Published in PLoS One on August 03, 2012
Mechanisms of cohesin-mediated gene regulation and lessons learned from cohesinopathies. Biochim Biophys Acta (2013) 0.97
Chemotherapy reduces PARP1 in cancers of the ovary: implications for future clinical trials involving PARP inhibitors. BMC Med (2015) 0.84
Transposable Elements and DNA Methylation Create in Embryonic Stem Cells Human-Specific Regulatory Sequences Associated with Distal Enhancers and Noncoding RNAs. Genome Biol Evol (2015) 0.79
Evidence-Based Theory for Integrated Genome Regulation of Ontogeny-An Unprecedented Role of Nuclear FGFR1 Signaling. J Cell Physiol (2016) 0.78
The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages. J Cell Biol (2016) 0.75
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
CTCF: master weaver of the genome. Cell (2009) 15.09
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature (2000) 14.91
An extended transcriptional network for pluripotency of embryonic stem cells. Cell (2008) 14.64
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 14.17
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature (2000) 12.97
Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature (2008) 12.01
Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol Cell (2002) 11.35
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell (1999) 9.74
Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell (2008) 7.80
Feeder-independent culture of human embryonic stem cells. Nat Methods (2006) 7.61
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41
Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat Methods (2005) 6.37
BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol (2002) 6.20
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95
Chemically defined conditions for human iPSC derivation and culture. Nat Methods (2011) 5.84
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development (2005) 5.80
An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol Cell Biol (1996) 5.74
CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species. Mol Cell (2004) 5.51
Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Nat Genet (2004) 5.47
Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive. Curr Biol (2000) 5.34
Transposable elements have rewired the core regulatory network of human embryonic stem cells. Nat Genet (2010) 5.26
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development (2005) 4.89
CTCF physically links cohesin to chromatin. Proc Natl Acad Sci U S A (2008) 4.89
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature (2010) 3.84
The transcriptome profile of human embryonic stem cells as defined by SAGE. Stem Cells (2004) 3.78
Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Nat Genet (2004) 3.56
Genetics and epigenetics of the multifunctional protein CTCF. Curr Top Dev Biol (2008) 3.01
Transgenic RNAi reveals essential function for CTCF in H19 gene imprinting. Science (2004) 2.98
Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer (2005) 2.84
Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis. Science (2007) 2.70
Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells. Proc Natl Acad Sci U S A (2008) 2.29
Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary. Mol Cell (2009) 2.21
Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. Cancer Res (2006) 1.94
CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators. Nucleic Acids Res (2007) 1.89
The c-myc insulator element and matrix attachment regions define the c-myc chromosomal domain. Mol Cell Biol (2003) 1.77
Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells. Genes Dev (2008) 1.68
Specific sites in the C terminus of CTCF interact with the SA2 subunit of the cohesin complex and are required for cohesin-dependent insulation activity. Mol Cell Biol (2011) 1.68
Positional enhancer-blocking activity of the chicken beta-globin insulator in transiently transfected cells. Proc Natl Acad Sci U S A (1999) 1.56
Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. Stem Cells (2004) 1.56
CTCF regulates cell cycle progression of alphabeta T cells in the thymus. EMBO J (2008) 1.55
The transcriptional network controlling pluripotency in ES cells. Cold Spring Harb Symp Quant Biol (2008) 1.41
Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. Development (2008) 1.32
GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene. Development (1994) 1.16
Role for Med12 in regulation of Nanog and Nanog target genes. J Biol Chem (2008) 1.16
Targeted deletion of multiple CTCF-binding elements in the human C-MYC gene reveals a requirement for CTCF in C-MYC expression. PLoS One (2009) 1.05
Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev (2006) 4.06
Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes. Mol Cell (2003) 3.06
p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Mol Cell (2003) 3.05
Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science (2011) 2.28
Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary. Mol Cell (2009) 2.21
BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. J Biol Chem (2008) 1.80
A methylation-mediator complex in hormone signaling. Genes Dev (2004) 1.61
An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. Nat Rev Cancer (2011) 1.58
Regulation of the p53 transcriptional response by structurally diverse core promoters. Genes Dev (2009) 1.52
The HS2 enhancer of the beta-globin locus control region initiates synthesis of non-coding, polyadenylated RNAs independent of a cis-linked globin promoter. J Mol Biol (2005) 1.23
Mechanisms of chromatin assembly and transcription. Curr Opin Cell Biol (2002) 1.10
Identification of mammalian cell lines using MALDI-TOF and LC-ESI-MS/MS mass spectrometry. J Am Soc Mass Spectrom (2006) 0.90
Identification of kinase inhibitors that target transcription initiation by RNA polymerase II. Oncotarget (2011) 0.88
Remodeling plans for cellular specialization: unique styles for every room. Curr Opin Genet Dev (2006) 0.87
Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response. Mol Cell (2013) 0.87
Is there an epigenetic component underlying the resistance of triple-negative breast cancers to parp inhibitors? Front Pharmacol (2012) 0.75
Cytokines and retinoic acid therapy for APL: new tricks from an old combination. Leuk Res (2004) 0.75