Published in Antimicrob Agents Chemother on October 24, 2011
Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world? Clin Microbiol Rev (2013) 2.01
Transferable plasmid-mediated resistance to linezolid due to cfr in a human clinical isolate of Enterococcus faecalis. Antimicrob Agents Chemother (2012) 1.31
First report of the multidrug resistance gene cfr in Enterococcus faecalis of animal origin. Antimicrob Agents Chemother (2011) 1.14
Phage ϕC2 mediates transduction of Tn6215, encoding erythromycin resistance, between Clostridium difficile strains. MBio (2013) 1.02
Mechanisms of linezolid resistance among coagulase-negative staphylococci determined by whole-genome sequencing. MBio (2014) 0.98
Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model. Antimicrob Agents Chemother (2014) 0.97
Unconventional circularizable bacterial genetic structures carrying antibiotic resistance determinants. Antimicrob Agents Chemother (2013) 0.95
Streptococcus pneumoniae transposon Tn1545/Tn6003 changes to Tn6002 due to spontaneous excision in circular form of the erm(B)- and aphA3-containing macrolide-aminoglycoside-streptothricin (MAS) element. Antimicrob Agents Chemother (2012) 0.92
Streptococcus sanguinis isolate displaying a phenotype with cross-resistance to several rRNA-targeting agents. J Clin Microbiol (2013) 0.90
The genetic environment of the cfr gene and the presence of other mechanisms account for the very high linezolid resistance of Staphylococcus epidermidis isolate 426-3147L. Antimicrob Agents Chemother (2012) 0.86
Toxin-Antitoxin Systems in Clinical Pathogens. Toxins (Basel) (2016) 0.86
Linezolid-resistant Staphylococcus aureus strain 1128105, the first known clinical isolate possessing the cfr multidrug resistance gene. Antimicrob Agents Chemother (2014) 0.86
First Report of cfr-Carrying Plasmids in the Pandemic Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Staphylococcal Cassette Chromosome mec Type IV Clone. Antimicrob Agents Chemother (2016) 0.83
Identification and characterization of linezolid-resistant cfr-positive Staphylococcus aureus USA300 isolates from a New York City medical center. Antimicrob Agents Chemother (2014) 0.81
Tedizolid Phosphate: a Next-Generation Oxazolidinone. Infect Dis Ther (2015) 0.80
Toxin-Antitoxin Systems of Staphylococcus aureus. Toxins (Basel) (2016) 0.79
Dissecting the mechanisms of linezolid resistance in a Drosophila melanogaster infection model of Staphylococcus aureus. J Infect Dis (2013) 0.79
Genetic Environment of Plasmid Mediated CTX-M-15 Extended Spectrum Beta-Lactamases from Clinical and Food Borne Bacteria in North-Eastern India. PLoS One (2015) 0.77
Occurrence of co-existing bla VIM-2 and bla NDM-1 in clinical isolates of Pseudomonas aeruginosa from India. Ann Clin Microbiol Antimicrob (2016) 0.75
Expansion of highly stable bla OXA-10 β-lactamase family within diverse host range among nosocomial isolates of Gram-negative bacilli within a tertiary referral hospital of Northeast India. BMC Res Notes (2017) 0.75
Transcriptional analysis of blaNDM-1 and copy number alteration under carbapenem stress. Antimicrob Resist Infect Control (2017) 0.75
Basic local alignment search tool. J Mol Biol (1990) 659.07
A sequencing method based on real-time pyrophosphate. Science (1998) 21.21
Linezolid resistance in a clinical isolate of Staphylococcus aureus. Lancet (2001) 5.90
Microbial Selection. Science (1952) 4.08
Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid. Lancet (2001) 3.94
The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics. Antimicrob Agents Chemother (2006) 3.94
Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. Mol Microbiol (2007) 3.47
Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions. Antimicrob Agents Chemother (1997) 3.33
Distribution of florfenicol resistance genes fexA and cfr among chloramphenicol-resistant Staphylococcus isolates. Antimicrob Agents Chemother (2006) 2.92
Identification of a plasmid-borne chloramphenicol-florfenicol resistance gene in Staphylococcus sciuri. Antimicrob Agents Chemother (2000) 2.90
A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Mol Microbiol (2005) 2.89
First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. Antimicrob Agents Chemother (2008) 2.63
Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA. J Infect Dis (2004) 2.48
Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action. J Bacteriol (2000) 2.25
Single-primer PCR procedure for rapid identification of transposon insertion sites. Biotechniques (2000) 2.25
Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype. J Infect Dis (2002) 2.18
Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700). Antimicrob Agents Chemother (2009) 2.17
Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus. Antimicrob Agents Chemother (2005) 2.14
Resistance of group A beta-hemolytic streptococci to lincomycin and erythromycin. Antimicrob Agents Chemother (1972) 2.13
Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center. J Mol Biol (1999) 2.10
Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid-resistant Staphylococcus aureus. Clin Infect Dis (2010) 2.02
Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin. Antimicrob Agents Chemother (2009) 1.81
Assessment of linezolid resistance mechanisms among Staphylococcus epidermidis causing bacteraemia in Rome, Italy. J Antimicrob Chemother (2010) 1.80
IS21-558 insertion sequences are involved in the mobility of the multiresistance gene cfr. Antimicrob Agents Chemother (2006) 1.74
Analysis of the stabilization system of pSM19035-derived plasmid pBT233 in Bacillus subtilis. Gene (1993) 1.74
Streptococcus pyogenes pSM19035 requires dynamic assembly of ATP-bound ParA and ParB on parS DNA during plasmid segregation. Nucleic Acids Res (2008) 1.62
Evaluation of Alamar colorimetric broth microdilution susceptibility testing method for staphylococci and enterococci. J Clin Microbiol (1996) 1.57
Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. Antimicrob Agents Chemother (2008) 1.57
Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. Antimicrob Agents Chemother (2008) 1.53
Gene organization of the Streptococcus pyogenes plasmid pDB101: sequence analysis of the orf eta-copS region. Gene (1994) 1.50
Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate. Antimicrob Agents Chemother (2010) 1.40
Clinical isolates of Staphylococcus aureus with ribosomal mutations conferring resistance to macrolides. Antimicrob Agents Chemother (2002) 1.32
Multicity outbreak of linezolid-resistant Staphylococcus epidermidis associated with clonal spread of a cfr-containing strain. Clin Infect Dis (2010) 1.28
A novel site-specific recombinase encoded by the Streptococcus pyogenes plasmid pSM19035. J Mol Biol (1994) 1.24
United States resistance surveillance results for linezolid (LEADER Program for 2007). Diagn Microbiol Infect Dis (2008) 1.24
Zyvox Annual Appraisal of Potency and Spectrum program: linezolid surveillance program results for 2008. Diagn Microbiol Infect Dis (2009) 1.22
Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. Antimicrob Agents Chemother (2010) 1.20
Characterization of the effectors required for stable inheritance of Streptococcus pyogenes pSM19035-derived plasmids in Bacillus subtilis. Mol Gen Genet (1993) 1.15
First report of Staphylococcal clinical isolates in Mexico with linezolid resistance caused by cfr: evidence of in vivo cfr mobilization. J Clin Microbiol (2010) 1.12
Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations. Antimicrob Agents Chemother (2010) 1.12
First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces. Antimicrob Agents Chemother (2010) 1.11
The Bacillus subtilis histone-like protein Hbsu is required for DNA resolution and DNA inversion mediated by the beta recombinase of plasmid pSM19035. J Biol Chem (1995) 1.04
Comparative DNA analysis of two vanA plasmids from Enterococcus faecium strains isolated from poultry and a poultry farmer in Norway. Antimicrob Agents Chemother (2006) 1.01
Cointegrase, a naturally occurring, truncated form of IS21 transposase, catalyzes replicon fusion rather than simple insertion of IS21. J Mol Biol (1998) 1.01
Low fitness cost of the multidrug resistance gene cfr. Antimicrob Agents Chemother (2011) 0.98
The beta recombinase of plasmid pSM19035 binds to two adjacent sites, making different contacts at each of them. Nucleic Acids Res (1995) 0.89
Site-specific recombination by the beta protein from the streptococcal plasmid pSM19035: minimal recombination sequences and crossing over site. Nucleic Acids Res (1996) 0.89
Pheromone-responsive conjugative vancomycin resistance plasmids in Enterococcus faecalis isolates from humans and chicken feces. Appl Environ Microbiol (2006) 0.88
Functional analysis of pSM19035-derived replicons in Bacillus subtilis. FEMS Microbiol Lett (1993) 0.86
Identification of the replication region of Streptococcus thermophilus No. 29 plasmid pST1. Biosci Biotechnol Biochem (1993) 0.83
Synapsis and strand exchange in the resolution and DNA inversion reactions catalysed by the beta recombinase. Nucleic Acids Res (2003) 0.83
Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. Mol Microbiol (2007) 3.47
The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria. Mol Cell (2007) 2.93
Molecular mechanism of drug-dependent ribosome stalling. Mol Cell (2008) 2.62
Selective protein synthesis by ribosomes with a drug-obstructed exit tunnel. Cell (2012) 2.57
Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc Natl Acad Sci U S A (2010) 2.38
Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700). Antimicrob Agents Chemother (2009) 2.17
Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center. Mol Cell (2011) 1.96
Nucleotide biosynthesis is critical for growth of bacteria in human blood. PLoS Pathog (2008) 1.83
Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin. Antimicrob Agents Chemother (2009) 1.81
A novel family of Escherichia coli toxin-antitoxin gene pairs. J Bacteriol (2003) 1.68
The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide. EMBO J (2010) 1.67
The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA. RNA (2007) 1.60
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA. J Am Chem Soc (2010) 1.60
Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. Antimicrob Agents Chemother (2008) 1.57
Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics. J Biol Chem (2003) 1.49
The ribosomal peptidyl transferase center: structure, function, evolution, inhibition. Crit Rev Biochem Mol Biol (2005) 1.42
Macrolide antibiotics: binding site, mechanism of action, resistance. Curr Top Med Chem (2003) 1.37
A protein component at the heart of an RNA machine: the importance of protein l27 for the function of the bacterial ribosome. Mol Cell (2005) 1.30
Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451. Nucleic Acids Res (2005) 1.29
Simultaneous analysis of host and pathogen interactions during an in vivo infection reveals local induction of host acute phase response proteins, a novel bacterial stress response, and evidence of a host-imposed metal ion limited environment. Cell Microbiol (2004) 1.27
Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis. Antimicrob Agents Chemother (2010) 1.27
Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action. Ann N Y Acad Sci (2011) 1.23
Essential mechanisms in the catalysis of peptide bond formation on the ribosome. J Biol Chem (2005) 1.23
Deleterious mutations in small subunit ribosomal RNA identify functional sites and potential targets for antibiotics. Proc Natl Acad Sci U S A (2005) 1.21
Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. Antimicrob Agents Chemother (2010) 1.20
Binding site of the bridged macrolides in the Escherichia coli ribosome. Antimicrob Agents Chemother (2005) 1.17
Tedizolid for the management of human infections: in vitro characteristics. Clin Infect Dis (2014) 1.17
Major families of multiresistant plasmids from geographically and epidemiologically diverse staphylococci. G3 (Bethesda) (2011) 1.14
Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations. Antimicrob Agents Chemother (2010) 1.12
Nosocomial superinfections due to linezolid-resistant Enterococcus faecalis: evidence for a gene dosage effect on linezolid MICs. Diagn Microbiol Infect Dis (2003) 1.09
Induction of erm(C) expression by noninducing antibiotics. Antimicrob Agents Chemother (2007) 1.09
Role of antibiotic ligand in nascent peptide-dependent ribosome stalling. Proc Natl Acad Sci U S A (2011) 1.07
Potential new antibiotic sites in the ribosome revealed by deleterious mutations in RNA of the large ribosomal subunit. J Biol Chem (2007) 1.04
An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors. J Mol Biol (2008) 1.04
Tools for characterizing bacterial protein synthesis inhibitors. Antimicrob Agents Chemother (2013) 1.01
Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistance. Antimicrob Agents Chemother (2011) 0.99
Low fitness cost of the multidrug resistance gene cfr. Antimicrob Agents Chemother (2011) 0.98
Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition. Nucleic Acids Res (2013) 0.97
Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains. Bioorg Med Chem Lett (2007) 0.92
Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: synthesis and preliminary SAR analysis. Bioorg Med Chem Lett (2007) 0.92
Identification of novel inhibitors of bacterial translation elongation factors. Antimicrob Agents Chemother (2005) 0.90
SPARK--a novel method to monitor ribosomal peptidyl transferase activity. Biochemistry (2002) 0.89
Fluorescently labeled ribosomes as a tool for analyzing antibiotic binding. RNA (2009) 0.87
The genetic environment of the cfr gene and the presence of other mechanisms account for the very high linezolid resistance of Staphylococcus epidermidis isolate 426-3147L. Antimicrob Agents Chemother (2012) 0.86
Structural signatures of antibiotic binding sites on the ribosome. Nucleic Acids Res (2010) 0.85
Selection of small peptides, inhibitors of translation. J Mol Biol (2009) 0.84
The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics. Proc Natl Acad Sci U S A (2010) 0.84
Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan. Nucleic Acids Res (2013) 0.83
Evaluation of the metS and murB loci for antibiotic discovery using targeted antisense RNA expression analysis in Bacillus anthracis. Antimicrob Agents Chemother (2007) 0.82
Comparison of the essential cellular functions of the two murA genes of Bacillus anthracis. Antimicrob Agents Chemother (2008) 0.81
Picky nascent peptides do not talk to foreign ribosomes. Proc Natl Acad Sci U S A (2011) 0.81
Deregulation of translation due to post-transcriptional modification of rRNA explains why erm genes are inducible. Nat Commun (2013) 0.80
Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines. J Med Chem (2014) 0.78
Affinity capillary electrophoresis for the screening of novel antimicrobial targets. J Biomol Screen (2004) 0.75
Synthesis and biological investigation of new 4''-malonyl tethered derivatives of erythromycin and clarithromycin. Bioorg Med Chem Lett (2006) 0.75