Published in EMBO Rep on October 20, 2006
Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene (2008) 3.63
Adherens junction: molecular architecture and regulation. Cold Spring Harb Perspect Biol (2009) 2.45
Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev Cell (2010) 2.25
Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol (2013) 1.89
Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis. Biochim Biophys Acta (2007) 1.74
Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis. Dev Cell (2013) 1.70
The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell (2010) 1.67
Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis. Proc Natl Acad Sci U S A (2008) 1.53
Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation. Fluids Barriers CNS (2012) 1.44
Organization of multiprotein complexes at cell-cell junctions. Histochem Cell Biol (2008) 1.33
VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nat Commun (2013) 1.13
An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms. PLoS One (2009) 1.10
Distal interactions within the par3-VE-cadherin complex. Biochemistry (2010) 1.00
Dynamic microtubules produce an asymmetric E-cadherin-Bazooka complex to maintain segment boundaries. J Cell Biol (2013) 1.00
A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress. J Cell Biol (2013) 0.95
Endothelial permeability and VE-cadherin: a wacky comradeship. Cell Adh Migr (2014) 0.93
TGF-{beta}-induced MiR-491-5p expression promotes Par-3 degradation in rat proximal tubular epithelial cells. J Biol Chem (2010) 0.92
Signaling required for blood vessel maintenance: molecular basis and pathological manifestations. Int J Vasc Med (2011) 0.91
Cellular and molecular mechanisms underlying blood vessel lumen formation. Bioessays (2013) 0.87
Regulation of actin dynamics and protein trafficking during spermatogenesis--insights into a complex process. Crit Rev Biochem Mol Biol (2013) 0.86
Par-3 partitioning defective 3 homolog (C. elegans) and androgen-induced prostate proliferative shutoff associated protein genes are mutationally inactivated in prostate cancer cells. BMC Cancer (2009) 0.85
Polarizing pathways: balancing endothelial polarity, permeability, and lumen formation. Exp Cell Res (2013) 0.82
Formation of a PKCζ/β-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting. Blood (2012) 0.82
Endothelial permeability and VE-cadherin: a wacky comradeship. Cell Adh Migr (2013) 0.80
An apical actin-rich domain drives the establishment of cell polarity during cell adhesion. Histochem Cell Biol (2012) 0.78
Rab5-mediated VE-cadherin internalization regulates the barrier function of the lung microvascular endothelium. Cell Mol Life Sci (2015) 0.78
A distinct mechanism of vascular lumen formation in Xenopus requires EGFL7. PLoS One (2015) 0.78
Discs large 1 (Dlg1) scaffolding protein participates with clathrin and adaptator protein complex 1 (AP-1) in forming Weibel-Palade bodies of endothelial cells. J Biol Chem (2013) 0.76
A VE-cadherin-PAR3-α-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A(2)α in endothelial cells. Mol Biol Cell (2012) 0.76
Apicobasal polarity of brain endothelial cells. J Cereb Blood Flow Metab (2015) 0.75
CCM1 and the second life of proteins in adhesion complexes. Cell Adh Migr (2014) 0.75
VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. Mol Biol Cell (2016) 0.75
The apical junctional complex in respiratory diseases. Chonnam Med J (2014) 0.75
AmotL2 integrates polarity and junctional cues to modulate cell shape. Sci Rep (2017) 0.75
The PAR-aPKC system: lessons in polarity. J Cell Sci (2006) 4.73
Par-3 controls tight junction assembly through the Rac exchange factor Tiam1. Nat Cell Biol (2005) 3.83
Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol (2003) 3.38
Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization. Nat Cell Biol (2003) 3.13
A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol (2003) 3.11
Parsing the polarity code. Nat Rev Mol Cell Biol (2004) 3.07
Direct interaction of two polarity complexes implicated in epithelial tight junction assembly. Nat Cell Biol (2003) 3.07
CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells. Mol Biol Cell (2004) 2.61
Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol (2003) 2.38
The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). EMBO J (2001) 2.28
Segmental differentiations of cell junctions in the vascular endothelium. The microvasculature. J Cell Biol (1975) 2.22
Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions. J Cell Biol (2001) 2.06
aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. J Cell Sci (2002) 2.04
The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex. J Cell Biol (2005) 2.03
The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity. J Cell Sci (2003) 1.84
Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse. J Biol Chem (2003) 1.60
Association of Csk to VE-cadherin and inhibition of cell proliferation. EMBO J (2005) 1.45
Cell-cell junctions of dermal microvascular endothelial cells contain tight and adherens junction proteins in spatial proximity. Biochemistry (2004) 1.04
Molecular anatomy of interendothelial junctions in human blood-brain barrier microvessels. Folia Histochem Cytobiol (2004) 0.95
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol (2002) 8.60
Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature (2011) 5.84
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev (2006) 5.59
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol (2002) 5.02
The PAR-aPKC system: lessons in polarity. J Cell Sci (2006) 4.73
Functionally specialized junctions between endothelial cells of lymphatic vessels. J Exp Med (2007) 4.10
Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep (2006) 4.06
The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res (2008) 4.04
Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science (2010) 3.98
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol (2005) 3.30
Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol (2008) 3.22
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol (2008) 2.85
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci (2009) 2.85
Diagnostic criteria, clinical features, and incidence of thyroid storm based on nationwide surveys. Thyroid (2012) 2.78
The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol (2003) 2.77
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature (2002) 2.68
Viscoelastic properties of individual glial cells and neurons in the CNS. Proc Natl Acad Sci U S A (2006) 2.64
Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron (2002) 2.59
Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature (2007) 2.48
Junctional adhesion molecules (JAMs): more molecules with dual functions? J Cell Sci (2004) 2.47
Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J (2007) 2.43
aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. Curr Biol (2004) 2.40
Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol (2003) 2.38
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease. Hum Mol Genet (2005) 2.28
Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes. J Clin Invest (2012) 2.26
PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest (2003) 2.23
Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol (2004) 2.19
Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes. Proc Natl Acad Sci U S A (2011) 2.11
Single injection of P-selectin or P-selectin glycoprotein ligand-1 monoclonal antibody blocks neointima formation after arterial injury in apolipoprotein E-deficient mice. Circulation (2003) 2.11
VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J (2002) 2.05
aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. J Cell Sci (2002) 2.04
Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house? Eur J Immunol (2004) 2.03
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev (2002) 2.02
GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med (2011) 2.01
Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization. Nat Genet (2010) 2.00
Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme. Acta Neuropathol (2003) 1.99
Flt3-dependent transformation by inactivating c-Cbl mutations in AML. Blood (2007) 1.99
Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. J Exp Med (2006) 1.98
Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. Proc Natl Acad Sci U S A (2006) 1.96
Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol (2013) 1.89
Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors. J Immunol (2002) 1.88
Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C. Nature (2004) 1.88
Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol (2013) 1.86
The canonical Wnt signalling pathway and its APC partner in colon cancer development. Gut (2006) 1.86
The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity. J Cell Sci (2003) 1.84
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev (2009) 1.82
Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex. Development (2006) 1.81
Peeling of the basal membrane in the human retina: ultrastructural effects. Ophthalmology (2004) 1.80
Transferrin receptor upregulation: in vitro labeling of rat mesenchymal stem cells with superparamagnetic iron oxide. Radiology (2007) 1.79
Coxsackievirus-adenovirus receptor (CAR) is essential for early embryonic cardiac development. J Cell Sci (2005) 1.79
Development of the zebrafish lymphatic system requires VEGFC signaling. Curr Biol (2006) 1.78
VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF. J Exp Med (2008) 1.78
Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention. J Cell Sci (2006) 1.78
ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. J Exp Med (2006) 1.75
The effect of periocular warming on accommodation. Ophthalmology (2005) 1.74
Isolation of mouse pancreatic ductal progenitor cells expressing CD133 and c-Met by flow cytometric cell sorting. Gastroenterology (2006) 1.74
Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration. J Cell Sci (2008) 1.74
Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. EMBO J (2011) 1.69
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev Cell (2012) 1.66
The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells. Science (2009) 1.65
Load-reducing therapy prevents development of arrhythmogenic right ventricular cardiomyopathy in plakoglobin-deficient mice. J Am Coll Cardiol (2011) 1.65
Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer. Proc Natl Acad Sci U S A (2006) 1.64
The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice. Blood (2008) 1.63
Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One (2010) 1.62
Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro. J Leukoc Biol (2002) 1.62
Multistep nature of microvascular recruitment of ex vivo-expanded embryonic endothelial progenitor cells during tumor angiogenesis. J Exp Med (2003) 1.58
The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1. J Biol Chem (2009) 1.56
Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Mol Cell Biol (2002) 1.55
Sialyl Lewis X-dependent lung colonization of B16 melanoma cells through a selectin-like endothelial receptor distinct from E- or P-selectin. Cancer Res (2002) 1.55
Wnt signaling inhibits Forkhead box O3a-induced transcription and apoptosis through up-regulation of serum- and glucocorticoid-inducible kinase 1. J Biol Chem (2008) 1.55
N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Nucleic Acids Res (2011) 1.55
Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells. Genes Cells (2002) 1.54
ASPP2 regulates epithelial cell polarity through the PAR complex. Curr Biol (2010) 1.54
Brain endothelial cells and the glio-vascular complex. Cell Tissue Res (2008) 1.53
Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system. Cell Metab (2009) 1.51
Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood (2006) 1.50
Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene (2003) 1.50
The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metabolism (2008) 1.50
The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts. J Cell Biol (2002) 1.49
The role of SMG-1 in nonsense-mediated mRNA decay. Biochim Biophys Acta (2005) 1.49
Prevalence and persistence of depression in patients with implantable cardioverter defibrillator: a 2-year longitudinal study. Pacing Clin Electrophysiol (2010) 1.48
Epoxycarotenoid-mediated synthesis of abscisic acid in Physcomitrella patens implicating conserved mechanisms for acclimation to hyperosmosis in embryophytes. New Phytol (2014) 1.48
ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish. Hum Mol Genet (2008) 1.47
PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrin. Blood (2003) 1.46