Published in Exp Cell Res on October 15, 2005
Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc Natl Acad Sci U S A (2006) 2.25
Claudins and the modulation of tight junction permeability. Physiol Rev (2013) 2.05
aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells. Cell (2010) 1.94
Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction. Mol Ther (2011) 1.61
Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Mol Biol Cell (2008) 1.53
The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression. PLoS One (2010) 1.10
Expression, localization, and function of junctional adhesion molecule-C (JAM-C) in human retinal pigment epithelium. Invest Ophthalmol Vis Sci (2008) 1.07
JAM-related proteins in mucosal homeostasis and inflammation. Semin Immunopathol (2014) 0.93
Genetic deletion of JAM-C reveals a role in myeloid progenitor generation. Blood (2008) 0.92
The nuclear receptor hepatocyte nuclear factor 4alpha acts as a morphogen to induce the formation of microvilli. J Cell Biol (2006) 0.90
Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones. J Cell Sci (2009) 0.89
Possible involvement of tight junctions, extracellular matrix and nuclear receptors in epithelial differentiation. J Biomed Biotechnol (2011) 0.87
Evidence for cross-reactivity of JAM-C antibodies: implications for cellular localization studies. Biol Cell (2009) 0.85
Association between genetic variants in the HNF4A gene and childhood-onset Crohn's disease. Genes Immun (2012) 0.83
Expression patterns of claudin family of tight-junction proteins in the mouse prostate. Histochem Cell Biol (2007) 0.81
The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells. PLoS One (2013) 0.80
HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation. Am J Pathol (2015) 0.78
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet (2010) 6.10
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev (2006) 5.59
The PAR-aPKC system: lessons in polarity. J Cell Sci (2006) 4.73
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol (2005) 3.30
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature (2002) 2.68
Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature (2007) 2.48
Junctional adhesion molecules (JAMs): more molecules with dual functions? J Cell Sci (2004) 2.47
c-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue). Am J Surg Pathol (2004) 2.46
aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. Curr Biol (2004) 2.40
Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol (2003) 2.38
PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest (2003) 2.23
Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol (2004) 2.19
aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. J Cell Sci (2002) 2.04
Transmembrane proteins of tight junctions. Biochim Biophys Acta (2007) 2.02
TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies. Am J Surg Pathol (2007) 1.94
TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res (2007) 1.93
Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol (2013) 1.89
Tight junctions and human diseases. Med Electron Microsc (2003) 1.87
Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol (2013) 1.86
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev (2009) 1.82
Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex. Development (2006) 1.81
Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women. J Clin Oncol (2007) 1.66
Transforming growth factor-beta induces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes. Liver Int (2007) 1.61
High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway. Clin Cancer Res (2012) 1.56
N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Nucleic Acids Res (2011) 1.55
Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells. Genes Cells (2002) 1.54
ASPP2 regulates epithelial cell polarity through the PAR complex. Curr Biol (2010) 1.54
Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Mol Biol Cell (2008) 1.53
Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene (2003) 1.50
The p53 family member genes are involved in the Notch signal pathway. J Biol Chem (2001) 1.50
The role of SMG-1 in nonsense-mediated mRNA decay. Biochim Biophys Acta (2005) 1.49
Autologous serum application in the treatment of neurotrophic keratopathy. Ophthalmology (2004) 1.48
Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells. J Cell Sci (2009) 1.45
Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells. J Cell Physiol (2006) 1.44
The comparison of solitary topical micafungin or fluconazole application in the treatment of Candida fungal keratitis. Br J Ophthalmol (2010) 1.43
Tear function and ocular surface findings in premature and term babies. Ophthalmology (2004) 1.41
Reduced expression of claudin-7 correlates with invasion and metastasis in squamous cell carcinoma of the esophagus. Hum Pathol (2006) 1.41
The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. J Neurosci (2006) 1.40
Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn (2002) 1.39
Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms. J Biochem (2003) 1.38
AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay. Sci Signal (2010) 1.38
Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation. J Cell Sci (2002) 1.35
A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep (2006) 1.35
Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity. J Cell Sci (2006) 1.33
An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics. Nat Cell Biol (2009) 1.31
Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis. Cancer Cell (2012) 1.28
The challenge of dry eye diagnosis. Clin Ophthalmol (2008) 1.28
In vivo confocal microscopy of the ocular surface: from bench to bedside. Curr Eye Res (2013) 1.27
Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer. Cancer Res (2003) 1.27
Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestine. J Histochem Cytochem (2006) 1.26
PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development (2006) 1.25
Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways. Exp Cell Res (2003) 1.22
Self-association of PAR-3-mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions. J Biol Chem (2003) 1.21
MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo. Development (2002) 1.21
The application of a new continuous functional visual acuity measurement system in dry eye syndromes. Am J Ophthalmol (2005) 1.21
Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth. Front Biosci (2008) 1.21
HLA-DR- and CD11c-positive dendritic cells penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitis. J Histochem Cytochem (2005) 1.21
Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction. Dev Biol (2005) 1.20
Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division. J Biol Chem (2005) 1.19
Fluid shear stress remodels expression and function of junctional proteins in cultured bone cells. Am J Physiol Cell Physiol (2002) 1.18
Nuclear expression of Y-box-binding protein-1 correlates with P-glycoprotein and topoisomerase II alpha expression, and with poor prognosis in synovial sarcoma. J Pathol (2003) 1.17
Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts. Mol Ther (2006) 1.17
Occludin expression decreases with the progression of human endometrial carcinoma. Hum Pathol (2004) 1.16
Cellular retinoic acid bioavailability determines epithelial integrity: Role of retinoic acid receptor alpha agonists in colitis. Mol Pharmacol (2006) 1.16
Identification of SCN3B as a novel p53-inducible proapoptotic gene. Oncogene (2004) 1.16
Malignant transformation of renal angiomyolipoma: a case report. Am J Surg Pathol (2002) 1.16
Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells. Virus Res (2011) 1.16
aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. Proc Natl Acad Sci U S A (2009) 1.15
The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors. Hum Pathol (2008) 1.14
Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease. Ann Neurol (2004) 1.14
ErbB2 expression is correlated with increased survival of patients with osteosarcoma. Cancer (2002) 1.14
Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions. Exp Cell Res (2004) 1.13
PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. J Clin Invest (2005) 1.12
Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells. Cancer Sci (2007) 1.12
Abnormal protein profiles in tears with dry eye syndrome. Am J Ophthalmol (2003) 1.12