Published in Mol Cancer on October 06, 2005
Phenotype and genotype of pancreatic cancer cell lines. Pancreas (2010) 3.06
Human milk oligosaccharides protect bladder epithelial cells against uropathogenic Escherichia coli invasion and cytotoxicity. J Infect Dis (2013) 2.18
Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion. Br J Cancer (2009) 1.60
Inhibition of cancer cell invasion and metastasis by genistein. Cancer Metastasis Rev (2010) 1.29
Interleukin-1alpha enhances the aggressive behavior of pancreatic cancer cells by regulating the alpha6beta1-integrin and urokinase plasminogen activator receptor expression. BMC Cell Biol (2006) 1.02
Visualizing and manipulating focal adhesion kinase regulation in live cells. J Biol Chem (2013) 1.01
Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras. Clin Cancer Res (2011) 1.00
Constitutive K-RasG12D activation of ERK2 specifically regulates 3D invasion of human pancreatic cancer cells via MMP-1. Mol Cancer Res (2011) 0.98
Biological approaches to therapy of pancreatic cancer. Pancreatology (2008) 0.91
The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth. Oncotarget (2013) 0.86
Tumor-Associated Glycans and Immune Surveillance. Vaccines (Basel) (2013) 0.86
Activation of focal adhesion kinase enhances the adhesion of Fusarium solani to human corneal epithelial cells via the tyrosine-specific protein kinase signaling pathway. Mol Vis (2011) 0.85
Integrin β1 regulates leiomyoma cytoskeletal integrity and growth. Matrix Biol (2012) 0.85
Causal inference of gene regulation with subnetwork assembly from genetical genomics data. Nucleic Acids Res (2013) 0.81
Evaluation of the correlation between focal adhesion kinase phosphorylation and cell adhesion force using "DEP" technology. Sensors (Basel) (2012) 0.80
PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase. Exp Mol Med (2011) 0.78
Soy isoflavones and cellular mechanics. J Bioenerg Biomembr (2013) 0.76
Integrin Ligation Results in Nephrin Tyrosine Phosphorylation In Vitro. PLoS One (2016) 0.75
Identification of biomarkers of intrahepatic cholangiocarcinoma via integrated analysis of mRNA and miRNA microarray data. Mol Med Rep (2017) 0.75
Targeting the C-terminal focal adhesion kinase scaffold in pancreatic cancer. Cancer Lett (2014) 0.75
Joint L1/2-Norm Constraint and Graph-Laplacian PCA Method for Feature Extraction. Biomed Res Int (2017) 0.75
Morus alba Leaf Lectin (MLL) Sensitizes MCF-7 Cells to Anoikis by Inhibiting Fibronectin Mediated Integrin-FAK Signaling through Ras and Activation of P(38) MAPK. Front Pharmacol (2017) 0.75
Integrins: bidirectional, allosteric signaling machines. Cell (2002) 36.25
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature (1995) 11.06
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat Med (1999) 7.97
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol (1994) 7.53
Regulation of cell motility by mitogen-activated protein kinase. J Cell Biol (1997) 7.14
Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J Cell Biol (1995) 6.74
Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell (2004) 4.34
Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J Cell Biol (1995) 4.26
A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK. Nature (1996) 3.88
IL-1 is required for tumor invasiveness and angiogenesis. Proc Natl Acad Sci U S A (2003) 3.80
Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol Biol Cell (1996) 3.60
Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways. J Cell Sci (2001) 2.91
Inhibition of pp125FAK in cultured fibroblasts results in apoptosis. J Cell Biol (1996) 2.38
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. J Biol Chem (1997) 2.34
Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation. Mol Cell Biol (1997) 2.29
Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells. Cell Growth Differ (1996) 2.09
Hypersialylation of beta1 integrins, observed in colon adenocarcinoma, may contribute to cancer progression by up-regulating cell motility. Cancer Res (2005) 2.08
Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Mol Cell Biol (2004) 1.79
Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization. J Biol Chem (1996) 1.62
Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor. J Hepatol (2004) 1.55
Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase. J Cell Biol (1999) 1.52
Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells. Surgery (2004) 1.45
Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells. Br J Cancer (2003) 1.31
Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases. Cancer Res (1994) 1.28
PTEN gene and integrin signaling in cancer. J Natl Cancer Inst (1999) 1.19
High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome. Breast Cancer Res (2005) 1.19
Interleukin-1 stimulates cytokines, prostaglandin E2 and matrix metalloproteinase-1 production via activation of MAPK/AP-1 and NF-kappaB in human gingival fibroblasts. Cytokine (2004) 1.16
Apoptosis detection: an overview. Exp Gerontol (1998) 1.16
Collagen IV-dependent ERK activation in human Caco-2 intestinal epithelial cells requires focal adhesion kinase. J Biol Chem (2000) 1.13
Integrin beta1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo. Br J Cancer (2005) 1.10
Overexpression of RhoA-GTP induces activation of the Epidermal Growth Factor Receptor, dephosphorylation of focal adhesion kinase and increased motility in breast cancer cells. Exp Cell Res (2005) 1.08
Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells. Cytokine (2002) 1.07
Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells. Clin Exp Metastasis (2004) 1.05
Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1. Mol Cancer (2005) 1.05
Human intestinal epithelial crypt cell survival and death: Complex modulations of Bcl-2 homologs by Fak, PI3-K/Akt-1, MEK/Erk, and p38 signaling pathways. J Cell Physiol (2004) 1.05
N-Myc overexpression leads to decreased beta1 integrin expression and increased apoptosis in human neuroblastoma cells. Oncogene (2003) 1.03
Interleukin-1alpha enhances integrin alpha(6)beta(1) expression and metastatic capability of human pancreatic cancer. Oncology (2003) 1.02
Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Mol Cell Biol (2005) 1.02
Recruitment of focal adhesion kinase and paxillin to beta1 integrin promotes cancer cell migration via mitogen activated protein kinase activation. BMC Cancer (2004) 0.99
Epidermal growth factor mediates detachment from and invasion through collagen I and Matrigel in Capan-1 pancreatic cancer cells. BMC Gastroenterol (2005) 0.96
Pancreatic stellate cells (PSCs) express cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs. Mol Cancer (2005) 0.94
Apoptosis of rat hepatic stellate cells induced by anti-focal adhesion kinase antibody. World J Gastroenterol (2002) 0.92
IL-1alpha gene-transfected human melanoma cells increase tumor-cell adhesion to endothelial cells and their retention in the lung of nude mice. Int J Cancer (1996) 0.90
Activation of focal adhesion kinase in human lung cancer cells involves multiple and potentially parallel signaling events. J Cell Mol Med (2005) 0.90
Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways. J Gastroenterol Hepatol (2001) 0.89
Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling. Mol Biol Cell (2003) 0.88
A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling. BMC Cell Biol (2002) 0.87
Rel/Nuclear factor-kappa B apoptosis pathways in human cervical cancer cells. Cancer Cell Int (2005) 0.84
Formation of focal adhesion and spreading of polarized human colon cancer cells in association with tyrosine phosphorylation of paxillin in response to phorbol ester. Lab Invest (1996) 0.83
Butyrate downregulates alpha2beta1 integrin: a possible role in the induction of apoptosis in colorectal cancer cell lines. Gut (2003) 0.82
Mitochondrial function is a critical determinant of IL-1-induced ERK activation. FASEB J (2005) 0.82
Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines. Mol Cell Biochem (2004) 0.81
Expression and prognostic roles of integrins and interleukin-1 receptor type I in patients with ductal adenocarcinoma of the pancreas. Dig Dis Sci (2003) 0.79
Role of Raf-1 and FAK in cell density-dependent regulation of integrin-dependent activation of MAP kinase. Carcinogenesis (2002) 0.79
Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor. BMC Mol Biol (2002) 0.78
Sequence-specific error profile of Illumina sequencers. Nucleic Acids Res (2011) 6.88
MassBank: a public repository for sharing mass spectral data for life sciences. J Mass Spectrom (2010) 6.16
Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis. Kidney Int (2010) 3.13
Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes (2003) 2.96
Proposal for diagnostic criteria for IgG4-related kidney disease. Clin Exp Nephrol (2011) 2.12
Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis. Am J Respir Crit Care Med (2006) 1.98
Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A. J Immunol (2003) 1.91
A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease. Mod Rheumatol (2006) 1.91
KNApSAcK family databases: integrated metabolite-plant species databases for multifaceted plant research. Plant Cell Physiol (2011) 1.82
Clinical and pathological characteristics of Mikulicz's disease (IgG4-related plasmacytic exocrinopathy). Autoimmun Rev (2004) 1.80
CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer. Int J Cancer (2009) 1.79
The prickle-related gene in vertebrates is essential for gastrulation cell movements. Curr Biol (2003) 1.76
Cinnamoyl-CoA reductase, a key enzyme in lignin biosynthesis, is an effector of small GTPase Rac in defense signaling in rice. Proc Natl Acad Sci U S A (2005) 1.75
Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation (2003) 1.62
Risk of malignancies in IgG4-related disease. Mod Rheumatol (2011) 1.61
A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther (2010) 1.58
SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity. Lab Invest (2011) 1.52
Serum levels of pigmentation markers are elevated in patients undergoing hemodialysis. Blood Purif (2007) 1.46
Need for preoperative computed tomography-guided localization in video-assisted thoracoscopic surgery pulmonary resections of metastatic pulmonary nodules. Ann Thorac Surg (2010) 1.46
Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Res (2008) 1.45
Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin signaling. Stem Cells Dev (2010) 1.44
Tophaceous gout in the cervical spine. Intern Med (2012) 1.40
Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease. Int J Rheumatol (2012) 1.39
Current aspects of the pathophysiology of acute pancreatitis and therapeutic effects of an inflammatory cell infiltration inhibitor. J Gastroenterol (2003) 1.39
Activation of a Rac GTPase by the NLR family disease resistance protein Pit plays a critical role in rice innate immunity. Cell Host Microbe (2010) 1.38
A combination of plaque components analyzed by integrated backscatter intravascular ultrasound and serum pregnancy-associated plasma protein a levels predict the no-reflow phenomenon during percutaneous coronary intervention. Catheter Cardiovasc Interv (2014) 1.38
Deficiency of Long Pentraxin PTX3 Promoted Neointimal Hyperplasia after Vascular Injury. J Atheroscler Thromb (2014) 1.38
A web-based interactive developmental table for the ascidian Ciona intestinalis, including 3D real-image embryo reconstructions: I. From fertilized egg to hatching larva. Dev Dyn (2007) 1.38
Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease. J Immunol (2006) 1.35
The clinical course of patients with IgG4-related kidney disease. Kidney Int (2013) 1.35
Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival. BMC Gastroenterol (2008) 1.34
High serum level of pentosidine, an advanced glycation end product (AGE), is a risk factor of patients with heart failure. J Card Fail (2007) 1.33
Pulmonary surfactant protein A augments the phagocytosis of Streptococcus pneumoniae by alveolar macrophages through a casein kinase 2-dependent increase of cell surface localization of scavenger receptor A. J Biol Chem (2004) 1.33
Value of serum IgG4 in the diagnosis of IgG4-related disease and in differentiation from rheumatic diseases and other diseases. Mod Rheumatol (2011) 1.33
Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. Am J Hum Genet (2012) 1.32
Genome-wide binding profiles of the Bacillus subtilis transition state regulator AbrB and its homolog Abh reveals their interactive role in transcriptional regulation. Nucleic Acids Res (2010) 1.30
The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells. Mol Cancer (2006) 1.25
Reactive lymphoid hyperplasia of the liver in a patient with colon cancer: report of two cases. BMC Gastroenterol (2006) 1.23
PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. Biochem Biophys Res Commun (2003) 1.22
A novel concept of Mikulicz's disease as IgG4-related disease. Auris Nasus Larynx (2011) 1.21
Surfactant protein A inhibits peptidoglycan-induced tumor necrosis factor-alpha secretion in U937 cells and alveolar macrophages by direct interaction with toll-like receptor 2. J Biol Chem (2001) 1.21
Pulmonary collectins enhance phagocytosis of Mycobacterium avium through increased activity of mannose receptor. J Immunol (2004) 1.21
Outcomes in patients with interrupted aortic arch and associated anomalies: a 20-year experience. Eur J Cardiothorac Surg (2006) 1.21
Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor. Cancer Res (2005) 1.17
Protein kinase D1 promotes anchorage-independent growth, invasion, and angiogenesis by human pancreatic cancer cells. J Cell Physiol (2011) 1.16
The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling. Cancer Res (2005) 1.14
Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia. Nat Med (2005) 1.13
Dynamic nuclear polarization experiments at 14.1 T for solid-state NMR. Phys Chem Chem Phys (2010) 1.12
Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers. Pancreas (2008) 1.12
Laparoscopic surgery for diagnosis and treatment of bowel obstruction: case report of paracecal hernia. Med Sci Monit (2007) 1.10
PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells. Mol Cell Biochem (2009) 1.09
Increased airway vascularity in newly diagnosed asthma using a high-magnification bronchovideoscope. Am J Respir Crit Care Med (2003) 1.09
Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males. Clin Endocrinol (Oxf) (2010) 1.08
Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors. J Biol Chem (2008) 1.07
Vascular endothelial growth factor C (VEGF-C) in esophageal cancer correlates with lymph node metastasis and poor patient prognosis. J Exp Clin Cancer Res (2010) 1.07
Contemporary outcomes after endovascular treatment for aorto-iliac artery disease. Circ J (2012) 1.07
IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells. J Surg Res (2008) 1.07
Cystatin C, a novel measure of renal function, is an independent predictor of cardiac events in patients with heart failure. J Card Fail (2005) 1.06
Expression of glial cell line-derived neurotrophic factor family members and their receptors in pancreatic cancers. Surgery (2005) 1.06
The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: extended analysis of the pirfenidone trial. Respir Res (2011) 1.06
Interleukin-2 potentiation of cetuximab antitumor activity for epidermal growth factor receptor-overexpressing gastric cancer xenografts through antibody-dependent cellular cytotoxicity. Cancer Sci (2008) 1.05
Interleukin-1alpha enhances integrin alpha(6)beta(1) expression and metastatic capability of human pancreatic cancer. Oncology (2003) 1.02
Interleukin-1alpha enhances the aggressive behavior of pancreatic cancer cells by regulating the alpha6beta1-integrin and urokinase plasminogen activator receptor expression. BMC Cell Biol (2006) 1.02
Cardiac-specific overexpression of diacylglycerol kinase zeta prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice. Circulation (2005) 1.02
Central role of endogenous Toll-like receptor-2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injury. Biochem Biophys Res Commun (2006) 1.02
Middle-colic artery aneurysm associated with segmental arterial mediolysis, successfully managed by transcatheter arterial embolization: report of a case. Surg Today (2009) 1.01
Analysis of serum IgG subclasses in Churg-Strauss syndrome--the meaning of elevated serum levels of IgG4. Intern Med (2010) 1.01
Metabolomics of medicinal plants: the importance of multivariate analysis of analytical chemistry data. Curr Comput Aided Drug Des (2010) 1.00