Published in J Biol Chem on May 19, 2003
PKC and the control of localized signal dynamics. Nat Rev Mol Cell Biol (2010) 2.41
Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation. Dev Cell (2010) 1.99
The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell (2010) 1.67
Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells. J Cell Biol (2007) 1.51
Widely conserved signaling pathways in the establishment of cell polarity. Cold Spring Harb Perspect Biol (2009) 1.47
Organization of multiprotein complexes at cell-cell junctions. Histochem Cell Biol (2008) 1.33
Protein complexes that control renal epithelial polarity. Am J Physiol Renal Physiol (2011) 1.22
aPKC Cycles between Functionally Distinct PAR Protein Assemblies to Drive Cell Polarity. Dev Cell (2017) 1.10
Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism. Mol Cell Biol (2010) 1.09
A Single-Cell Biochemistry Approach Reveals PAR Complex Dynamics during Cell Polarization. Dev Cell (2017) 1.07
aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation. J Cell Biol (2012) 1.07
The PAR network: redundancy and robustness in a symmetry-breaking system. Philos Trans R Soc Lond B Biol Sci (2013) 1.06
The assembly and maintenance of epithelial junctions in C. elegans. Front Biosci (Landmark Ed) (2009) 1.01
Signaling pathways in cell polarity. Cold Spring Harb Perspect Biol (2012) 0.92
Different domains of C. elegans PAR-3 are required at different times in development. Dev Biol (2010) 0.92
Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity. Dev Cell (2012) 0.92
The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localization. EMBO J (2007) 0.91
PAR-3 oligomerization may provide an actin-independent mechanism to maintain distinct par protein domains in the early Caenorhabditis elegans embryo. Biophys J (2011) 0.88
The Mammalian Blood-Testis Barrier: Its Biology and Regulation. Endocr Rev (2015) 0.88
Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice. Am J Pathol (2007) 0.86
PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion. Cancer Res (2015) 0.84
Establishment of epithelial polarity--GEF who's minding the GAP? J Cell Sci (2014) 0.84
Radial intercalation is regulated by the Par complex and the microtubule-stabilizing protein CLAMP/Spef1. J Cell Biol (2014) 0.82
Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity. J Cell Biol (2012) 0.82
Association study between polymorphisms of the PARD3 gene and schizophrenia. Exp Ther Med (2012) 0.80
Pard3 regulates contact between neural crest cells and the timing of Schwann cell differentiation but is not essential for neural crest migration or myelination. Dev Dyn (2014) 0.77
Bazooka/PAR3 is dispensable for polarity in Drosophila follicular epithelial cells. Biol Open (2015) 0.77
Par3 Integrates Tiam1 and Phosphatidylinositol 3-Kinase Signaling to Change Apical Membrane Identity. Mol Biol Cell (2016) 0.75
Loss of Par3 promotes lung adenocarcinoma metastasis through 14-3-3ζ protein. Oncotarget (2016) 0.75
Protein clustering for cell polarity: Par-3 as a paradigm. F1000Res (2017) 0.75
Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature (2011) 5.84
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev (2006) 5.59
The PAR-aPKC system: lessons in polarity. J Cell Sci (2006) 4.73
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol (2005) 3.30
Diagnostic criteria, clinical features, and incidence of thyroid storm based on nationwide surveys. Thyroid (2012) 2.78
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature (2002) 2.68
Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature (2007) 2.48
Junctional adhesion molecules (JAMs): more molecules with dual functions? J Cell Sci (2004) 2.47
aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. Curr Biol (2004) 2.40
Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol (2003) 2.38
Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes. J Clin Invest (2012) 2.26
PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest (2003) 2.23
Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol (2004) 2.19
aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. J Cell Sci (2002) 2.04
Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol (2013) 1.89
Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol (2013) 1.86
The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity. J Cell Sci (2003) 1.84
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev (2009) 1.82
Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex. Development (2006) 1.81
Isolation of mouse pancreatic ductal progenitor cells expressing CD133 and c-Met by flow cytometric cell sorting. Gastroenterology (2006) 1.74
The effect of periocular warming on accommodation. Ophthalmology (2005) 1.74
The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells. Science (2009) 1.65
Sialyl Lewis X-dependent lung colonization of B16 melanoma cells through a selectin-like endothelial receptor distinct from E- or P-selectin. Cancer Res (2002) 1.55
N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Nucleic Acids Res (2011) 1.55
Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells. Genes Cells (2002) 1.54
ASPP2 regulates epithelial cell polarity through the PAR complex. Curr Biol (2010) 1.54
Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system. Cell Metab (2009) 1.51
Prepubertal angiotensin blockade exerts long-term therapeutic effect through sustained ATRAP activation in salt-sensitive hypertensive rats. J Hypertens (2011) 1.51
Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene (2003) 1.50
The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metabolism (2008) 1.50
The role of SMG-1 in nonsense-mediated mRNA decay. Biochim Biophys Acta (2005) 1.49
Prevalence and persistence of depression in patients with implantable cardioverter defibrillator: a 2-year longitudinal study. Pacing Clin Electrophysiol (2010) 1.48
Epoxycarotenoid-mediated synthesis of abscisic acid in Physcomitrella patens implicating conserved mechanisms for acclimation to hyperosmosis in embryophytes. New Phytol (2014) 1.48
CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. Blood (2011) 1.46
Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells. J Cell Sci (2009) 1.45
Thrombocytopenia is more severe in patients with advanced chronic hepatitis C than B with the same grade of liver stiffness and splenomegaly. J Gastroenterol (2010) 1.43
The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. J Neurosci (2006) 1.40
Diagnosis and Detection of Myocardial Injury in Active Cardiac Sarcoidosis - Significance of Myocardial Fatty Acid Metabolism and Myocardial Perfusion Mismatch. Circ J (2015) 1.39
Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn (2002) 1.39
Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms. J Biochem (2003) 1.38
AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay. Sci Signal (2010) 1.38
alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. Int J Cancer (2002) 1.36
Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation. J Cell Sci (2002) 1.35
A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep (2006) 1.35
Ocean acidification reduces sperm flagellar motility in broadcast spawning reef invertebrates. Zygote (2010) 1.34
Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity. J Cell Sci (2006) 1.33
Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. Diabetes (2009) 1.33
An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics. Nat Cell Biol (2009) 1.31
Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis. Cancer Cell (2012) 1.28
PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development (2006) 1.25
Coral larvae under ocean acidification: survival, metabolism, and metamorphosis. PLoS One (2011) 1.23
Dysferlin interacts with affixin (beta-parvin) at the sarcolemma. J Neuropathol Exp Neurol (2005) 1.23
Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth. Front Biosci (2008) 1.21
MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo. Development (2002) 1.21
Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction. Dev Biol (2005) 1.20
Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division. J Biol Chem (2005) 1.19
Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J Clin Invest (2010) 1.17
Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts. Mol Ther (2006) 1.17
Interplay between the tumor suppressor p53 and TGF beta signaling shapes embryonic body axes in Xenopus. Development (2003) 1.16
High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery. J Bone Miner Metab (2011) 1.15
aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. Proc Natl Acad Sci U S A (2009) 1.15
The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors. Hum Pathol (2008) 1.14
Tear evaporation dynamics in normal subjects and subjects with obstructive meibomian gland dysfunction. Invest Ophthalmol Vis Sci (2003) 1.14
Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease. Ann Neurol (2004) 1.14
Polysialic acid facilitates tumor invasion by glioma cells. Glycobiology (2005) 1.13
PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. J Clin Invest (2005) 1.12
Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina. J Neurosci (2005) 1.12
Role of hypothalamic AMP-kinase in food intake regulation. Nutrition (2008) 1.11
Analysis of anatomic variants of mesenteric veins by 3-dimensional portography using multidetector-row computed tomography. Am J Surg (2010) 1.11
Glycogen synthase kinase 3 β-dependent Snail degradation directs hepatocyte proliferation in normal liver regeneration. Proc Natl Acad Sci U S A (2011) 1.11
An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms. PLoS One (2009) 1.10
Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay. J Biol Chem (2007) 1.09
Effects of acidified seawater on coral calcification and symbiotic algae on the massive coral Porites australiensis. Mar Environ Res (2011) 1.09
Retroperitoneal primary mucinous adenocarcinoma with a mural nodule of anaplastic tumor: a case report and literature review. Int J Gynecol Pathol (2003) 1.08
aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation. J Cell Biol (2012) 1.07
Axon formation in neocortical neurons depends on stage-specific regulation of microtubule stability by the dual leucine zipper kinase-c-Jun N-terminal kinase pathway. J Neurosci (2011) 1.07
Lymph node metastasis in grossly apparent stages I and II epithelial ovarian cancer. Int J Gynecol Cancer (2010) 1.06
The relationship between glycemic control and plasma vascular endothelial growth factor and endothelin-1 concentration in diabetic patients. Metabolism (2004) 1.05
The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8. Genes Dev (2011) 1.05
Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human. Cancer Res (2006) 1.04
Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction. J Cell Biol (2004) 1.03
KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells. Curr Biol (2011) 1.03