Acute kidney injury, mortality, length of stay, and costs in hospitalized patients.

Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care (2007) 29.89

RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care (2006) 9.29

Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis (2009) 6.54

Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med (2008) 5.89

The risk of acute renal failure in patients with chronic kidney disease. Kidney Int (2008) 5.87

Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest (2011) 5.75

Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease. Kidney Int (2009) 5.28

Community-based incidence of acute renal failure. Kidney Int (2007) 4.22

Epidemiology of Acute Kidney Injury in Critically Ill Children and Young Adults. N Engl J Med (2016) 4.07

Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial. Lancet (2015) 3.62

The severity of acute kidney injury predicts progression to chronic kidney disease. Kidney Int (2011) 3.32

Nonrecovery of kidney function and death after acute on chronic renal failure. Clin J Am Soc Nephrol (2009) 3.28

Temporal changes in incidence of dialysis-requiring AKI. J Am Soc Nephrol (2012) 3.23

Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study. Crit Care (2007) 3.19

Larger vancomycin doses (at least four grams per day) are associated with an increased incidence of nephrotoxicity. Antimicrob Agents Chemother (2008) 3.09

Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies. Nat Biotechnol (2010) 3.07

Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clin Transl Sci (2008) 2.98

Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: a multicenter prospective cohort study. J Am Coll Cardiol (2012) 2.97

Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol (2009) 2.96

Estimating baseline kidney function in hospitalized patients with impaired kidney function. Clin J Am Soc Nephrol (2012) 2.94

Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury. Kidney Int (2007) 2.86

Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults. J Am Soc Nephrol (2009) 2.77

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis. Kidney Int (2012) 2.74

Next-generation biomarkers for detecting kidney toxicity. Nat Biotechnol (2010) 2.64

Acute kidney injury episodes and chronic kidney disease risk in diabetes mellitus. Clin J Am Soc Nephrol (2011) 2.62

Reduced production of creatinine limits its use as marker of kidney injury in sepsis. J Am Soc Nephrol (2009) 2.61

Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med (2011) 2.55

Commonly used surrogates for baseline renal function affect the classification and prognosis of acute kidney injury. Kidney Int (2009) 2.53

Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients. Crit Care (2010) 2.51

The reno-vascular A2B adenosine receptor protects the kidney from ischemia. PLoS Med (2008) 2.43

Albuminuria and estimated glomerular filtration rate independently associate with acute kidney injury. J Am Soc Nephrol (2010) 2.41

Defining urine output criterion for acute kidney injury in critically ill patients. Nephrol Dial Transplant (2010) 2.36

Identification of a microRNA signature of renal ischemia reperfusion injury. Proc Natl Acad Sci U S A (2010) 2.31

Concern Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest (2012) 2.23

Ascertainment and epidemiology of acute kidney injury varies with definition interpretation. Clin J Am Soc Nephrol (2008) 2.18

Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in children with chronic kidney disease. Pediatr Nephrol (2006) 2.18

Body mass index and acute kidney injury in the acute respiratory distress syndrome. Crit Care Med (2012) 2.16

Standardized endpoint definitions for transcatheter aortic valve implantation clinical trials: a consensus report from the Valve Academic Research Consortium. Eur Heart J (2011) 2.11

Outcome of critically ill patients with acute kidney injury using the Acute Kidney Injury Network criteria. Crit Care Med (2011) 2.11

Clinical review: RIFLE and AKIN--time for reappraisal. Crit Care (2009) 2.00

Sepsis as a cause and consequence of acute kidney injury: Program to Improve Care in Acute Renal Disease. Intensive Care Med (2010) 2.00

Acute kidney injury in childhood: should we be worried about progression to CKD? Pediatr Nephrol (2010) 2.00

Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury. Nat Biotechnol (2010) 2.00

Acute kidney injury and mortality in hospitalized patients. Am J Nephrol (2012) 1.99

Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol Sci (2007) 1.94

Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury. Kidney Int (2009) 1.94

Methods of blood pressure measurement in the ICU. Crit Care Med (2013) 1.89

Albumin administration is associated with acute kidney injury in cardiac surgery: a propensity score analysis. Crit Care (2014) 1.88

Empirical relationships among oliguria, creatinine, mortality, and renal replacement therapy in the critically ill. Intensive Care Med (2012) 1.86

Correlation between the AKI classification and outcome. Crit Care (2008) 1.85

The cell cycle and acute kidney injury. Kidney Int (2009) 1.81

The growth of acute kidney injury: a rising tide or just closer attention to detail? Kidney Int (2014) 1.80

Imperfect gold standards for kidney injury biomarker evaluation. J Am Soc Nephrol (2011) 1.79

A comparison of RIFLE with and without urine output criteria for acute kidney injury in critically ill patients. Crit Care (2012) 1.78

Risk of AKI with gentamicin as surgical prophylaxis. J Am Soc Nephrol (2014) 1.78

Obesity and oxidative stress predict AKI after cardiac surgery. J Am Soc Nephrol (2012) 1.77

Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med (2007) 1.73

Genetic deficiency of adiponectin protects against acute kidney injury. Kidney Int (2013) 1.71

The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury. Kidney Int (2013) 1.70

Effect of remote ischemic preconditioning on acute kidney injury in nondiabetic patients undergoing coronary artery bypass graft surgery: a secondary analysis of 2 small randomized trials. Am J Kidney Dis (2010) 1.68

Raising awareness of acute kidney injury: a global perspective of a silent killer. Kidney Int (2013) 1.68

Tight blood glucose control is renoprotective in critically ill patients. J Am Soc Nephrol (2008) 1.67

BCL2 genetic variants are associated with acute kidney injury in septic shock*. Crit Care Med (2012) 1.61

Comparison of absolute serum creatinine changes versus Kidney Disease: Improving Global Outcomes consensus definitions for characterizing stages of acute kidney injury. Nephrol Dial Transplant (2013) 1.61

Subclinical AKI is still AKI. Crit Care (2012) 1.59

Incidence, outcomes, and comparisons across definitions of AKI in hospitalized individuals. Clin J Am Soc Nephrol (2013) 1.58

Protective effect of milk fat globule-epidermal growth factor-factor VIII after renal ischemia-reperfusion injury in mice. Crit Care Med (2011) 1.58

Renal impairment predicts long-term mortality risk after acute myocardial infarction. J Am Soc Nephrol (2007) 1.57

Higher serum chloride concentrations are associated with acute kidney injury in unselected critically ill patients. BMC Nephrol (2013) 1.56

Pathophysiology of acute kidney injury. Compr Physiol (2012) 1.56

Biomarkers of nephrotoxic acute kidney injury. Toxicology (2008) 1.55

Determinants of postoperative acute kidney injury. Crit Care (2009) 1.54

A trial of in-hospital, electronic alerts for acute kidney injury: design and rationale. Clin Trials (2014) 1.52

RGS4, a GTPase activator, improves renal function in ischemia-reperfusion injury. Kidney Int (2011) 1.51

Acute loss of renal function attenuates slow leukocyte rolling and transmigration by interfering with intracellular signaling. Kidney Int (2011) 1.51

The incidence and prognostic significance of acute kidney injury. Curr Opin Nephrol Hypertens (2007) 1.49

Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: the NGAL EvaLuation Along with B-type NaTriuretic Peptide in acutely decompensated heart failure (GALLANT) trial. Eur J Heart Fail (2011) 1.48

Impact of timing of renal replacement therapy initiation on outcome of septic acute kidney injury. Crit Care (2011) 1.47

Vancomycin-associated nephrotoxicity: grave concern or death by character assassination? Am J Med (2010) 1.43

Accessing the public MIMIC-II intensive care relational database for clinical research. BMC Med Inform Decis Mak (2013) 1.42

Plasma FGF23 levels increase rapidly after acute kidney injury. Kidney Int (2013) 1.42

Opioid use after cardiac surgery in children with Down syndrome. Pediatr Crit Care Med (2013) 1.40

Does NGAL reduce costs? A cost analysis of urine NGAL (uNGAL) & serum creatinine (sCr) for acute kidney injury (AKI) diagnosis. PLoS One (2017) 1.39

Association between AKI, recovery of renal function, and long-term outcomes after hospital discharge. Clin J Am Soc Nephrol (2012) 1.37

Plasma neutrophil gelatinase-associated lipocalin and acute postoperative kidney injury in adult cardiac surgical patients. Anesth Analg (2010) 1.34

Epidemiology and outcomes in community-acquired versus hospital-acquired AKI. Clin J Am Soc Nephrol (2014) 1.33

Secular trends in acute dialysis after elective major surgery--1995 to 2009. CMAJ (2012) 1.33

Epidemiology of acute kidney injury in the intensive care unit. Crit Care Res Pract (2013) 1.32

Prevalence and risk factors for aminoglycoside nephrotoxicity in intensive care units. Antimicrob Agents Chemother (2009) 1.31

A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex With Acute Kidney Injury. Am J Kidney Dis (2015) 1.30

Evaluation of trial outcomes in acute kidney injury by creatinine modeling. Clin J Am Soc Nephrol (2009) 1.29

Clinical review: Volume of fluid resuscitation and the incidence of acute kidney injury - a systematic review. Crit Care (2012) 1.28

Derivation and validation of the renal angina index to improve the prediction of acute kidney injury in critically ill children. Kidney Int (2013) 1.28

Contemporary incidence, predictors, and outcomes of acute kidney injury in patients undergoing percutaneous coronary interventions: insights from the NCDR Cath-PCI registry. JACC Cardiovasc Interv (2014) 1.27

Outpatient nephrology referral rates after acute kidney injury. J Am Soc Nephrol (2011) 1.27

Perioperative organ injury. Anesthesiology (2013) 1.27

Referral patterns and outcomes in noncritically ill patients with hospital-acquired acute kidney injury. Clin J Am Soc Nephrol (2011) 1.27

Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges. Clin Kidney J (2012) 1.27

Tubular p53 regulates multiple genes to mediate AKI. J Am Soc Nephrol (2014) 1.26

Neutrophil gelatinase-associated lipocalin: pathophysiology and clinical applications. Acta Physiol (Oxf) (2013) 1.26

The incidence and severity of adverse events affecting patients after discharge from the hospital. Ann Intern Med (2003) 13.45

Adverse drug events in ambulatory care. N Engl J Med (2003) 13.38

Effect of reducing interns' work hours on serious medical errors in intensive care units. N Engl J Med (2004) 13.16

Effects of computerized physician order entry and clinical decision support systems on medication safety: a systematic review. Arch Intern Med (2003) 12.98

Incidence and preventability of adverse drug events among older persons in the ambulatory setting. JAMA (2003) 12.94

Personal health records: definitions, benefits, and strategies for overcoming barriers to adoption. J Am Med Inform Assoc (2005) 12.34

The value of health care information exchange and interoperability. Health Aff (Millwood) (2006) 8.89

Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int (2002) 8.03

What practices will most improve safety? Evidence-based medicine meets patient safety. JAMA (2002) 7.53

Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol (2009) 7.34

A cost-benefit analysis of electronic medical records in primary care. Am J Med (2003) 7.00

Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell (2008) 6.54

Medication-related clinical decision support in computerized provider order entry systems: a review. J Am Med Inform Assoc (2006) 6.39

Safety of patients isolated for infection control. JAMA (2003) 5.90

Clinician use of a palmtop drug reference guide. J Am Med Inform Assoc (2002) 5.85

Electronic health record use and the quality of ambulatory care in the United States. Arch Intern Med (2007) 5.85

A research agenda for personal health records (PHRs). J Am Med Inform Assoc (2008) 5.61

Role of pharmacist counseling in preventing adverse drug events after hospitalization. Arch Intern Med (2006) 5.58

A consensus action agenda for achieving the national health information infrastructure. J Am Med Inform Assoc (2004) 5.44

Factors and forces affecting EHR system adoption: report of a 2004 ACMI discussion. J Am Med Inform Assoc (2004) 5.34

Improving acceptance of computerized prescribing alerts in ambulatory care. J Am Med Inform Assoc (2005) 5.29

The Critical Care Safety Study: The incidence and nature of adverse events and serious medical errors in intensive care. Crit Care Med (2005) 4.98

Effect of bar-code technology on the safety of medication administration. N Engl J Med (2010) 4.87

Health care-associated infections: a meta-analysis of costs and financial impact on the US health care system. JAMA Intern Med (2013) 4.77

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med (2010) 4.76

Adverse drug events occurring following hospital discharge. J Gen Intern Med (2005) 4.70

Medication errors observed in 36 health care facilities. Arch Intern Med (2002) 4.64

Overcoming barriers to adopting and implementing computerized physician order entry systems in U.S. hospitals. Health Aff (Millwood) (2004) 4.36

E-cigarettes: a rapidly growing Internet phenomenon. Ann Intern Med (2010) 4.34

Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule. Crit Care Med (2003) 4.25

Characteristics and consequences of drug allergy alert overrides in a computerized physician order entry system. J Am Med Inform Assoc (2004) 4.23

Grand challenges in clinical decision support. J Biomed Inform (2007) 4.15

Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest (2005) 4.10

What evidence supports the use of computerized alerts and prompts to improve clinicians' prescribing behavior? J Am Med Inform Assoc (2009) 4.07

The use of computers for clinical care: a case series of advanced U.S. sites. J Am Med Inform Assoc (2003) 3.98

Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol (2005) 3.94

The costs of a national health information network. Ann Intern Med (2005) 3.93

Effect of a pharmacist intervention on clinically important medication errors after hospital discharge: a randomized trial. Ann Intern Med (2012) 3.85

"I wish I had seen this test result earlier!": Dissatisfaction with test result management systems in primary care. Arch Intern Med (2004) 3.81

Do emergency department blood cultures change practice in patients with pneumonia? Ann Emerg Med (2005) 3.80

Evaluation and treatment of pharyngitis in primary care practice: the difference between guidelines is largely academic. Arch Intern Med (2006) 3.79

Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate. Kidney Int (2010) 3.78

KnowledgeLink: impact of context-sensitive information retrieval on clinicians' information needs. J Am Med Inform Assoc (2005) 3.69

The digital divide in adoption and use of a personal health record. Arch Intern Med (2011) 3.69

Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am J Physiol Renal Physiol (2003) 3.61

Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J Clin Invest (2008) 3.59

Risk of thiazide-induced hyponatremia in patients with hypertension. Am J Med (2011) 3.56

Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J Am Soc Nephrol (2007) 3.48

Primary care closed claims experience of Massachusetts malpractice insurers. JAMA Intern Med (2013) 3.47

The incidence of adverse drug events in two large academic long-term care facilities. Am J Med (2005) 3.43

Correlates of electronic health record adoption in office practices: a statewide survey. J Am Med Inform Assoc (2006) 3.37

Physicians and electronic health records: a statewide survey. Arch Intern Med (2007) 3.31

Medication safety in the ambulatory chemotherapy setting. Cancer (2005) 3.29

Use of chart and record reviews to detect medication errors in a state psychiatric hospital. Psychiatr Serv (2003) 3.26

A randomized trial of electronic clinical reminders to improve quality of care for diabetes and coronary artery disease. J Am Med Inform Assoc (2005) 3.25

The relationship between electronic health record use and quality of care over time. J Am Med Inform Assoc (2009) 3.15

Biomarkers of acute kidney injury. Annu Rev Pharmacol Toxicol (2008) 3.10

Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies. Nat Biotechnol (2010) 3.07

Comparison of methods for detecting medication errors in 36 hospitals and skilled-nursing facilities. Am J Health Syst Pharm (2002) 3.07

Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney Int (2011) 3.05

Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury. Clin J Am Soc Nephrol (2010) 3.03

Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest (2013) 3.03

Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clin Transl Sci (2008) 2.98

Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol (2009) 2.96

Return on investment for a computerized physician order entry system. J Am Med Inform Assoc (2006) 2.95

Prioritizing strategies for preventing medication errors and adverse drug events in pediatric inpatients. Pediatrics (2003) 2.90

Patient-reported medication symptoms in primary care. Arch Intern Med (2005) 2.89

A controlled trial of smart infusion pumps to improve medication safety in critically ill patients. Crit Care Med (2005) 2.85

The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med (2006) 2.84

Assessing the level of healthcare information technology adoption in the United States: a snapshot. BMC Med Inform Decis Mak (2006) 2.76

Resolvin D series and protectin D1 mitigate acute kidney injury. J Immunol (2006) 2.75

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis. Kidney Int (2012) 2.74

Can electronic clinical documentation help prevent diagnostic errors? N Engl J Med (2010) 2.73

Opportunities to enhance patient and physician e-mail contact. Int J Med Inform (2003) 2.69

Design and implementation of a comprehensive outpatient Results Manager. J Biomed Inform (2003) 2.69

Preoperative hypernatremia predicts increased perioperative morbidity and mortality. Am J Med (2013) 2.69

Primary care physician time utilization before and after implementation of an electronic health record: a time-motion study. J Biomed Inform (2004) 2.68

Supratherapeutic dosing of acetaminophen among hospitalized patients. Arch Intern Med (2012) 2.65

Outpatient prescribing errors and the impact of computerized prescribing. J Gen Intern Med (2005) 2.64

Somatization increases medical utilization and costs independent of psychiatric and medical comorbidity. Arch Gen Psychiatry (2005) 2.62

Tiering drug-drug interaction alerts by severity increases compliance rates. J Am Med Inform Assoc (2008) 2.57

U.S. Regional health information organizations: progress and challenges. Health Aff (Millwood) (2009) 2.54

Acute renal failure in zebrafish: a novel system to study a complex disease. Am J Physiol Renal Physiol (2004) 2.50

A rapid urine test for early detection of kidney injury. Kidney Int (2009) 2.50

Analysis of medication-related malpractice claims: causes, preventability, and costs. Arch Intern Med (2002) 2.48

The state of regional health information organizations: current activities and financing. Health Aff (Millwood) (2007) 2.46

What can hospitalized patients tell us about adverse events? Learning from patient-reported incidents. J Gen Intern Med (2005) 2.46

Advancing the science of patient safety. Ann Intern Med (2011) 2.45

Psychological effects of a suspicious prostate cancer screening test followed by a benign biopsy result. Am J Med (2004) 2.44

Kidney tubular epithelium is restored without replacement with bone marrow-derived cells during repair after ischemic injury. Kidney Int (2005) 2.43

Preoperative hyponatremia and perioperative complications. Arch Intern Med (2012) 2.42

Conditional ablation of macrophages halts progression of crescentic glomerulonephritis. Am J Pathol (2005) 2.38