Published in J Biol Chem on September 14, 2005
A novel class of modular transporters for vitamins in prokaryotes. J Bacteriol (2008) 2.16
The complete genome sequence of 'Candidatus Liberibacter solanacearum', the bacterium associated with potato zebra chip disease. PLoS One (2011) 1.79
Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations. BMC Genomics (2007) 1.47
Biosynthesis of 7-deazaguanosine-modified tRNA nucleosides: a new role for GTP cyclohydrolase I. J Bacteriol (2008) 1.25
Host origin of plastid solute transporters in the first photosynthetic eukaryotes. Genome Biol (2007) 1.24
Two essential arginine residues in the T components of energy-coupling factor transporters. J Bacteriol (2009) 1.22
Targeting purine and pyrimidine metabolism in human apicomplexan parasites. Curr Drug Targets (2007) 1.14
Arabidopsis SAMT1 defines a plastid transporter regulating plastid biogenesis and plant development. Plant Cell (2006) 1.09
Chloroplast envelope membranes: a dynamic interface between plastids and the cytosol. Photosynth Res (2007) 1.09
A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life. Proc Natl Acad Sci U S A (2010) 0.98
The plant mitochondrial carrier family: functional and evolutionary aspects. Front Plant Sci (2012) 0.97
The folylpolyglutamate synthetase plastidial isoform is required for postembryonic root development in Arabidopsis. Plant Physiol (2011) 0.96
Pterin and folate salvage. Plants and Escherichia coli lack capacity to reduce oxidized pterins. Plant Physiol (2007) 0.89
Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria. J Bacteriol (2007) 0.89
Plant Vacuolar ATP-binding Cassette Transporters That Translocate Folates and Antifolates in Vitro and Contribute to Antifolate Tolerance in Vivo. J Biol Chem (2009) 0.87
Promiscuous and adaptable enzymes fill "holes" in the tetrahydrofolate pathway in Chlamydia species. MBio (2014) 0.87
The metabolite transporters of the plastid envelope: an update. Front Plant Sci (2011) 0.86
6-pyruvoyltetrahydropterin synthase paralogs replace the folate synthesis enzyme dihydroneopterin aldolase in diverse bacteria. J Bacteriol (2009) 0.86
Origin of robustness in generating drug-resistant malaria parasites. Mol Biol Evol (2014) 0.85
Transport proteins of parasitic protists and their role in nutrient salvage. Front Plant Sci (2014) 0.84
Biofortification of plant-based food: enhancing folate levels by metabolic engineering. Proc Natl Acad Sci U S A (2007) 0.84
The import and export business in plastids: transport processes across the inner envelope membrane. Plant Physiol (2011) 0.84
Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate. ACS Chem Biol (2012) 0.84
Identification of transport-critical residues in a folate transporter from the folate-biopterin transporter (FBT) family. J Biol Chem (2009) 0.83
Characterisation of exogenous folate transport in Plasmodium falciparum. Mol Biochem Parasitol (2007) 0.83
High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family. J Biol Chem (2010) 0.81
Comparative genomics and functional analysis of the NiaP family uncover nicotinate transporters from bacteria, plants, and mammals. Funct Integr Genomics (2011) 0.81
The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters. J Biol Chem (2011) 0.81
Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I. Malar J (2014) 0.80
Deciphering Mineral Homeostasis in Barley Seed Transfer Cells at Transcriptional Level. PLoS One (2015) 0.78
Identification of a plastidial phenylalanine exporter that influences flux distribution through the phenylalanine biosynthetic network. Nat Commun (2015) 0.78
Variations in metabolic pathways create challenges for automated metabolic reconstructions: Examples from the tetrahydrofolate synthesis pathway. Comput Struct Biotechnol J (2014) 0.78
Folates in Plants: Research Advances and Progress in Crop Biofortification. Front Chem (2017) 0.75
The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei. J Biol Chem (2016) 0.75
Identification and functional expression of the mitochondrial pyruvate carrier. Science (2012) 3.15
Overcoming barriers to membrane protein structure determination. Nat Biotechnol (2011) 2.49
Effect of food fortification on folic acid intake in the United States. Am J Clin Nutr (2003) 2.32
Tomato aromatic amino acid decarboxylases participate in synthesis of the flavor volatiles 2-phenylethanol and 2-phenylacetaldehyde. Proc Natl Acad Sci U S A (2006) 2.30
A novel class of modular transporters for vitamins in prokaryotes. J Bacteriol (2008) 2.16
A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J Nutr (2006) 1.82
A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi. Nature (2008) 1.66
C1 metabolism and chlorophyll synthesis: the Mg-protoporphyrin IX methyltransferase activity is dependent on the folate status. New Phytol (2008) 1.56
Methionine metabolism in plants: chloroplasts are autonomous for de novo methionine synthesis and can import S-adenosylmethionine from the cytosol. J Biol Chem (2004) 1.52
Metabolite damage and its repair or pre-emption. Nat Chem Biol (2013) 1.50
Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations. BMC Genomics (2007) 1.47
Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor. Am J Physiol Endocrinol Metab (2003) 1.44
Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr (2011) 1.43
Biomarkers of folate status in NHANES: a roundtable summary. Am J Clin Nutr (2011) 1.43
Methylenetetrahydrofolate reductase 677C-->T polymorphism affects DNA methylation in response to controlled folate intake in young women. J Nutr Biochem (2004) 1.43
The mechanism of transport by mitochondrial carriers based on analysis of symmetry. Proc Natl Acad Sci U S A (2008) 1.41
Mitochondrial carriers in the cytoplasmic state have a common substrate binding site. Proc Natl Acad Sci U S A (2006) 1.40
Metabolic engineering of osmoprotectant accumulation in plants. Metab Eng (2002) 1.34
Vitamin deficiencies in humans: can plant science help? Plant Cell (2012) 1.33
Synthesis and turnover of folates in plants. Curr Opin Plant Biol (2002) 1.30
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses. Proc Natl Acad Sci U S A (2006) 1.27
Plant gamma-glutamyl hydrolases and folate polyglutamates: characterization, compartmentation, and co-occurrence in vacuoles. J Biol Chem (2005) 1.20
A nudix enzyme removes pyrophosphate from dihydroneopterin triphosphate in the folate synthesis pathway of bacteria and plants. J Biol Chem (2004) 1.19
Identification of genes encoding the folate- and thiamine-binding membrane proteins in Firmicutes. J Bacteriol (2008) 1.19
Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides. J Nutr (2005) 1.17
The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth. Mol Biol Cell (2007) 1.16
Phylogenomic and functional analysis of pterin-4a-carbinolamine dehydratase family (COG2154) proteins in plants and microorganisms. Plant Physiol (2008) 1.16
Folate biofortification in tomatoes by engineering the pteridine branch of folate synthesis. Proc Natl Acad Sci U S A (2004) 1.15
DNA methylation determination by liquid chromatography-tandem mass spectrometry using novel biosynthetic [U-15N]deoxycytidine and [U-15N]methyldeoxycytidine internal standards. Nucleic Acids Res (2008) 1.15
The yeast mitochondrial ADP/ATP carrier functions as a monomer in mitochondrial membranes. Proc Natl Acad Sci U S A (2007) 1.15
A novel ADP/ATP transporter in the mitosome of the microaerophilic human parasite Entamoeba histolytica. Curr Biol (2005) 1.14
Folate metabolism in plants: an Arabidopsis homolog of the mammalian mitochondrial folate transporter mediates folate import into chloroplasts. J Biol Chem (2005) 1.13
Conserved properties of hydrogenosomal and mitochondrial ADP/ATP carriers: a common origin for both organelles. EMBO J (2002) 1.12
Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism. Proc Natl Acad Sci U S A (2014) 1.12
In silico experimentation with a model of hepatic mitochondrial folate metabolism. Theor Biol Med Model (2006) 1.10
One-carbon metabolism in plants. Regulation of tetrahydrofolate synthesis during germination and seedling development. Plant Physiol (2003) 1.10
DNA digestion to deoxyribonucleoside: a simplified one-step procedure. Anal Biochem (2007) 1.08
Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate. J Biol Chem (2004) 1.08
Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis. Cancer Epidemiol Biomarkers Prev (2008) 1.08
Evolution of enzymes and pathways for the biosynthesis of cofactors. Nat Prod Rep (2007) 1.07
Folate biosynthesis, turnover, and transport in plants. Annu Rev Plant Biol (2011) 1.07
Folate biofortification of tomato fruit. Proc Natl Acad Sci U S A (2007) 1.06
Yeast mitochondrial ADP/ATP carriers are monomeric in detergents. Proc Natl Acad Sci U S A (2006) 1.06
Folate synthesis in plants: the p-aminobenzoate branch is initiated by a bifunctional PabA-PabB protein that is targeted to plastids. Proc Natl Acad Sci U S A (2004) 1.05
Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G diets. J Nutr (2006) 1.04
Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary vitamin B-6 restriction in young men and women. J Nutr (2006) 1.04
Functional expression of eukaryotic membrane proteins in Lactococcus lactis. Protein Sci (2005) 1.03
Hypothesis/review: contribution of putrescine to 4-aminobutyrate (GABA) production in response to abiotic stress. Plant Sci (2012) 1.02
5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves. J Biol Chem (2005) 1.02
Folate status response to controlled folate intake is affected by the methylenetetrahydrofolate reductase 677C-->T polymorphism in young women. J Nutr (2003) 1.02
Arabidopsis 10-formyl tetrahydrofolate deformylases are essential for photorespiration. Plant Cell (2008) 1.02
Plant B vitamin pathways and their compartmentation: a guide for the perplexed. J Exp Bot (2012) 1.02
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway. Plant Cell Physiol (2006) 1.02
The analysis of folate and its metabolic precursors in biological samples. Anal Biochem (2005) 1.02
MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline. Am J Clin Nutr (2010) 1.01
Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men. Am J Clin Nutr (2005) 1.01
The hydrophobic proteome of mitochondrial membranes from Arabidopsis cell suspensions. Phytochemistry (2004) 1.01
Glycine turnover and decarboxylation rate quantified in healthy men and women using primed, constant infusions of [1,2-(13)C2]glycine and [(2)H3]leucine. J Nutr (2007) 1.01
The folate precursor p-aminobenzoate is reversibly converted to its glucose ester in the plant cytosol. J Biol Chem (2003) 1.01
Folate biofortification in food plants. Trends Plant Sci (2007) 1.01
Frontiers in metabolic reconstruction and modeling of plant genomes. J Exp Bot (2012) 1.00
Biotin synthesis in plants. The first committed step of the pathway is catalyzed by a cytosolic 7-keto-8-aminopelargonic acid synthase. Plant Physiol (2005) 1.00
Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease. J Hepatol (2010) 0.99
Nonflowering plants possess a unique folate-dependent phenylalanine hydroxylase that is localized in chloroplasts. Plant Cell (2010) 0.99
Characterization and metabolic function of a peroxisomal sarcosine and pipecolate oxidase from Arabidopsis. J Biol Chem (2004) 0.99
Folate intake, MTHFR genotype, and sex modulate choline metabolism in mice. J Nutr (2011) 0.98
Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I. Proc Natl Acad Sci U S A (2002) 0.98
Activities of hepatic cytosolic and mitochondrial forms of serine hydroxymethyltransferase and hepatic glycine concentration are affected by vitamin B-6 intake in rats. J Nutr (2005) 0.98
A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life. Proc Natl Acad Sci U S A (2010) 0.98
Identification of six novel allosteric effectors of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase isoforms. Physiological context sets the specificity. J Biol Chem (2005) 0.98
Evidence for folate-salvage reactions in plants. Plant J (2006) 0.97