Published in J Biol Chem on January 21, 2011
Inflammatory links between obesity and metabolic disease. J Clin Invest (2011) 6.73
Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response. Nat Med (2014) 2.33
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nat Med (2013) 2.19
Obesity and type 2 diabetes: what can be unified and what needs to be individualized? J Clin Endocrinol Metab (2011) 1.63
The neurobiology of food intake in an obesogenic environment. Proc Nutr Soc (2012) 1.43
Obesity and type 2 diabetes: what can be unified and what needs to be individualized? Diabetes Care (2011) 1.31
Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes (2012) 1.27
Type 2 diabetes mellitus--an autoimmune disease? Nat Rev Endocrinol (2013) 1.06
Developmental origins of nonalcoholic fatty liver disease. Pediatr Res (2013) 1.03
Bone marrow-CNS connections: implications in the pathogenesis of diabetic retinopathy. Prog Retin Eye Res (2012) 1.01
Brain glucose sensors play a significant role in the regulation of pancreatic glucose-stimulated insulin secretion. Diabetes (2011) 0.95
microRNAs as a new mechanism regulating adipose tissue inflammation in obesity and as a novel therapeutic strategy in the metabolic syndrome. J Immunol Res (2014) 0.89
Central inflammation and leptin resistance are attenuated by ginsenoside Rb1 treatment in obese mice fed a high-fat diet. PLoS One (2014) 0.86
Loss of survival factors and activation of inflammatory cascades in brain sympathetic centers in type 1 diabetic mice. Am J Physiol Endocrinol Metab (2015) 0.81
Hypothalamic inflammation and gliosis in obesity. Curr Opin Endocrinol Diabetes Obes (2015) 0.80
Identification of optimal reference genes for RT-qPCR in the rat hypothalamus and intestine for the study of obesity. Int J Obes (Lond) (2013) 0.80
An overview of the identification and management of the metabolic syndrome in chiropractic practice. J Chiropr Med (2014) 0.79
Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity. J Neuroinflammation (2017) 0.78
Microglia activation due to obesity programs metabolic failure leading to type two diabetes. Nutr Diabetes (2017) 0.78
Fermenting soybeans with Bacillus licheniformis potentiates their capacity to improve cognitive function and glucose homeostaisis in diabetic rats with experimental Alzheimer's type dementia. Eur J Nutr (2014) 0.76
Non-Neuronal Cells in the Hypothalamic Adaptation to Metabolic Signals. Front Endocrinol (Lausanne) (2017) 0.75
Hypothalamic inflammation in obesity and metabolic disease. J Clin Invest (2017) 0.75
RNA-seq analysis of the hypothalamic transcriptome reveals the networks regulating physiopathological progress in the diabetic GK rat. Sci Rep (2016) 0.75
Beneficial Effects of Metformin and/or Salicylate on Palmitate- or TNFα-Induced Neuroinflammatory Marker and Neuropeptide Gene Regulation in Immortalized NPY/AgRP Neurons. PLoS One (2016) 0.75
Inflammation and metabolic disorders. Nature (2006) 33.33
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes (2003) 16.62
Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature (2006) 15.48
Macrophages, inflammation, and insulin resistance. Annu Rev Physiol (2010) 11.77
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia (2003) 7.88
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell (2008) 6.83
Obesity wars: molecular progress confronts an expanding epidemic. Cell (2004) 5.29
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology (2005) 4.35
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes (1995) 4.33
beta-cell failure in diabetes and preservation by clinical treatment. Endocr Rev (2007) 3.85
Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic sujbjects. J Clin Invest (1967) 3.60
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci (2009) 3.22
Autonomic regulation of islet hormone secretion--implications for health and disease. Diabetologia (2000) 3.03
Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Cell (2005) 2.63
Fatty acid signaling in the beta-cell and insulin secretion. Diabetes (2006) 2.22
The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality. Diabetologia (2009) 1.83
A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans. Diabetologia (1981) 1.63
Beta cell function and its relation to insulin action in humans: a critical appraisal. Diabetologia (2004) 1.57
Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes. Diabetologia (2010) 1.48
Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J Hepatol (2008) 1.47
ER stress in pancreatic beta cells: the thin red line between adaptation and failure. Sci Signal (2010) 1.40
Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology (2004) 1.39
p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress. J Biol Chem (2010) 1.39
Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes. Diabetes (2009) 1.33
Hypothalamic inflammation and energy homeostasis: resolving the paradox. Front Neuroendocrinol (2009) 1.24
Importance of early phase insulin secretion to intravenous glucose tolerance in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab (2001) 1.19
Diet-induced inflammation of the hypothalamus in obesity. Neuroimmunomodulation (2008) 1.18
Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action. FASEB J (2007) 1.17
Receptor-mediated adenylate cyclase-coupled mechanism for PGE2 inhibition of insulin secretion in HIT cells. Diabetes (1987) 1.13
Predominant expression of an arachidonate epoxygenase in islets of Langerhans cells in human and rat pancreas. Endocrinology (1997) 1.11
TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient--effects on leptin and insulin signaling pathways. Peptides (2007) 1.10
Role of phosphoinositide signaling in the control of insulin exocytosis. Mol Endocrinol (2005) 1.09
Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression. J Clin Invest (1993) 1.09
Overexpression of beta 2-microglobulin in transgenic mouse islet beta cells results in defective insulin secretion. Proc Natl Acad Sci U S A (1991) 1.01
Hypothalamic actions of tumor necrosis factor alpha provide the thermogenic core for the wastage syndrome in cachexia. Endocrinology (2009) 0.98
The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2. Proc Natl Acad Sci U S A (1995) 0.96
Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors. Am J Physiol (1995) 0.94
Nutrient modulation of insulin secretion. Vitam Horm (2009) 0.90
Tumor necrosis factor-alpha activates signal transduction in hypothalamus and modulates the expression of pro-inflammatory proteins and orexigenic/anorexigenic neurotransmitters. J Neurochem (2006) 0.90
Short-term inhibition of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice. Diabetologia (2005) 0.89
Peroxisome proliferator-activated receptor gamma coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion. Diabetologia (2003) 0.88
Insulin induces tyrosine phosphorylation of JAK2 in insulin-sensitive tissues of the intact rat. J Biol Chem (1996) 0.87
Intracerebroventricular injection of citrate inhibits hypothalamic AMPK and modulates feeding behavior and peripheral insulin signaling. J Endocrinol (2008) 0.86
Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight. Endocrinology (2006) 0.85
Islet cell thymidine kinase activity as indicator of islet cell proliferation in rat pancreas. Diabetes (1990) 0.83
Effects of intracerebroventricular insulin microinjection on renal sodium handling in kidney-denervated rats. Brain Res Bull (2002) 0.81
Decreased cholinergic stimulation of insulin secretion by islets from rats fed a low protein diet is associated with reduced protein kinase calpha expression. J Nutr (2003) 0.78
Retracted Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes (2007) 5.67
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology (2005) 4.35
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci (2009) 3.22
IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition. PLoS Biol (2010) 2.21
S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance. Diabetes (2005) 1.91
Retracted Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J Biol Chem (2009) 1.88
TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys. Cell Metab (2013) 1.74
High-fat diet induces apoptosis of hypothalamic neurons. PLoS One (2009) 1.73
Retracted A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss. Diabetes (2007) 1.59
Retracted Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats. Diabetes (2006) 1.57
Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation. J Physiol (2006) 1.56
Cross-talk between the insulin and leptin signaling systems in rat hypothalamus. Obes Res (2005) 1.48
Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PLoS One (2012) 1.47
Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J Hepatol (2008) 1.47
Impact of corticosteroid on intestinal injury in a gastroschisis rat model: morphometric analysis. J Pediatr Surg (2006) 1.44
Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet. J Endocrinol (2008) 1.41
[Regulation of glucose and fatty acid metabolism in skeletal muscle during contraction]. Arq Bras Endocrinol Metabol (2011) 1.39
Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats. J Physiol (2007) 1.38
Diet-induced inflammation of the hypothalamus in obesity. Neuroimmunomodulation (2008) 1.18
Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action. FASEB J (2007) 1.17
Concern Acute exercise reduces hepatic glucose production through inhibition of the Foxo1/HNF-4alpha pathway in insulin resistant mice. J Physiol (2010) 1.15
Maternal high-fat feeding through pregnancy and lactation predisposes mouse offspring to molecular insulin resistance and fatty liver. J Nutr Biochem (2011) 1.15
Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet. J Endocrinol (2007) 1.13
Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta/IRS-1 and Akt and insulin resistance in muscle of mice. Am J Physiol Endocrinol Metab (2006) 1.13
Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretion. Endocrinology (2011) 1.12
Amelioration of diet-induced diabetes mellitus by removal of visceral fat. J Endocrinol (2006) 1.12
TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient--effects on leptin and insulin signaling pathways. Peptides (2007) 1.10
Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes. Endocrinology (2007) 1.09
Retracted EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice. Diabetes (2009) 1.08
Cold exposure induces tissue-specific modulation of the insulin-signalling pathway in Rattus norvegicus. J Physiol (2003) 1.07
Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanisms. Endocrinology (2012) 1.06
Central exercise action increases the AMPK and mTOR response to leptin. PLoS One (2008) 1.05
AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus. FEBS Lett (2008) 1.04
Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver. Biol Chem (2003) 1.03
Antineoplastic effect of rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts. J Cancer Res Clin Oncol (2008) 1.03
Participation of prolactin receptors and phosphatidylinositol 3-kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to glucose during pregnancy. J Endocrinol (2004) 1.02
Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial. PLoS One (2012) 1.01
The clock gene Rev-erbα regulates pancreatic β-cell function: modulation by leptin and high-fat diet. Endocrinology (2011) 1.00
High doses of dexamethasone induce increased beta-cell proliferation in pancreatic rat islets. Am J Physiol Endocrinol Metab (2009) 0.99
Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism. Mol Cell Endocrinol (2009) 0.97
Cold-induced PGC-1alpha expression modulates muscle glucose uptake through an insulin receptor/Akt-independent, AMPK-dependent pathway. Am J Physiol Endocrinol Metab (2004) 0.96
Targeted disruption of inducible nitric oxide synthase protects against aging, S-nitrosation, and insulin resistance in muscle of male mice. Diabetes (2012) 0.96
Concern Acute exercise modulates the Foxo1/PGC-1alpha pathway in the liver of diet-induced obesity rats. J Physiol (2009) 0.95
Regulation of Cbl-associated protein/Cbl pathway in muscle and adipose tissues of two animal models of insulin resistance. Endocrinology (2003) 0.94
A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia. Endocrinology (2007) 0.94
Angiotensin II (AngII) induces the expression of suppressor of cytokine signaling (SOCS)-3 in rat hypothalamus - a mechanism for desensitization of AngII signaling. J Endocrinol (2004) 0.93
Proline homozygosity in codon 72 of p53 is a factor of susceptibility for thyroid cancer. Cancer Lett (2004) 0.93
Leptin inhibits apoptosis in thymus through a janus kinase-2-independent, insulin receptor substrate-1/phosphatidylinositol-3 kinase-dependent pathway. Endocrinology (2006) 0.93
Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats. Endocrinology (2003) 0.92
Identification of insulin in the tear film and insulin receptor and IGF-1 receptor on the human ocular surface. Invest Ophthalmol Vis Sci (2002) 0.92
Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold. Am J Physiol Endocrinol Metab (2003) 0.92
The cross-talk between angiotensin and insulin differentially affects phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-mediated signaling in rat heart: implications for insulin resistance. Endocrinology (2003) 0.91
Short-term in vivo inhibition of insulin receptor substrate-1 expression leads to insulin resistance, hyperinsulinemia, and increased adiposity. Endocrinology (2004) 0.91
Tumor necrosis factor-alpha activates signal transduction in hypothalamus and modulates the expression of pro-inflammatory proteins and orexigenic/anorexigenic neurotransmitters. J Neurochem (2006) 0.90
Ciliary neurotrophic factor (CNTF) signals through STAT3-SOCS3 pathway and protects rat pancreatic islets from cytokine-induced apoptosis. Cytokine (2009) 0.90
Altered glucose homeostasis and hepatic function in obese mice deficient for both kinin receptor genes. PLoS One (2012) 0.90
Prospective evaluation of HSV, Candida spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia. Support Care Cancer (2011) 0.90
Acute exercise reduces insulin resistance-induced TRB3 expression and amelioration of the hepatic production of glucose in the liver of diabetic mice. J Cell Physiol (2009) 0.89
Retracted Tub has a key role in insulin and leptin signaling and action in vivo in hypothalamic nuclei. Diabetes (2012) 0.89
Suppressor of cytokine signaling 3 is induced by angiotensin II in heart and isolated cardiomyocytes, and participates in desensitization. Endocrinology (2003) 0.89
The role of proliferator-activated receptor gamma coactivator-1alpha in the fatty-acid-dependent transcriptional control of interleukin-10 in hepatic cells of rodents. Metabolism (2009) 0.89
Exercise intensity, inflammatory signaling, and insulin resistance in obese rats. Med Sci Sports Exerc (2010) 0.88
UCP2 protects hypothalamic cells from TNF-alpha-induced damage. FEBS Lett (2008) 0.88
Glucocorticoids in vivo induce both insulin hypersecretion and enhanced glucose sensitivity of stimulus-secretion coupling in isolated rat islets. Endocrinology (2009) 0.87
Ciliary neurotrophic factor promotes survival of neonatal rat islets via the BCL-2 anti-apoptotic pathway. J Endocrinol (2007) 0.87
Freeze-dried jaboticaba peel powder improves insulin sensitivity in high-fat-fed mice. Br J Nutr (2013) 0.87
Exercise training reduces insulin resistance and upregulates the mTOR/p70S6k pathway in cardiac muscle of diet-induced obesity rats. J Cell Physiol (2011) 0.86
Efficient gene transfer into the mouse lung by fetal intratracheal injection of rAAV2/6.2. Mol Ther (2010) 0.86
Intracerebroventricular injection of citrate inhibits hypothalamic AMPK and modulates feeding behavior and peripheral insulin signaling. J Endocrinol (2008) 0.86
Reactive oxygen species production is increased in the peripheral blood monocytes of obese patients. Metabolism (2009) 0.86
Hypothalamic inflammation and obesity. Vitam Horm (2010) 0.85
Decreased insulin secretion in islets from rats fed a low protein diet is associated with a reduced PKAalpha expression. J Nutr (2004) 0.85
Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight. Endocrinology (2006) 0.85
Acute exercise reverses aged-induced impairments in insulin signaling in rodent skeletal muscle. Mech Ageing Dev (2010) 0.85