose by resistin. Science (2004) 3.54
Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc Natl Acad Sci U S A (2004) 3.45
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci U S A (2007) 3.40
Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc Natl Acad Sci U S A (1995) 3.28
Acquirement of brown fat cell features by human white adipocytes. J Biol Chem (2003) 3.05
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol Cell Biol (2004) 3.00
Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells. Blood (2005) 2.93
Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol Cell Biol (2002) 2.78
Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. Cell Metab (2005) 2.76
Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J Clin Invest (2005) 2.69
In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation. Biotechniques (2006) 2.46
Isolation and mass spectrometry of transcription factor complexes. Methods (2002) 2.46
Structure and catalytic mechanism of a SET domain protein methyltransferase. Cell (2002) 2.45
The function of leptin in nutrition, weight, and physiology. Nutr Rev (2002) 2.33
Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci U S A (2005) 2.31
Physiology and pathophysiology of the adipose tissue renin-angiotensin system. Hypertension (2000) 2.30
Transcriptional regulation by C-terminal binding proteins. Int J Biochem Cell Biol (2007) 2.28
Formation of normally differentiated subcutaneous fat pads by an established preadipose cell line. J Cell Physiol (1979) 2.27
C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs. Proc Natl Acad Sci U S A (2003) 2.25
Regulatory circuits controlling white versus brown adipocyte differentiation. Biochem J (2006) 2.23
Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J (2001) 2.09
The current biology of resistin. J Intern Med (2004) 2.06
A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells. Blood (2000) 1.86
A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation. Blood (2003) 1.49
PPARgamma in the control of brown adipocyte differentiation. Biochim Biophys Acta (2005) 1.42
Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice. J Clin Invest (2007) 1.30
Hypofibrinolysis and increased PAI-1 are linked to atherothrombosis via insulin resistance and obesity. Ann Med (2000) 1.16
Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells. Blood (2003) 1.13
Emerging patterns and gene expression data. Genome Inform (2001) 1.08
Energy balance following sympathetic denervation of brown adipose tissue. Can J Physiol Pharmacol (1984) 1.01
Phosphorylation of CtBP1 by cAMP-dependent protein kinase modulates induction of CYP17 by stimulating partnering of CtBP1 and 2. J Biol Chem (2008) 0.98
Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell (2002) 18.22
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol (2004) 16.83
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature (2012) 14.67
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature (2002) 14.37
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08
PRDM16 controls a brown fat/skeletal muscle switch. Nature (2008) 13.08
Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab (2005) 11.66
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell (2012) 11.03
Histone demethylation by a family of JmjC domain-containing proteins. Nature (2005) 10.36
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell (2006) 10.18
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev (2003) 9.93
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature (2003) 9.77
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol (2009) 9.67
Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem (2008) 9.56
Adipocytes as regulators of energy balance and glucose homeostasis. Nature (2006) 9.52
Role of histone H2A ubiquitination in Polycomb silencing. Nature (2004) 9.48
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell (2004) 8.58
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A (2007) 8.23
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell (2005) 7.75
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature (2008) 7.18
Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell (2005) 7.07
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest (2010) 6.96
Transcriptional control of brown fat determination by PRDM16. Cell Metab (2007) 6.79
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev (2006) 6.68
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A (2004) 6.53
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev (2002) 6.46
The many faces of PPARgamma. Cell (2005) 6.24
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science (2011) 5.91
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature (2008) 5.85
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78
Regulation of p53 activity through lysine methylation. Nature (2004) 5.78
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev (2012) 5.71
Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell (2002) 5.59
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell (2006) 5.54
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol (2002) 5.53
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature (2006) 5.51
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev (2002) 5.43
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell (2004) 5.37
The role of exercise and PGC1alpha in inflammation and chronic disease. Nature (2008) 5.31
Brown and beige fat: development, function and therapeutic potential. Nat Med (2013) 5.29
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci U S A (2006) 5.28
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell (2003) 5.21
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell (2007) 5.20
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell (2002) 5.19
Histone deimination antagonizes arginine methylation. Cell (2004) 5.19
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab (2006) 5.01
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature (2010) 5.01
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature (2009) 4.98
PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev (2008) 4.83
Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol (2011) 4.72
Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science (2007) 4.68
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab (2005) 4.65
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem (2007) 4.58
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol (2008) 4.56
Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration. Cell (2003) 4.38
Retracted Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A (2009) 4.37
Differential exoprotease activities confer tumor-specific serum peptidome patterns. J Clin Invest (2006) 4.37
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc Natl Acad Sci U S A (2003) 4.34
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc Natl Acad Sci U S A (2003) 4.31
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature (2011) 4.23
Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Dev (2007) 4.23
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem (2001) 4.20
Physiology. The health risk of obesity--better metrics imperative. Science (2013) 4.19