Functional analysis of human hematopoietic stem cell gene expression using zebrafish.

PubWeight™: 1.52‹?› | Rank: Top 4%

🔗 View Article (PMC 1166352)

Published in PLoS Biol on July 05, 2005

Authors

Craig E Eckfeldt1, Eric M Mendenhall, Catherine M Flynn, Tzu-Fei Wang, Michael A Pickart, Suzanne M Grindle, Stephen C Ekker, Catherine M Verfaillie

Author Affiliations

1: Division of Hematology, Oncology, and Transplantation, Department of Medicine, Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA.

Articles citing this

Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet (2009) 6.35

A primer for morpholino use in zebrafish. Zebrafish (2009) 2.60

A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. Blood (2009) 2.18

Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS. Blood (2008) 1.95

Zebrafish in hematology: sushi or science? Blood (2008) 1.69

Genome-wide reverse genetics framework to identify novel functions of the vertebrate secretome. PLoS One (2006) 1.60

Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells. Blood (2009) 1.35

Pathway and gene-set activation measurement from mRNA expression data: the tissue distribution of human pathways. Genome Biol (2006) 1.29

HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis. Nucleic Acids Res (2012) 1.29

A weighted average difference method for detecting differentially expressed genes from microarray data. Algorithms Mol Biol (2008) 1.27

Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides. PLoS Genet (2006) 1.25

N-terminal RASSF family: RASSF7-RASSF10. Epigenetics (2011) 1.17

Lessons from morpholino-based screening in zebrafish. Brief Funct Genomics (2011) 1.14

Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase. Cancer Res (2010) 1.10

A PATO-compliant zebrafish screening database (MODB): management of morpholino knockdown screen information. BMC Bioinformatics (2008) 1.07

Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment. Blood (2013) 1.03

Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q. J Biol Chem (2011) 0.97

Reverse genetics in eukaryotes. Biol Cell (2010) 0.97

Meta-analysis of microarray studies reveals a novel hematopoietic progenitor cell signature and demonstrates feasibility of inter-platform data integration. PLoS One (2008) 0.96

Transgene excision in zebrafish using the phiC31 integrase. Genesis (2010) 0.93

Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear. Matrix Biol (2008) 0.92

IRAK signalling in cancer. Br J Cancer (2014) 0.91

Sparc protein is required for normal growth of zebrafish otoliths. J Assoc Res Otolaryngol (2008) 0.89

HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4. Haematologica (2012) 0.86

Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2. Blood (2012) 0.83

Advancements in zebrafish applications for 21st century toxicology. Pharmacol Ther (2016) 0.82

miR-216a regulates snx5, a novel notch signaling pathway component, during zebrafish retinal development. Dev Biol (2015) 0.81

A distinct gene expression signature characterizes human neuroblastoma cancer stem cells. Stem Cell Res (2015) 0.80

Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function. PLoS One (2011) 0.79

SNX5 is essential for efficient macropinocytosis and antigen processing in primary macrophages. Biol Open (2012) 0.78

Complex interactions in EML cell stimulation by stem cell factor and IL-3. Proc Natl Acad Sci U S A (2011) 0.78

Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response. J Immunol (2014) 0.77

Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish. PLoS One (2015) 0.75

Neonatal expression of RNA-binding protein IGF2BP3 regulates the human fetal-adult megakaryocyte transition. J Clin Invest (2017) 0.75

Articles cited by this

"Stemness": transcriptional profiling of embryonic and adult stem cells. Science (2002) 15.55

A stem cell molecular signature. Science (2002) 14.47

Effective targeted gene 'knockdown' in zebrafish. Nat Genet (2000) 14.40

A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature (2003) 12.81

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell (1999) 12.50

Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science (2000) 10.81

The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (1996) 8.87

Comment on " 'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature". Science (2003) 8.79

IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79

LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]. Genes Dev (1991) 5.95

Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nat Genet (2002) 5.43

The biology of hematopoietic stem cells. Annu Rev Cell Dev Biol (1995) 4.77

The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell (1994) 4.58

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med (2000) 4.55

Id proteins in development, cell cycle and cancer. Trends Cell Biol (2003) 4.53

Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol (2001) 3.97

Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci U S A (1997) 3.84

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev (1995) 3.81

Modulation of signalling by Sprouty: a developing story. Nat Rev Mol Cell Biol (2004) 3.46

The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis. Dev Biol (1998) 3.31

Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants. Development (2001) 3.06

SPARC, a matricellular protein: at the crossroads of cell-matrix communication. Matrix Biol (2001) 2.75

Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev Cell (2005) 2.12

Gene expression analysis of purified hematopoietic stem cells and committed progenitors. Blood (2003) 2.05

Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. EMBO J (1998) 1.83

HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation. Exp Hematol (2001) 1.81

dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. Development (1996) 1.78

Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci U S A (2003) 1.72

Differential gene expression profiling of adult murine hematopoietic stem cells. Blood (2002) 1.69

Organogenesis--heart and blood formation from the zebrafish point of view. Science (2002) 1.67

sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish. Development (2001) 1.64

Morphants: a new systematic vertebrate functional genomics approach. Yeast (2000) 1.60

Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells. Blood (2004) 1.58

Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines. Mol Cell Biol (1998) 1.48

Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development. EMBO J (1998) 1.41

Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies. Blood (2001) 1.36

Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish. Development (2000) 1.32

The role of EVI1 in normal and leukemic cells. Blood Cells Mol Dis (2003) 1.31

Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. Blood (2002) 1.30

Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes. Proc Natl Acad Sci U S A (2000) 1.24

Localization of the human pim oncogene (PIM) to a region of chromosome 6 involved in translocations in acute leukemias. Proc Natl Acad Sci U S A (1986) 1.20

Disruption of protein kinase Ceta results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis. Cancer Res (2003) 1.12

Zebrafish: a genetic model for vertebrate organogenesis and human disorders. Front Biosci (2003) 1.09

Regulation of hematopoietic stem cell fate. Oncogene (2002) 1.07

Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos. Dev Biol (2005) 1.07

Functional genomics tools for the analysis of zebrafish pigment. Pigment Cell Res (2004) 0.98

Hindbrain patterning: FGFs regulate Krox20 and mafB/kr expression in the otic/preotic region. Development (2000) 0.91

E2A-HLF usurps control of evolutionarily conserved survival pathways. Oncogene (2001) 0.89

Myeloid-lymphoid initiating cells (ML-IC) are highly enriched in the rhodamine-c-kit(+)CD33(-)CD38(-) fraction of umbilical cord CD34(+) cells. Exp Hematol (2002) 0.85

Translocation (3;6)(q21;p21) in acute myeloid leukemia with abnormal thrombopoiesis and basophilia. Cancer Genet Cytogenet (1988) 0.83

Differential gene expression of human stem progenitor cells derived from early stages of in utero human hematopoiesis. Blood (2003) 0.82

Downregulation of mafB expression in T-helper cells during early differentiation in vitro. Scand J Immunol (2003) 0.79

Articles by these authors

Pluripotency of mesenchymal stem cells derived from adult marrow. Nature (2002) 19.57

Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet (2008) 11.17

In vivo genome editing using a high-efficiency TALEN system. Nature (2012) 7.11

Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood (2004) 7.09

p53 activation by knockdown technologies. PLoS Genet (2007) 6.85

Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest (2002) 4.38

Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest (2002) 3.90

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells. PLoS Biol (2004) 3.48

Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. PLoS Genet (2006) 2.99

In vivo protein trapping produces a functional expression codex of the vertebrate proteome. Nat Methods (2011) 2.85

Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Exp Neurol (2002) 2.72

Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol (2002) 2.71

A primer for morpholino use in zebrafish. Zebrafish (2009) 2.60

Public stem cell banks: considerations of justice in stem cell research and therapy. Hastings Cent Rep (2004) 2.53

Mammalian germ-line transgenesis by transposition. Proc Natl Acad Sci U S A (2002) 2.13

Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling. Circulation (2007) 2.02

Efficient gene delivery and gene expression in zebrafish using the Sleeping Beauty transposon. Dev Biol (2003) 2.01

Islet-derived fibroblast-like cells are not derived via epithelial-mesenchymal transition from Pdx-1 or insulin-positive cells. Diabetes (2006) 1.94

WNT5A mutations in patients with autosomal dominant Robinow syndrome. Dev Dyn (2010) 1.91

Differential gene expression in ovarian carcinoma: identification of potential biomarkers. Am J Pathol (2004) 1.79

The molecular repertoire of the 'almighty' stem cell. Nat Rev Mol Cell Biol (2005) 1.75

Enhancer trapping in zebrafish using the Sleeping Beauty transposon. BMC Genomics (2004) 1.73

Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis. Development (2010) 1.64

Genome-wide reverse genetics framework to identify novel functions of the vertebrate secretome. PLoS One (2006) 1.60

Sleeping beauty transposon-mediated gene therapy for prolonged expression. Adv Genet (2005) 1.60

Neuroectodermal differentiation from mouse multipotent adult progenitor cells. Proc Natl Acad Sci U S A (2003) 1.59

Self-renewal and differentiation capacity of young and aged stem cells. Exp Cell Res (2008) 1.58

Gene-breaking transposon mutagenesis reveals an essential role for histone H2afza in zebrafish larval development. Mech Dev (2006) 1.53

Stem cells for ischemic brain injury: a critical review. J Comp Neurol (2009) 1.53

Revealing the role of phospholipase Cβ3 in the regulation of VEGF-induced vascular permeability. Blood (2012) 1.51

Thymidine analogs are transferred from prelabeled donor to host cells in the central nervous system after transplantation: a word of caution. Stem Cells (2005) 1.51

Mesenchymal stem cells migration homing and tracking. Stem Cells Int (2013) 1.49

Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells. J Clin Invest (2006) 1.47

Efficient transfection of embryonic and adult stem cells. Stem Cells (2004) 1.47

Nicotine response genetics in the zebrafish. Proc Natl Acad Sci U S A (2009) 1.45

Whole genome transcription profiling of Anaplasma phagocytophilum in human and tick host cells by tiling array analysis. BMC Genomics (2008) 1.45

Wnt5 signaling in vertebrate pancreas development. BMC Biol (2005) 1.45

Comparative transcriptome analysis of embryonic and adult stem cells with extended and limited differentiation capacity. Genome Biol (2007) 1.41

Genetic determinants of hyaloid and retinal vasculature in zebrafish. BMC Dev Biol (2007) 1.40

Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells. Proc Natl Acad Sci U S A (2003) 1.40

Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair. J Clin Invest (2006) 1.39

Gene transfer efficiency and genome-wide integration profiling of Sleeping Beauty, Tol2, and piggyBac transposons in human primary T cells. Mol Ther (2010) 1.38

Combinatorial antiangiogenic gene therapy by nonviral gene transfer using the sleeping beauty transposon causes tumor regression and improves survival in mice bearing intracranial human glioblastoma. Mol Ther (2005) 1.38

Syndecan-2 is essential for angiogenic sprouting during zebrafish development. Blood (2003) 1.38

Identifying secretomes in people, pufferfish and pigs. Nucleic Acids Res (2004) 1.35

Expression of VE-cadherin in zebrafish embryos: a new tool to evaluate vascular development. Dev Dyn (2004) 1.34

The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish. Blood (2006) 1.34

Neuropilin-1 modulates p53/caspases axis to promote endothelial cell survival. PLoS One (2007) 1.32

Immunological characteristics of human mesenchymal stem cells and multipotent adult progenitor cells. Immunol Cell Biol (2013) 1.29

Multipotent adult progenitor cells sustain function of ischemic limbs in mice. J Clin Invest (2008) 1.29

Mojo Hand, a TALEN design tool for genome editing applications. BMC Bioinformatics (2013) 1.29

Differentiation potential of human postnatal mesenchymal stem cells, mesoangioblasts, and multipotent adult progenitor cells reflected in their transcriptome and partially influenced by the culture conditions. Stem Cells (2011) 1.28

Wnt5a is required for cardiac outflow tract septation in mice. Pediatr Res (2007) 1.27

SCORE imaging: specimen in a corrected optical rotational enclosure. Zebrafish (2010) 1.26

Endothelium-mediated hepatocyte recruitment in the establishment of liver-like tissue in vitro. Tissue Eng (2006) 1.23

Laser-guided direct writing for three-dimensional tissue engineering. Biotechnol Bioeng (2005) 1.21

Messenger RNA as a source of transposase for sleeping beauty transposon-mediated correction of hereditary tyrosinemia type I. Mol Ther (2007) 1.21

Culture systems for pluripotent stem cells. J Biosci Bioeng (2005) 1.19

Dynamic gene expression after systemic delivery of plasmid DNA as determined by in vivo bioluminescence imaging. Hum Gene Ther (2005) 1.18

Defined conditions for development of functional hepatic cells from human embryonic stem cells. Stem Cells Dev (2005) 1.16

Functional genomics of Enterococcus faecalis: multiple novel genetic determinants for biofilm formation in the core genome. J Bacteriol (2009) 1.15

Lessons from morpholino-based screening in zebrafish. Brief Funct Genomics (2011) 1.14

A TALE of two nucleases: gene targeting for the masses? Zebrafish (2011) 1.14

Effects of MRI contrast agents on the stem cell phenotype. Cell Transplant (2010) 1.13

The CRISPR system--keeping zebrafish gene targeting fresh. Zebrafish (2013) 1.13

Platelet factor 4 promotes adhesion of hematopoietic progenitor cells and binds IL-8: novel mechanisms for modulation of hematopoiesis. Blood (2003) 1.13

A unique role for 6-O sulfation modification in zebrafish vascular development. Dev Biol (2005) 1.12

Zebrafish as a genomics research model. Curr Pharm Biotechnol (2004) 1.12

Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus. J Hepatol (2012) 1.11

Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells. J Exp Med (2007) 1.09

A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver. Hepatology (2008) 1.09

Cell membrane glycosylation mediates the adhesion, migration, and invasion of ovarian carcinoma cells. Clin Exp Metastasis (2003) 1.08

In vitro and in vivo arterial differentiation of human multipotent adult progenitor cells. Blood (2006) 1.08

Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells. Blood (2006) 1.08

Efficacy and safety of high-dose thromboprophylaxis in morbidly obese inpatients. Thromb Haemost (2013) 1.08

A PATO-compliant zebrafish screening database (MODB): management of morpholino knockdown screen information. BMC Bioinformatics (2008) 1.07

Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos. Dev Biol (2005) 1.07

Biology of umbilical cord blood progenitors in bone marrow niches. Blood (2007) 1.06

Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos. Cell Transplant (2003) 1.05

Syndecan-2. Int J Biochem Cell Biol (2005) 1.04

Mechanisms underlying abnormal trafficking and expansion of malignant progenitors in CML: BCR/ABL-induced defects in integrin function in CML. Oncogene (2002) 1.03

Zebrafish: a model for the study of addiction genetics. Hum Genet (2011) 1.03

Use of recombinase-based in vivo expression technology to characterize Enterococcus faecalis gene expression during infection identifies in vivo-expressed antisense RNAs and implicates the protease Eep in pathogenesis. Infect Immun (2011) 1.03

Functional analysis of zebrafish microfibril-associated glycoprotein-1 (Magp1) in vivo reveals roles for microfibrils in vascular development and function. Blood (2006) 1.02

The lineage-specific gene ponzr1 is essential for zebrafish pronephric and pharyngeal arch development. Development (2012) 1.02

Insertional mutagenesis strategies in zebrafish. Genome Biol (2007) 1.02

Stressing zebrafish for behavioral genetics. Rev Neurosci (2011) 1.02

Cryopreserved reticulocytes derived from hematopoietic stem cells can be invaded by cryopreserved Plasmodium vivax isolates. PLoS One (2012) 1.01

Emerging hurdles in stem cell therapy for peripheral vascular disease. J Mol Med (Berl) (2008) 1.00

Development and Notch signaling requirements of the zebrafish choroid plexus. PLoS One (2008) 1.00

Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS One (2010) 0.99

Functional genomics tools for the analysis of zebrafish pigment. Pigment Cell Res (2004) 0.98

Gene expression profiles in esophageal adenocarcinoma. Ann Thorac Surg (2004) 0.98