Published in Bone on September 02, 2005
Silk as a Biomaterial. Prog Polym Sci (2007) 4.13
In vivo degradation of three-dimensional silk fibroin scaffolds. Biomaterials (2008) 3.39
Biomimetic materials for tissue engineering. Adv Drug Deliv Rev (2007) 3.34
Craniofacial tissue engineering by stem cells. J Dent Res (2006) 2.48
Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering. J Control Release (2008) 1.72
Biodegradation of silk biomaterials. Int J Mol Sci (2009) 1.55
Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells. PLoS One (2008) 1.37
Hypoxia and stem cell-based engineering of mesenchymal tissues. Biotechnol Prog (2009) 1.36
Collagen scaffolds populated with human marrow stromal cells reduce lesion volume and improve functional outcome after traumatic brain injury. Neurosurgery (2007) 1.24
Bone grafts engineered from human adipose-derived stem cells in perfusion bioreactor culture. Tissue Eng Part A (2010) 1.24
BMP-silk composite matrices heal critically sized femoral defects. Bone (2007) 1.22
Stem cell- and scaffold-based tissue engineering approaches to osteochondral regenerative medicine. Semin Cell Dev Biol (2009) 1.21
Molecular mechanics of mineralized collagen fibrils in bone. Nat Commun (2013) 1.20
Comparison of skeletal effects of ovariectomy versus chemically induced ovarian failure in mice. J Bone Miner Res (2008) 1.11
Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing. Acta Biomater (2008) 1.08
Mice lacking beta-adrenergic receptors have increased bone mass but are not protected from deleterious skeletal effects of ovariectomy. Endocrinology (2008) 1.07
Critical-size calvarial bone defects healing in a mouse model with silk scaffolds and SATB2-modified iPSCs. Biomaterials (2011) 1.07
Microarchitecture influences microdamage accumulation in human vertebral trabecular bone. J Bone Miner Res (2008) 1.06
Ingrowth of human mesenchymal stem cells into porous silk particle reinforced silk composite scaffolds: An in vitro study. Acta Biomater (2010) 1.06
Systemically transplanted bone marrow stromal cells contributing to bone tissue regeneration. J Cell Physiol (2008) 1.05
Apatite-coated silk fibroin scaffolds to healing mandibular border defects in canines. Bone (2009) 1.03
Osterix enhances BMSC-associated osseointegration of implants. J Dent Res (2009) 1.02
Specimen size and porosity can introduce error into microCT-based tissue mineral density measurements. Bone (2008) 1.01
Effects of chondrogenic and osteogenic regulatory factors on composite constructs grown using human mesenchymal stem cells, silk scaffolds and bioreactors. J R Soc Interface (2008) 1.01
Mechanical improvements to reinforced porous silk scaffolds. J Biomed Mater Res A (2011) 0.97
Silk fibroin as a biomaterial substrate for corneal epithelial cell sheet generation. Invest Ophthalmol Vis Sci (2012) 0.95
Silk-based biomaterials for sustained drug delivery. J Control Release (2014) 0.94
Three-dimensional scaffolds for tissue engineering: the importance of uniformity in pore size and structure. Langmuir (2010) 0.93
Concise review: personalized human bone grafts for reconstructing head and face. Stem Cells Transl Med (2011) 0.89
Engineering cartilage and bone using human mesenchymal stem cells. J Orthop Sci (2007) 0.89
Biocompatibility evaluation of a novel hydroxyapatite-polymer coating for medical implants (in vitro tests). J Mater Sci Mater Med (2007) 0.89
Silk microfiber-reinforced silk hydrogel composites for functional cartilage tissue repair. Acta Biomater (2014) 0.88
Hypoxia and amino acid supplementation synergistically promote the osteogenesis of human mesenchymal stem cells on silk protein scaffolds. Tissue Eng Part A (2010) 0.87
Remodeling of tissue-engineered bone structures in vivo. Eur J Pharm Biopharm (2013) 0.87
Bioelectric modulation of wound healing in a 3D in vitro model of tissue-engineered bone. Biomaterials (2013) 0.86
Depolarization alters phenotype, maintains plasticity of predifferentiated mesenchymal stem cells. Tissue Eng Part A (2013) 0.85
The homing of bone marrow MSCs to non-osseous sites for ectopic bone formation induced by osteoinductive calcium phosphate. Biomaterials (2013) 0.85
Silk constructs for delivery of musculoskeletal therapeutics. Adv Drug Deliv Rev (2012) 0.84
Human dental pulp progenitor cell behavior on aqueous and hexafluoroisopropanol based silk scaffolds. J Biomed Mater Res A (2011) 0.83
Treatment of traumatic brain injury in mice with bone marrow stromal cell-impregnated collagen scaffolds. J Neurosurg (2009) 0.83
The treatment of TBI with human marrow stromal cells impregnated into collagen scaffold: functional outcome and gene expression profile. Brain Res (2010) 0.83
The influence of scaffold material on chondrocytes under inflammatory conditions. Acta Biomater (2013) 0.83
High-yield activation of scaffold polymer surfaces to attach cell adhesion molecules. J Am Chem Soc (2007) 0.82
Osteoinductive recombinant silk fusion proteins for bone regeneration. Acta Biomater (2016) 0.80
Multiple silk coatings on biphasic calcium phosphate scaffolds: effect on physical and mechanical properties and in vitro osteogenic response of human mesenchymal stem cells. Biomacromolecules (2013) 0.80
Multifunctionalized electrospun silk fibers promote axon regeneration in central nervous system. Adv Funct Mater (2011) 0.80
Postcranial skeletal pneumaticity: a case study in the use of quantitative microCT to assess vertebral structure in birds. J Anat (2007) 0.80
Repair of large segmental bone defects: BMP-2 gene activated muscle grafts vs. autologous bone grafting. BMC Biotechnol (2013) 0.80
An ectopic study of apatite-coated silk fibroin scaffolds seeded with AdBMP-2-modified canine bMSCs. J Biomater Sci Polym Ed (2011) 0.80
Tissue-engineered autologous grafts for facial bone reconstruction. Sci Transl Med (2016) 0.79
Enhanced cell affinity of the silk fibroin- modified PHBHHx material. J Mater Sci Mater Med (2009) 0.78
Electrospun silk fibroin nanofibers promote Schwann cell adhesion, growth and proliferation. Neural Regen Res (2012) 0.78
Radially and axially graded multizonal bone graft substitutes targeting critical-sized bone defects from polycaprolactone/hydroxyapatite/tricalcium phosphate. Tissue Eng Part A (2012) 0.78
Optimization of macroporous 3-D silk fibroin scaffolds by salt-leaching procedure in organic solvent-free conditions. J Mater Sci Mater Med (2011) 0.78
Porous silk scaffolds for delivery of growth factors and stem cells to enhance bone regeneration. PLoS One (2014) 0.78
Effects of clodronate and alendronate on osteoclast and osteoblast co-cultures on silk-hydroxyapatite films. Acta Biomater (2013) 0.78
Culture & differentiation of mesenchymal stem cell into osteoblast on degradable biomedical composite scaffold: In vitro study. Indian J Med Res (2015) 0.77
Modulation of Host Osseointegration during Bone Regeneration by Controlling Exogenous Stem Cells Differentiation Using a Material Approach. Biomater Sci (2014) 0.77
Patterned silk film scaffolds for aligned lamellar bone tissue engineering. Macromol Biosci (2012) 0.77
Human mesenchymal stem cells cultured on silk hydrogels with variable stiffness and growth factor differentiate into mature smooth muscle cell phenotype. Acta Biomater (2015) 0.77
Comparative study of bone repair using porous hydroxyapatite/ β-tricalcium phosphate and xenograft scaffold in rabbits with tibia defect. Iran Biomed J (2012) 0.77
Quantitative characterization of mineralized silk film remodeling during long-term osteoblast-osteoclast co-culture. Biomaterials (2014) 0.77
Will silk fibroin nanofiber scaffolds ever hold a useful place in Translational Regenerative Medicine? Int J Burns Trauma (2011) 0.76
Phenotypic analysis of Dlx5 overexpression in post-natal bone. J Dent Res (2008) 0.76
Cell-tethered ligands modulate bone remodeling by osteoblasts and osteoclasts. Adv Funct Mater (2014) 0.76
Cell proliferation by silk gut incorporating FGF-2 protein microcrystals. Sci Rep (2015) 0.76
Silk fibroin/chitosan-hyaluronic acid versus silk fibroin scaffolds for tissue engineering: promoting cell proliferations in vitro. J Mater Sci Mater Med (2010) 0.76
Tissue response and biodegradation of composite scaffolds prepared from Thai silk fibroin, gelatin and hydroxyapatite. J Mater Sci Mater Med (2010) 0.76
Silk Nanofiber Hydrogels with Tunable Modulus to Regulate Nerve Stem Cell Fate. J Mater Chem B Mater Biol Med (2014) 0.76
The e-incubator: a magnetic resonance imaging-compatible mini incubator. Tissue Eng Part C Methods (2014) 0.75
Characterization of Silk Fibroin/Chitosan 3D Porous Scaffold and In Vitro Cytology. PLoS One (2015) 0.75
A Comparison of Tissue Engineering Scaffolds Incorporated with Manuka Honey of Varying UMF. Biomed Res Int (2017) 0.75
Minocycline Loaded Hybrid Composites Nanoparticles for Mesenchymal Stem Cells Differentiation into Osteogenesis. Int J Mol Sci (2016) 0.75
Characterizing the Effects of Washing by Different Detergents on the Wavelength-Scale Microstructures of Silk Samples Using Mueller Matrix Polarimetry. Int J Mol Sci (2016) 0.75
Influence of the protocol of fibroin extraction on the antibiotic activities of the constructed composites. Prog Biomater (2015) 0.75
Osteogenic Differentiation of Mesenchymal Stem Cells by Mimicking the Cellular Niche of the Endochondral Template. Tissue Eng Part A (2016) 0.75
Flow velocity-driven differentiation of human mesenchymal stromal cells in silk fibroin scaffolds: A combined experimental and computational approach. PLoS One (2017) 0.75
Silk fibroin scaffolds with inverse opal structure for bone tissue engineering. J Biomed Mater Res B Appl Biomater (2016) 0.75
Hollow hydroxyapatite microspheres/chitosan composite as a sustained delivery vehicle for rhBMP-2 in the treatment of bone defects. J Mater Sci Mater Med (2015) 0.75
Local delivery of HMGB1 in gelatin sponge scaffolds combined with mesenchymal stem cell sheets to accelerate fracture healing. Oncotarget (2017) 0.75
Bone Regeneration Induced by Bone Porcine Block with Bone Marrow Stromal Stem Cells in a Minipig Model of Mandibular "Critical Size" Defect. Stem Cells Int (2017) 0.75
Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol (2007) 17.80
Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov (2009) 12.46
Engineering vascularized skeletal muscle tissue. Nat Biotechnol (2005) 7.73
Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials (2005) 7.55
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci U S A (2006) 6.90
Impact of nanotechnology on drug delivery. ACS Nano (2009) 6.87
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol (2008) 6.81
Microscale technologies for tissue engineering and biology. Proc Natl Acad Sci U S A (2006) 6.66
Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile. Sci Transl Med (2012) 5.92
Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells. Nat Biotechnol (2004) 5.51
Transdermal drug delivery. Nat Biotechnol (2008) 5.11
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev (2008) 4.85
Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci U S A (2002) 4.77
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A (2008) 4.57
Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells. Cancer Res (2004) 4.56
Combined postmenopausal hormone therapy and cardiovascular disease: toward resolving the discrepancy between observational studies and the Women's Health Initiative clinical trial. Am J Epidemiol (2005) 4.55
DisProt: the Database of Disordered Proteins. Nucleic Acids Res (2006) 4.46
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events. Nat Biotechnol (2008) 4.46
A tough biodegradable elastomer. Nat Biotechnol (2002) 4.35
Lipid-like materials for low-dose, in vivo gene silencing. Proc Natl Acad Sci U S A (2010) 4.25
Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds. Proc Natl Acad Sci U S A (2004) 4.13
Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials (2006) 4.09
Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. J Gene Med (2005) 4.04
Accordion-like honeycombs for tissue engineering of cardiac anisotropy. Nat Mater (2008) 4.00
A reversibly switching surface. Science (2003) 3.97
Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol (2011) 3.95
Small-scale systems for in vivo drug delivery. Nat Biotechnol (2003) 3.90
Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers. Proc Natl Acad Sci U S A (2008) 3.80
Nanoparticle delivery of cancer drugs. Annu Rev Med (2011) 3.75
Endothelial cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A (2002) 3.66
Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc Natl Acad Sci U S A (2008) 3.62
First-in-human testing of a wirelessly controlled drug delivery microchip. Sci Transl Med (2012) 3.56
Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks. Biomacromolecules (2005) 3.44
Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov (2004) 3.41
Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nat Neurosci (2006) 3.35
Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci U S A (2002) 3.35
Treating metastatic cancer with nanotechnology. Nat Rev Cancer (2011) 3.30
Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A (2007) 3.19
Outbreak of adverse reactions associated with contaminated heparin. N Engl J Med (2008) 3.16
Nanotechnological strategies for engineering complex tissues. Nat Nanotechnol (2010) 3.15
Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nat Mater (2010) 3.11
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nat Nanotechnol (2012) 3.09
Engineering substrate topography at the micro- and nanoscale to control cell function. Angew Chem Int Ed Engl (2009) 3.09
Stem cell-based tissue engineering with silk biomaterials. Biomaterials (2006) 2.88
Microengineered hydrogels for tissue engineering. Biomaterials (2007) 2.87
Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds. Proc Natl Acad Sci U S A (2003) 2.86
Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. Angew Chem Int Ed Engl (2003) 2.83
The inflammatory responses to silk films in vitro and in vivo. Biomaterials (2005) 2.79
Biodegradable, elastic shape-memory polymers for potential biomedical applications. Science (2002) 2.79
Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform. ACS Nano (2008) 2.76
Nanomedicine: developing smarter therapeutic and diagnostic modalities. Adv Drug Deliv Rev (2006) 2.69
Multi-pulse drug delivery from a resorbable polymeric microchip device. Nat Mater (2003) 2.65
A combinatorial polymer library approach yields insight into nonviral gene delivery. Acc Chem Res (2008) 2.63
A biodegradable and biocompatible gecko-inspired tissue adhesive. Proc Natl Acad Sci U S A (2008) 2.58
Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. Nat Mater (2012) 2.57
Cell differentiation by mechanical stress. FASEB J (2001) 2.56
Engineering complex tissues. Tissue Eng (2006) 2.53
Light-induced shape-memory polymers. Nature (2005) 2.52
Risk of cardiovascular disease by hysterectomy status, with and without oophorectomy: the Women's Health Initiative Observational Study. Circulation (2005) 2.49
Engineered microenvironments for controlled stem cell differentiation. Tissue Eng Part A (2009) 2.48
Medium perfusion enables engineering of compact and contractile cardiac tissue. Am J Physiol Heart Circ Physiol (2003) 2.42
Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer. Nano Lett (2007) 2.40
A vector-free microfluidic platform for intracellular delivery. Proc Natl Acad Sci U S A (2013) 2.40
Development of lipidoid-siRNA formulations for systemic delivery to the liver. Mol Ther (2009) 2.39
An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform. Angew Chem Int Ed Engl (2006) 2.38
Bio-inspired polymer composite actuator and generator driven by water gradients. Science (2013) 2.38
Engineering anatomically shaped human bone grafts. Proc Natl Acad Sci U S A (2009) 2.37
Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett (2010) 2.35
Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells. Lab Chip (2007) 2.30
Biocompatibility and biofouling of MEMS drug delivery devices. Biomaterials (2003) 2.27
Bone tissue engineering using human mesenchymal stem cells: effects of scaffold material and medium flow. Ann Biomed Eng (2004) 2.26
Endothelialized microvasculature based on a biodegradable elastomer. Tissue Eng (2005) 2.23
PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery. Biomaterials (2008) 2.21
Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy. Proc Natl Acad Sci U S A (2010) 2.21
Number sense growth in kindergarten: a longitudinal investigation of children at risk for mathematics difficulties. Child Dev (2006) 2.21
A longitudinal study of mathematical competencies in children with specific mathematics difficulties versus children with comorbid mathematics and reading difficulties. Child Dev (2003) 2.20
Biomimetic approach to cardiac tissue engineering: oxygen carriers and channeled scaffolds. Tissue Eng (2006) 2.20
Composite scaffold provides a cell delivery platform for cardiovascular repair. Proc Natl Acad Sci U S A (2011) 2.14
Micromolding of shape-controlled, harvestable cell-laden hydrogels. Biomaterials (2006) 2.12
Nanostructured materials for applications in drug delivery and tissue engineering. J Biomater Sci Polym Ed (2007) 2.12
Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle like cells and form vascular networks in vivo. Circ Res (2007) 2.12
Progress in tissue engineering. Sci Am (2009) 2.08
In vivo engineering of organs: the bone bioreactor. Proc Natl Acad Sci U S A (2005) 2.04
Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines. Nat Mater (2004) 2.03
Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proc Natl Acad Sci U S A (2004) 2.03
Arithmetic fact mastery in young children: a longitudinal investigation. J Exp Child Psychol (2003) 2.02
Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue. Biotechnol Bioeng (2006) 2.01