Published in Protein J on April 01, 2005
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology (2005) 4.35
Retracted Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J Biol Chem (2009) 1.88
Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway. Diabetologia (2005) 1.28
Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action. FASEB J (2007) 1.17
Retracted Inflammation of the hypothalamus leads to defective pancreatic islet function. J Biol Chem (2011) 1.16
Proteome analysis of the plant pathogen Xylella fastidiosa reveals major cellular and extracellular proteins and a peculiar codon bias distribution. Proteomics (2003) 1.16
Binding studies of alpha-GalNAc-specific lectins to the alpha-GalNAc (Tn-antigen) form of porcine submaxillary mucin and its smaller fragments. J Biol Chem (2007) 1.06
Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanisms. Endocrinology (2012) 1.06
Participation of prolactin receptors and phosphatidylinositol 3-kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to glucose during pregnancy. J Endocrinol (2004) 1.02
The clock gene Rev-erbα regulates pancreatic β-cell function: modulation by leptin and high-fat diet. Endocrinology (2011) 1.00
Potential of KM+ lectin in immunization against Leishmania amazonensis infection. Vaccine (2006) 1.00
High doses of dexamethasone induce increased beta-cell proliferation in pancreatic rat islets. Am J Physiol Endocrinol Metab (2009) 0.99
Structural, enzymatic and biological properties of new PLA(2) isoform from Crotalus durissus terrificus venom. Toxicon (2003) 0.96
Crystallization and preliminary X-ray diffraction analysis of the lectin from Canavalia gladiata seeds. Acta Crystallogr D Biol Crystallogr (2004) 0.96
Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors. Am J Physiol (1995) 0.94
Binding of netropsin to several DNA constructs: evidence for at least two different 1:1 complexes formed from an -AATT-containing ds-DNA construct and a single minor groove binding ligand. Biophys Chem (2006) 0.93
Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats. Endocrinology (2003) 0.92
HCA and HML isolated from the red marine algae Hypnea cervicornis and Hypnea musciformis define a novel lectin family. Protein Sci (2005) 0.92
Pharmacological and structural characterization of a novel phospholipase A2 from Micrurus dumerilii carinicauda venom. Toxicon (2005) 0.92
Identification of insulin in the tear film and insulin receptor and IGF-1 receptor on the human ocular surface. Invest Ophthalmol Vis Sci (2002) 0.92
Hypoglycaemic activity and molecular mechanisms of Caesalpinia ferrea Martius bark extract on streptozotocin-induced diabetes in Wistar rats. J Ethnopharmacol (2011) 0.92
Ciliary neurotrophic factor (CNTF) protects non-obese Swiss mice against type 2 diabetes by increasing beta cell mass and reducing insulin clearance. Diabetologia (2012) 0.91
Short-term in vivo inhibition of insulin receptor substrate-1 expression leads to insulin resistance, hyperinsulinemia, and increased adiposity. Endocrinology (2004) 0.91
A clinico-epidemiological study of bites by spiders of the genus Phoneutria. Rev Inst Med Trop Sao Paulo (2000) 0.90
Tumor necrosis factor-alpha activates signal transduction in hypothalamus and modulates the expression of pro-inflammatory proteins and orexigenic/anorexigenic neurotransmitters. J Neurochem (2006) 0.90
Prolactin-signal transduction in neonatal rat pancreatic islets and interaction with the insulin-signaling pathway. Horm Metab Res (2003) 0.90
Ciliary neurotrophic factor (CNTF) signals through STAT3-SOCS3 pathway and protects rat pancreatic islets from cytokine-induced apoptosis. Cytokine (2009) 0.90
Antibacterial and antiparasitic effects of Bothrops marajoensis venom and its fractions: Phospholipase A2 and L-amino acid oxidase. Toxicon (2009) 0.89
Glucose- and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets. FEBS Lett (1995) 0.89
The structure of the D49 phospholipase A2 piratoxin III from Bothrops pirajai reveals unprecedented structural displacement of the calcium-binding loop: possiblerelationship to cooperative substrate binding. Acta Crystallogr D Biol Crystallogr (2003) 0.89
Isolation and preliminary enzymatic characterization of a novel PLA2 from Crotalus durissus collilineatus venom. J Protein Chem (2002) 0.89
Systemic and local myotoxicity induced by snake venom group II phospholipases A2: comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue. Toxicon (2007) 0.89
Renal alterations promoted by the lectins from Canavalia ensiformis (ConA) and Dioclea guianensis (DguiL) seeds. Protein Pept Lett (2003) 0.88
Neuromuscular activity of BaTX, a presynaptic basic PLA2 isolated from Bothrops alternatus snake venom. Comp Biochem Physiol C Toxicol Pharmacol (2009) 0.88
Peroxisome proliferator-activated receptor gamma coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion. Diabetologia (2003) 0.88
Lectin extracted from Canavalia grandiflora seeds presents potential anti-inflammatory and analgesic effects. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.88
Purification and characterization of an N-acetylglucosamine-binding lectin from Koelreuteria paniculata seeds and its effect on the larval development of Callosobruchus maculatus (Coleoptera: Bruchidae) and Anagasta kuehniella (Lepidoptera: Pyralidae). J Agric Food Chem (2003) 0.87
Inhibition of carrageenin-induced rat paw oedema by crotapotin, a polypeptide complexed with phospholipase A2. Br J Pharmacol (1995) 0.87
The untiring search for the most complete proteome representation: reviewing the methods. Brief Funct Genomic Proteomic (2008) 0.87
Glucocorticoids in vivo induce both insulin hypersecretion and enhanced glucose sensitivity of stimulus-secretion coupling in isolated rat islets. Endocrinology (2009) 0.87
cDNA cloning and 1.75 A crystal structure determination of PPL2, an endochitinase and N-acetylglucosamine-binding hemagglutinin from Parkia platycephala seeds. FEBS J (2006) 0.87
Ciliary neurotrophic factor promotes survival of neonatal rat islets via the BCL-2 anti-apoptotic pathway. J Endocrinol (2007) 0.87
Agglutinin isolated from the red marine alga Hypnea cervicornis J. Agardh reduces inflammatory hypernociception: involvement of nitric oxide. Pharmacol Biochem Behav (2010) 0.87
Isolation and enzymatic characterization of a basic phospholipase A2 from Bothrops jararacussu snake venom. J Protein Chem (2001) 0.87
Anti-diabetic activity of extract from Persea americana Mill. leaf via the activation of protein kinase B (PKB/Akt) in streptozotocin-induced diabetic rats. J Ethnopharmacol (2012) 0.87
Human neutrophil migration in vitro induced by secretory phospholipases A2: a role for cell surface glycosaminoglycans. Biochem Pharmacol (2002) 0.86
In vivo anti-inflammatory effect of a sulfated polysaccharide isolated from the marine brown algae Lobophora variegata. Pharm Biol (2010) 0.86
Structural and functional properties of BaTX, a new Lys49 phospholipase A2 homologue isolated from the venom of the snake Bothrops alternatus. Biochim Biophys Acta (2006) 0.86
Blood amino acids concentration during insulin induced hypoglycemia in rats: the role of alanine and glutamine in glucose recovery. Amino Acids (2006) 0.86
Inflammatory responses induced by poly-L-arginine in rat lungs in vivo. Agents Actions (1993) 0.86
Protein deficiency and nutritional recovery modulate insulin secretion and the early steps of insulin action in rats. J Nutr (1998) 0.86
Crystallization and preliminary X-ray diffraction analysis of a lectin from Canavalia maritima seeds. Acta Crystallogr Sect F Struct Biol Cryst Commun (2004) 0.86
Porcine spermadhesin PSP-I/PSP-II stimulates macrophages to release a neutrophil chemotactic substance: modulation by mast cells. Biol Reprod (2002) 0.86
Biochemical, pharmacological, and structural characterization of new basic PLA2 Bbil-TX from Bothriopsis bilineata snake venom. Biomed Res Int (2012) 0.86
A catalytically inactive Lys49 PLA2 isoform from Bothrops jararacussu venom that stimulates insulin secretion in pancreatic beta cells. Protein Pept Lett (2011) 0.85
Neutralizing capacity of commercial bothropic antivenom against Bothrops jararacussu venom and bothropstoxin-I. Muscle Nerve (2000) 0.85
Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade. Am J Physiol Endocrinol Metab (2002) 0.85
Biological and biochemical characterization of new basic phospholipase A(2) BmTX-I isolated from Bothrops moojeni snake venom. Toxicon (2008) 0.85
Decreased insulin secretion in islets from rats fed a low protein diet is associated with a reduced PKAalpha expression. J Nutr (2004) 0.85
Purification and characterization of the biological effects of phospholipase A(2) from sea anemone Bunodosoma caissarum. Toxicon (2009) 0.85
Biological and structural characterization of a new PLA2 from the Crotalus durissus collilineatus venom. Protein J (2005) 0.85
Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight. Endocrinology (2006) 0.85
Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.85
Leucine supplementation does not affect protein turnover and impairs the beneficial effects of endurance training on glucose homeostasis in healthy mice. Amino Acids (2015) 0.85
Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production. Int Immunopharmacol (2007) 0.84
Purification and biological effects of L-amino acid oxidase isolated from Bothrops insularis venom. Toxicon (2007) 0.84
Anti-leishmanial effects of purified compounds from aerial parts of Baccharis uncinella C. DC. (Asteraceae). Parasitol Res (2010) 0.84
Functional alterations in endocrine pancreas of rats with different degrees of dexamethasone-induced insulin resistance. Pancreas (2008) 0.84
Cholesterol reduction ameliorates glucose-induced calcium handling and insulin secretion in islets from low-density lipoprotein receptor knockout mice. Biochim Biophys Acta (2013) 0.84
Isolation and functional characterization of a new acidic PLA(2) Ba SpII RP4 of the Bothrops alternatus snake venom from Argentina. Toxicon (2010) 0.84
Neutralizing capacity of antisera raised in horses and rabbits against Crotalus durissus terrificus (South American rattlesnake) venom and its main toxin, crotoxin. Toxicon (1999) 0.84
Expression of PDX-1 is reduced in pancreatic islets from pups of rat dams fed a low protein diet during gestation and lactation. J Nutr (2002) 0.84
Presynaptic action of Bothriopsis bilineata smargadina (forest viper) venom in vitro. Toxicon (2011) 0.84
The effect of phospholipase A2 from Crotalus durissus collilineatus on Leishmania (Leishmania) amazonensis infection. Parasitol Res (2008) 0.84
Identification of two novel cytolysins from the hydrozoan Olindias sambaquiensis (Cnidaria). J Venom Anim Toxins Incl Trop Dis (2014) 0.83
Renal and antibacterial effects induced by myotoxin I and II isolated from Bothrops jararacussu venom. Toxicon (2005) 0.83
Cafeteria diet inhibits insulin clearance by reduced insulin-degrading enzyme expression and mRNA splicing. J Endocrinol (2013) 0.83
Structural and functional characterization of brazilitoxins II and III (BbTX-II and -III), two myotoxins from the venom of Bothrops brazili snake. Toxicon (2009) 0.83
A low protein diet alters gene expression in rat pancreatic islets. J Nutr (2004) 0.83
Ionic mechanisms involved in the regulation of insulin secretion by muscarinic agonists. J Membr Biol (1995) 0.83
The first crystal structure of a Mimosoideae lectin reveals a novel quaternary arrangement of a widespread domain. J Mol Biol (2005) 0.83
Endurance training stimulates growth and survival pathways and the redox balance in rat pancreatic islets. J Appl Physiol (1985) (2011) 0.83
Subsensitivity to insulin in adipocytes from rats submitted to foot-shock stress. Can J Physiol Pharmacol (2002) 0.83
Crystal structures of Cratylia floribunda seed lectin at acidic and basic pHs. Insights into the structural basis of the pH-dependent dimer-tetramer transition. J Struct Biol (2006) 0.83
Taurine supplementation enhances nutrient-induced insulin secretion in pancreatic mice islets. Diabetes Metab Res Rev (2009) 0.83
Energetics of 5-bromo-4-chloro-3-indolyl-alpha-D-mannose binding to the Parkia platycephala seed lectin and its use for MAD phasing. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.83
Novel protein from Labramia bojeri A. DC. seeds homologue to Kunitz-type trypsin inhibitor with lectin-like properties. J Agric Food Chem (2004) 0.83
Purification and biological effects of C-type lectin isolated from Bothrops insularis venom. Toxicon (2006) 0.83
Isolation of a new L-amino acid oxidase from Crotalus durissus cascavella venom. Toxicon (2005) 0.82
Modulation of the peroxiredoxin system by cytokines in insulin-producing RINm5F cells: down-regulation of PRDX6 increases susceptibility of beta cells to oxidative stress. Mol Cell Endocrinol (2013) 0.82
Restoration of insulin secretion in pancreatic islets of protein-deficient rats by reduced expression of insulin receptor substrate (IRS)-1 and IRS-2. J Endocrinol (2004) 0.82
Circulating leukocyte heat shock protein 70 (HSP70) and oxidative stress markers in rats after a bout of exhaustive exercise. Stress (2006) 0.82
Pregnancy restores insulin secretion from pancreatic islets in cafeteria diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol (2009) 0.82
Unmasking snake venom of Bothrops leucurus: purification and pharmacological and structural characterization of new PLA2 Bleu TX-III. Biomed Res Int (2013) 0.82
New insights into the complex mixture of latex cysteine peptidases in Calotropis procera. Int J Biol Macromol (2013) 0.82
Structural analysis of Tityus serrulatus Ts1 neurotoxin at atomic resolution: insights into interactions with Na+ channels. Acta Crystallogr D Biol Crystallogr (2003) 0.82
Functional and structural adaptations in the pancreatic α-cell and changes in glucagon signaling during protein malnutrition. Endocrinology (2012) 0.82
Insulin release, peripheral insulin resistance and muscle function in protein malnutrition: a role of tricarboxylic acid cycle anaplerosis. Br J Nutr (2009) 0.81