Published in Nat Rev Mol Cell Biol on June 01, 2004
A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell (2006) 6.96
(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway. Proc Natl Acad Sci U S A (2009) 6.78
The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner. Proc Natl Acad Sci U S A (2010) 6.54
The aged niche disrupts muscle stem cell quiescence. Nature (2012) 3.46
Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas. Cancer Cell (2012) 3.37
Tumor adaptation and resistance to RAF inhibitors. Nat Med (2013) 3.11
Hormonal and local control of mammary branching morphogenesis. Differentiation (2006) 2.60
Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma. J Clin Invest (2007) 2.53
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors. Cancer Discov (2012) 2.47
Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex. Proc Natl Acad Sci U S A (2010) 2.45
Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis. Nat Genet (2015) 2.43
Modeling precision treatment of breast cancer. Genome Biol (2013) 2.42
Models from experiments: combinatorial drug perturbations of cancer cells. Mol Syst Biol (2008) 2.33
Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell (2006) 2.27
Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration. Cell Stem Cell (2010) 2.03
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev (2007) 1.81
Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response. Clin Cancer Res (2010) 1.77
MicroRNA-29c is a signature microRNA under high glucose conditions that targets Sprouty homolog 1, and its in vivo knockdown prevents progression of diabetic nephropathy. J Biol Chem (2011) 1.68
Novel mechanisms of early upper and lower urinary tract patterning regulated by RetY1015 docking tyrosine in mice. Development (2012) 1.64
Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program. Genes Dev (2008) 1.59
Critical and distinct roles for key RET tyrosine docking sites in renal development. Genes Dev (2006) 1.54
Functional analysis of human hematopoietic stem cell gene expression using zebrafish. PLoS Biol (2005) 1.52
Intermolecular interactions of Sprouty proteins and their implications in development and disease. Mol Pharmacol (2009) 1.52
FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. Neural Dev (2008) 1.40
Comparative mechanisms of branching morphogenesis in diverse systems. J Mammary Gland Biol Neoplasia (2006) 1.39
c-MYC-regulated miR-23a/24-2/27a cluster promotes mammary carcinoma cell invasion and hepatic metastasis by targeting Sprouty2. J Biol Chem (2013) 1.37
FGF signaling is strictly required to maintain early telencephalic precursor cell survival. Development (2009) 1.26
Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal. BMC Dev Biol (2007) 1.21
Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Carcinogenesis (2010) 1.14
Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling. Development (2011) 1.08
Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: a severe form of human achondroplasia. Cell Signal (2008) 1.08
FGF signaling in gastrulation and neural development in Nematostella vectensis, an anthozoan cnidarian. Dev Genes Evol (2007) 1.08
Regulation of EphB2 activation and cell repulsion by feedback control of the MAPK pathway. J Cell Biol (2008) 1.07
Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure. EMBO Rep (2015) 1.07
DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation. J Cell Biol (2007) 1.06
Synergistic role of Sprouty2 inactivation and c-Met up-regulation in mouse and human hepatocarcinogenesis. Hepatology (2010) 1.05
Sprouty-2 overexpression in C2C12 cells confers myogenic differentiation properties in the presence of FGF2. Mol Biol Cell (2005) 1.05
The many faces of RET dysfunction in kidney. Organogenesis (2009) 1.05
Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects. Arterioscler Thromb Vasc Biol (2010) 1.05
Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation. Cancer Res (2009) 1.05
FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size. PLoS Genet (2011) 1.04
The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. Genes Dev (2012) 1.04
Regulation of sprouty stability by Mnk1-dependent phosphorylation. Mol Cell Biol (2006) 1.03
Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. Blood (2009) 1.03
Overexpression of Sprouty 2 in mouse lung epithelium inhibits urethane-induced tumorigenesis. Am J Respir Cell Mol Biol (2008) 1.00
MEK inhibitors as a chemotherapeutic intervention in multiple myeloma. Blood Cancer J (2013) 0.99
Sprouty-2 controls c-Met expression and metastatic potential of colon cancer cells: sprouty/c-Met upregulation in human colonic adenocarcinomas. Oncogene (2010) 0.99
Mammalian sprouty proteins assemble into large monodisperse particles having the properties of intracellular nanobatteries. Proc Natl Acad Sci U S A (2005) 0.98
Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. EMBO Rep (2005) 0.97
Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times. J Neurosci (2010) 0.97
Sprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation. FASEB J (2010) 0.97
SHP-2 is required for the maintenance of cardiac progenitors. Development (2007) 0.96
Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis. PLoS One (2009) 0.96
Xema, a foxi-class gene expressed in the gastrula stage Xenopus ectoderm, is required for the suppression of mesendoderm. Development (2005) 0.96
The developing story of Sprouty and cancer. Cancer Metastasis Rev (2014) 0.96
Sprouty is a negative regulator of transforming growth factor β-induced epithelial-to-mesenchymal transition and cataract. Mol Med (2012) 0.95
Molecular pathways: adaptive kinome reprogramming in response to targeted inhibition of the BRAF-MEK-ERK pathway in cancer. Clin Cancer Res (2014) 0.94
Characterisation of a new regulator of BDNF signalling, Sprouty3, involved in axonal morphogenesis in vivo. Development (2010) 0.94
Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells. Development (2014) 0.92
A novel role of Sprouty 2 in regulating cellular apoptosis. J Biol Chem (2007) 0.92
Adaptive resistance to RAF inhibitors in melanoma. Pigment Cell Melanoma Res (2014) 0.91
Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses. J Biol Chem (2012) 0.90
Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling. Dev Biol (2011) 0.89
Sef and Sprouty expression in the developing ocular lens: implications for regulating lens cell proliferation and differentiation. Semin Cell Dev Biol (2006) 0.89
Fibroblast growth factor signaling in mammalian tooth development. Odontology (2013) 0.88
Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells. Biol Reprod (2009) 0.88
Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease. Nat Rev Mol Cell Biol (2016) 0.87
Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning. Nat Cell Biol (2009) 0.87
Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors. Cereb Cortex (2013) 0.87
Sprouty 2 regulates DNA damage-induced apoptosis in Ras-transformed human fibroblasts. J Biol Chem (2008) 0.87
Targeting oncogenic BRAF in human cancer. Curr Top Microbiol Immunol (2012) 0.86
Sprouty genes regulate proliferation and survival of human embryonic stem cells. Sci Rep (2013) 0.86
Gephyrin phosphorylation in the functional organization and plasticity of GABAergic synapses. Front Cell Neurosci (2014) 0.85
SPRED proteins provide a NF-ty link to Ras suppression. Genes Dev (2012) 0.84
Gli3 controls corpus callosum formation by positioning midline guideposts during telencephalic patterning. Cereb Cortex (2012) 0.84
Mnk kinase pathway: Cellular functions and biological outcomes. World J Biol Chem (2014) 0.84
Lrp4: A novel modulator of extracellular signaling in craniofacial organogenesis. Am J Med Genet A (2010) 0.84
Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction. Mol Cell Biol (2011) 0.83
Initial report on differential expression of sprouty proteins 1 and 2 in human epithelial ovarian cancer cell lines. J Oncol (2012) 0.83
Decreased expression of Sprouty2 in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder: a correlation with BDNF expression. PLoS One (2008) 0.82
Autoregulatory loop between TGF-β1/miR-411-5p/SPRY4 and MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation. Cell Death Dis (2015) 0.81
Expression and functional role of sprouty-2 in breast morphogenesis. PLoS One (2013) 0.81
Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions. J Biol Chem (2010) 0.81
Directing traffic in neural cells: determinants of receptor tyrosine kinase localization and cellular responses. J Neurochem (2008) 0.81
The role of wild type RAS isoforms in cancer. Semin Cell Dev Biol (2016) 0.81
Wnt signaling in the murine diastema. Eur J Orthod (2011) 0.80
G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation. J Biol Chem (2012) 0.80
RTK/ERK pathway under natural selection associated with prostate cancer. PLoS One (2013) 0.79
Clinical and therapeutic implications of Sprouty2 feedback dysregulation in BRAF V600E-mutation-positive papillary thyroid cancer. Surgery (2013) 0.79
A high throughput messenger RNA differential display screen identifies discrete domains of gene expression and novel patterning processes along the developing neural tube. BMC Dev Biol (2006) 0.79
Sprouty is a cytoplasmic target of adenoviral E1A oncoproteins to regulate the receptor tyrosine kinase signalling pathway. Virol J (2011) 0.79
The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation. Proc Natl Acad Sci U S A (2016) 0.79
Compensatory regulation of the size of the inner ear in response to excess induction of otic progenitors by fibroblast growth factor signaling. Dev Dyn (2014) 0.78
MT1-MMP dependent repression of the tumor suppressor SPRY4 contributes to MT1-MMP driven melanoma cell motility. Oncotarget (2015) 0.78
Change or die: targeting adaptive signaling to kinase inhibition in cancer cells. Biochem Pharmacol (2014) 0.78
DA-Raf-Mediated Suppression of the Ras--ERK Pathway Is Essential for TGF-β1-Induced Epithelial-Mesenchymal Transition in Alveolar Epithelial Type 2 Cells. PLoS One (2015) 0.78
Regulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1. PLoS One (2012) 0.78
ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition. Cell Rep (2017) 0.78
Tissue-specific expression of Sprouty1 in mice protects against high-fat diet-induced fat accumulation, bone loss and metabolic dysfunction. Br J Nutr (2011) 0.77
The difference in biological properties between parental and v-Ha-ras transformed NIH3T3 cells. Cancer Res Treat (2009) 0.77
RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer (2011) 6.45
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature (2013) 4.71
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nat Genet (2006) 4.68
Redox-dependent downregulation of Rho by Rac. Nat Cell Biol (2003) 4.46
Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell (2004) 4.23
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell (2012) 4.16
Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nat Cell Biol (2007) 3.68
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell (2003) 3.66
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol (2002) 3.00
Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol (2008) 2.82
Regulating the regulator: post-translational modification of RAS. Nat Rev Mol Cell Biol (2011) 2.81
In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. J Clin Invest (2009) 2.53
Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature (2007) 2.43
Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell (2004) 2.38
Role of boundary conditions in an experimental model of epithelial wound healing. Am J Physiol Cell Physiol (2006) 2.01
An orthosteric inhibitor of the Ras-Sos interaction. Nat Chem Biol (2011) 1.91
MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med (2012) 1.82
Differential modification of Ras proteins by ubiquitination. Mol Cell (2006) 1.80
Regulation of ras signaling dynamics by Sos-mediated positive feedback. Curr Biol (2006) 1.70
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell (2010) 1.58
A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci U S A (2006) 1.57
hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl. Curr Biol (2003) 1.52
Ras/MAPK signaling from endomembranes. Mol Oncol (2009) 1.51
A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology (2006) 1.48
Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes Dev (2003) 1.48
Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin Cancer Res (2008) 1.43
The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proc Natl Acad Sci U S A (2008) 1.42
Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor. J Leukoc Biol (2009) 1.37
Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene. Radiat Res (2003) 1.35
The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins. Proc Natl Acad Sci U S A (2002) 1.33
The structural basis for the transition from Ras-GTP to Ras-GDP. Proc Natl Acad Sci U S A (2002) 1.32
Design, synthesis, and biological evaluation of new-generation taxoids. J Med Chem (2008) 1.29
Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination. Curr Biol (2010) 1.27
Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis. Nat Commun (2012) 1.26
Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells. Cancer Res (2004) 1.23
The two hats of SOS. Sci STKE (2002) 1.22
Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc Natl Acad Sci U S A (2010) 1.22
VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression. Cancer Res (2012) 1.21
Structure of the G60A mutant of Ras: implications for the dominant negative effect. J Biol Chem (2005) 1.21
Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless. Proc Natl Acad Sci U S A (2005) 1.20
Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems. Methods Enzymol (2006) 1.19
Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between. Cell Res (2005) 1.13
Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless. Structure (2003) 1.12
Spatial regulation of EGFR signaling by Sprouty2. Curr Biol (2007) 1.09
EZH2 couples pancreatic regeneration to neoplastic progression. Genes Dev (2012) 1.07
Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy. Biol Blood Marrow Transplant (2002) 1.05
Regulation of sprouty stability by Mnk1-dependent phosphorylation. Mol Cell Biol (2006) 1.03
Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. Blood (2009) 1.03
Fibronectin growth factor-binding domains are required for fibroblast survival. J Invest Dermatol (2010) 1.02
Regulation of RAS oncogenicity by acetylation. Proc Natl Acad Sci U S A (2012) 1.02
The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation. Mol Cell Biol (2002) 0.98
Allosteric gating of Son of sevenless activity by the histone domain. Proc Natl Acad Sci U S A (2010) 0.98
Ras and Rac as activators of reactive oxygen species (ROS). Methods Mol Biol (2002) 0.98
Signaling endosomes: seeing is believing. Curr Opin Cell Biol (2010) 0.95
Characterization of a Ras mutant with identical GDP- and GTP-bound structures . Biochemistry (2009) 0.89
Spry2 expression correlates with BRAF mutation in thyroid cancer. Surgery (2010) 0.88
Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. J Clin Invest (2013) 0.88
Autoinhibition of Sos by intramolecular interactions. Front Biosci (2002) 0.84
Ras oncogene and inflammation: partners in crime. Cell Cycle (2005) 0.83
Microdissection and culture of murine pancreatic ductal epithelial cells. Methods Mol Biol (2013) 0.81
Analysis of Ras:RasGEF interactions by phage display and static multi-angle light scattering. Methods (2005) 0.81
Clinical and therapeutic implications of Sprouty2 feedback dysregulation in BRAF V600E-mutation-positive papillary thyroid cancer. Surgery (2013) 0.79
Perturbation of cytoskeleton dynamics by the opposing effects of Rac1 and Rac1b. Small GTPases (2010) 0.79
Raf-1 and squamous cell carcinoma: Rok-ing the boat. Cancer Cell (2009) 0.78
Mapping cellular routes of Ras: a ubiquitin trail. Cell Cycle (2006) 0.77
Escorting Ras. Small GTPases (2012) 0.76
Biochemical and biophysical analyses of Ras modification by ubiquitin. Methods Enzymol (2008) 0.75