Published in J Biol Chem on August 29, 2005
Changes produced by bound tryptophan in the ribosome peptidyl transferase center in response to TnaC, a nascent leader peptide. Proc Natl Acad Sci U S A (2006) 1.43
Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria. Nucleic Acids Res (2007) 1.30
A structural view on the mechanism of the ribosome-catalyzed peptide bond formation. Biochim Biophys Acta (2009) 1.08
pH-dependent dynamics of complex RNA macromolecules. J Chem Theory Comput (2013) 1.05
pH-dependent structural changes of helix 69 from Escherichia coli 23S ribosomal RNA. RNA (2008) 0.98
Rapid peptide bond formation on isolated 50S ribosomal subunits. EMBO Rep (2006) 0.98
An uncharged amine in the transition state of the ribosomal peptidyl transfer reaction. Chem Biol (2008) 0.97
Different substrate-dependent transition states in the active site of the ribosome. Nature (2011) 0.96
Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. Antimicrob Agents Chemother (2010) 0.96
The transition state for peptide bond formation reveals the ribosome as a water trap. Proc Natl Acad Sci U S A (2010) 0.93
Isolation of bacterial ribosomes with monolith chromatography. PLoS One (2011) 0.91
Large facilities and the evolving ribosome, the cellular machine for genetic-code translation. J R Soc Interface (2009) 0.88
Towards Accurate Prediction of Protonation Equilibrium of Nucleic Acids. J Phys Chem Lett (2013) 0.88
Modulating the activity of the peptidyl transferase center of the ribosome. RNA (2008) 0.87
Mutations at the accommodation gate of the ribosome impair RF2-dependent translation termination. RNA (2010) 0.87
Novel base triples in RNA structures revealed by graph theoretical searching methods. BMC Bioinformatics (2011) 0.86
Mutations of highly conserved bases in the peptidyltransferase center induce compensatory rearrangements in yeast ribosomes. RNA (2011) 0.86
Interaction between the ribosomal subunits: 16S rRNA suppressors of the lethal DeltaA1916 mutation in the 23S rRNA of Escherichia coli. Mol Genet Genomics (2007) 0.84
Transition state chirality and role of the vicinal hydroxyl in the ribosomal peptidyl transferase reaction. Biochemistry (2008) 0.83
The role of the universally conserved A2450-C2063 base pair in the ribosomal peptidyl transferase center. Nucleic Acids Res (2010) 0.82
Activities of the peptidyl transferase center of ribosomes lacking protein L27. RNA (2015) 0.78
Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase. RNA (2016) 0.76
Peptide Bond Formation Mechanism Catalyzed by Ribosome. J Am Chem Soc (2015) 0.76
Kinetic and thermodynamic studies of peptidyltransferase in ribosomes from the extreme thermophile Thermus thermophilus. RNA (2008) 0.76
Essential structural elements in tRNA(Pro) for EF-P-mediated alleviation of translation stalling. Nat Commun (2016) 0.76
Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis. Proc Natl Acad Sci U S A (2016) 0.75
Identification of the methyltransferase targeting C2499 in Deinococcus radiodurans 23S ribosomal RNA. Extremophiles (2015) 0.75
Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy. Nature (2010) 3.48
An elongation factor G-induced ribosome rearrangement precedes tRNA-mRNA translocation. Mol Cell (2003) 3.48
Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. Mol Microbiol (2007) 3.47
Kinetic determinants of high-fidelity tRNA discrimination on the ribosome. Mol Cell (2004) 3.40
Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy. Arch Gen Psychiatry (2004) 3.33
Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation. Cell (2005) 2.97
The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria. Mol Cell (2007) 2.93
Structure of ratcheted ribosomes with tRNAs in hybrid states. Proc Natl Acad Sci U S A (2008) 2.77
Molecular mechanism of drug-dependent ribosome stalling. Mol Cell (2008) 2.62
Selective protein synthesis by ribosomes with a drug-obstructed exit tunnel. Cell (2012) 2.57
EF-P is essential for rapid synthesis of proteins containing consecutive proline residues. Science (2012) 2.44
Conformational changes of the small ribosomal subunit during elongation factor G-dependent tRNA-mRNA translocation. J Mol Biol (2004) 2.41
The ribosome as an entropy trap. Proc Natl Acad Sci U S A (2004) 2.40
Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc Natl Acad Sci U S A (2010) 2.38
Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex. Nat Struct Biol (2002) 2.24
Essential role of histidine 84 in elongation factor Tu for the chemical step of GTP hydrolysis on the ribosome. J Mol Biol (2003) 2.14
Fitness cost of chromosomal drug resistance-conferring mutations. Antimicrob Agents Chemother (2002) 2.07
Directional switching of the kinesin Cin8 through motor coupling. Science (2011) 2.06
Quantitative drug susceptibility testing of Mycobacterium tuberculosis by use of MGIT 960 and EpiCenter instrumentation. J Clin Microbiol (2009) 1.98
Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center. Mol Cell (2011) 1.96
Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression. Arch Gen Psychiatry (2010) 1.92
Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome. Mol Cell (2002) 1.91
GTPase activation of elongation factors Tu and G on the ribosome. Biochemistry (2002) 1.85
Nucleotide biosynthesis is critical for growth of bacteria in human blood. PLoS Pathog (2008) 1.83
GTPgammaS microtubules mimic the growing microtubule end structure recognized by end-binding proteins (EBs). Proc Natl Acad Sci U S A (2011) 1.79
Control of phosphate release from elongation factor G by ribosomal protein L7/12. EMBO J (2005) 1.79
Sequence of steps in ribosome recycling as defined by kinetic analysis. Mol Cell (2005) 1.78
Role and timing of GTP binding and hydrolysis during EF-G-dependent tRNA translocation on the ribosome. Proc Natl Acad Sci U S A (2006) 1.73
A uniform response to mismatches in codon-anticodon complexes ensures ribosomal fidelity. Mol Cell (2006) 1.73
Signal sequence-independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel. Nat Struct Mol Biol (2008) 1.70
The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide. EMBO J (2010) 1.67
gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis. J Antimicrob Chemother (2012) 1.65
The rationale for using rifabutin in the treatment of MDR and XDR tuberculosis outbreaks. PLoS One (2013) 1.62
Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid. Proc Natl Acad Sci U S A (2012) 1.62
Kinetic checkpoint at a late step in translation initiation. Mol Cell (2008) 1.62
The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA. RNA (2007) 1.60
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA. J Am Chem Soc (2010) 1.60
The molecular basis for A-site mutations conferring aminoglycoside resistance: relationship between ribosomal susceptibility and X-ray crystal structures. Chembiochem (2003) 1.60
The signal recognition particle binds to protein L23 at the peptide exit of the Escherichia coli ribosome. RNA (2003) 1.59
Peptide bond formation does not involve acid-base catalysis by ribosomal residues. Nat Struct Mol Biol (2006) 1.58
Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. Antimicrob Agents Chemother (2008) 1.57
Phosphorylation relieves autoinhibition of the kinetochore motor Cenp-E. Mol Cell (2008) 1.54
Coupling of GTP hydrolysis by elongation factor G to translocation and factor recycling on the ribosome. Biochemistry (2002) 1.54
Distinct functions of elongation factor G in ribosome recycling and translocation. RNA (2009) 1.54
Kinetic mechanism of elongation factor Ts-catalyzed nucleotide exchange in elongation factor Tu. Biochemistry (2002) 1.52
Spontaneous reverse movement of mRNA-bound tRNA through the ribosome. Nat Struct Mol Biol (2007) 1.51
Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics. J Biol Chem (2003) 1.49
Poleward transport of Eg5 by dynein-dynactin in Xenopus laevis egg extract spindles. J Cell Biol (2008) 1.49
Streptomycin interferes with conformational coupling between codon recognition and GTPase activation on the ribosome. Nat Struct Mol Biol (2004) 1.44
Transient kinetics, fluorescence, and FRET in studies of initiation of translation in bacteria. Methods Enzymol (2007) 1.43
The nucleotide-binding site of bacterial translation initiation factor 2 (IF2) as a metabolic sensor. Proc Natl Acad Sci U S A (2006) 1.43
Purine bases at position 37 of tRNA stabilize codon-anticodon interaction in the ribosomal A site by stacking and Mg2+-dependent interactions. RNA (2004) 1.43
The ribosomal peptidyl transferase center: structure, function, evolution, inhibition. Crit Rev Biochem Mol Biol (2005) 1.42
Modulation of the rate of peptidyl transfer on the ribosome by the nature of substrates. J Biol Chem (2008) 1.42
Energy barriers and driving forces in tRNA translocation through the ribosome. Nat Struct Mol Biol (2013) 1.41
Kinetic analysis of interaction of eukaryotic release factor 3 with guanine nucleotides. J Biol Chem (2006) 1.37
Macrolide antibiotics: binding site, mechanism of action, resistance. Curr Top Med Chem (2003) 1.37
Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin. Proc Natl Acad Sci U S A (2012) 1.36
The ribosomal peptidyl transferase. Mol Cell (2007) 1.36
The Cryo-EM structure of a complete 30S translation initiation complex from Escherichia coli. PLoS Biol (2011) 1.35
The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination. Mol Cell (2003) 1.32
The functions of OmpATb, a pore-forming protein of Mycobacterium tuberculosis. Mol Microbiol (2002) 1.32
A protein component at the heart of an RNA machine: the importance of protein l27 for the function of the bacterial ribosome. Mol Cell (2005) 1.30
Evolutionary optimization of speed and accuracy of decoding on the ribosome. Philos Trans R Soc Lond B Biol Sci (2011) 1.30
Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria. Nucleic Acids Res (2007) 1.30
Delayed release of inorganic phosphate from elongation factor Tu following GTP hydrolysis on the ribosome. Biochemistry (2006) 1.30
Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451. Nucleic Acids Res (2005) 1.29
Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in Mycobacterium tuberculosis. Microb Drug Resist (2011) 1.29
Mitochondrial deafness alleles confer misreading of the genetic code. Proc Natl Acad Sci U S A (2008) 1.29
Trigger factor binds to ribosome-signal-recognition particle (SRP) complexes and is excluded by binding of the SRP receptor. Proc Natl Acad Sci U S A (2004) 1.28
Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity. Proc Natl Acad Sci U S A (2008) 1.27
Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis. Antimicrob Agents Chemother (2010) 1.27
Effects of clinical breakpoint changes in CLSI guidelines 2010/2011 and EUCAST guidelines 2011 on antibiotic susceptibility test reporting of Gram-negative bacilli. J Antimicrob Chemother (2011) 1.25
Identification of Gram-positive cocci by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry: comparison of different preparation methods and implementation of a practical algorithm for routine diagnostics. J Clin Microbiol (2013) 1.25
23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G. Proc Natl Acad Sci U S A (2005) 1.24
The ribosome-bound initiation factor 2 recruits initiator tRNA to the 30S initiation complex. EMBO Rep (2010) 1.24
DNA damage induction of recA in Mycobacterium tuberculosis independently of RecA and LexA. Mol Microbiol (2002) 1.23
Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action. Ann N Y Acad Sci (2011) 1.23
Integrating the Xpert MTB/RIF assay into a diagnostic workflow for rapid detection of Mycobacterium tuberculosis in a low-prevalence area. J Clin Microbiol (2013) 1.23
tRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding. Proc Natl Acad Sci U S A (2013) 1.23
Broad-range 16S rRNA gene polymerase chain reaction for diagnosis of culture-negative bacterial infections. Clin Infect Dis (2011) 1.22
The crystal structure of unmodified tRNAPhe from Escherichia coli. Nucleic Acids Res (2010) 1.22
Deleterious mutations in small subunit ribosomal RNA identify functional sites and potential targets for antibiotics. Proc Natl Acad Sci U S A (2005) 1.21
Lack of mismatch correction facilitates genome evolution in mycobacteria. Mol Microbiol (2004) 1.21
Genetic environment and stability of cfr in methicillin-resistant Staphylococcus aureus CM05. Antimicrob Agents Chemother (2011) 1.21
Obstacles on the microtubule reduce the processivity of Kinesin-1 in a minimal in vitro system and in cell extract. Biophys J (2009) 1.19
Practical approach for reliable detection of AmpC beta-lactamase-producing Enterobacteriaceae. J Clin Microbiol (2011) 1.18
Evaluation of Cobas TaqMan MTB for direct detection of the Mycobacterium tuberculosis complex in comparison with Cobas Amplicor MTB. J Clin Microbiol (2013) 1.18
Binding site of the bridged macrolides in the Escherichia coli ribosome. Antimicrob Agents Chemother (2005) 1.17
Binding of neomycin-class aminoglycoside antibiotics to mutant ribosomes with alterations in the A site of 16S rRNA. Antimicrob Agents Chemother (2006) 1.15