Published in Cell on August 31, 2012
Structure of a mammalian ryanodine receptor. Nature (2014) 1.61
Ryanodine Receptor Activation Induces Long-Term Plasticity of Spine Calcium Dynamics. PLoS Biol (2015) 1.44
Dysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseases. J Mol Cell Cardiol (2013) 1.08
Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: from adaptive responses to psychopathologies. Neurobiol Learn Mem (2013) 0.96
Physiology and pathophysiology of excitation-contraction coupling: the functional role of ryanodine receptor. J Muscle Res Cell Motil (2017) 0.89
Endoplasmic reticulum calcium stores in dendritic spines. Front Neuroanat (2014) 0.85
cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex. Proc Natl Acad Sci U S A (2014) 0.85
Ryanodine receptors: physiological function and deregulation in Alzheimer disease. Mol Neurodegener (2014) 0.82
Structural basis of conformational transitions in the active site and 80's loop in the FK506-binding protein FKBP12. Biochem J (2014) 0.80
Short-coupled polymorphic ventricular tachycardia at rest linked to a novel ryanodine receptor (RyR2) mutation: leaky RyR2 channels under non-stress conditions. Int J Cardiol (2014) 0.79
Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Neurosci Lett (2014) 0.79
Chronic cocaine disrupts mesocortical learning mechanisms. Brain Res (2015) 0.78
Intracellular calcium release channels: an update. J Physiol (2017) 0.78
RYR2, PTDSS1 and AREG genes are implicated in a Lebanese population-based study of copy number variation in autism. Sci Rep (2016) 0.77
Crystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6. Acta Crystallogr D Biol Crystallogr (2014) 0.77
Heat shock response and ionstasis: axis against neurodegeneration. Aging (Albany NY) (2012) 0.77
Emerging pathways driving early synaptic pathology in Alzheimer's disease. Biochem Biophys Res Commun (2016) 0.76
Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons. Biochim Biophys Acta (2013) 0.76
Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect. Sci Rep (2015) 0.76
Receptors: Leaky receptors in stressed brains. Nat Rev Neurosci (2012) 0.75
mGluR long-term depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum. EMBO J (2016) 0.75
Knockout of the BK β4-subunit promotes a functional coupling of BK channels and ryanodine receptors that mediate a fAHP-induced increase in excitability. J Neurophysiol (2016) 0.75
Axonal Endoplasmic Reticulum Ca(2+) Content Controls Release Probability in CNS Nerve Terminals. Neuron (2017) 0.75
Calstabin 2: An important regulator for learning and memory in mice. Sci Rep (2016) 0.75
Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol (2003) 18.97
Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods (1984) 16.43
Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev (2007) 11.15
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell (2000) 10.25
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods (1985) 9.05
Glutamate neurotoxicity and diseases of the nervous system. Neuron (1988) 8.26
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem (1999) 7.94
Neuronal calcium signaling. Neuron (1998) 7.03
From marrow to brain: expression of neuronal phenotypes in adult mice. Science (2000) 6.53
In vivo dendritic calcium dynamics in neocortical pyramidal neurons. Nature (1997) 6.33
Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol (2008) 4.82
Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science (1995) 4.25
The stressed hippocampus, synaptic plasticity and lost memories. Nat Rev Neurosci (2002) 4.14
Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann N Y Acad Sci (2004) 4.13
Stress and cognitive function. Curr Opin Neurobiol (1995) 4.12
Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'. Nat Protoc (2006) 3.71
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science (2004) 3.45
Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat Med (2009) 3.27
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science (2007) 3.13
Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci (1988) 3.13
Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation. Neuron (1998) 3.08
Calcium and neurodegeneration. Aging Cell (2007) 2.90
The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues. J Cell Biol (1995) 2.87
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A (2006) 2.81
Neuroendocrine pharmacology of stress. Eur J Pharmacol (2003) 2.77
Stress and adult neurogenesis. Hippocampus (2006) 2.74
Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase. Neuron (2001) 2.59
FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure. Circulation (2003) 2.57
Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis. Endocrinology (2004) 2.50
Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. J Clin Invest (2008) 2.45
Induction of deltaFosB in reward-related brain structures after chronic stress. J Neurosci (2004) 2.27
Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity. Proc Natl Acad Sci U S A (2008) 2.16
Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab (2011) 2.06
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A (2005) 1.99
Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biol Psychiatry (1999) 1.97
Relationship between posttraumatic stress disorder characteristics of Holocaust survivors and their adult offspring. Am J Psychiatry (1998) 1.96
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A (2006) 1.87
PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure. J Cell Biol (2003) 1.78
Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice. J Clin Invest (2010) 1.77
Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol. J Biol Chem (2002) 1.73
Calcium hypothesis of Alzheimer's disease and brain aging. Ann N Y Acad Sci (1994) 1.69
Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation. Annu Rev Neurosci (1989) 1.65
Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. J Clin Invest (2010) 1.60
Regulation of pituitary ACTH secretion during chronic stress. Front Neuroendocrinol (1994) 1.48
4- to 6-week-old adult-born hippocampal neurons influence novelty-evoked exploration and contextual fear conditioning. Hippocampus (2011) 1.47
Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. J Neurosci (1993) 1.44
Establishing an agenda for translational research on PTSD. Ann N Y Acad Sci (2006) 1.36
Defects in ryanodine receptor calcium release in skeletal muscle from post-myocardial infarct rats. FASEB J (2003) 1.35
Calcium hypothesis of Alzheimer's disease. Pflugers Arch (2009) 1.33
Cardiac ryanodine receptor function and regulation in heart disease. Ann N Y Acad Sci (2004) 1.27
Stressed out: the skeletal muscle ryanodine receptor as a target of stress. J Clin Invest (2008) 1.24
Post-traumatic stress disorder: the neurobiological impact of psychological trauma. Dialogues Clin Neurosci (2011) 1.22
Calcium stores and synaptic plasticity. Cell Calcium (2003) 1.05
Late memory-related genes in the hippocampus revealed by RNA fingerprinting. Proc Natl Acad Sci U S A (1997) 1.03
Spatial learning induced changes in expression of the ryanodine type II receptor in the rat hippocampus. FASEB J (2000) 1.03
Alterations in neuronal calcium levels are associated with cognitive deficits after traumatic brain injury. Neurosci Lett (2008) 1.02
Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory. Learn Mem (2008) 0.99
Inositol 1,4,5-triphosphate receptors and NAD(P)H mediate Ca2+ signaling required for hypoxic preconditioning of hippocampal neurons. Neuroscience (2009) 0.94
Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes. Learn Mem (2008) 0.93
Regulation of tyrosine hydroxylase and dopamine beta-hydroxylase mRNA levels in rat adrenals by a single and repeated immobilization stress. J Neurochem (1992) 0.92
Enhanced dopamine uptake in the striatum following repeated restraint stress. Synapse (2005) 0.91
Identifying the stress transcriptome in the adrenal medulla following acute and repeated immobilization. Ann N Y Acad Sci (2008) 0.90
Paradoxical kinesia in parkinsonism is not caused by dopamine release. Studies in an animal model. Arch Neurol (1989) 0.89
Differential effects of stress on gene transcription factors in catecholaminergic systems. Ann N Y Acad Sci (2004) 0.87
Increased susceptibility to transcriptional changes with novel stressor in adrenal medulla of rats exposed to prolonged cold stress. Brain Res Mol Brain Res (2005) 0.86
The restraint stress-induced reduction in lymphocyte cell number in lymphoid organs correlates with the suppression of in vivo antibody production. J Neuroimmunol (1997) 0.82
[Somatic factors in cognitive impairment]. Fortschr Neurol Psychiatr (2009) 0.80
Differential changes in noradrenaline turnover in specific regions of rat brain produced by controllable and uncontrollable shocks. Behav Neurosci (1985) 0.78
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science (2003) 16.14
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol (2003) 6.34
Rescuing the NIH before it is too late. J Clin Invest (2006) 4.85
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science (2004) 4.81
FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell (2003) 4.68
Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science (2002) 4.49
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res (2004) 4.11
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med (2008) 3.69
Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. J Neurosci (2006) 3.69
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science (2004) 3.45
Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat Med (2009) 3.27
Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J Neurosci (2008) 3.21
Intracellular calcium release and cardiac disease. Annu Rev Physiol (2005) 3.14
Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory. Cell (2006) 3.01
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell (2005) 3.01
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A (2006) 2.81
Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation (2004) 2.69
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol (2009) 2.66
Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation (2003) 2.57
Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proc Natl Acad Sci U S A (2002) 2.57
Use of rapamycin slows progression of cardiac transplantation vasculopathy. Circulation (2003) 2.46
Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. J Clin Invest (2008) 2.45
The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model. J Clin Invest (2002) 2.26
Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity. Proc Natl Acad Sci U S A (2008) 2.16
Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation (2005) 2.15
Modulation of the ryanodine receptor and intracellular calcium. Annu Rev Biochem (2007) 2.14
Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. J Clin Invest (2004) 2.13
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc Natl Acad Sci U S A (2008) 2.09
Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab (2011) 2.06
FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell (2012) 2.03
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A (2005) 1.99
A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors. Heart Rhythm (2007) 1.98
ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction. FASEB J (2005) 1.89
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A (2006) 1.87
Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice. Ann Neurol (2004) 1.87
A GluR1-cGKII interaction regulates AMPA receptor trafficking. Neuron (2007) 1.83
Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia. Circ Res (2012) 1.80
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest (2008) 1.79
PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure. J Cell Biol (2003) 1.78
Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice. J Clin Invest (2010) 1.77
Quarky calcium release in the heart. Circ Res (2010) 1.75
Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circ Res (2010) 1.74
Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol. J Biol Chem (2002) 1.73
Reversal of long-term dendritic spine alterations in Alzheimer disease models. Proc Natl Acad Sci U S A (2009) 1.69
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy. Proc Natl Acad Sci U S A (2010) 1.67
Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction. J Neurosci (2008) 1.67
Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure. Proc Natl Acad Sci U S A (2010) 1.63
Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. J Clin Invest (2010) 1.60
alpha-Synuclein produces a long-lasting increase in neurotransmitter release. EMBO J (2004) 1.54
Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome. Proc Natl Acad Sci U S A (2008) 1.54
A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J Clin Invest (2014) 1.52
Vascular smooth muscle cell proliferation in restenosis. Circ Cardiovasc Interv (2011) 1.52
Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. Cell Metab (2012) 1.51
Desperately seeking diversity. J Clin Invest (2005) 1.50
Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. J Neurosci (2010) 1.49
Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity. J Neurosci (2005) 1.47
How to support the basic sciences. J Clin Invest (2005) 1.46
Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism. Nat Neurosci (2008) 1.46
Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. J Clin Invest (2011) 1.41
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. J Pharmacol Exp Ther (2008) 1.41
Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model. J Neurosci (2009) 1.39
RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer's disease. Curr Mol Med (2007) 1.38
Calcium release channel RyR2 regulates insulin release and glucose homeostasis. J Clin Invest (2015) 1.38
Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory. Ann Neurol (2011) 1.35
Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease. J Alzheimers Dis (2009) 1.34
Ryanodine receptor channelopathies. Pflugers Arch (2010) 1.33
BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci (2006) 1.33
Ryanodine receptor-targeted anti-arrhythmic therapy. Ann N Y Acad Sci (2005) 1.31
Altered function and regulation of cardiac ryanodine receptors in cardiac disease. Trends Biochem Sci (2003) 1.31
Cardiac ryanodine receptor function and regulation in heart disease. Ann N Y Acad Sci (2004) 1.27
Bidirectional regulation of Ca2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes. Cardiovasc Res (2007) 1.26
Noninvasive neuron pinning with nanopillar arrays. Nano Lett (2010) 1.26
Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation. EMBO J (2003) 1.25
Stressed out: the skeletal muscle ryanodine receptor as a target of stress. J Clin Invest (2008) 1.24
Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease. Am J Pathol (2004) 1.24
Presynaptic CaMKII is necessary for synaptic plasticity in cultured hippocampal neurons. Neuron (2004) 1.22
Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia. Neuropsychopharmacology (2009) 1.20
β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia. EMBO Mol Med (2012) 1.20
Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging. Curr Mol Pharmacol (2015) 1.18
Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nat Rev Drug Discov (2004) 1.17
Ca2+ cycling and new therapeutic approaches for heart failure. Circulation (2010) 1.16
Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release. J Biol Chem (2007) 1.15
A guide for the perplexed: towards an understanding of the molecular basis of heart failure. Circulation (2003) 1.14
Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor p27Kip1. J Biol Chem (2010) 1.14
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis. J Neurosci (2010) 1.14
Imaging atrial arrhythmic intracellular calcium in intact heart. J Mol Cell Cardiol (2013) 1.14