Published in J Immunol on November 01, 2005
Toll-like receptors control autophagy. EMBO J (2008) 4.50
Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29
Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages. Immunity (2007) 4.17
Activation of antibacterial autophagy by NADPH oxidases. Proc Natl Acad Sci U S A (2009) 3.87
Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab (2010) 3.29
Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol (2013) 3.23
CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. J Neurosci (2009) 2.69
Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. J Biol Chem (2009) 2.33
Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system. PLoS Pathog (2007) 1.93
Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways. Circ Res (2011) 1.83
SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages. Nat Immunol (2010) 1.68
Air pollution and type 2 diabetes: mechanistic insights. Diabetes (2012) 1.54
Autophagy and pattern recognition receptors in innate immunity. Immunol Rev (2009) 1.51
Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction. Infect Immun (2008) 1.40
ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. Circ Res (2010) 1.37
The many roles of NOX2 NADPH oxidase-derived ROS in immunity. Semin Immunopathol (2010) 1.36
MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei. PLoS One (2008) 1.33
ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli. J Biol Chem (2009) 1.21
Vav proteins control MyD88-dependent oxidative burst. Blood (2006) 1.19
NOX enzymes and Toll-like receptor signaling. Semin Immunopathol (2008) 1.13
Cross-talk between IRAK-4 and the NADPH oxidase. Biochem J (2007) 1.07
IL-10 modulates DSS-induced colitis through a macrophage-ROS-NO axis. Mucosal Immunol (2013) 1.07
Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia. Blood (2009) 1.06
Regulation of MyD88-dependent signaling events by S nitrosylation retards toll-like receptor signal transduction and initiation of acute-phase immune responses. Mol Cell Biol (2007) 1.06
The Role of the spv Genes in Salmonella Pathogenesis. Front Microbiol (2011) 1.04
Thiol peroxidase protects Salmonella enterica from hydrogen peroxide stress in vitro and facilitates intracellular growth. J Bacteriol (2010) 1.03
CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice. J Immunol (2010) 0.98
Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K. J Immunol (2009) 0.94
The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun (2008) 0.93
Proteomic investigation of the time course responses of RAW 264.7 macrophages to infection with Salmonella enterica. Infect Immun (2009) 0.93
Intracellular events regulating cross-presentation. Front Immunol (2012) 0.93
Insights into phagocytosis-coupled activation of pattern recognition receptors and inflammasomes. Curr Opin Immunol (2013) 0.91
Map kinase phosphatase 5 protects against sepsis-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol (2012) 0.90
Reactive oxygen species and nitric oxide in cutaneous leishmaniasis. J Parasitol Res (2012) 0.89
The Wingless homolog Wnt5a stimulates phagocytosis but not bacterial killing. Proc Natl Acad Sci U S A (2012) 0.88
Complement receptor 3 and Toll-like receptor 4 act sequentially in uptake and intracellular killing of unopsonized Salmonella enterica serovar Typhimurium by human neutrophils. Infect Immun (2007) 0.88
TLR Cross-Talk Mechanism of Hemorrhagic Shock-Primed Pulmonary Neutrophil Infiltration. Open Crit Care Med J (2010) 0.88
Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2. Elife (2015) 0.86
MyD88 associated ROS generation is crucial for Lactobacillus induced IL-12 production in macrophage. PLoS One (2012) 0.86
Chronic pulmonary LPS tolerance induces selective immunosuppression while maintaining the neutrophilic response. Shock (2010) 0.83
Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria. Elife (2015) 0.83
SB203580, a p38 inhibitor, improved cardiac function but worsened lung injury and survival during Escherichia coli pneumonia in mice. J Trauma (2010) 0.82
Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase. Am J Respir Cell Mol Biol (2010) 0.82
NADPH phagocyte oxidase knockout mice control Trypanosoma cruzi proliferation, but develop circulatory collapse and succumb to infection. PLoS Negl Trop Dis (2012) 0.81
Expression of Toll/IL-1R domain-containing adaptor protein (TIRAP) is detrimental to primary clearance of Salmonella and is not required for the generation of protective immunity. Immunol Lett (2007) 0.80
TAK1 regulates Paneth cell integrity partly through blocking necroptosis. Cell Death Dis (2016) 0.79
'Nodophagy': New crossroads in Crohn disease pathogenesis. Gut Microbes (2010) 0.79
Fine-mapping and phenotypic analysis of the Ity3 Salmonella susceptibility locus identify a complex genetic structure. PLoS One (2014) 0.79
Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis. PLoS Pathog (2014) 0.79
TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis. J Immunol (2014) 0.78
Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in mice. PLoS One (2013) 0.78
Intracellular regulation of cross-presentation during dendritic cell maturation. PLoS One (2013) 0.78
Impact of reactive oxygen species (ROS) on the control of parasite loads and inflammation in Leishmania amazonensis infection. Parasit Vectors (2016) 0.77
Syk phosphorylation - a gravisensitive step in macrophage signalling. Cell Commun Signal (2015) 0.77
MyD88-dependent signaling prolongs survival and reduces bacterial burden during pulmonary infection with virulent Francisella tularensis. Am J Pathol (2013) 0.76
Hyper-responsive Toll-like receptor 7 and 9 activation in NADPH oxidase-deficient B lymphoblasts. Immunology (2015) 0.75
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell (2005) 24.00
Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load. Immunity (2011) 3.19
Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity (2007) 3.02
Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer. Blood (2007) 2.70
SAP couples Fyn to SLAM immune receptors. Nat Cell Biol (2003) 2.27
The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease. Nat Rev Immunol (2003) 2.26
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus. J Clin Invest (2016) 2.06
Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells. Blood (2013) 1.98
Signaling lymphocytic activation molecule-associated protein controls NKT cell functions. J Immunol (2005) 1.98
Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry. Cell Immunol (2005) 1.79
Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression. J Immunol (2004) 1.79
The SLAM and SAP gene families control innate and adaptive immune responses. Adv Immunol (2008) 1.79
Colitis is associated with thymic destruction attenuating CD4+25+ regulatory T cells in the periphery. Gastroenterology (2004) 1.78
The cell surface receptor SLAM controls T cell and macrophage functions. J Exp Med (2004) 1.77
T cells as therapeutic targets in SLE. Nat Rev Rheumatol (2010) 1.75
SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages. Nat Immunol (2010) 1.68
The SLAM-associated protein signaling pathway is required for development of CD4+ T cells selected by homotypic thymocyte interaction. Immunity (2007) 1.58
Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology (2002) 1.45
Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer. Hum Gene Ther (2009) 1.36
Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency. J Exp Med (2010) 1.35
Enhanced antitumor immunity in mice deficient in CD69. J Exp Med (2003) 1.29
CD molecules 2005: human cell differentiation molecules. Blood (2005) 1.27
B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood (2012) 1.27
GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells. Int Immunol (2010) 1.24
SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions. Semin Immunopathol (2010) 1.23
CD molecules 2006--human cell differentiation molecules. J Immunol Methods (2006) 1.23
Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation. Immunity (2004) 1.22
Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation. Blood (2002) 1.21
Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions. J Immunol (2005) 1.21
Defective B cell responses in the absence of SH2D1A. Proc Natl Acad Sci U S A (2005) 1.21
Neisseria gonorrhoeae enhances infection of dendritic cells by HIV type 1. J Immunol (2005) 1.20
Relative roles of ICAM-1 and VCAM-1 in the pathogenesis of experimental radiation-induced intestinal inflammation. Int J Radiat Oncol Biol Phys (2003) 1.19
Nonredundant roles of IL-10 and TGF-β in suppression of immune responses to hepatic AAV-factor IX gene transfer. Mol Ther (2011) 1.18
Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling. Blood (2005) 1.18
Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity. PLoS One (2009) 1.17
A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J (2002) 1.15
Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation. Immunity (2012) 1.15
Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. Blood (2012) 1.13
New B-cell CD molecules. Immunol Lett (2010) 1.10
The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production. Blood (2002) 1.10
CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse. J Immunol (2005) 1.10
Control freaks: immune regulatory cells. Nat Immunol (2004) 1.08
Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse. J Immunol (2010) 1.07
A novel isoform of the Ly108 gene ameliorates murine lupus. J Exp Med (2011) 1.07
Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. Proc Natl Acad Sci U S A (2010) 1.04
SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9. Int Immunol (2004) 1.04
Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2. Int Immunol (2004) 1.00
The role of P-selectin in experimental colitis as determined by antibody immunoblockade and genetically deficient mice. J Leukoc Biol (2002) 1.00
Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation. J Immunol (2011) 1.00
The adaptor protein 3BP2 binds human CD244 and links this receptor to Vav signaling, ERK activation, and NK cell killing. J Immunol (2005) 0.99
Expression of SLAM (CD150) cell-surface receptors on human B-cell subsets: from pro-B to plasma cells. Immunol Lett (2010) 0.99
Increased proliferation of CD8+ T cells in SAP-deficient mice is associated with impaired activation-induced cell death. Eur J Immunol (2007) 0.98
Dynamic redistribution of the activating 2B4/SAP complex at the cytotoxic NK cell immune synapse. J Immunol (2004) 0.98
Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229. J Immunol (2005) 0.96
Mechanism of oral tolerance induction to therapeutic proteins. Adv Drug Deliv Rev (2012) 0.96
Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism. J Immunol (2012) 0.95
SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells. Blood (2005) 0.95
Signaling lymphocyte activation molecule-associated protein is a negative regulator of the CD8 T cell response in mice. J Immunol (2005) 0.95
Role of the CD5 molecule on TCR gammadelta T cell-mediated immune functions: development of germinal centers and chronic intestinal inflammation. Int Immunol (2003) 0.94
Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule. Am J Pathol (2007) 0.93
CD48 controls T-cell and antigen-presenting cell functions in experimental colitis. Gastroenterology (2006) 0.93
SAP expression in invariant NKT cells is required for cognate help to support B-cell responses. Blood (2012) 0.92
Identification and characterization of SF2000 and SF2001, two new members of the immune receptor SLAM/CD2 family. Immunogenetics (2002) 0.92
Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters. Immunogenetics (2006) 0.92
Substance P autocrine signaling contributes to persistent HER2 activation that drives malignant progression and drug resistance in breast cancer. Cancer Res (2013) 0.92
Cutting edge: an NK cell-independent role for Slamf4 in controlling humoral autoimmunity. J Immunol (2011) 0.91
Blocking CD27-CD70 costimulatory pathway suppresses experimental colitis. J Immunol (2009) 0.91
Syndecan-2 and -4 expressed on activated primary human CD4+ lymphocytes can regulate T cell activation. Mol Immunol (2008) 0.91
p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation. J Immunol (2012) 0.91
The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading. PLoS One (2011) 0.91
Induction of tumor NK-cell immunity by anti-CD69 antibody therapy. Blood (2005) 0.91
SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells. Autoimmunity (2011) 0.91
Rab5 activation by Toll-like receptor 2 is required for Trypanosoma cruzi internalization and replication in macrophages. Traffic (2008) 0.90
Concanavalin-A-induced liver injury is severely impaired in mice deficient in P-selectin. J Leukoc Biol (2002) 0.89
Sinusoidal endothelial COX-1-derived prostanoids modulate the hepatic vascular tone of cirrhotic rat livers. Am J Physiol Gastrointest Liver Physiol (2004) 0.89
T cell-specific expression of the murine CD3delta promoter. J Biol Chem (2002) 0.88
Glucocorticoid-induced tumor necrosis factor receptor family-related protein regulates CD4(+)T cell-mediated colitis in mice. Gastroenterology (2011) 0.88
Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages. J Immunol (2012) 0.88
I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion. J Immunol (2004) 0.88
Cutting edge: Ly9 (CD229), a SLAM family receptor, negatively regulates the development of thymic innate memory-like CD8+ T and invariant NKT cells. J Immunol (2012) 0.88
Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice. Int Immunol (2011) 0.87
Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry. Immunol Lett (2010) 0.87
Differential expression of CD150 (SLAM) family receptors by human hematopoietic stem and progenitor cells. Exp Hematol (2008) 0.87