Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection.

PubWeight™: 2.96‹?› | Rank: Top 1%

🔗 View Article (PMID 12606496)

Published in Diabetes on March 01, 2003

Authors

R Paul Robertson1, Jamie Harmon, Phuong Oanh Tran, Yoshito Tanaka, Hiroki Takahashi

Author Affiliations

1: Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA.

Associated clinical trials:

Treating Type 2 Diabetes by Reducing Postprandial Glucose Elevations: A Paradigm Shift in Lifestyle Modification | NCT03196895

Benefits of Continuous Glucose Monitoring With GEM Lifestyle Modification for Adults With Type 2 Diabetes | NCT03207893

Articles citing this

(truncated to the top 100)

Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev (2007) 4.91

Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes (2008) 3.05

Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proc Natl Acad Sci U S A (2006) 2.59

Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. J Physiol (2007) 2.13

Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. J Biol Chem (2009) 2.04

Endoplasmic reticulum stress and pancreatic β-cell death. Trends Endocrinol Metab (2011) 2.01

Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders. Diabetes (2013) 1.79

A practical guide to rodent islet isolation and assessment. Biol Proced Online (2009) 1.74

Small G proteins in islet beta-cell function. Endocr Rev (2009) 1.68

Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models. Antioxid Redox Signal (2010) 1.59

Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes (2009) 1.53

Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis. Mediators Inflamm (2010) 1.49

Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line. Clin Sci (Lond) (2011) 1.44

Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties. Cardiovasc Diabetol (2011) 1.41

Increased 1,5-anhydroglucitol predicts glycemic remission in patients with newly diagnosed type 2 diabetes treated with short-term intensive insulin therapy. Diabetes Technol Ther (2012) 1.40

Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets. Diabetes (2007) 1.38

Effect of 3-month yoga on oxidative stress in type 2 diabetes with or without complications: a controlled clinical trial. Diabetes Care (2011) 1.35

Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World J Diabetes (2015) 1.33

A radical explanation for glucose-induced beta cell dysfunction. J Clin Invest (2003) 1.28

Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells. Proc Natl Acad Sci U S A (2008) 1.23

Oxidative stress and beta-cell dysfunction. Pflugers Arch (2010) 1.22

Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes. Curr Diabetes Rev (2013) 1.21

Renin inhibition attenuates insulin resistance, oxidative stress, and pancreatic remodeling in the transgenic Ren2 rat. Endocrinology (2008) 1.21

Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression. Endocrinology (2009) 1.18

The stimulus-induced tyrosine phosphorylation of Munc18c facilitates vesicle exocytosis. J Biol Chem (2006) 1.18

Exercise therapy in type 2 diabetes. Acta Diabetol (2009) 1.12

FoxO1, the transcriptional chief of staff of energy metabolism. Bone (2011) 1.12

Protein O-GlcNAcylation in diabetes and diabetic complications. Expert Rev Proteomics (2013) 1.12

Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation. Endocr Rev (2008) 1.12

The role of FOXO1 in β-cell failure and type 2 diabetes mellitus. Nat Rev Endocrinol (2013) 1.07

Diabetes mellitus: The epidemic of the century. World J Diabetes (2015) 1.06

Minireview: Thioredoxin-interacting protein: regulation and function in the pancreatic β-cell. Mol Endocrinol (2014) 1.05

Evaluation of glutathione S-transferase P1 genetic variants affecting type-2 diabetes susceptibility and glycemic control. Arch Med Sci (2012) 1.04

Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction. J Biol Chem (2009) 1.04

Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets. Diabetes (2009) 1.02

Diabetes and beta cell function: from mechanisms to evaluation and clinical implications. Biochem Med (Zagreb) (2013) 1.01

Involvement of oxidative stress and the JNK pathway in glucose toxicity. Rev Diabet Stud (2005) 1.01

Maternal obesity in ewes results in reduced fetal pancreatic β-cell numbers in late gestation and decreased circulating insulin concentration at term. Domest Anim Endocrinol (2010) 0.98

Unrecognized glucose intolerance is not associated with depression. Screening for Impaired Glucose Tolerance study 3 (SIGT 3). Diabet Med (2008) 0.98

AGEs decrease insulin synthesis in pancreatic β-cell by repressing Pdx-1 protein expression at the post-translational level. PLoS One (2011) 0.96

Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin. Cell Death Dis (2011) 0.94

Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: report of twelve cases and discussion of mechanism of action. Int J Med Sci (2009) 0.94

Uncoupling proteins: role in insulin resistance and insulin insufficiency. Curr Diabetes Rev (2006) 0.93

Induction of apoptosis in cancer cells by NiZn ferrite nanoparticles through mitochondrial cytochrome C release. Int J Nanomedicine (2013) 0.92

Azelnidipine protects myocardium in hyperglycemia-induced cardiac damage. Cardiovasc Diabetol (2010) 0.92

Natural history of β-cell adaptation and failure in type 2 diabetes. Mol Aspects Med (2014) 0.91

Oxidative DNA damage in early pregnancy and risk of gestational diabetes mellitus: A pilot study. Clin Biochem (2011) 0.90

Glucose excursions between states of glycemia with progression to type 1 diabetes in the diabetes prevention trial-type 1 (DPT-1). Diabetes (2010) 0.89

Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion. J Biol Chem (2012) 0.89

UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells. PLoS One (2008) 0.88

Epigenetic and microRNA-mediated regulation in diabetes. Nephrol Dial Transplant (2009) 0.88

Retracted Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization. J Biol Chem (2011) 0.88

The diabetic β-cell: hyperstimulated vs. hyperexcited. Diabetes Obes Metab (2012) 0.87

Augmented beta cell loss and mitochondrial abnormalities in sucrose-fed GK rats. Virchows Arch (2008) 0.87

PKA-independent cAMP stimulation of white adipocyte exocytosis and adipokine secretion: modulations by Ca2+ and ATP. J Physiol (2014) 0.86

Role of N-ε- carboxy methyl lysine, advanced glycation end products and reactive oxygen species for the development of nonproliferative and proliferative retinopathy in type 2 diabetes mellitus. Mol Vis (2013) 0.86

Chinese herbal medicine for impaired glucose tolerance: a randomized placebo controlled trial. BMC Complement Altern Med (2013) 0.85

ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells. J Biol Chem (2011) 0.85

GLUT2 immunoreactivity in Gomori-positive astrocytes of the hypothalamus. J Histochem Cytochem (2004) 0.84

The level of menadione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion. Toxicol Appl Pharmacol (2011) 0.84

The antioxidant effect of the Malaysian Gelam honey on pancreatic hamster cells cultured under hyperglycemic conditions. Clin Exp Med (2013) 0.83

Nebivolol improves insulin sensitivity in the TGR(Ren2)27 rat. Metabolism (2011) 0.83

Oral administration of ginseng ameliorates cyclosporine-induced pancreatic injury in an experimental mouse model. PLoS One (2013) 0.83

MafA promotes the reprogramming of placenta-derived multipotent stem cells into pancreatic islets-like and insulin+ cells. J Cell Mol Med (2011) 0.83

Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells. J Biol Chem (2013) 0.82

Early Pregnancy Maternal Lipid Profiles and the Risk of Gestational Diabetes Mellitus Stratified for Body Mass Index. Reprod Sci (2014) 0.82

Role of oxidative stress in pathogenesis of metabolic syndrome. Caspian J Intern Med (2012) 0.82

PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet β-cells. FEBS Open Bio (2012) 0.81

Involvement of oxidative stress in suppression of insulin biosynthesis under diabetic conditions. Int J Mol Sci (2012) 0.81

Intermittent hypoxia-induced rat pancreatic β-cell apoptosis and protective effects of antioxidant intervention. Nutr Diabetes (2014) 0.81

Pleiotropic Roles of PDX-1 in the Pancreas. Rev Diabet Stud (2008) 0.81

Update on the protective molecular pathways improving pancreatic beta-cell dysfunction. Mediators Inflamm (2013) 0.81

Molecular mechanisms underlying the fetal programming of adult disease. J Cell Commun Signal (2012) 0.80

Small-molecule inhibition of inflammatory β-cell death. Diabetes Obes Metab (2013) 0.80

The role of peroxidation of mitochondrial membrane phospholipids in pancreatic β -cell failure. Curr Diabetes Rev (2012) 0.80

Total Antioxidant Status in Type 2 Diabetic Patients in Palestine. J Diabetes Res (2015) 0.80

Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity. Diabetes Res Clin Pract (2010) 0.79

Characterization of age-associated alterations of islet function and structure in diabetic mutant cryptochrome 1 transgenic mice. J Diabetes Investig (2013) 0.79

Gliclazide may have an antiapoptotic effect related to its antioxidant properties in human normal and cancer cells. Mol Biol Rep (2011) 0.79

An Update on the Effect of Incretin-Based Therapies on β-Cell Function and Mass. Diabetes Metab J (2016) 0.79

Glucagon-like peptide-1 triggers protective pathways in pancreatic beta-cells exposed to glycated serum. Mediators Inflamm (2013) 0.79

Role of Oxidative Stress in the Pathogenesis of Pancreatitis: Effect of Antioxidant Therapy. Pancreat Disord Ther (2013) 0.79

Metabolic Inflammation-Differential Modulation by Dietary Constituents. Nutrients (2016) 0.78

β-cell mass in people with type 2 diabetes. J Diabetes Investig (2011) 0.78

Protective effects of Quercus salicina on alloxan-induced oxidative stress in HIT-T15 pancreatic β cells. Exp Ther Med (2013) 0.78

Metabolomics applied to the pancreatic islet. Arch Biochem Biophys (2015) 0.78

Toward improving human islet isolation from younger donors: rescue purification is efficient for trapped islets. Cell Transplant (2009) 0.78

Down-regulation of pancreatic transcription factors and incretin receptors in type 2 diabetes. World J Diabetes (2013) 0.78

Role of pancreatic transcription factors in maintenance of mature β-cell function. Int J Mol Sci (2015) 0.77

Future detection and monitoring of diabetes may entail analysis of both β-cell function and volume: how markers of β-cell loss may assist. J Transl Med (2012) 0.77

Decreased Expression and Induced Nucleocytoplasmic Translocation of Pancreatic and Duodenal Homeobox 1 in INS-1 Cells Exposed to High Glucose and Palmitate. Diabetes Metab J (2011) 0.77

Insulin combined with Chinese medicine improves glycemic outcome through multiple pathways in patients with type 2 diabetes mellitus. J Diabetes Investig (2015) 0.77

Thioredoxin-mimetic peptide CB3 lowers MAPKinase activity in the Zucker rat brain. Redox Biol (2014) 0.77

Therapeutic potential of pterostilbene against pancreatic beta-cell apoptosis mediated through Nrf2. Br J Pharmacol (2014) 0.77

Thioglycosides as inhibitors of hSGLT1 and hSGLT2: potential therapeutic agents for the control of hyperglycemia in diabetes. Int J Med Sci (2007) 0.77

Inflammatory stress of pancreatic beta cells drives release of extracellular heat-shock protein 90α. Immunology (2017) 0.76

Catalase Deletion Promotes PreDiabetic Phenotype in Mice. Free Radic Biol Med (2016) 0.76

The effect of different volumes of high-intensity interval training on proinsulin in participants with the metabolic syndrome: a randomised trial. Diabetologia (2016) 0.76

Heat Shock Protein 27 is down-regulated in Ballooned Hepatocytes of Patients with Nonalcoholic Steatohepatitis (NASH). Sci Rep (2016) 0.76

Chokeberry Anthocyanin Extract as Pancreatic β-Cell Protectors in Two Models of Induced Oxidative Stress. Oxid Med Cell Longev (2015) 0.76

Articles by these authors

(truncated to the top 100)

Sequence-specific error profile of Illumina sequencers. Nucleic Acids Res (2011) 6.88

MassBank: a public repository for sharing mass spectral data for life sciences. J Mass Spectrom (2010) 6.16

Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis. Kidney Int (2010) 3.13

Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes (2004) 3.11

Proposal for diagnostic criteria for IgG4-related kidney disease. Clin Exp Nephrol (2011) 2.12

Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis. Am J Respir Crit Care Med (2006) 1.98

Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A. J Immunol (2003) 1.91

A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease. Mod Rheumatol (2006) 1.91

KNApSAcK family databases: integrated metabolite-plant species databases for multifaceted plant research. Plant Cell Physiol (2011) 1.82

Clinical and pathological characteristics of Mikulicz's disease (IgG4-related plasmacytic exocrinopathy). Autoimmun Rev (2004) 1.80

A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity. Proc Natl Acad Sci U S A (2002) 1.79

CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer. Int J Cancer (2009) 1.79

The prickle-related gene in vertebrates is essential for gastrulation cell movements. Curr Biol (2003) 1.76

Cinnamoyl-CoA reductase, a key enzyme in lignin biosynthesis, is an effector of small GTPase Rac in defense signaling in rice. Proc Natl Acad Sci U S A (2005) 1.75

Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation (2003) 1.62

Risk of malignancies in IgG4-related disease. Mod Rheumatol (2011) 1.61

SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity. Lab Invest (2011) 1.52

Serum levels of pigmentation markers are elevated in patients undergoing hemodialysis. Blood Purif (2007) 1.46

Need for preoperative computed tomography-guided localization in video-assisted thoracoscopic surgery pulmonary resections of metastatic pulmonary nodules. Ann Thorac Surg (2010) 1.46

Tophaceous gout in the cervical spine. Intern Med (2012) 1.40

Bone marrow cells enhance liver regeneration after massive hepatectomy in mice. Dig Dis Sci (2014) 1.40

Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease. Int J Rheumatol (2012) 1.39

Activation of a Rac GTPase by the NLR family disease resistance protein Pit plays a critical role in rice innate immunity. Cell Host Microbe (2010) 1.38

A combination of plaque components analyzed by integrated backscatter intravascular ultrasound and serum pregnancy-associated plasma protein a levels predict the no-reflow phenomenon during percutaneous coronary intervention. Catheter Cardiovasc Interv (2014) 1.38

A web-based interactive developmental table for the ascidian Ciona intestinalis, including 3D real-image embryo reconstructions: I. From fertilized egg to hatching larva. Dev Dyn (2007) 1.38

Deficiency of Long Pentraxin PTX3 Promoted Neointimal Hyperplasia after Vascular Injury. J Atheroscler Thromb (2014) 1.38

Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease. J Immunol (2006) 1.35

The clinical course of patients with IgG4-related kidney disease. Kidney Int (2013) 1.35

Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival. BMC Gastroenterol (2008) 1.34

High serum level of pentosidine, an advanced glycation end product (AGE), is a risk factor of patients with heart failure. J Card Fail (2007) 1.33

Pulmonary surfactant protein A augments the phagocytosis of Streptococcus pneumoniae by alveolar macrophages through a casein kinase 2-dependent increase of cell surface localization of scavenger receptor A. J Biol Chem (2004) 1.33

Value of serum IgG4 in the diagnosis of IgG4-related disease and in differentiation from rheumatic diseases and other diseases. Mod Rheumatol (2011) 1.33

Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. Am J Hum Genet (2012) 1.32

Genome-wide binding profiles of the Bacillus subtilis transition state regulator AbrB and its homolog Abh reveals their interactive role in transcriptional regulation. Nucleic Acids Res (2010) 1.30

The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells. Mol Cancer (2006) 1.25

Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica. J Biol Chem (2002) 1.24

A novel concept of Mikulicz's disease as IgG4-related disease. Auris Nasus Larynx (2011) 1.21

Surfactant protein A inhibits peptidoglycan-induced tumor necrosis factor-alpha secretion in U937 cells and alveolar macrophages by direct interaction with toll-like receptor 2. J Biol Chem (2001) 1.21

Pulmonary collectins enhance phagocytosis of Mycobacterium avium through increased activity of mannose receptor. J Immunol (2004) 1.21

Dynamic nuclear polarization experiments at 14.1 T for solid-state NMR. Phys Chem Chem Phys (2010) 1.12

Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation. Mol Cancer (2005) 1.11

Genes for direct methylation of glycine provide high levels of glycinebetaine and abiotic-stress tolerance in Synechococcus and Arabidopsis. Proc Natl Acad Sci U S A (2005) 1.11

PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells. Mol Cell Biochem (2009) 1.09

Increased airway vascularity in newly diagnosed asthma using a high-magnification bronchovideoscope. Am J Respir Crit Care Med (2003) 1.09

Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males. Clin Endocrinol (Oxf) (2010) 1.08

Intrahepatic glucose flux as a mechanism for defective intrahepatic islet alpha-cell response to hypoglycemia. Diabetes (2008) 1.08

Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors. J Biol Chem (2008) 1.07

Contemporary outcomes after endovascular treatment for aorto-iliac artery disease. Circ J (2012) 1.07

IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells. J Surg Res (2008) 1.07

Cystatin C, a novel measure of renal function, is an independent predictor of cardiac events in patients with heart failure. J Card Fail (2005) 1.06

The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: extended analysis of the pirfenidone trial. Respir Res (2011) 1.06

Cardiac-specific overexpression of diacylglycerol kinase zeta prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice. Circulation (2005) 1.02

Central role of endogenous Toll-like receptor-2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injury. Biochem Biophys Res Commun (2006) 1.02

Interleukin-1alpha enhances the aggressive behavior of pancreatic cancer cells by regulating the alpha6beta1-integrin and urokinase plasminogen activator receptor expression. BMC Cell Biol (2006) 1.02

Analysis of serum IgG subclasses in Churg-Strauss syndrome--the meaning of elevated serum levels of IgG4. Intern Med (2010) 1.01

Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: a retrospective multicenter study. Arthritis Res Ther (2014) 1.00

Metabolomics of medicinal plants: the importance of multivariate analysis of analytical chemistry data. Curr Comput Aided Drug Des (2010) 1.00

Specialized inpatient psychiatry for serious behavioral disturbance in autism and intellectual disability. J Autism Dev Disord (2014) 1.00

Epidemiologic survey of Japanese patients with idiopathic pulmonary fibrosis and investigation of ethnic differences. Am J Respir Crit Care Med (2014) 1.00

Suppressed expression of the apoplastic ascorbate oxidase gene increases salt tolerance in tobacco and Arabidopsis plants. J Exp Bot (2005) 0.99

How was the notochord born? Evol Dev (2012) 0.99

Exploratory analysis of a phase III trial of pirfenidone identifies a subpopulation of patients with idiopathic pulmonary fibrosis as benefiting from treatment. Respir Res (2011) 0.98

Serum KL-6 and surfactant proteins A and D in pediatric interstitial lung disease. Chest (2005) 0.98

Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway. Dig Dis Sci (2007) 0.98

Prevalence of HSP47 antigen and autoantibodies to HSP47 in the sera of patients with mixed connective tissue disease. Biochem Biophys Res Commun (2003) 0.97

High-yield peptide-extraction method for the discovery of subnanomolar biomarkers from small serum samples. J Proteome Res (2010) 0.97

Optimal prediction of the central venous catheter insertion depth on a routine chest x-ray. Nutrition (2010) 0.97

Curatively resected isolated inguinal lymph node metastasis from cecum cancer: report of a case. Surg Today (2012) 0.97

Brachyury-downstream gene sets in a chordate, Ciona intestinalis: integrating notochord specification, morphogenesis and chordate evolution. Evol Dev (2008) 0.97

T-box genes in the ascidian Ciona intestinalis: characterization of cDNAs and spatial expression. Dev Dyn (2004) 0.96

Functional characterization of betaine/proline transporters in betaine-accumulating mangrove. J Biol Chem (2002) 0.96

Metabolic engineering for betaine accumulation in microbes and plants. J Biol Chem (2007) 0.96

Dynamic transcriptional and metabolic responses in yeast adapting to temperature stress. OMICS (2010) 0.95

Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadenitis: results from the SMART database. Mod Rheumatol (2014) 0.95

Enhanced angiogenesis due to inflammatory cytokines from pancreatic cancer cell lines and relation to metastatic potential. Pancreas (2004) 0.95

Novel spliced form of a lens protein as a novel lung cancer antigen, Lengsin splicing variant 4. Cancer Sci (2009) 0.95

Brominated labdane-type diterpenoids from an Okinawan Laurencia sp. J Nat Prod (2002) 0.95

Clinicopathologic similarities between Mikulicz disease and Küttner tumor. Am J Otolaryngol (2009) 0.95

The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis. Metabolism (2008) 0.94

Immunohistochemical Characteristics of IgG4-Related Tubulointerstitial Nephritis: Detailed Analysis of 20 Japanese Cases. Int J Rheumatol (2012) 0.94

Gefitinib-induced interstitial lung disease showing improvement after cessation: disassociation of serum markers. Respirology (2006) 0.94

Life-event stress induced by the Great East Japan Earthquake was associated with relapse in ulcerative colitis but not Crohn's disease: a retrospective cohort study. BMJ Open (2013) 0.94

Laparoscopic anterior resection for colorectal cancer without minilaparotomy using transanal bowel reversing retrieval. Surg Laparosc Endosc Percutan Tech (2011) 0.93

Clinical usefulness of anti-RNA polymerase III antibody measurement by enzyme-linked immunosorbent assay. Rheumatology (Oxford) (2009) 0.93

Successful paclitaxel-based chemotherapy for an alpha-fetoprotein-producing gastric cancer patient with multiple liver metastases. World J Surg Oncol (2007) 0.93

Cardiac nuclear high mobility group box 1 prevents the development of cardiac hypertrophy and heart failure. Cardiovasc Res (2013) 0.93

Halotolerant cyanobacterium Aphanothece halophytica contains NapA-type Na+/H+ antiporters with novel ion specificity that are involved in salt tolerance at alkaline pH. Appl Environ Microbiol (2005) 0.92

Necessity of early intervention for IgG4-related disease--delayed treatment induces fibrosis progression. Rheumatology (Oxford) (2012) 0.91

Nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan. Respir Investig (2013) 0.91

Increased left atrial volume index predicts a poor prognosis in patients with heart failure. J Card Fail (2010) 0.91

Prognostic importance of objective nutritional indexes in patients with chronic heart failure. J Cardiol (2013) 0.90

D-Glyceraldehyde causes production of intracellular peroxide in pancreatic islets, oxidative stress, and defective beta cell function via non-mitochondrial pathways. J Biol Chem (2004) 0.90

A short version of a HRQoL questionnaire for Italian and Japanese patients with Primary Biliary Cirrhosis. Dig Liver Dis (2010) 0.90

Leukoencephalopathy during administration of etanercept for refractory rheumatoid arthritis. Mod Rheumatol (2007) 0.90

The analysis of interleukin-6 in patients with systemic IgG4-related plasmacytic syndrome--expansion of SIPS to the territory of Castleman's disease. Rheumatology (Oxford) (2009) 0.90

Assessment of transcriptional responses of Bacillus subtilis cells to the antibiotic enduracidin, which interferes with cell wall synthesis, using a high-density tiling chip. Genes Genet Syst (2009) 0.90

Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophila and suppress its intracellular growth. J Biol Chem (2010) 0.90

Combination of heart-type fatty acid binding protein and brain natriuretic peptide can reliably risk stratify patients hospitalized for chronic heart failure. Circ J (2005) 0.90

IL-1alpha secreted by colon cancer cells enhances angiogenesis: the relationship between IL-1alpha release and tumor cells' potential for liver metastasis. J Surg Oncol (2009) 0.90

Case report of pseudoaneurysm caused by core needle biopsy of the breast. Breast Cancer (2009) 0.89