Increase of microcirculatory blood flow enhances penetration of ciprofloxacin into soft tissue.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 1251507)

Published in Antimicrob Agents Chemother on October 01, 2005

Authors

Christian Joukhadar1, Pejman Dehghanyar, Friederike Traunmüller, Robert Sauermann, Bernhard Mayer-Helm, Apostolos Georgopoulos, Markus Müller

Author Affiliations

1: Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, Vienna, Austria. christian.joukhadar@meduniwien.ac.at

Articles cited by this

Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol (1985) (1999) 3.65

Skin blood flow in adult human thermoregulation: how it works, when it does not, and why. Mayo Clin Proc (2003) 3.08

Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans. Antimicrob Agents Chemother (1996) 1.83

Effect of whole-body and local heating on cutaneous vasoconstrictor responses in humans. Auton Neurosci (2002) 1.61

Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock. Crit Care Med (2001) 1.50

Acetylcholine released from cholinergic nerves contributes to cutaneous vasodilation during heat stress. J Appl Physiol (1985) (2002) 1.36

Methodological aspects of the use of a calibrator in in vivo microdialysis-further development of the retrodialysis method. Pharm Res (1998) 1.36

Role of sympathetic nerves in the vascular effects of local temperature in human forearm skin. Am J Physiol (1993) 1.35

Microdialysis. A novel tool for clinical studies of anti-infective agents. Eur J Clin Pharmacol (2001) 1.34

Surgery and intensive care procedures affect the target site distribution of piperacillin. Crit Care Med (2000) 1.16

The pharmacokinetics of once-daily dosing of ceftriaxone in critically ill patients. J Antimicrob Chemother (2001) 1.15

Distribution and antimicrobial activity of ciprofloxacin in human soft tissues. Antimicrob Agents Chemother (1999) 1.15

Penetration of linezolid into soft tissues of healthy volunteers after single and multiple doses. Antimicrob Agents Chemother (2005) 1.10

Plasma and tissue pharmacokinetics of cefpirome in patients with sepsis. Crit Care Med (2002) 1.09

Penetration of ciprofloxacin into the interstitial space of inflamed foot lesions in non-insulin-dependent diabetes mellitus patients. Antimicrob Agents Chemother (1999) 1.04

A combined in vivo pharmacokinetic-in vitro pharmacodynamic approach to simulate target site pharmacodynamics of antibiotics in humans. J Antimicrob Chemother (2000) 0.99

Penetration of fosfomycin into inflammatory lesions in patients with cellulitis or diabetic foot syndrome. Antimicrob Agents Chemother (2003) 0.95

The effect of warming on adrenergic neurotransmission in canine cutaneous vein. Circ Res (1984) 0.93

Angioplasty increases target site concentrations of ciprofloxacin in patients with peripheral arterial occlusive disease. Clin Pharmacol Ther (2001) 0.93

Validation of laser Doppler flowmetry coupled with intra-dermal injection for investigating effects of vasoactive agents on the skin microcirculation in man. Eur J Clin Pharmacol (2003) 0.81

Pharmacokinetics of intravenous ciprofloxacin at three different doses. J Antimicrob Chemother (1988) 0.81

Effect of norepinephrine on cefpirome tissue concentrations in healthy subjects. J Antimicrob Chemother (2004) 0.78

Articles by these authors

pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics (2011) 16.75

Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates. PLoS One (2010) 6.38

The discovery of 5-formylcytosine in embryonic stem cell DNA. Angew Chem Int Ed Engl (2011) 4.39

Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell (2013) 4.16

SuperHirn - a novel tool for high resolution LC-MS-based peptide/protein profiling. Proteomics (2007) 3.60

Quantification of the sixth DNA base hydroxymethylcytosine in the brain. Angew Chem Int Ed Engl (2010) 3.50

Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial. Lancet Infect Dis (2013) 3.46

A clinical trial of a whole-virus H5N1 vaccine derived from cell culture. N Engl J Med (2008) 3.28

An integrated mass spectrometric and computational framework for the analysis of protein interaction networks. Nat Biotechnol (2007) 2.59

High resolution PTR-TOF: quantification and formula confirmation of VOC in real time. J Am Soc Mass Spectrom (2010) 1.72

Annexin A3 in urine: a highly specific noninvasive marker for prostate cancer early detection. J Urol (2008) 1.68

Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas. Int J Mol Med (2005) 1.67

In vitro and in vivo evaluation of [18F]ciprofloxacin for the imaging of bacterial infections with PET. Eur J Nucl Med Mol Imaging (2004) 1.67

Bioinformatics for protein biomarker panel classification: what is needed to bring biomarker panels into in vitro diagnostics? Expert Rev Proteomics (2009) 1.61

Comparison of three severity scores for critically ill cancer patients. Intensive Care Med (2003) 1.57

A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET. J Nucl Med (2009) 1.56

Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil. Epilepsia (2007) 1.55

Cost-effectiveness of preoperative SPECT/CT combined with lymphoscintigraphy vs. lymphoscintigraphy for sentinel lymph node excision in patients with cutaneous malignant melanoma. Eur J Nucl Med Mol Imaging (2014) 1.49

An open-system quantum simulator with trapped ions. Nature (2011) 1.46

In vivo profile of the human leukocyte microRNA response to endotoxemia. Biochem Biophys Res Commun (2009) 1.45

Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET. J Nucl Med (2008) 1.44

Bactericidal effect of different laser systems in the deep layers of dentin. Lasers Surg Med (2004) 1.43

Processing and classification of protein mass spectra. Mass Spectrom Rev (2006) 1.42

Search strategies-identified reports on "off-label" drug use in MEDLINE. J Clin Epidemiol (2012) 1.41

Stage-adapted treatment of HIV-associated Hodgkin lymphoma: results of a prospective multicenter study. J Clin Oncol (2012) 1.41

Automated protein identification by tandem mass spectrometry: issues and strategies. Mass Spectrom Rev (2006) 1.40

Quantitative proteomic analysis of protein complexes: concurrent identification of interactors and their state of phosphorylation. Mol Cell Proteomics (2007) 1.38

AAPS-FDA workshop white paper: microdialysis principles, application and regulatory perspectives. Pharm Res (2007) 1.35

Mechanism and stem-cell activity of 5-carboxycytosine decarboxylation determined by isotope tracing. Angew Chem Int Ed Engl (2012) 1.34

Blood-brain barrier P-glycoprotein function in Alzheimer's disease. Brain (2011) 1.33

Principles of antibiotic penetration into abscess fluid. Pharmacology (2006) 1.30

Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors. Int J Cancer (2012) 1.30

Dissociable network properties of anesthetic state transitions. Anesthesiology (2011) 1.29

Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients. Eur J Nucl Med Mol Imaging (2007) 1.25

Quantum Google in a complex network. Sci Rep (2013) 1.24

Rational dosing of antibiotics: the use of plasma concentrations versus tissue concentrations. Int J Antimicrob Agents (2002) 1.23

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET. Eur J Nucl Med Mol Imaging (2009) 1.23

Antibiotic abscess penetration: fosfomycin levels measured in pus and simulated concentration-time profiles. Antimicrob Agents Chemother (2005) 1.22

A combined CXCL10, CXCL8 and H-FABP panel for the staging of human African trypanosomiasis patients. PLoS Negl Trop Dis (2009) 1.20

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor. Bioorg Med Chem (2010) 1.20

EasyProt--an easy-to-use graphical platform for proteomics data analysis. J Proteomics (2012) 1.20

Influence of functional haplotypes in the drug transporter gene ABCB1 on central nervous system drug distribution in humans. Clin Pharmacol Ther (2005) 1.19

Asymmetric dimethylarginine predicts major adverse cardiovascular events in patients with advanced peripheral artery disease. Arterioscler Thromb Vasc Biol (2006) 1.18

Mutation in the Scyl1 gene encoding amino-terminal kinase-like protein causes a recessive form of spinocerebellar neurodegeneration. EMBO Rep (2007) 1.18

Detection of plant volatiles after leaf wounding and darkening by proton transfer reaction "time-of-flight" mass spectrometry (PTR-TOF). PLoS One (2011) 1.15

High fosfomycin concentrations in bone and peripheral soft tissue in diabetic patients presenting with bacterial foot infection. J Antimicrob Chemother (2009) 1.14

Parallel isotope-based quantification of modified tRNA nucleosides. Angew Chem Int Ed Engl (2009) 1.14

pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution. J Physiol (2007) 1.13

Treatment of AIDS-related lymphomas: rituximab is beneficial even in severely immunosuppressed patients. AIDS (2012) 1.12

Role for staphylococci in misguided thrombus resolution of chronic thromboembolic pulmonary hypertension. Arterioscler Thromb Vasc Biol (2008) 1.11

A cell culture (Vero)-derived H5N1 whole-virus vaccine induces cross-reactive memory responses. J Infect Dis (2009) 1.10

Microdialysis: current applications in clinical pharmacokinetic studies and its potential role in the future. Clin Pharmacokinet (2005) 1.10

Penetration of linezolid into soft tissues of healthy volunteers after single and multiple doses. Antimicrob Agents Chemother (2005) 1.10

Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier. J Med Chem (2009) 1.09

Plasma and tissue pharmacokinetics of cefpirome in patients with sepsis. Crit Care Med (2002) 1.09

Trace mycotoxin analysis in complex biological and food matrices by liquid chromatography-atmospheric pressure ionisation mass spectrometry. J Chromatogr A (2006) 1.07

Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair. Nat Chem (2011) 1.07

Gastric cancer growth control by BEZ235 in vivo does not correlate with PI3K/mTOR target inhibition but with [18F]FLT uptake. Clin Cancer Res (2011) 1.06

On-line breath analysis with PTR-TOF. J Breath Res (2009) 1.06

Limitations of small animal PET imaging with [18F]FDDNP and FDG for quantitative studies in a transgenic mouse model of Alzheimer's disease. Mol Imaging Biol (2009) 1.06

Tumor necrosis factor-alpha inhibits renin gene expression. Am J Physiol Regul Integr Comp Physiol (2002) 1.05

Alternative pathway for atmospheric particles growth. Proc Natl Acad Sci U S A (2012) 1.02

Polyphenylene Nanostructures. Chem Rev (1999) 1.02

Penetration of moxifloxacin into healthy and inflamed subcutaneous adipose tissues in humans. Antimicrob Agents Chemother (2003) 1.02

A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier. J Neurosci (2011) 1.02

Exercise training lowers plasma visfatin concentrations in patients with type 1 diabetes. J Clin Endocrinol Metab (2006) 1.02

Structure and function of noncanonical nucleobases. Angew Chem Int Ed Engl (2012) 1.02

Dosing of daptomycin in intensive care unit patients with acute kidney injury undergoing extended dialysis--a pharmacokinetic study. Nephrol Dial Transplant (2009) 1.02

Polymorphic membrane protein (PMP) 20 and PMP 21 of Chlamydia pneumoniae induce proinflammatory mediators in human endothelial cells in vitro by activation of the nuclear factor-kappaB pathway. J Infect Dis (2003) 1.02

Age dependency of cerebral P-gp function measured with (R)-[11C]verapamil and PET. Eur J Clin Pharmacol (2009) 1.01

AAPS-FDA Workshop White Paper: microdialysis principles, application, and regulatory perspectives. J Clin Pharmacol (2007) 1.01

Impaired target site penetration of vancomycin in diabetic patients following cardiac surgery. Antimicrob Agents Chemother (2006) 1.00

Open source libraries and frameworks for mass spectrometry based proteomics: a developer's perspective. Biochim Biophys Acta (2013) 1.00

Unrestricted identification of modified proteins using MS/MS. Proteomics (2010) 1.00

Target site concentrations of ciprofloxacin after single intravenous and oral doses. Antimicrob Agents Chemother (2002) 0.99

DNA alterations in body fluids as molecular tumor markers for urological malignancies. Eur Urol (2002) 0.98

Effects of olanzapine and ziprasidone on glucose tolerance in healthy volunteers. Neuropsychopharmacology (2007) 0.98

Influence of vancomycin on renal function in critically ill patients after cardiac surgery: continuous versus intermittent infusion. Anesthesiology (2009) 0.98

Tumor necrosis factor-alpha activates NFkappaB to inhibit renin transcription by targeting cAMP-responsive element. J Biol Chem (2003) 0.97

Systems-based analysis of modified tRNA bases. Angew Chem Int Ed Engl (2011) 0.97

Pharmacokinetics of a new diclofenac sodium formulation developed for subcutaneous and intramuscular administration. Int J Clin Pharmacol Ther (2012) 0.96

Pharmacokinetics of unbound linezolid in plasma and tissue interstitium of critically ill patients after multiple dosing using microdialysis. Antimicrob Agents Chemother (2006) 0.96

Innovative wavelengths in endodontic treatment. Lasers Surg Med (2006) 0.96

Association of a functional polymorphism in the clopidogrel target receptor gene, P2Y12, and the risk for ischemic cerebrovascular events in patients with peripheral artery disease. Stroke (2005) 0.96

Porcine gastric mucin (PGM) at the water/poly(dimethylsiloxane) (PDMS) interface: influence of pH and ionic strength on its conformation, adsorption, and aqueous lubrication properties. Langmuir (2005) 0.96

Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood-brain barrier. J Cereb Blood Flow Metab (2009) 0.96

Small interfering RNA targeting bcl-2 sensitizes malignant melanoma. Oligonucleotides (2003) 0.95

Glycation isotopic labeling with 13C-reducing sugars for quantitative analysis of glycated proteins in human plasma. Mol Cell Proteomics (2009) 0.95

Target site penetration of fosfomycin in critically ill patients. J Antimicrob Chemother (2003) 0.95

Effect of severity of sepsis on tissue concentrations of linezolid. J Antimicrob Chemother (2007) 0.95

Dependence of brain intravoxel incoherent motion perfusion parameters on the cardiac cycle. PLoS One (2013) 0.95

All reversible dynamics in maximally nonlocal theories are trivial. Phys Rev Lett (2010) 0.94

Plasma protein binding of fluoroquinolones affects antimicrobial activity. J Antimicrob Chemother (2008) 0.94

Closed-chest microdialysis to measure antibiotic penetration into human lung tissue. Am J Respir Crit Care Med (2002) 0.94

Interaction of 11C-tariquidar and 11C-elacridar with P-glycoprotein and breast cancer resistance protein at the human blood-brain barrier. J Nucl Med (2013) 0.94

Interstitial tissue concentrations of cefpodoxime. J Antimicrob Chemother (2002) 0.93

(R)-[(11)C]verapamil is selectively transported by murine and human P-glycoprotein at the blood-brain barrier, and not by MRP1 and BCRP. Nucl Med Biol (2013) 0.93

Treatment options in vertebrobasilar dolichoectasia--case report and review of the literature. Eur Neurol (2003) 0.93