Published in Ann N Y Acad Sci on June 01, 2005
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32
Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation (2011) 2.21
Parameter sensitivity analysis in electrophysiological models using multivariable regression. Biophys J (2009) 1.96
Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity. Pharmacol Ther (2009) 1.63
Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. Biochem Biophys Res Commun (2008) 1.57
Bisphenol A and 17β-estradiol promote arrhythmia in the female heart via alteration of calcium handling. PLoS One (2011) 1.26
Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation. Circ Res (2014) 1.22
Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease. Circ Res (2014) 1.06
Fixing ryanodine receptor Ca leak - a novel therapeutic strategy for contractile failure in heart and skeletal muscle. Drug Discov Today Dis Mech (2010) 1.04
Rapid estrogen receptor-mediated mechanisms determine the sexually dimorphic sensitivity of ventricular myocytes to 17β-estradiol and the environmental endocrine disruptor bisphenol A. Endocrinology (2011) 1.04
Molecular basis of diastolic dysfunction. Heart Fail Clin (2008) 0.97
Functional characterization of TNNC1 rare variants identified in dilated cardiomyopathy. J Biol Chem (2011) 0.92
Targeting ryanodine receptors for anti-arrhythmic therapy. Acta Pharmacol Sin (2011) 0.88
The molecular basis of catecholaminergic polymorphic ventricular tachycardia: what are the different hypotheses regarding mechanisms? Heart Rhythm (2006) 0.83
CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release. Heart Rhythm (2010) 0.82
Impact of Mendelian inheritance in cardiovascular disease. Ann N Y Acad Sci (2010) 0.80
[Primary electrical heart disease in adulthood--electrophysiological findings and therapy]. Herzschrittmacherther Elektrophysiol (2005) 0.77
Illicit organogenesis: Methods and substances of doping and manipulation. Organogenesis (2008) 0.76
Extinguishing intracellular calcium leak: a promising antiarrhythmic approach. Heart Rhythm (2012) 0.75
The Relationship between Estrogen and Nitric Oxide in the Prevention of Cardiac and Vascular Anomalies in the Developing Zebrafish (Danio Rerio). Brain Sci (2016) 0.75
Mechanisms of SR calcium release in healthy and failing human hearts. Biophys Rev (2014) 0.75
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol (2003) 6.34
Rescuing the NIH before it is too late. J Clin Invest (2006) 4.85
FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell (2003) 4.68
Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science (2002) 4.49
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res (2004) 4.11
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science (2004) 3.45
Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat Med (2009) 3.27
Intracellular calcium release and cardiac disease. Annu Rev Physiol (2005) 3.14
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell (2005) 3.01
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A (2006) 2.81
Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation (2004) 2.69
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol (2009) 2.66
Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation (2003) 2.57
Use of rapamycin slows progression of cardiac transplantation vasculopathy. Circulation (2003) 2.46
Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. J Clin Invest (2008) 2.45
The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model. J Clin Invest (2002) 2.26
SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes. Circ Res (2010) 2.24
Differential cardiac remodeling in preload versus afterload. Circulation (2010) 2.20
Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity. Proc Natl Acad Sci U S A (2008) 2.16
Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation (2005) 2.15
Modulation of the ryanodine receptor and intracellular calcium. Annu Rev Biochem (2007) 2.14
Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab (2011) 2.06
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A (2005) 1.99
A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors. Heart Rhythm (2007) 1.98
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A (2006) 1.87
Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia. Circ Res (2012) 1.80
PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure. J Cell Biol (2003) 1.78
Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice. J Clin Invest (2010) 1.77
Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction. Cell (2012) 1.75
Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol. J Biol Chem (2002) 1.73
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy. Proc Natl Acad Sci U S A (2010) 1.67
Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins. Hum Mol Genet (2008) 1.64
Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure. Proc Natl Acad Sci U S A (2010) 1.63
Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. J Clin Invest (2010) 1.60
A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J Clin Invest (2014) 1.52
Vascular smooth muscle cell proliferation in restenosis. Circ Cardiovasc Interv (2011) 1.52
Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. Cell Metab (2012) 1.51
Desperately seeking diversity. J Clin Invest (2005) 1.50
Stimulated emission depletion live-cell super-resolution imaging shows proliferative remodeling of T-tubule membrane structures after myocardial infarction. Circ Res (2012) 1.47
How to support the basic sciences. J Clin Invest (2005) 1.46
Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. J Clin Invest (2011) 1.41
Calcium release channel RyR2 regulates insulin release and glucose homeostasis. J Clin Invest (2015) 1.38
Ryanodine receptor channelopathies. Pflugers Arch (2010) 1.33
Altered function and regulation of cardiac ryanodine receptors in cardiac disease. Trends Biochem Sci (2003) 1.31
Cardiac ryanodine receptor function and regulation in heart disease. Ann N Y Acad Sci (2004) 1.27
Stressed out: the skeletal muscle ryanodine receptor as a target of stress. J Clin Invest (2008) 1.24
Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging. Curr Mol Pharmacol (2015) 1.18
Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nat Rev Drug Discov (2004) 1.17
Ca2+ cycling and new therapeutic approaches for heart failure. Circulation (2010) 1.16
A guide for the perplexed: towards an understanding of the molecular basis of heart failure. Circulation (2003) 1.14
Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor p27Kip1. J Biol Chem (2010) 1.14
Imaging atrial arrhythmic intracellular calcium in intact heart. J Mol Cell Cardiol (2013) 1.14
Left ventricular assist device support normalizes left and right ventricular beta-adrenergic pathway properties. J Am Coll Cardiol (2005) 1.13
Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proc Natl Acad Sci U S A (2006) 1.13
Protein kinase A and two phosphatases are components of the inositol 1,4,5-trisphosphate receptor macromolecular signaling complex. J Biol Chem (2002) 1.09
The ryanodine receptor in cardiac physiology and disease. Adv Pharmacol (2010) 1.09
Drug-eluting stents. Annu Rev Med (2004) 1.09
Dysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseases. J Mol Cell Cardiol (2013) 1.08
Reprogramming of the microRNA transcriptome mediates resistance to rapamycin. J Biol Chem (2013) 1.06
Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion. Proc Natl Acad Sci U S A (2011) 1.05
Regulation of the type 1 inositol 1,4,5-trisphosphate receptor by phosphorylation at tyrosine 353. J Biol Chem (2004) 1.05
Fixing ryanodine receptor Ca leak - a novel therapeutic strategy for contractile failure in heart and skeletal muscle. Drug Discov Today Dis Mech (2010) 1.04
Rescuing the NIH: the response. J Clin Invest (2006) 1.04
Rapamycin resistance is linked to defective regulation of Skp2. Cancer Res (2012) 1.04
Regulation of ryanodine receptors in the heart. Circ Res (2007) 1.00
Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochem Biophys Res Commun (2004) 1.00
Stress-induced increase in skeletal muscle force requires protein kinase A phosphorylation of the ryanodine receptor. J Physiol (2012) 0.97
A novel ryanodine receptor mutation linked to sudden death increases sensitivity to cytosolic calcium. Circ Res (2011) 0.96
A function for tyrosine phosphorylation of type 1 inositol 1,4,5-trisphosphate receptor in lymphocyte activation. J Cell Biol (2007) 0.96
Nonshivering thermogenesis protects against defective calcium handling in muscle. FASEB J (2008) 0.95
Leaky ryanodine receptors in β-sarcoglycan deficient mice: a potential common defect in muscular dystrophy. Skelet Muscle (2012) 0.95
Molecular BKology: the study of splicing and dicing. Sci STKE (2002) 0.95
Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes. FASEB J (2011) 0.94
Ryanodine receptor studies using genetically engineered mice. FEBS Lett (2010) 0.92
Immunophilins and coupled gating of ryanodine receptors. Curr Top Med Chem (2003) 0.91
Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors. Proc Natl Acad Sci U S A (2008) 0.90
The economy of science. J Clin Invest (2004) 0.90
Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes. J Cell Sci (2014) 0.89
Regulation of the ryanodine receptor in heart failure. Basic Res Cardiol (2002) 0.88
K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Res Cardiol (2009) 0.87
Calcium release channel RyR2 regulates insulin release and glucose homeostasis. J Clin Invest (2015) 0.87
Clinical implications of cardiac ryanodine receptor/calcium release channel mutations linked to sudden cardiac death. Circulation (2002) 0.86
Molecular determinants of altered contractility in heart failure. Ann Med (2004) 0.86
Manipulating L-type calcium channels in cardiomyocytes using split-intein protein transsplicing. Proc Natl Acad Sci U S A (2013) 0.85
Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency. J Vet Cardiol (2008) 0.85
Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion. Cardiovasc Res (2012) 0.85