Published in Cancer on November 15, 2005
Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells (2009) 2.59
Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells. J Biol Chem (2008) 2.42
Induced pluripotent stem cells: opportunities and challenges. Philos Trans R Soc Lond B Biol Sci (2011) 2.09
Radiation-induced reprogramming of breast cancer cells. Stem Cells (2012) 1.83
Concise review: isoforms of OCT4 contribute to the confusing diversity in stem cell biology. Stem Cells (2010) 1.74
Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells. Oncogene (2011) 1.67
Human embryonic and neuronal stem cell markers in retinoblastoma. Mol Vis (2007) 1.66
Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers. BMC Cancer (2006) 1.58
Aldehyde dehydrogenase activity as a functional marker for lung cancer. Chem Biol Interact (2008) 1.52
Characterization of the murine myeloid precursor cell line MuMac-E8. PLoS One (2014) 1.39
Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells? Cancer Res (2011) 1.33
The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition. J Mol Signal (2010) 1.26
Oct4A is expressed by a subpopulation of prostate neuroendocrine cells. Prostate (2009) 1.25
OCT4 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells by miR-125b/BAK1 pathway. Cell Death Dis (2013) 1.20
Oct-4 and Nanog promote the epithelial-mesenchymal transition of breast cancer stem cells and are associated with poor prognosis in breast cancer patients. Oncotarget (2014) 1.20
Clinicopathological significance of non-small cell lung cancer with high prevalence of Oct-4 tumor cells. J Exp Clin Cancer Res (2012) 1.17
Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment. Cell Death Dis (2014) 1.17
Specificity factors in cytoplasmic polyadenylation. Wiley Interdiscip Rev RNA (2013) 1.15
The expressions of stem cell markers: Oct4, Nanog, Sox2, nucleostemin, Bmi, Zfx, Tcl1, Tbx3, Dppa4, and Esrrb in bladder, colon, and prostate cancer, and certain cancer cell lines. Anat Cell Biol (2014) 1.15
The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis. Oncogene (2013) 1.13
Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. J Gastroenterol Hepatol (2012) 1.12
Deficiency of growth differentiation factor 3 protects against diet-induced obesity by selectively acting on white adipose. Mol Endocrinol (2008) 1.11
Cancer vaccines targeting the epithelial-mesenchymal transition: tissue distribution of brachyury and other drivers of the mesenchymal-like phenotype of carcinomas. Semin Oncol (2012) 1.10
Bmi1 regulates self-renewal and epithelial to mesenchymal transition in breast cancer cells through Nanog. BMC Cancer (2014) 1.09
Targeting cancer stem cells: emerging role of Nanog transcription factor. Onco Targets Ther (2013) 1.06
Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours. Br J Cancer (2011) 1.05
Emerging roles of nodal and Cripto-1: from embryogenesis to breast cancer progression. Breast Dis (2008) 1.03
Male infertility: a risk factor for testicular cancer. Nat Rev Urol (2009) 1.02
Pluripotency transcription factors and cancer stem cells: small genes make a big difference. Chin J Cancer (2013) 1.02
Tumor-initiating function of nucleostemin-enriched mammary tumor cells. Cancer Res (2010) 1.02
Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma. J Transl Med (2010) 1.02
Overexpression of NANOG in gestational trophoblastic diseases: effect on apoptosis, cell invasion, and clinical outcome. Am J Pathol (2008) 1.01
Downregulation of KPNA2 in non-small-cell lung cancer is associated with Oct4 expression. J Transl Med (2013) 1.01
Oct4 mediates tumor initiating properties in oral squamous cell carcinomas through the regulation of epithelial-mesenchymal transition. PLoS One (2014) 1.00
Sox2 is an androgen receptor-repressed gene that promotes castration-resistant prostate cancer. PLoS One (2013) 1.00
Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells. Int J Dev Biol (2010) 0.98
Pluripotent transcription factors possess distinct roles in normal versus transformed human stem cells. PLoS One (2009) 0.96
MiR-134 regulates the proliferation and invasion of glioblastoma cells by reducing Nanog expression. Int J Oncol (2013) 0.96
OCT4 positively regulates Survivin expression to promote cancer cell proliferation and leads to poor prognosis in esophageal squamous cell carcinoma. PLoS One (2012) 0.95
Expression of the stem cell marker, Nanog, in human endometrial adenocarcinoma. Int J Gynecol Pathol (2011) 0.93
Follicle-stimulating hormone inhibits apoptosis in ovarian cancer cells by regulating the OCT4 stem cell signaling pathway. Int J Oncol (2013) 0.91
Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells. Nucleic Acids Res (2010) 0.90
A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis. PLoS One (2010) 0.89
Statins inhibit the growth of variant human embryonic stem cells and cancer cells in vitro but not normal human embryonic stem cells. Br J Pharmacol (2009) 0.89
TLRs, Alcohol, HCV, and Tumorigenesis. Gastroenterol Res Pract (2011) 0.88
Evaluation of radiotherapy effect in resveratrol-treated medulloblastoma cancer stem-like cells. Childs Nerv Syst (2009) 0.88
Expression of seven stem-cell-associated markers in human airway biopsy specimens obtained via fiberoptic bronchoscopy. J Exp Clin Cancer Res (2013) 0.88
BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma. PLoS Genet (2015) 0.88
The human pluripotency gene NANOG/NANOGP8 is expressed in gastric cancer and associated with tumor development. Oncol Lett (2010) 0.87
Nanog: a potential biomarker for liver metastasis of colorectal cancer. Dig Dis Sci (2012) 0.87
Challenges to the clinical application of pluripotent stem cells: towards genomic and functional stability. Genome Med (2012) 0.86
Over-expression of Oct4 in human esophageal squamous cell carcinoma. Mol Cells (2011) 0.85
Expression and differentiation between OCT4A and its Pseudogenes in human ESCs and differentiated adult somatic cells. PLoS One (2014) 0.85
OCT4 expression and vasculogenic mimicry formation positively correlate with poor prognosis in human breast cancer. Int J Mol Sci (2014) 0.85
Downregulation of the transcription factor, FoxD3, is associated with lymph node metastases in invasive ductal carcinomas of the breast. Int J Clin Exp Pathol (2014) 0.84
Common stemness regulators of embryonic and cancer stem cells. World J Stem Cells (2015) 0.84
Clinical significance of POU5F1P1 rs10505477 polymorphism in Chinese gastric cancer patients receving cisplatin-based chemotherapy after surgical resection. Int J Mol Sci (2014) 0.84
Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer. Nucleic Acids Res (2015) 0.84
Expression of the pluripotency markers Oct3/4, Nanog and Sox2 in human breast cancer cell lines. Oncol Lett (2012) 0.84
Increased multi-drug resistance and reduced apoptosis in osteosarcoma side population cells are crucial factors for tumor recurrence. Exp Ther Med (2016) 0.83
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth. Mol Cell Biol (2014) 0.83
CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance. Oncotarget (2015) 0.83
Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals. Oncotarget (2014) 0.83
Differential expression profiling between atypical teratoid/rhabdoid and medulloblastoma tumor in vitro and in vivo using microarray analysis. Childs Nerv Syst (2009) 0.83
TRA-1-60(+), SSEA-4(+), POU5F1(+), SOX2(+), NANOG(+) Clones of Pluripotent Stem Cells in the Embryonal Carcinomas of the Testes. J Stem Cell Res Ther (2013) 0.83
Functional and molecular characterization of the role of CTCF in human embryonic stem cell biology. PLoS One (2012) 0.82
High Expression of SOX2 and OCT4 Indicates Radiation Resistance and an Independent Negative Prognosis in Cervical Squamous Cell Carcinoma. J Histochem Cytochem (2014) 0.82
NANOG expression correlates with differentiation, metastasis and resistance to preoperative adjuvant therapy in oral squamous cell carcinoma. Oncol Lett (2013) 0.81
Effect of shRNA-mediated inhibition of Nanog gene expression on the behavior of human gastric cancer cells. Oncol Lett (2013) 0.81
PSCA and Oct-4 expression in the benign and malignant lesions of gallbladder: implication for carcinogenesis, progression, and prognosis of gallbladder adenocarcinoma. Biomed Res Int (2013) 0.81
Testicular germline stem cells. Nat Rev Urol (2010) 0.81
Comprehensive analysis of clinical significance of stem-cell related factors in renal cell cancer. World J Surg Oncol (2011) 0.81
GDF3 inhibits the growth of breast cancer cells and promotes the apoptosis induced by Taxol. J Cancer Res Clin Oncol (2012) 0.81
Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W species. PLoS One (2014) 0.81
An embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma. J Exp Clin Cancer Res (2010) 0.81
The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells. BMC Biol (2016) 0.80
The network of pluripotency, epithelial-mesenchymal transition, and prognosis of breast cancer. Breast Cancer (Dove Med Press) (2015) 0.80
Pin1-Nanog expression in human glioma is correlated with advanced tumor progression. Oncol Rep (2013) 0.80
Human adult stem cells as the target cells for the initiation of carcinogenesis and for the generation of "cancer stem cells". Int J Stem Cells (2008) 0.80
Breast cancer-initiating cells: insights into novel treatment strategies. Cancers (Basel) (2011) 0.79
Developmental pluripotency-associated 4: a novel predictor for prognosis and a potential therapeutic target for colon cancer. J Exp Clin Cancer Res (2015) 0.79
OCT4 pseudogenes present in human leukemia cells. Clin Exp Med (2011) 0.79
NANOG: a promising target for digestive malignant tumors. World J Gastroenterol (2014) 0.79
Male reproductive cancers and infertility: a mutual relationship. Int J Mol Sci (2015) 0.79
Phytoestrogens regulate the proliferation and expression of stem cell factors in cell lines of malignant testicular germ cell tumors. Int J Oncol (2013) 0.79
Nanog siRNA plus Cisplatin may enhance the sensitivity of chemotherapy in esophageal cancer. J Cancer Res Clin Oncol (2012) 0.79
Autochthonous mouse melanoma and mammary tumors do not express the pluripotency genes Oct4 and Nanog. PLoS One (2013) 0.79
Growth and differentiation factor 3 induces expression of genes related to differentiation in a model of cancer stem cells and protects them from retinoic acid-induced apoptosis. PLoS One (2013) 0.78
Insights on neoplastic stem cells from gel-based proteomics of childhood germ cell tumors. Pediatr Blood Cancer (2011) 0.78
Canine epidermal neural crest stem cells: characterization and potential as therapy candidate for a large animal model of spinal cord injury. Stem Cells Transl Med (2014) 0.78
293FT cells transduced with four transcription factors (OCT4, SOX2, NANOG, and LIN28) generate aberrant ES-like cells. J Stem Cells Regen Med (2010) 0.78
A test for comparing two groups of samples when analyzing multiple omics profiles. BMC Bioinformatics (2014) 0.78
A three-gene signature and clinical outcome in esophageal squamous cell carcinoma. Int J Cancer (2014) 0.78
Stemness-related transcriptional factors and homing gene expression profiles in hepatic differentiation and cancer. Mol Med (2016) 0.76
A Combination of Culture Conditions and Gene Expression Analysis Can Be Used to Investigate and Predict hES Cell Differentiation Potential towards Male Gonadal Cells. PLoS One (2015) 0.76
Matrix Hyaluronan Promotes Specific MicroRNA Upregulation Leading to Drug Resistance and Tumor Progression. Int J Mol Sci (2016) 0.76
FOXA1 expression affects the proliferation activity of luminal breast cancer stem cell populations. Cancer Sci (2016) 0.76
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell (2009) 8.62
Identification and classification of chromosomal aberrations in human induced pluripotent stem cells. Cell Stem Cell (2010) 7.16
Relationship between nucleosome positioning and DNA methylation. Nature (2010) 5.27
Unique gene expression signatures of independently-derived human embryonic stem cell lines. Hum Mol Genet (2004) 3.77
Functional genetic analysis of mouse chromosome 11. Nature (2003) 2.87
Female human iPSCs retain an inactive X chromosome. Cell Stem Cell (2010) 2.59
Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells (2009) 2.51
The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation. Nat Cell Biol (2012) 2.41
Prepubertal orchiopexy for cryptorchidism may be associated with lower risk of testicular cancer. J Urol (2007) 2.39
Hydrodynamic stretching of single cells for large population mechanical phenotyping. Proc Natl Acad Sci U S A (2012) 2.37
Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Mol Cell (2009) 2.27
Isolation and characterization of pluripotent human spermatogonial stem cell-derived cells. Stem Cells (2009) 2.05
Increased risk of high-grade prostate cancer among infertile men. Cancer (2010) 2.00
Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells. Stem Cells (2009) 1.94
Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. Proc Natl Acad Sci U S A (2003) 1.85
Bone morphogenetic proteins induce germ cell differentiation from human embryonic stem cells. Stem Cells Dev (2006) 1.73
A novel application of 1H magnetic resonance spectroscopy: non-invasive identification of spermatogenesis in men with non-obstructive azoospermia. Hum Reprod (2010) 1.56
Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells. Stem Cells (2011) 1.56
Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. Stem Cells (2004) 1.56
Markov modeling of vasectomy reversal and ART for infertility: how do obstructive interval and female partner age influence cost effectiveness? Fertil Steril (2007) 1.50
Wet heat exposure: a potentially reversible cause of low semen quality in infertile men. Int Braz J Urol (2007) 1.47
Surgery or assisted reproduction? A decision analysis of treatment costs in male infertility. J Urol (2005) 1.45
Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells. Cell Stem Cell (2013) 1.40
Increased risk of testicular germ cell cancer among infertile men. Arch Intern Med (2009) 1.39
Defective recombination in infertile men. Hum Mol Genet (2004) 1.22
Sexual, marital, and social impact of a man's perceived infertility diagnosis. J Sex Med (2009) 1.16
Human BOULE gene rescues meiotic defects in infertile flies. Hum Mol Genet (2003) 1.15
Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status. Stem Cell Res Ther (2013) 1.14
Single cell analysis facilitates staging of Blimp1-dependent primordial germ cells derived from mouse embryonic stem cells. PLoS One (2011) 1.12
The relative accuracy of a questionnaire compared with pedigree analysis in genetic risk assessment for infertility. J Urol (2008) 1.08
Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions. Lab Chip (2010) 1.02
Can varicocelectomy significantly change the way couples use assisted reproductive technologies? J Urol (2002) 1.02
Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions. J Biol Chem (2013) 1.02
Derivation of new human embryonic stem cell lines reveals rapid epigenetic progression in vitro that can be prevented by chemical modification of chromatin. Hum Mol Genet (2011) 1.02
A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors. Stem Cells (2009) 0.98
The genetics of male infertility. Semin Reprod Med (2009) 0.98
Aneuploidy and early human embryo development. Hum Mol Genet (2008) 0.97
Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men. Reprod Biol Endocrinol (2006) 0.95
Feasibility of global gene expression analysis in testicular biopsies from infertile men. Mol Reprod Dev (2003) 0.93
Analysis of replication protein A (RPA) in human spermatogenesis. Mol Hum Reprod (2007) 0.91
Definition and current evaluation of subfertile men. Int Braz J Urol (2006) 0.91
Variants in Deleted in AZoospermia-Like (DAZL) are correlated with reproductive parameters in men and women. Hum Genet (2005) 0.91
Posthumous sperm retrieval: analysis of time interval to harvest sperm. Hum Reprod (2006) 0.91
The kinetics of the return of motile sperm to the ejaculate after vasectomy reversal. J Urol (2007) 0.89
Ejaculatory duct obstruction. Urol Clin North Am (2008) 0.89
What every graduating medical student should know about urology: the stakeholder viewpoint. Urology (2008) 0.86
Centromere protein A dynamics in human pluripotent stem cell self-renewal, differentiation and DNA damage. Hum Mol Genet (2010) 0.86
Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins. Hum Reprod (2014) 0.86
The value of testicular 'mapping' in men with non-obstructive azoospermia. Asian J Androl (2011) 0.85
Recombination in men with Klinefelter syndrome. Reproduction (2005) 0.84
PRMT5 is required for human embryonic stem cell proliferation but not pluripotency. Stem Cell Rev (2014) 0.84
A prospective comparison of 3 diagnostic methods to evaluate ejaculatory duct obstruction. J Urol (2004) 0.84
An assessment of new sperm tests for male infertility. Urology (2011) 0.83
Clinically symptomatic vasitis: clinical correlations in a rare condition. Syst Biol Reprod Med (2010) 0.83
Variability in testis biopsy interpretation: implications for male infertility care in the era of intracytoplasmic sperm injection. Fertil Steril (2005) 0.82
Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog. PLoS One (2011) 0.82
Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation. J Biol Chem (2009) 0.82
Improved detection of cystic fibrosis mutations in infertility patients with DNA sequence analysis. Hum Reprod (2004) 0.82
Racial differences among boys with testicular germ cell tumors in the United States. J Urol (2008) 0.81
Testicular germline stem cells. Nat Rev Urol (2010) 0.81
Ejaculatory duct manometry in normal men and in patients with ejaculatory duct obstruction. J Urol (2008) 0.80
Sperm retrieval techniques. Nat Rev Urol (2013) 0.79
Bilateral but not unilateral testicular hypotrophy predicts for severe impairment of semen quality in men with varicocele undergoing infertility evaluation. Urology (2008) 0.79
The difficult MESA: findings from tubuli recti sperm aspiration. J Assist Reprod Genet (2004) 0.78
A seminal molecular marker for sperm presence in non-obstructive azoospermia? Reprod Biomed Online (2016) 0.77
Intermolecular interactions of homologs of germ plasm components in mammalian germ cells. Dev Biol (2006) 0.77
Differences in the clinical characteristics of primarily and secondarily infertile men with varicocele. Fertil Steril (2008) 0.77
Vardenafil allows successful intercourse initiated rapidly after dosing in Japanese patients with diabetes mellitus and erectile dysfunction. J Sex Med (2009) 0.76
Cdk2ap2 is a novel regulator for self-renewal of murine embryonic stem cells. Stem Cells Dev (2012) 0.76
The genetic and phenotypic basis of infertility in men with pediatric urologic disorders. Urology (2010) 0.75
Retracted Epigenetically reprogramming of human embryonic stem cells by 3-deazaneplanocin a and sodium butyrate. Int J Prev Med (2011) 0.75
Use of viscoelastic solution to improve visualization during urologic microsurgery: evaluation of patency after vasovasostomy. Urology (2008) 0.75
The cost-effectiveness of treatments for male infertility. Expert Rev Pharmacoecon Outcomes Res (2008) 0.75
Spermatoceles in adults: when does size matter? Arch Androl (2008) 0.75
Erratum: MORC1 represses transposable elements in the mouse male germline. Nat Commun (2015) 0.75
Synopsis: 2005 annual meeting of the American Society of Andrology. J Androl (2005) 0.75
Correction: In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse. Elife (2017) 0.75
Avoiding toxins including spermatotoxic medications. Semin Reprod Med (2013) 0.75
Use of human chorionic gonadotropin in a male Pacific walrus (Odobenus rosmarus divergens) to induce rut and achieve a pregnancy in a nulliparous female. J Androl (2011) 0.75