Published in J Immunol on October 20, 2010
Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load. Immunity (2011) 3.19
Merck Ad5/HIV induces broad innate immune activation that predicts CD8⁺ T-cell responses but is attenuated by preexisting Ad5 immunity. Proc Natl Acad Sci U S A (2012) 1.46
2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses. J Exp Med (2014) 1.06
EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization. J Exp Med (2014) 1.00
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NK cell cytotoxicity mediated by 2B4 and NTB-A is dependent on SAP acting downstream of receptor phosphorylation. Front Immunol (2013) 0.76
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Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase. Immunity (2010) 1.25
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SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell (2005) 24.00
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Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity (2007) 3.02
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SAP couples Fyn to SLAM immune receptors. Nat Cell Biol (2003) 2.27
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Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells. Blood (2013) 1.98
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Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria. J Immunol (2005) 1.87
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Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression. J Immunol (2004) 1.79
The SLAM and SAP gene families control innate and adaptive immune responses. Adv Immunol (2008) 1.79
Colitis is associated with thymic destruction attenuating CD4+25+ regulatory T cells in the periphery. Gastroenterology (2004) 1.78
The cell surface receptor SLAM controls T cell and macrophage functions. J Exp Med (2004) 1.77
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Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing. Proc Natl Acad Sci U S A (2003) 1.75
SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages. Nat Immunol (2010) 1.68
The SLAM-associated protein signaling pathway is required for development of CD4+ T cells selected by homotypic thymocyte interaction. Immunity (2007) 1.58
Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology (2002) 1.45
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B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood (2012) 1.27
GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells. Int Immunol (2010) 1.24
SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions. Semin Immunopathol (2010) 1.23
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Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation. Immunity (2004) 1.22
Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation. Blood (2002) 1.21
Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions. J Immunol (2005) 1.21
Defective B cell responses in the absence of SH2D1A. Proc Natl Acad Sci U S A (2005) 1.21
Relative roles of ICAM-1 and VCAM-1 in the pathogenesis of experimental radiation-induced intestinal inflammation. Int J Radiat Oncol Biol Phys (2003) 1.19
Nonredundant roles of IL-10 and TGF-β in suppression of immune responses to hepatic AAV-factor IX gene transfer. Mol Ther (2011) 1.18
Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling. Blood (2005) 1.18
Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity. PLoS One (2009) 1.17
A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J (2002) 1.15
Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation. Immunity (2012) 1.15
Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2. Mol Ther (2005) 1.15
Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. Blood (2012) 1.13
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The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production. Blood (2002) 1.10
CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse. J Immunol (2005) 1.10
Reciprocal responsiveness to interleukin-12 and interferon-alpha specifies human CD8+ effector versus central memory T-cell fates. Blood (2009) 1.08
Control freaks: immune regulatory cells. Nat Immunol (2004) 1.08
A novel isoform of the Ly108 gene ameliorates murine lupus. J Exp Med (2011) 1.07
Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. Proc Natl Acad Sci U S A (2010) 1.04
SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9. Int Immunol (2004) 1.04
Association of KIR genotypes and haplotypes with susceptibility to chronic hepatitis B virus infection in Chinese Han population. Cell Mol Immunol (2008) 1.03
A combination of mutations enhances the neurotropism of AAV-2. Virology (2005) 1.02
Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2. Int Immunol (2004) 1.00
The role of P-selectin in experimental colitis as determined by antibody immunoblockade and genetically deficient mice. J Leukoc Biol (2002) 1.00
Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation. J Immunol (2011) 1.00
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The adaptor protein 3BP2 binds human CD244 and links this receptor to Vav signaling, ERK activation, and NK cell killing. J Immunol (2005) 0.99
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Dynamic redistribution of the activating 2B4/SAP complex at the cytotoxic NK cell immune synapse. J Immunol (2004) 0.98
Increased proliferation of CD8+ T cells in SAP-deficient mice is associated with impaired activation-induced cell death. Eur J Immunol (2007) 0.98
Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229. J Immunol (2005) 0.96
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Signaling lymphocyte activation molecule-associated protein is a negative regulator of the CD8 T cell response in mice. J Immunol (2005) 0.95
SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells. Blood (2005) 0.95
Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism. J Immunol (2012) 0.95
2B4 is constitutively associated with linker for the activation of T cells in glycolipid-enriched microdomains: properties required for 2B4 lytic function. J Immunol (2002) 0.94
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Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule. Am J Pathol (2007) 0.93
CD48 controls T-cell and antigen-presenting cell functions in experimental colitis. Gastroenterology (2006) 0.93
SAP expression in invariant NKT cells is required for cognate help to support B-cell responses. Blood (2012) 0.92
Identification and characterization of SF2000 and SF2001, two new members of the immune receptor SLAM/CD2 family. Immunogenetics (2002) 0.92
Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters. Immunogenetics (2006) 0.92
The murine NK receptor 2B4 (CD244) exhibits inhibitory function independent of signaling lymphocytic activation molecule-associated protein expression. J Immunol (2004) 0.92
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Optimized adeno-associated virus 8 produces hepatocyte-specific Cre-mediated recombination without toxicity or affecting liver regeneration. Am J Physiol Gastrointest Liver Physiol (2008) 0.91
Cutting edge: an NK cell-independent role for Slamf4 in controlling humoral autoimmunity. J Immunol (2011) 0.91
Blocking CD27-CD70 costimulatory pathway suppresses experimental colitis. J Immunol (2009) 0.91
The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading. PLoS One (2011) 0.91
Induction of tumor NK-cell immunity by anti-CD69 antibody therapy. Blood (2005) 0.91
SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells. Autoimmunity (2011) 0.91
p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation. J Immunol (2012) 0.91
Syndecan-2 and -4 expressed on activated primary human CD4+ lymphocytes can regulate T cell activation. Mol Immunol (2008) 0.91
Rab5 activation by Toll-like receptor 2 is required for Trypanosoma cruzi internalization and replication in macrophages. Traffic (2008) 0.90
Concanavalin-A-induced liver injury is severely impaired in mice deficient in P-selectin. J Leukoc Biol (2002) 0.89
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Glucocorticoid-induced tumor necrosis factor receptor family-related protein regulates CD4(+)T cell-mediated colitis in mice. Gastroenterology (2011) 0.88
Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages. J Immunol (2012) 0.88