Published in Proc Natl Acad Sci U S A on August 22, 2005
Hts/Adducin controls synaptic elaboration and elimination. Neuron (2011) 1.93
Membrane domains based on ankyrin and spectrin associated with cell-cell interactions. Cold Spring Harb Perspect Biol (2009) 1.59
Pleiotrophin disrupts calcium-dependent homophilic cell-cell adhesion and initiates an epithelial-mesenchymal transition. Proc Natl Acad Sci U S A (2006) 1.07
Adducins regulate remodeling of apical junctions in human epithelial cells. Mol Biol Cell (2010) 1.07
Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironment. Proc Natl Acad Sci U S A (2007) 1.00
Insulin-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling. Mol Cell Biol (2012) 0.97
Structure and function of midkine as the basis of its pharmacological effects. Br J Pharmacol (2014) 0.94
Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells. J Cell Physiol (2008) 0.91
Anaplastic lymphoma kinase is expressed in different subtypes of human breast cancer. Biochem Biophys Res Commun (2007) 0.87
Targeting midkine and pleiotrophin signalling pathways in addiction and neurodegenerative disorders: recent progress and perspectives. Br J Pharmacol (2014) 0.87
The role of pleiotrophin and beta-catenin in fetal lung development. Respir Res (2010) 0.87
The receptor protein tyrosine phosphatase (RPTP)beta/zeta is expressed in different subtypes of human breast cancer. Biochem Biophys Res Commun (2007) 0.85
Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility. Oncotarget (2014) 0.84
The membrane cytoskeletal protein adducin is phosphorylated by protein kinase C in D1 neurons of the nucleus accumbens and dorsal striatum following cocaine administration. J Neurochem (2009) 0.83
Loss of receptor protein tyrosine phosphatase β/ζ (RPTPβ/ζ) promotes prostate cancer metastasis. J Biol Chem (2012) 0.82
Phosphorylation controls a dual-function polybasic nuclear localization sequence in the adapter protein SH2B1β to regulate its cellular function and distribution. J Cell Sci (2011) 0.81
Should I stay or should I go? Shedding of RPTPs in cancer cells switches signals from stabilizing cell-cell adhesion to driving cell migration. Cell Adh Migr (2011) 0.80
Phospho-regulated Drosophila adducin is a determinant of synaptic plasticity in a complex with Dlg and PIP2 at the larval neuromuscular junction. Biol Open (2014) 0.79
Dominant negative pleiotrophin induces tetraploidy and aneuploidy in U87MG human glioblastoma cells. Biochem Biophys Res Commun (2006) 0.79
Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. Gut (2015) 0.77
The synthetic peptide P111-136 derived from the C-terminal domain of heparin affin regulatory peptide inhibits tumour growth of prostate cancer PC-3 cells. BMC Cancer (2011) 0.76
Dynamic interplay of spectrosome and centrosome organelles in asymmetric stem cell divisions. PLoS One (2015) 0.75
Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. Physiol Rev (2001) 6.31
Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J Cell Biol (1993) 5.86
Regulation of E-cadherin/Catenin association by tyrosine phosphorylation. J Biol Chem (1999) 3.53
p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system. EMBO J (1993) 3.06
The spectrin-actin junction of erythrocyte membrane skeletons. Biochim Biophys Acta (1989) 2.50
Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. Proc Natl Acad Sci U S A (2000) 2.15
Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. Science (1990) 2.00
Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis. J Biochem (2002) 2.00
Tyrosine phosphorylation and cadherin/catenin function. Bioessays (1997) 1.97
Modulation of spectrin-actin assembly by erythrocyte adducin. Nature (1987) 1.89
Differential expression of pleiotrophin and midkine in advanced neuroblastomas. Cancer Res (1995) 1.72
Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex. J Cell Biol (1996) 1.69
An 18-kd heparin-binding protein of developing brain that is distinct from fibroblast growth factors. EMBO J (1989) 1.57
Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C. J Biol Chem (1996) 1.53
Marked increase of the growth factors pleiotrophin and fibroblast growth factor-2 in serum of testicular cancer patients. Ann Oncol (2003) 1.53
Pleiotrophin: a cytokine with diverse functions and a novel signaling pathway. Arch Biochem Biophys (2002) 1.52
Adducin: a physical model with implications for function in assembly of spectrin-actin complexes. J Biol Chem (1995) 1.49
Glioblastoma and cerebral microvascular endothelial cell migration in response to tumor-associated growth factors. Neurosurgery (2003) 1.40
Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer. J Biol Chem (1992) 1.37
Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice. Proc Natl Acad Sci U S A (1993) 1.22
Retracted Beta-catenin N- and C-terminal tails modulate the coordinated binding of adherens junction proteins to beta-catenin. J Biol Chem (2002) 1.16
Upregulation of pleiotrophin gene expression in developing microvasculature, macrophages, and astrocytes after acute ischemic brain injury. J Neurosci (1998) 1.15
A novel 17 kD heparin-binding growth factor (HBGF-8) in bovine uterus: purification and N-terminal amino acid sequence. Biochem Biophys Res Commun (1989) 1.13
Ribozyme-targeting elucidates a direct role of pleiotrophin in tumor growth. J Biol Chem (1994) 1.11
Melanoma angiogenesis and metastasis modulated by ribozyme targeting of the secreted growth factor pleiotrophin. Proc Natl Acad Sci U S A (1996) 1.10
Human breast cancer growth inhibited in vivo by a dominant negative pleiotrophin mutant. J Biol Chem (1997) 1.09
Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway: regulation of tyrosine phosphorylation of Fyn by pleiotrophin. Biochem Biophys Res Commun (2005) 1.06
N-cadherin function is required for differentiation-dependent cytoskeletal reorganization in lens cells in vitro. Exp Cell Res (2000) 1.06
Pleiotrophin and midkine, a family of mitogenic and angiogenic heparin-binding growth and differentiation factors. Curr Opin Hematol (1999) 1.05
Mitogenic properties of a new endothelial cell growth factor related to pleiotrophin. Biochem Biophys Res Commun (1991) 1.04
Heparin-binding growth-associated molecule contains two heparin-binding beta -sheet domains that are homologous to the thrombospondin type I repeat. J Biol Chem (2000) 1.03
Contributions of the beta-subunit to spectrin structure and function. Cell Motil Cytoskeleton (1989) 1.01
Mitogenic and in vitro angiogenic activity of human recombinant heparin affin regulatory peptide. Growth Factors (1994) 1.01
Identification of the spectrin subunit and domains required for formation of spectrin/adducin/actin complexes. J Biol Chem (1996) 0.98
Differential expression and biological activity of the heparin-binding growth-associated molecule (HB-GAM) in lung cancer cell lines. Int J Cancer (1997) 0.97
Pleiotrophin, an angiogenic and mitogenic growth factor, is expressed in human gliomas. J Neurochem (2002) 0.93
Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells. J Biol Chem (2000) 0.93
Significance of the expression of the growth factor pleiotrophin in pancreatic cancer patients. Clin Cancer Res (2002) 0.91
The expression of 80K/MARCKS, a major substrate of protein kinase C (PKC), is down-regulated through both PKC-dependent and -independent pathways. Effects of bombesin, platelet-derived growth factor, and cAMP. J Biol Chem (1992) 0.91
The potential role of the heparin-binding growth factor pleiotrophin in breast cancer. Breast Cancer Res Treat (1994) 0.91
Effect of heparin on bovine epithelial lens cell proliferation induced by heparin affin regulatory peptide. J Cell Physiol (1995) 0.88
Tyrosine phosphorylation translocates beta-catenin from cell-->cell interface to the cytoplasm, but does not significantly enhance the LEF-1-dependent transactivating function. Cell Biol Int (2001) 0.86
Domain structure of pleiotrophin required for transformation. J Biol Chem (1999) 0.83
Interaction of the SH2 domain of Fyn with a cytoskeletal protein, beta-adducin. J Biol Chem (2001) 0.80
Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes. Dev Biol (1991) 0.77
Midkine gene and the m4 muscarinic acid receptor gene are linked on mouse chromosome 2. Genomics (1996) 0.77
Identification, cloning, and expression of human estrogen receptor-alpha36, a novel variant of human estrogen receptor-alpha66. Biochem Biophys Res Commun (2005) 2.37
A variant of estrogen receptor-{alpha}, hER-{alpha}36: transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling. Proc Natl Acad Sci U S A (2006) 2.29
Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients. Mol Ther (2013) 1.63
Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation. J Biol Chem (2007) 1.21
Pleiotrophin, a multifunctional tumor promoter through induction of tumor angiogenesis, remodeling of the tumor microenvironment, and activation of stromal fibroblasts. Cell Cycle (2007) 1.11
Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. Cell Rep (2012) 1.08
Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway: regulation of tyrosine phosphorylation of Fyn by pleiotrophin. Biochem Biophys Res Commun (2005) 1.06
Pleiotrophin stimulates tyrosine phosphorylation of beta-adducin through inactivation of the transmembrane receptor protein tyrosine phosphatase beta/zeta. Biochem Biophys Res Commun (2005) 1.05
Pleiotrophin, a multifunctional angiogenic factor: mechanisms and pathways in normal and pathological angiogenesis. Curr Opin Hematol (2008) 1.01
Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironment. Proc Natl Acad Sci U S A (2007) 1.00
Value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease. J Alzheimers Dis (2008) 0.94
Midkine regulates pleiotrophin organ-specific gene expression: evidence for transcriptional regulation and functional redundancy within the pleiotrophin/midkine developmental gene family. Biochem Biophys Res Commun (2005) 0.93
Identification of the angiogenesis signaling domain in pleiotrophin defines a mechanism of the angiogenic switch. Biochem Biophys Res Commun (2006) 0.93
Constitutive expression of Rb associated protein 46 (RbAp46) reverts transformed phenotypes of breast cancer cells. Anticancer Res (2003) 0.93
Activating human genes with zinc finger proteins, transcription activator-like effectors and CRISPR/Cas9 for gene therapy and regenerative medicine. Expert Opin Ther Targets (2014) 0.90
Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage. Proc Natl Acad Sci U S A (2014) 0.89
Pleiotrophin induces formation of functional neovasculature in vivo. Biochem Biophys Res Commun (2005) 0.89
Midkine, a newly discovered regulator of the renin-angiotensin pathway in mouse aorta: significance of the pleiotrophin/midkine developmental gene family in angiotensin II signaling. Biochem Biophys Res Commun (2005) 0.83
Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth. Blood (2007) 0.82
Morphine and yohimbine regulate midkine gene expression in the rat hippocampus. Eur J Pharmacol (2006) 0.82
Yohimbine prevents morphine-induced changes of glial fibrillary acidic protein in brainstem and alpha2-adrenoceptor gene expression in hippocampus. Neurosci Lett (2006) 0.81
The neurotrophic factor pleiotrophin modulates amphetamine-seeking behaviour and amphetamine-induced neurotoxic effects: evidence from pleiotrophin knockout mice. Addict Biol (2010) 0.81
Regulation of leptin distribution between plasma and cerebrospinal fluid by cholecystokinin receptors. Br J Pharmacol (2003) 0.81
Noradrenergic and opioidergic alterations in neuropathy in different rat strains. Neurosci Lett (2008) 0.80
Pleiotrophin expression during odontogenesis. J Histochem Cytochem (2012) 0.80
Pleiotrophin inhibits hippocampal long-term potentiation: a role of pleiotrophin in learning and memory. Growth Factors (2009) 0.80
Place conditioning in a two- or three-conditioning compartment apparatus: a comparative study with morphine and U-50,488. Addict Biol (2007) 0.80
Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain. Growth Factors (2008) 0.79
Blocking receptor protein tyrosine phosphatase beta/zeta: a potential therapeutic strategy for Parkinson's disease. Curr Med Chem (2009) 0.79
Pleiotrophin is an important regulator of the renin-angiotensin system in mouse aorta. Biochem Biophys Res Commun (2004) 0.79
Dominant negative pleiotrophin induces tetraploidy and aneuploidy in U87MG human glioblastoma cells. Biochem Biophys Res Commun (2006) 0.79
Changes in BDNF gene expression correlate with rat strain differences in neuropathic pain. Neurosci Lett (2007) 0.78
Targeting the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta signaling pathway to limit neurotoxicity induced by drug abuse. Mini Rev Med Chem (2009) 0.78
Uncovering new pharmacological targets to treat neuropathic pain by understanding how the organism reacts to nerve injury. Curr Pharm Des (2011) 0.78
Characterization of the role of endogenous cholecystokinin on the activity of the paraventricular nucleus of the hypothalamus in rats. Br J Pharmacol (2003) 0.77
Pleiotrophin prevents cocaine-induced toxicity in vitro. Eur J Pharmacol (2008) 0.77
Pleiotrophin is a major regulator of the catecholamine biosynthesis pathway in mouse aorta. Biochem Biophys Res Commun (2004) 0.77
Morphine differentially regulates hsp90beta expression in the nucleus accumbens of Lewis and Fischer 344 rats. Brain Res Bull (2007) 0.76
The heparin binding growth factors midkine and pleiotrophin regulate the antinociceptive effects of morphine through α(2)-adrenergic independent mechanisms. Pharmacol Biochem Behav (2012) 0.76
Genetic deletion of pleiotrophin leads to disruption of spinal nociceptive transmission: evidence for pleiotrophin modulation of morphine-induced analgesia. Eur J Pharmacol (2010) 0.76
Midkine is a potent regulator of the catecholamine biosynthesis pathway in mouse aorta. Life Sci (2006) 0.75
Lewis and Fischer 344 strain differences in alpha2-adrenoceptors and tyrosine hydroxylase expression. Life Sci (2005) 0.75
Oral iron treatment has a positive effect on iron metabolism in elite soccer players. Biol Trace Elem Res (2010) 0.75