Published in Circulation on February 14, 2005
Inflammation and the Metabolic Syndrome in Humans (LPS) | NCT00954824
CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44
Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc Diabetol (2006) 3.31
Adipokines and insulin resistance. Mol Med (2008) 2.97
Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis (2006) 2.25
Resistin, adiponectin, and risk of heart failure the Framingham offspring study. J Am Coll Cardiol (2008) 2.18
Association between adiponectin, resistin, insulin resistance, and colorectal tumors. Int J Colorectal Dis (2009) 1.84
Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Sleep (2009) 1.76
Adipokines and the peripheral and neural control of energy balance. Mol Endocrinol (2008) 1.66
Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. J Clin Invest (2009) 1.63
Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation (2008) 1.62
The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators Inflamm (2010) 1.59
Homocysteine promotes vascular smooth muscle cell migration by induction of the adipokine resistin. Am J Physiol Cell Physiol (2009) 1.57
Plasma resistin levels associate with risk for hypertension among nondiabetic women. J Am Soc Nephrol (2010) 1.54
Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients. Crit Care (2009) 1.54
Adipokines, insulin resistance, and coronary artery calcification. J Am Coll Cardiol (2008) 1.53
Human resistin: found in translation from mouse to man. Trends Endocrinol Metab (2011) 1.51
Adipocytokines in obesity and metabolic disease. J Endocrinol (2014) 1.49
Serum resistin and glomerular filtration rate in patients with type 2 diabetes. PLoS One (2015) 1.41
Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum. Ann Rheum Dis (2006) 1.40
The vicious circle between oxidative stress and inflammation in atherosclerosis. J Cell Mol Med (2009) 1.35
Adipocytokine levels in gastric cancer patients: resistin and visfatin as biomarkers of gastric cancer. J Gastroenterol (2009) 1.34
Pediatric non alcoholic fatty liver disease: old and new concepts on development, progression, metabolic insight and potential treatment targets. BMC Pediatr (2013) 1.32
Adherence to healthy eating patterns is associated with higher circulating total and high-molecular-weight adiponectin and lower resistin concentrations in women from the Nurses' Health Study. Am J Clin Nutr (2008) 1.27
Metabolic syndrome, inflammation and atherosclerosis. Vasc Health Risk Manag (2006) 1.23
Resistin: functional roles and therapeutic considerations for cardiovascular disease. Br J Pharmacol (2012) 1.22
Relationship of serum adiponectin and resistin levels with breast cancer risk. J Korean Med Sci (2007) 1.19
Biomarkers of obesity and subsequent cardiovascular events. Epidemiol Rev (2007) 1.17
Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. Compr Physiol (2013) 1.17
Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells. Am J Pathol (2006) 1.14
Metabolic syndrome: the danger signal in atherosclerosis. Vasc Health Risk Manag (2006) 1.13
Serum resistin, cardiovascular disease and all-cause mortality in patients with type 2 diabetes. PLoS One (2013) 1.13
Hypothalamic resistin induces hepatic insulin resistance. J Clin Invest (2007) 1.10
Adipocytokines in systemic lupus erythematosus: relationship to inflammation, insulin resistance and coronary atherosclerosis. Lupus (2009) 1.10
Distinct vascular and metabolic effects of different classes of anti-hypertensive drugs. Int J Cardiol (2008) 1.07
Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes. Cell Metab (2014) 1.06
Resistin induces expression of proinflammatory cytokines and chemokines in human articular chondrocytes via transcription and messenger RNA stabilization. Arthritis Rheum (2010) 1.04
Resistin in rodents and humans. Diabetes Metab J (2013) 1.03
Apolipoprotein B but not LDL cholesterol is associated with coronary artery calcification in type 2 diabetic whites. Diabetes (2009) 1.02
Regulation of vascular tone by adipocytes. BMC Med (2011) 1.01
Microvesicles/exosomes as potential novel biomarkers of metabolic diseases. Diabetes Metab Syndr Obes (2012) 1.01
Central resistin overexposure induces insulin resistance through Toll-like receptor 4. Diabetes (2012) 1.01
The usefulness of circulating adipokine levels for the assessment of obesity-related health problems. Int J Med Sci (2008) 0.99
Genetic markers of cardiovascular disease in rheumatoid arthritis. Mediators Inflamm (2012) 0.99
Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations with clinical variables and cardiovascular co-morbidity. Cardiovasc Diabetol (2010) 0.97
Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function. Eur J Endocrinol (2009) 0.97
Mechanisms Linking Inflammation to Insulin Resistance. Int J Endocrinol (2015) 0.96
Serum resistin concentrations and risk of new onset heart failure in older persons: the health, aging, and body composition (Health ABC) study. Arterioscler Thromb Vasc Biol (2009) 0.96
Diabetes and hypertension markedly increased the risk of ischemic stroke associated with high serum resistin concentration in a general Japanese population: the Hisayama Study. Cardiovasc Diabetol (2009) 0.96
Genetic analysis implicates resistin in HIV lipodystrophy. AIDS (2008) 0.96
Lifetime exposure to traumatic psychological stress is associated with elevated inflammation in the Heart and Soul Study. Brain Behav Immun (2012) 0.96
Clinical implications of adipocytokines and newly emerging metabolic factors with relation to insulin resistance and cardiovascular health. Front Endocrinol (Lausanne) (2013) 0.94
Plasma resistin, adiponectin, and risk of incident atrial fibrillation: the Framingham Offspring Study. Am Heart J (2011) 0.94
Novel adipokines, high molecular weight adiponectin and resistin, are associated with outcomes following lower extremity revascularization with autogenous vein. J Vasc Surg (2010) 0.93
Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians. Clin Endocrinol (Oxf) (2008) 0.93
Resistin, an adipocytokine, offers protection against acute myocardial infarction. J Mol Cell Cardiol (2007) 0.91
Obesity and lipodystrophy--where do the circles intersect? Endocrinology (2008) 0.91
Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease. Circ Res (2016) 0.91
Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden. PLoS Pathog (2015) 0.90
Adipokines as a novel link between obesity and atherosclerosis. World J Diabetes (2014) 0.90
Inflammatory induction of human resistin causes insulin resistance in endotoxemic mice. Diabetes (2011) 0.90
Association of resistin polymorphism, its serum levels and prevalence of stroke in Japanese type 2 diabetic patients. J Diabetes Investig (2010) 0.90
Serum resistin and kidney function: a family-based study in non-diabetic, untreated individuals. PLoS One (2012) 0.89
Peripheral mononuclear cell resistin mRNA expression is increased in type 2 diabetic women. Mediators Inflamm (2008) 0.89
Adipocytokine levels mark endothelial function in normotensive individuals. Cardiovasc Diabetol (2012) 0.88
Resistin increases monolayer permeability of human coronary artery endothelial cells. PLoS One (2013) 0.87
Relationship between resistin level in serum and acute coronary syndrome or stable angina pectoris. J Zhejiang Univ Sci B (2007) 0.87
Oxidized LDL and the metabolic syndrome. Future Lipidol (2008) 0.87
Role of adipokines signaling in the modulation of T cells function. Front Immunol (2013) 0.87
The early origins of obesity and insulin resistance: timing, programming and mechanisms. Int J Obes (Lond) (2015) 0.86
Mechanism of inhibitory effect of atorvastatin on resistin expression induced by tumor necrosis factor-alpha in macrophages. J Biomed Sci (2009) 0.85
Adipose tissue and vascular inflammation in coronary artery disease. World J Cardiol (2014) 0.84
Relationship between obesity, adipocytokines and inflammatory markers in type 2 diabetes: relevance for cardiovascular risk prevention. Int J Environ Res Public Health (2014) 0.84
Correlates of resistin in children with chronic kidney disease: the chronic kidney disease in children cohort. J Pediatr (2012) 0.84
Effects of regular exercise on obesity and type 2 diabete mellitus in Korean children: improvements glycemic control and serum adipokines level. J Phys Ther Sci (2015) 0.84
Resistin in inflammatory and degenerative rheumatologic diseases. Relationship between resistin and rheumatoid arthritis disease progression. Z Rheumatol (2013) 0.83
Association between resistin levels and all-cause and cardiovascular mortality: a new study and a systematic review and meta-analysis. PLoS One (2015) 0.83
Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia (2014) 0.83
Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. Hum Mol Genet (2012) 0.83
On the function and homeostasis of PCSK9: reciprocal interaction with LDLR and additional lipid effects. Atherosclerosis (2014) 0.82
Resistin in serum and gingival crevicular fluid as a marker of periodontal inflammation and its correlation with single-nucleotide polymorphism in human resistin gene at -420. Contemp Clin Dent (2013) 0.82
Efficacy of antioxidant treatment in reducing resistin serum levels: a randomized study. PLoS Clin Trials (2007) 0.82
High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells. Biomed Res Int (2012) 0.82
Obesity and coronary microvascular disease - implications for adipose tissue-mediated remote inflammatory response. Curr Vasc Pharmacol (2014) 0.82
Resistin is associated with mortality in patients with traumatic brain injury. Crit Care (2010) 0.81
The serum levels of resistin in ankylosing spondylitis patients: a pilot study. Rheumatol Int (2010) 0.81
Sirt1 inhibits resistin expression in aortic stenosis. PLoS One (2012) 0.81
Transcription of human resistin gene involves an interaction of Sp1 with peroxisome proliferator-activating receptor gamma (PPARgamma). PLoS One (2010) 0.81
Proprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity. PLoS One (2013) 0.79
Association of circulating resistin with metabolic risk factors in Indian females having metabolic syndrome. Toxicol Int (2011) 0.79
The association of resistin with cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis (2014) 0.79
Low cytochrome oxidase 4I1 links mitochondrial dysfunction to obesity and type 2 diabetes in humans and mice. Int J Obes (Lond) (2015) 0.79
Resistin enhances the expansion of regulatory T cells through modulation of dendritic cells. BMC Immunol (2010) 0.79
Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia. Biogerontology (2017) 0.79
Evaluation of serum adipokines in peripheral arterial occlusive disease. Mediators Inflamm (2012) 0.78
Association of circulating neuregulin 4 with metabolic syndrome in obese adults: a cross-sectional study. BMC Med (2016) 0.78
Rheumatic diseases and obesity: adipocytokines as potential comorbidity biomarkers for cardiovascular diseases. Mediators Inflamm (2013) 0.78
Measurement of salivary resistin level in patients with type 2 diabetes. Int J Endocrinol (2012) 0.78
Association of insulin resistance with adipocytokine levels in patients with metabolic syndrome. Indian J Clin Biochem (2014) 0.78
Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease. Biochem Med (Zagreb) (2015) 0.78
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med (2004) 19.42
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N Engl J Med (2011) 13.55
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med (2003) 9.23
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet (2009) 6.83
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet (2008) 6.72
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
The many faces of PPARgamma. Cell (2005) 6.24
Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA (2010) 6.11
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science (2011) 5.91
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88
Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes (2005) 5.22
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell (2002) 5.19
Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94
Implementing genomic medicine in the clinic: the future is here. Genet Med (2013) 4.89
PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev (2008) 4.83
Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol (2011) 4.72
Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science (2007) 4.68
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol (2008) 4.56
New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circ Res (2005) 4.47
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet (2005) 4.45
Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial. Ann Intern Med (2009) 4.45
NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J Biol Chem (2004) 4.37
Appropriate use and clinical impact of transthoracic echocardiography. JAMA Intern Med (2013) 4.36
Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Dev (2007) 4.23
Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest (2007) 4.20
Physiology. The health risk of obesity--better metrics imperative. Science (2013) 4.19
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest (2004) 4.16
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev (2008) 3.90
Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: a randomized trial. Ann Intern Med (2010) 3.73
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. N Engl J Med (2007) 3.70
Regulation of fasted blood glucose by resistin. Science (2004) 3.54
Human secretory phospholipase A2 mediates decreased plasma levels of HDL cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice. Arterioscler Thromb Vasc Biol (2002) 3.51
Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. N Engl J Med (2004) 3.49
Macrophage reverse cholesterol transport: key to the regression of atherosclerosis? Circulation (2006) 3.49
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev (2006) 3.48
New developments in adipogenesis. Trends Endocrinol Metab (2009) 3.44
Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation (2012) 3.38
The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat Med (2004) 3.34
Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev (2005) 3.30
Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis. Arterioscler Thromb Vasc Biol (2003) 3.26
Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo. Circulation (2005) 3.25
Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo. Circulation (2003) 3.24
Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature (2008) 3.23
A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat Med (2002) 3.22
The metabolic syndrome: more than the sum of its parts? Circulation (2003) 3.22
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages. Arterioscler Thromb Vasc Biol (2010) 3.20
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet (2010) 3.15
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet (2011) 3.07
HDAC3 is a critical negative regulator of long-term memory formation. J Neurosci (2011) 3.06
RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. Proc Natl Acad Sci U S A (2004) 3.05
Renin-angiotensin system and atherothrombotic disease: from genes to treatment. Arch Intern Med (2003) 2.98
Adipokines and insulin resistance. Mol Med (2008) 2.97
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Candidate gene association resource (CARe): design, methods, and proof of concept. Circ Cardiovasc Genet (2010) 2.91
COX-2-derived prostacyclin confers atheroprotection on female mice. Science (2004) 2.87
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat Genet (2009) 2.85
Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function. Genes Dev (2012) 2.83
Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock. Science (2006) 2.62
Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339. J Lipid Res (2005) 2.61
Resistin and obesity-associated insulin resistance. Trends Endocrinol Metab (2001) 2.54
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients. J Lipid Res (2008) 2.51
An inflammatory cascade leading to hyperresistinemia in humans. PLoS Med (2004) 2.51
CPAP, weight loss, or both for obstructive sleep apnea. N Engl J Med (2014) 2.50
Innate immunity modulates adipokines in humans. J Clin Endocrinol Metab (2007) 2.48
Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo. J Clin Invest (2005) 2.47
Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages. Mol Cell Biol (2010) 2.47
Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches. J Am Coll Cardiol (2008) 2.41
The roles of different pathways in the release of cholesterol from macrophages. J Lipid Res (2007) 2.38
Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression. J Clin Invest (2011) 2.37
The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene. Mol Endocrinol (2005) 2.36
Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis. Arterioscler Thromb Vasc Biol (2009) 2.33
Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial. JAMA (2003) 2.32
Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study. Am J Kidney Dis (2011) 2.25