Published in J Immunol on October 01, 2005
Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev (2009) 4.55
Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. Proc Natl Acad Sci U S A (2006) 1.82
Dynamic expression of epidermal caspase 8 simulates a wound healing response. Nature (2009) 1.71
Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production. J Gen Virol (2009) 1.56
The Impact of Macrophage- and Microglia-Secreted TNFα on Oncolytic HSV-1 Therapy in the Glioblastoma Tumor Microenvironment. Clin Cancer Res (2015) 1.52
The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis. J Virol (2008) 1.36
Innate immune sensing of DNA viruses. Virology (2011) 1.30
Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes. J Immunol (2011) 1.26
Innate recognition network driving herpes simplex virus-induced corneal immunopathology: role of the toll pathway in early inflammatory events in stromal keratitis. J Virol (2007) 1.24
Epstein-Barr virus induces MCP-1 secretion by human monocytes via TLR2. J Virol (2007) 1.17
Toll-like receptors in skin. Adv Dermatol (2008) 1.17
The virion host shut-off (vhs) protein blocks a TLR-independent pathway of herpes simplex virus type 1 recognition in human and mouse dendritic cells. PLoS One (2010) 1.15
Innate and adaptive immune responses to herpes simplex virus. Viruses (2009) 1.14
HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood (2008) 1.14
Interferon regulatory factor 3-dependent pathways are critical for control of herpes simplex virus type 1 central nervous system infection. J Virol (2010) 1.10
Role of specific innate immune responses in herpes simplex virus infection of the central nervous system. J Virol (2011) 1.09
Interferon-γ mediates chemokine-dependent recruitment of natural killer cells during viral infection. Proc Natl Acad Sci U S A (2012) 1.08
The role of chemokines during herpes simplex virus-1 infection. Front Biosci (2008) 1.06
Role of microglia in neuronal degeneration and regeneration. Semin Immunopathol (2009) 1.06
Herpes simplex virus type 1 and Alzheimer's disease: increasing evidence for a major role of the virus. Front Aging Neurosci (2014) 1.05
Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia. J Neuroinflammation (2011) 1.05
Herpes simplex virus induces neural oxidative damage via microglial cell Toll-like receptor-2. J Neuroinflammation (2010) 1.05
Toll-like receptors regulation of viral infection and disease. Adv Drug Deliv Rev (2007) 1.04
Microglia and a functional type I IFN pathway are required to counter HSV-1-driven brain lateral ventricle enlargement and encephalitis. J Immunol (2013) 1.01
The role of chemokines during viral infection of the CNS. PLoS Pathog (2010) 1.00
HSV Recombinant Vectors for Gene Therapy. Open Virol J (2010) 0.99
Theiler's virus infection induces TLR3-dependent upregulation of TLR2 critical for proinflammatory cytokine production. Glia (2009) 0.97
Intrinsic cellular defenses against virus infection by antiviral type I interferon. Yonsei Med J (2009) 0.97
Toll-like receptor 2 signaling is a mediator of apoptosis in herpes simplex virus-infected microglia. J Neuroinflammation (2007) 0.96
Activation and evasion of innate antiviral immunity by herpes simplex virus. Viruses (2009) 0.94
Functional genomics reveals an essential and specific role for Stat1 in protection of the central nervous system following herpes simplex virus corneal infection. J Virol (2011) 0.92
Herpes simplex virus type 1 induces simultaneous activation of Toll-like receptors 2 and 4 and expression of the endogenous ligand serum amyloid A in astrocytes. Med Microbiol Immunol (2012) 0.92
TRAM is required for TLR2 endosomal signaling to type I IFN induction. J Immunol (2014) 0.91
Innate immune activation in the pathogenesis of a murine model of globoid cell leukodystrophy. Am J Pathol (2013) 0.91
Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis. J Virol (2009) 0.90
Inhibition of toll-like receptor signaling in primary murine microglia. J Neuroimmune Pharmacol (2007) 0.90
Interplay between modified vaccinia virus Ankara and dendritic cells: phenotypic and functional maturation of bystander dendritic cells. J Virol (2011) 0.88
The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway. PLoS One (2013) 0.87
Modulation of experimental herpes encephalitis-associated neurotoxicity through sulforaphane treatment. PLoS One (2012) 0.86
Herpes simplex virus US3 tegument protein inhibits Toll-like receptor 2 signaling at or before TRAF6 ubiquitination. Virology (2013) 0.86
Toll-like receptor sensing of human herpesvirus infection. Front Cell Infect Microbiol (2012) 0.86
Both TRIF and IPS-1 adaptor proteins contribute to the cerebral innate immune response against herpes simplex virus 1 infection. J Virol (2013) 0.85
Seizures and epilepsy in herpes simplex virus encephalitis: current concepts and future directions of pathogenesis and management. J Neurol (2012) 0.84
Recognition of herpes simplex viruses: toll-like receptors and beyond. J Mol Biol (2013) 0.84
Immunobiology of herpes simplex virus and cytomegalovirus infections of the fetus and newborn. Curr Immunol Rev (2010) 0.83
Infiltrating regulatory B cells control neuroinflammation following viral brain infection. J Immunol (2014) 0.83
HSV-1-induced chemokine expression via IFI16-dependent and IFI16-independent pathways in human monocyte-derived macrophages. Herpesviridae (2012) 0.82
Transcriptional Regulation of CXCL5 in HIV-1-Infected Macrophages and Its Functional Consequences on CNS Pathology. J Interferon Cytokine Res (2014) 0.81
Astragalus Polysaccharide Protects Astrocytes from Being Infected by HSV-1 through TLR3/NF-κB Signaling Pathway. Evid Based Complement Alternat Med (2014) 0.81
Modulation of neural stem/progenitor cell proliferation during experimental Herpes Simplex encephalitis is mediated by differential FGF-2 expression in the adult brain. Neurobiol Dis (2013) 0.81
Rifampicin Inhibits the LPS-induced Expression of Toll-like Receptor 2 via the Suppression of NF-kappaB DNA-binding Activity in RAW 264.7 Cells. Korean J Physiol Pharmacol (2009) 0.81
RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1. Glia (2015) 0.81
Linkage mapping of toll-like receptors (TLRs) in Japanese flounder, Paralichthys olivaceus. Mar Biotechnol (NY) (2011) 0.80
Prophylactic and therapeutic modulation of innate and adaptive immunity against mucosal infection of herpes simplex virus. Immune Netw (2014) 0.80
Mice lacking the β2 adrenergic receptor have a unique genetic profile before and after focal brain ischaemia. ASN Neuro (2012) 0.80
Histoplasma capsulatum yeast phase-specific protein Yps3p induces Toll-like receptor 2 signaling. J Neuroinflammation (2008) 0.79
Combined effect of TLR2 gene polymorphism and early life stress on the age at onset of bipolar disorders. PLoS One (2015) 0.79
Identification of an important immunological difference between virulent varicella-zoster virus and its avirulent vaccine: viral disruption of dendritic cell instruction. J Immunol (2010) 0.79
The case for immunomodulatory approaches in treating HSV encephalitis. Future Virol (2013) 0.78
Human herpesviruses-encoded dUTPases: a family of proteins that modulate dendritic cell function and innate immunity. Front Microbiol (2014) 0.78
The immune response to herpes simplex virus encephalitis in mice is modulated by dietary vitamin E. J Nutr (2008) 0.77
Pathogenicity of duck plague and innate immune responses of the Cherry Valley ducks to duck plague virus. Sci Rep (2016) 0.77
Met-CCL5 represents an immunotherapy strategy to ameliorate rabies virus infection. J Neuroinflammation (2014) 0.77
Immune responses to herpesviral vectors. Hum Gene Ther (2009) 0.76
Herpesviral infection and Toll-like receptor 2. Protein Cell (2012) 0.76
Toxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: a gene-environment interaction study. Int J Bipolar Disord (2016) 0.76
Prophylactic vaccine strategies and the potential of therapeutic vaccines against herpes simplex virus. Curr Pharm Des (2007) 0.76
Analysis of chemokines and receptors expression profile in the myelin mutant taiep rat. Oxid Med Cell Longev (2015) 0.75
Signal transducer and activator of transcription 3 (Stat3) regulates host defense and protects mice against herpes simplex virus-1 (HSV-1) infection. J Leukoc Biol (2016) 0.75
Black ginseng-enriched Chong-Myung-Tang extracts improve spatial learning behavior in rats and elicit anti-inflammatory effects in vitro. J Ginseng Res (2016) 0.75
Primate neural retina upregulates IL-6 and IL-10 in response to a herpes simplex vector suggesting the presence of a pro-/anti-inflammatory axis. Exp Eye Res (2016) 0.75
Role of microglia in central nervous system infections. Clin Microbiol Rev (2004) 2.69
Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention. Clin Microbiol Rev (2009) 1.90
Morphine induces apoptosis of human microglia and neurons. Neuropharmacology (2002) 1.61
Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes. Glia (2005) 1.49
Prolonged microglial cell activation and lymphocyte infiltration following experimental herpes encephalitis. J Immunol (2008) 1.48
Interleukin-10 attenuates production of HSV-induced inflammatory mediators by human microglia. Glia (2004) 1.26
Toll-like receptors in defense and damage of the central nervous system. J Neuroimmune Pharmacol (2007) 1.24
Morphine potentiates HIV-1 gp120-induced neuronal apoptosis. J Infect Dis (2005) 1.20
Microglial cells initiate vigorous yet non-protective immune responses during HSV-1 brain infection. Virus Res (2006) 1.18
Differential responses of human brain cells to West Nile virus infection. J Neurovirol (2005) 1.17
Mycobacterium tuberculosis-induced cytokine and chemokine expression by human microglia and astrocytes: effects of dexamethasone. J Infect Dis (2005) 1.17
TNF-alpha-induced chemokine production and apoptosis in human neural precursor cells. J Leukoc Biol (2005) 1.14
High-level expression of functional chemokine receptor CXCR4 on human neural precursor cells. Brain Res Dev Brain Res (2004) 1.09
Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-beta1. Int Immunopharmacol (2006) 1.08
CXCL10 production from cytomegalovirus-stimulated microglia is regulated by both human and viral interleukin-10. J Virol (2003) 1.08
Neural precursor cell susceptibility to human cytomegalovirus diverges along glial or neuronal differentiation pathways. J Neurosci Res (2005) 1.07
Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia. J Neuroinflammation (2011) 1.05
Herpes simplex virus induces neural oxidative damage via microglial cell Toll-like receptor-2. J Neuroinflammation (2010) 1.05
Intracerebral infection with murine cytomegalovirus induces CXCL10 and is restricted by adoptive transfer of splenocytes. J Neurovirol (2004) 1.03
Chronic cortical and subcortical pathology with associated neurological deficits ensuing experimental herpes encephalitis. Brain Pathol (2009) 1.02
Interferon lambda inhibits herpes simplex virus type I infection of human astrocytes and neurons. Glia (2010) 1.02
Murine cytomegalovirus infection of neural stem cells alters neurogenesis in the developing brain. PLoS One (2011) 1.01
Cocaine alters proliferation, migration, and differentiation of human fetal brain-derived neural precursor cells. J Pharmacol Exp Ther (2006) 1.01
Dysregulated interferon-gamma responses during lethal cytomegalovirus brain infection of IL-10-deficient mice. Virus Res (2007) 1.00
Differential apoptotic signaling in primary glial cells infected with herpes simplex virus 1. J Neurovirol (2006) 0.99
WIN55,212-2-mediated inhibition of HIV-1 expression in microglial cells: involvement of cannabinoid receptors. J Neuroimmune Pharmacol (2006) 0.96
Activation of Toll-like receptors inhibits herpes simplex virus-1 infection of human neuronal cells. J Neurosci Res (2009) 0.96
Toll-like receptor 2 signaling is a mediator of apoptosis in herpes simplex virus-infected microglia. J Neuroinflammation (2007) 0.96
Memory T cells persisting in the brain following MCMV infection induce long-term microglial activation via interferon-γ. J Neurovirol (2011) 0.95
Microglia are the major cellular source of inducible nitric oxide synthase during experimental herpes encephalitis. J Neurovirol (2008) 0.94
U50,488 inhibits HIV-1 Tat-induced monocyte chemoattractant protein-1 (CCL2) production by human astrocytes. Biochem Pharmacol (2003) 0.93
Infection and activation of bursal macrophages by virulent infectious bursal disease virus. Virus Res (2005) 0.93
Morphine stimulates CCL2 production by human neurons. J Neuroinflammation (2006) 0.92
T cell-mediated restriction of intracerebral murine cytomegalovirus infection displays dependence upon perforin but not interferon-gamma. J Neurovirol (2005) 0.91
Glial cell responses to herpesvirus infections: role in defense and immunopathogenesis. J Infect Dis (2002) 0.90
Inhibition of toll-like receptor signaling in primary murine microglia. J Neuroimmune Pharmacol (2007) 0.90
Anti-HIV-1 activity of propolis in CD4(+) lymphocyte and microglial cell cultures. J Ethnopharmacol (2005) 0.88
Kappa-opioid receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells. J Pharmacol Exp Ther (2004) 0.88
Induction of interferon-γ contributes to Toll-like receptor 3-mediated herpes simplex virus type 1 inhibition in astrocytes. J Neurosci Res (2011) 0.87
Potentiation of HIV-1 expression in microglial cells by nicotine: involvement of transforming growth factor-beta 1. J Neuroimmune Pharmacol (2007) 0.87
Cytomegalovirus-induced sensorineural hearing loss with persistent cochlear inflammation in neonatal mice. J Neurovirol (2011) 0.86
Modulation of experimental herpes encephalitis-associated neurotoxicity through sulforaphane treatment. PLoS One (2012) 0.86
Persistent humoral immune responses in the CNS limit recovery of reactivated murine cytomegalovirus. PLoS One (2012) 0.86
Preferential sensitivity of human dopaminergic neurons to gp120-induced oxidative damage. J Neurovirol (2009) 0.86
Cytomegalovirus infection and interferon-gamma modulate major histocompatibility complex class I expression on neural stem cells. J Neurovirol (2008) 0.85
T-cell reconstitution during murine acquired immunodeficiency syndrome (MAIDS) produces neuroinflammation and mortality in animals harboring opportunistic viral brain infection. J Neuroinflammation (2013) 0.85
Reduced lymphocyte infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice. J Neurovirol (2009) 0.83
Excess neutrophil infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice. J Neuroimmunol (2010) 0.83
Reactive oxygen species from human astrocytes induced functional impairment and oxidative damage. Neurochem Res (2013) 0.82
Glial cells suppress postencephalitic CD8+ T lymphocytes through PD-L1. Glia (2014) 0.82
Modulation of neural stem/progenitor cell proliferation during experimental Herpes Simplex encephalitis is mediated by differential FGF-2 expression in the adult brain. Neurobiol Dis (2013) 0.81
Hemin inhibits NO production by IL-1β-stimulated human astrocytes through induction of heme oxygenase-1 and reduction of p38 MAPK activation. J Neuroinflammation (2010) 0.80
Systematic variation of metal-metal bond order in metal-chromium complexes. J Am Chem Soc (2013) 0.80
Histoplasma capsulatum yeast phase-specific protein Yps3p induces Toll-like receptor 2 signaling. J Neuroinflammation (2008) 0.79
Changes in the NMR metabolic profile of human microglial cells exposed to lipopolysaccharide or morphine. J Neuroimmune Pharmacol (2010) 0.76
Human neural precursor cells express functional kappa-opioid receptors. J Pharmacol Exp Ther (2007) 0.76
Establishment of a porcine pancreatic stem cell line using T-REx(™) system-inducible Wnt3a expression. Cell Prolif (2015) 0.75