Published in Cell on September 09, 2005
Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology (2008) 5.19
Mechanisms in eukaryotic mismatch repair. J Biol Chem (2006) 3.55
The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell (2013) 2.87
DNA mismatch repair: molecular mechanism, cancer, and ageing. Mech Ageing Dev (2008) 2.40
Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease. J Biol Chem (2007) 2.09
Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates. Cell (2011) 2.02
Replication protein A: directing traffic at the intersection of replication and repair. Front Biosci (Landmark Ed) (2010) 1.77
Beta clamp directs localization of mismatch repair in Bacillus subtilis. Mol Cell (2008) 1.73
Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. Cell (2011) 1.73
Postreplicative mismatch repair. Cold Spring Harb Perspect Biol (2013) 1.67
HMGB1 in health and disease. Mol Aspects Med (2014) 1.67
Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus. J Biol Chem (2007) 1.51
The N terminus of Saccharomyces cerevisiae Msh6 is an unstructured tether to PCNA. Mol Cell (2007) 1.51
HMGB1 is a cofactor in mammalian base excision repair. Mol Cell (2007) 1.49
A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair. Proc Natl Acad Sci U S A (2009) 1.43
Saccharomyces cerevisiae Msh2-Msh3 acts in repair of base-base mispairs. Mol Cell Biol (2007) 1.40
Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha. Mol Cell (2008) 1.38
Nucleosome remodeling by hMSH2-hMSH6. Mol Cell (2009) 1.36
Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication. Science (2011) 1.34
DNA end resection by CtIP and exonuclease 1 prevents genomic instability. EMBO Rep (2010) 1.33
Structure of the endonuclease domain of MutL: unlicensed to cut. Mol Cell (2010) 1.24
Human PMS2 deficiency is associated with impaired immunoglobulin class switch recombination. J Exp Med (2008) 1.22
Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway. J Biol Chem (2009) 1.21
Evidence that nucleosomes inhibit mismatch repair in eukaryotic cells. J Biol Chem (2009) 1.20
HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic. Mol Carcinog (2009) 1.20
Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired. Proc Natl Acad Sci U S A (2010) 1.20
Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis. Nucleic Acids Res (2006) 1.19
Functional characterization of pathogenic human MSH2 missense mutations in Saccharomyces cerevisiae. Genetics (2007) 1.17
Mutations affecting a putative MutLalpha endonuclease motif impact multiple mismatch repair functions. DNA Repair (Amst) (2007) 1.17
DNA repair in antibody somatic hypermutation. Trends Immunol (2006) 1.17
Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1. Nucleic Acids Res (2008) 1.13
Sequence context effect for hMSH2-hMSH6 mismatch-dependent activation. Proc Natl Acad Sci U S A (2009) 1.13
Incision-dependent and error-free repair of (CAG)(n)/(CTG)(n) hairpins in human cell extracts. Nat Struct Mol Biol (2009) 1.12
AIDing antibody diversity by error-prone mismatch repair. Semin Immunol (2012) 1.10
Exonuclease 1 preferentially repairs mismatches generated by DNA polymerase α. DNA Repair (Amst) (2012) 1.07
HMGB1: roles in base excision repair and related function. Biochim Biophys Acta (2010) 1.07
DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets. Br J Pharmacol (2009) 1.07
Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility. J Biol Chem (2012) 1.07
Mismatch Repair. J Biol Chem (2015) 1.06
A panoply of errors: polymerase proofreading domain mutations in cancer. Nat Rev Cancer (2016) 1.06
Genome dynamics in major bacterial pathogens. FEMS Microbiol Rev (2009) 1.06
The ageing epigenome: damaged beyond repair? Ageing Res Rev (2009) 1.05
Mismatch recognition protein MutSbeta does not hijack (CAG)n hairpin repair in vitro. J Biol Chem (2009) 1.04
Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth. Mol Cancer Ther (2011) 1.02
DNA mismatch repair gene polymorphisms affect survival in pancreatic cancer. Oncologist (2011) 1.02
Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair. J Biol Chem (2009) 1.00
Distinct nucleotide binding/hydrolysis properties and molar ratio of MutSalpha and MutSbeta determine their differential mismatch binding activities. J Biol Chem (2009) 1.00
Chemical trapping of the dynamic MutS-MutL complex formed in DNA mismatch repair in Escherichia coli. J Biol Chem (2011) 1.00
Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair. Nucleic Acids Res (2006) 0.99
A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survival. Clin Cancer Res (2012) 0.99
HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Mol Cell (2014) 0.98
CTG/CAG repeat instability is modulated by the levels of human DNA ligase I and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair. J Biol Chem (2009) 0.97
Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins. Proc Natl Acad Sci U S A (2013) 0.97
PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair. Mol Cell (2014) 0.97
MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta. J Biol Chem (2010) 0.96
Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches. PLoS Genet (2013) 0.95
Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis. Proc Natl Acad Sci U S A (2015) 0.94
Biochemical mechanism of DSB end resection and its regulation. DNA Repair (Amst) (2015) 0.94
The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome. Fam Cancer (2013) 0.94
Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools. Environ Mol Mutagen (2012) 0.93
Human MSH2 (hMSH2) protein controls ATP processing by hMSH2-hMSH6. J Biol Chem (2011) 0.93
Finding of widespread viral and bacterial revolution dsDNA translocation motors distinct from rotation motors by channel chirality and size. Cell Biosci (2014) 0.93
Insights into protein - DNA interactions, stability and allosteric communications: a computational study of mutSα-DNA recognition complexes. J Biomol Struct Dyn (2012) 0.92
Mismatch repair during homologous and homeologous recombination. Cold Spring Harb Perspect Biol (2015) 0.92
The endonuclease domain of MutL interacts with the β sliding clamp. DNA Repair (Amst) (2010) 0.91
Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions. Proc Natl Acad Sci U S A (2008) 0.91
Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities. Mutat Res (2013) 0.91
Aberrant protein expression and frequent allelic loss of MSH3 in colorectal cancer with low-level microsatellite instability. Int J Colorectal Dis (2012) 0.91
Functional studies and homology modeling of Msh2-Msh3 predict that mispair recognition involves DNA bending and strand separation. Mol Cell Biol (2010) 0.90
Human MutLalpha: the jack of all trades in MMR is also an endonuclease. DNA Repair (Amst) (2006) 0.89
Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays. Hered Cancer Clin Pract (2012) 0.89
Instability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesis. Cell Biosci (2012) 0.89
The dual nature of mismatch repair as antimutator and mutator: for better or for worse. Front Genet (2014) 0.88
Exonuclease 1-dependent and independent mismatch repair. DNA Repair (Amst) (2015) 0.88
Single-molecule views of MutS on mismatched DNA. DNA Repair (Amst) (2014) 0.88
Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex. EMBO J (2015) 0.88
Modulation of microRNA processing by mismatch repair protein MutLα. Cell Res (2012) 0.87
In vitro studies of DNA mismatch repair proteins. Anal Biochem (2011) 0.87
Biochemical analysis of the human mismatch repair proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D). J Biol Chem (2012) 0.87
Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1. DNA Repair (Amst) (2010) 0.87
PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro. DNA Repair (Amst) (2011) 0.87
Mismatch-mediated error prone repair at the immunoglobulin genes. Biomed Pharmacother (2011) 0.86
MutSbeta exceeds MutSalpha in dinucleotide loop repair. Br J Cancer (2010) 0.86
The Role of XPG in Processing (CAG)n/(CTG)n DNA Hairpins. Cell Biosci (2011) 0.86
Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression. Mol Cell Proteomics (2014) 0.86
DNA mismatch repair efficiency and fidelity are elevated during DNA synthesis in human cells. Mutat Res (2008) 0.86
Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway. PLoS Genet (2013) 0.86
Mispair-specific recruitment of the Mlh1-Pms1 complex identifies repair substrates of the Saccharomyces cerevisiae Msh2-Msh3 complex. J Biol Chem (2014) 0.86
Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture). Angew Chem Int Ed Engl (2016) 0.86
14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. DNA Repair (Amst) (2012) 0.85
HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. EMBO Mol Med (2014) 0.85
Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats. J Immunol (2009) 0.85
Chromosome integrity at a double-strand break requires exonuclease 1 and MRX. DNA Repair (Amst) (2010) 0.85
Acetylation regulates DNA repair mechanisms in human cells. Cell Cycle (2016) 0.85
In vitro repair of DNA hairpins containing various numbers of CAG/CTG trinucleotide repeats. DNA Repair (Amst) (2011) 0.85
Single molecule studies of DNA mismatch repair. DNA Repair (Amst) (2014) 0.84
Hydrolytic function of Exo1 in mammalian mismatch repair. Nucleic Acids Res (2014) 0.83
Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage. DNA Repair (Amst) (2009) 0.83
Assessment of anti-recombination and double-strand break-induced gene conversion in human cells by a chromosomal reporter. J Biol Chem (2012) 0.83
Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo. Hum Mutat (2010) 0.83
AP endonuclease-independent DNA base excision repair in human cells. Mol Cell (2004) 3.37
The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell (2013) 2.87
Human DNA ligase I completely encircles and partially unwinds nicked DNA. Nature (2004) 2.85
Mechanism of DNA double-strand break repair by non-homologous end joining. DNA Repair (Amst) (2005) 2.53
Eukaryotic DNA ligases: structural and functional insights. Annu Rev Biochem (2008) 2.44
A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Mol Cell (2006) 2.23
Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine. Science (2004) 2.04
Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination. Nat Struct Mol Biol (2007) 1.87
XRCC1 co-localizes and physically interacts with PCNA. Nucleic Acids Res (2004) 1.70
Proteasome regulation of ULBP1 transcription. J Immunol (2009) 1.61
SiteFinding-PCR: a simple and efficient PCR method for chromosome walking. Nucleic Acids Res (2005) 1.61
Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair. Mol Cell Biol (2003) 1.50
Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks. Blood (2008) 1.48
NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. DNA Repair (Amst) (2006) 1.45
A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joining. J Biol Chem (2002) 1.42
Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res (2008) 1.36
Cutting edge: microRNA-181 promotes human NK cell development by regulating Notch signaling. J Immunol (2011) 1.32
Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states. Biochemistry (2010) 1.32
Two DNA-binding and nick recognition modules in human DNA ligase III. J Biol Chem (2008) 1.30
Physical and functional interaction between the XPF/ERCC1 endonuclease and hRad52. J Biol Chem (2004) 1.29
Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway. J Biol Chem (2011) 1.21
Differential requirement for proliferating cell nuclear antigen in 5' and 3' nick-directed excision in human mismatch repair. J Biol Chem (2004) 1.21
The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase. Nucleic Acids Res (2007) 1.21
Evidence that nucleosomes inhibit mismatch repair in eukaryotic cells. J Biol Chem (2009) 1.20
Evidence for involvement of HMGB1 protein in human DNA mismatch repair. J Biol Chem (2004) 1.19
Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase. J Virol (2005) 1.18
Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A. Mol Cell Biol (2002) 1.18
Genetic and epigenetic modification of mismatch repair genes hMSH2 and hMLH1 in sporadic breast cancer with microsatellite instability. Oncogene (2002) 1.12
Incision-dependent and error-free repair of (CAG)(n)/(CTG)(n) hairpins in human cell extracts. Nat Struct Mol Biol (2009) 1.12
Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem (2008) 1.10
Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain. Free Radic Biol Med (2008) 1.10
Processing and joining of DNA ends coordinated by interactions among Dnl4/Lif1, Pol4, and FEN-1. J Biol Chem (2004) 1.09
Effect of amino acid substitutions in the rad50 ATP binding domain on DNA double strand break repair in yeast. J Biol Chem (2004) 1.08
Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair. Mol Cell Biol (2011) 1.07
Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility. J Biol Chem (2012) 1.07
Targeting abnormal DNA repair in therapy-resistant breast cancers. Mol Cancer Res (2011) 1.07
hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair. EMBO Rep (2005) 1.06
Identification and characterization of OGG1 mutations in patients with Alzheimer's disease. Nucleic Acids Res (2007) 1.06
Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins. Proc Natl Acad Sci U S A (2013) 1.04
Mismatch recognition protein MutSbeta does not hijack (CAG)n hairpin repair in vitro. J Biol Chem (2009) 1.04
Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population. Nucleic Acids Res (2010) 1.04
Human DNA ligases I, III, and IV-purification and new specific assays for these enzymes. Methods Enzymol (2006) 1.04
Human NK cells proliferate and die in vivo more rapidly than T cells in healthy young and elderly adults. J Immunol (2011) 1.03
A conserved interaction between the replicative clamp loader and DNA ligase in eukaryotes: implications for Okazaki fragment joining. J Biol Chem (2004) 1.03
Targeting abnormal DNA double strand break repair in cancer. Cell Mol Life Sci (2010) 1.01
Distinct nucleotide binding/hydrolysis properties and molar ratio of MutSalpha and MutSbeta determine their differential mismatch binding activities. J Biol Chem (2009) 1.00
Genetic instability induced by overexpression of DNA ligase I in budding yeast. Genetics (2005) 0.98
Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage. J Biol Chem (2010) 0.97
CTG/CAG repeat instability is modulated by the levels of human DNA ligase I and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair. J Biol Chem (2009) 0.97
Combination of curcumin and green tea catechins prevents dimethylhydrazine-induced colon carcinogenesis. Food Chem Toxicol (2009) 0.96
Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair. DNA Repair (Amst) (2009) 0.96
Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches. PLoS Genet (2013) 0.95
Bi-directional processing of DNA loops by mismatch repair-dependent and -independent pathways in human cells. J Biol Chem (2002) 0.95
BCR-ABL1 mediates up-regulation of Fyn in chronic myelogenous leukemia. Blood (2008) 0.94
A conserved physical and functional interaction between the cell cycle checkpoint clamp loader and DNA ligase I of eukaryotes. J Biol Chem (2007) 0.93
Roles of mismatch repair proteins hMSH2 and hMLH1 in the development of sporadic breast cancer. Cancer Lett (2004) 0.92
The putative vitamin K-dependent gamma-glutamyl carboxylase internal propeptide appears to be the propeptide binding site. J Biol Chem (2002) 0.92
Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2. DNA Repair (Amst) (2012) 0.92
Translocation of XRCC1 and DNA ligase IIIalpha from centrosomes to chromosomes in response to DNA damage in mitotic human cells. Nucleic Acids Res (2005) 0.92
Regulation of replication protein A functions in DNA mismatch repair by phosphorylation. J Biol Chem (2006) 0.91
Yeast Nej1 is a key participant in the initial end binding and final ligation steps of nonhomologous end joining. J Biol Chem (2010) 0.91
The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision repair outcome at CAG/CTG repeats. Biochemistry (2012) 0.91
The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1. DNA Repair (Amst) (2009) 0.91
Reduced repair of DNA double-strand breaks by homologous recombination in a DNA ligase I-deficient human cell line. DNA Repair (Amst) (2005) 0.91
Phosphorylation of human DNA ligase I regulates its interaction with replication factor C and its participation in DNA replication and DNA repair. Mol Cell Biol (2009) 0.91
Electron microscopy visualization of DNA-protein complexes formed by Ku and DNA ligase IV. DNA Repair (Amst) (2011) 0.90
The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. Nucleic Acids Res (2003) 0.90
Oridonin nanosuspension was more effective than free oridonin on G2/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line. Int J Nanomedicine (2012) 0.90
Genomic analysis of freshwater cyanophage Pf-WMP3 Infecting cyanobacterium Phormidium foveolarum: the conserved elements for a phage. Microb Ecol (2008) 0.89
Replication protein A safeguards genome integrity by controlling NER incision events. J Cell Biol (2011) 0.89
Mismatch repair deficiency in hematological malignancies with microsatellite instability. Oncogene (2002) 0.89
A high-throughput scintillation proximity-based assay for human DNA ligase IV. Assay Drug Dev Technol (2011) 0.88
Cyanophage Pf-WMP4, a T7-like phage infecting the freshwater cyanobacterium Phormidium foveolarum: complete genome sequence and DNA translocation. Virology (2007) 0.88
dBre1/dSet1-dependent pathway for histone H3K4 trimethylation has essential roles in controlling germline stem cell maintenance and germ cell differentiation in the Drosophila ovary. Dev Biol (2013) 0.88
Modulation of microRNA processing by mismatch repair protein MutLα. Cell Res (2012) 0.87